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International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study

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Chinese Journal of Cancer 2014年第10期33卷 481-491页

作者： Stephen L.Chan Philip J.Johnson frankie Mo Sarah Berhane Mabel Teng Anthony w.H.Chan Ming C.poon paul B.S.Lai Simon Yu Anthony T.C.Chan winnie Yeo State Key Laboratory in Oncology in South China Sir YK Pao Center for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong School of Cancer Sciences University of Birmingham the Department of Molecular and Clinical Cancer Medicine Institute of Translational MedicineUniversity of Liverpool Department of Anatomical Cellular and PathologyThe Chinese University of Hong Kong Department of Surgery The Chinese University of Hong Kong Department of Radiology and Organ Imaging The Chinese University of Hong Kong

The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) for the prognostication of HCC among the Asian HCC patient population. In the current study, we aimed to validate the CUPI using an international cohort of patients with HCC and to compare the CUPI to two widely used staging systems, the Barcelona Clinic Liver Cancer(BCLC) classification and the Cancer of the Liver Italian Program(CLIP). To accomplish this goal, two cohorts of patients were enrolled in the United Kingdom(UK; n = 567; 2006-2011) and Hong Kong(HK; n = 517; 2007-2012). The baseline clinical data were recorded. The performances of the CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. The results revealed that the median follow-up durations of the UK and HK cohorts were 27.9 and 29.8 months, respectively. The median overall survival of the UK and HK cohorts were 22.9 and 8.6 months, respectively. The CUPI stratified the patients in both cohorts into three risk subgroups corresponding to distinct outcomes. The median overall survival of the CUPI low-, intermediate-, and high-risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in the UK cohort and were 2.07, 0.32, and 0.10 years, respectively, in the HK cohort. for the patients who underwent curative treatment, the prognostic performance did not differ between the three staging systems, and all were suboptimal. for those who underwent palliative treatment, the CUPI displayed the highest C-index, indicating that this staging system was the most informative for both cohorts. In conclusion, the CUPI is applicable to both western and eastern HCC patient populations. The performances of the three staging systems differed according to treatment intent, and the CUPI was demonstrated to be opti

关键词：香港英国预后肝癌验证国际大学中国

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Contribution of molecular cladistics to the taxonomy of Rutaceae in China

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Journal of Systematics and Evolution 2009年第2期47卷 144-150页

作者： paul Pui-Hay BUT Alice wing-Sem poon Pang-Chui SHAw Mark P.SIMMONS Harald GREGER Department of Biology Chinese University of Hong Kong Department of Biochemistry Chinese University of Hong Kong Department of Biology Colorado State UniversityFort Collins Comparative and Ecological Phytochemistry Faculty Center of BotanyUniversity of Vienna

The treatment of Rutaceae in the Chinese flora chose to follow Engler in recognizing Rutoideae and Toddalioideae as two separate *** and chemical comparisons,however,suggested group-ing those two subfamilies in one subfamily,*** move has received support from molecular phyloge-netic analyses,which also showed that the Chinese taxa in Euodia should be placed in Tetradium and Melicope following *** into the chemistry and molecular phylogeny of Murraya also indicated that the species in the section Bergera without yuehchukene should be removed from *** findings clearly show the value of molecular cladistics to the taxonomy of Rutaceae in China and also directions for further inves-tigations.

关键词： Bergera Euodia Melicope Murraya Rutaceae Rutoideae Tetradium Toddalioideae

Prospective,multicentre study of screening,investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland

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Stroke & Vascular Neurology 2023年第3期8卷 207-216,I0028-I0059页

作者： James J M Loan Steven Tominey Kirun Baweja Julie woodfield Thomas J G Chambers Mark Haley Simran S Kundu H Y Josephine Tang Anthony N wiggins Michael T C poon paul M Brennan Translational Neurosurgery The University of Edinburgh Centre for Clinical Brain SciencesEdinburghUK Neurosurgery NHS LothianEdinburghUK Neurosurgery Institute of Neurological SciencesGlasgowUK Department of Medicine School of MedicineDentisty and NuringUniversity of GlasgowGlasgowUK Internal Medicine Queen's UniversityKingstonOntarioCanada Centre for Discovery Brain Sciences University of EdinburghEdinburghUK Edinburgh Centre for Diabetes and Endocrinology NHS LothianEdinburghUK Radiology University Hospitals Plymouth NHS TrustPlymouthUK Department of Medicine Cork University HospitalUniversity College CorkCorkIreland

Background Hyponatraemia often occurs after subarachnoid haemorrhage(SAH).However,its clinical significance and optimal management are *** audited the screening,investigation and management of hyponatraemia after *** we prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or *** reviewed medical records daily from admission to discharge,21 days or death and extracted all measurements of serum sodium to identify hyponatraemia(were death/dependency at discharge or 21 days and admission duration>10 *** of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission *** assessed hyponatraemia-free survival using multivariable Cox *** 175/407(43%)patients admitted to 24 neurosurgical units developed hyponatraemia.5976 serum sodium measurements were *** osmolality,urine osmolality and urine sodium were measured in 30/166(18%)hyponatraemic patients with complete *** most frequently target daily fluid intake was>3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes.26%(n/N=42/164)patients with hyponatraemia received sodium supplementation.133(35%)patients were dead or dependent within the study period and 240(68%)patients had hospital admission for over 10 *** the multivariable analyses,hyponatraemia was associated with less dependency(adjusted OR(aOR)=0.35(95%CI 0.17 to 0.69))but longer admissions(aOR=3.2(1.8 to 5.7)).world federation of Neurosurgical Societies grade I-III,modified fisher 2-4 and posterior circulation aneurysms were associated with greater hazards of *** In this comprehensive multicentre prospective-adjusted analysis of patients with SAH,hyponatraemia was investigated inconsistently and,for most patients,was not associated with changes in management or clinical outcome.T

关键词： admitted urine centre

Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma

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world Journal of Gastroenterology 2005年第42期11卷 6701-6706页

作者： Terence Cw poon Clarissa HS Chiu paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson Department of Medicine and Therapeutics Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Department of Clinical Oncology Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Department of Surgery Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Cancer Research UK Institute for Cancer Studies University of Birmingham Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom

AIM： To investigate the correlation between tissue ST6Gal I and serum msAfP in HCC patients, and to investigate their prognostic significance. METHODS： Preoperative sera, paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC. ST6Gal I activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAfP in the sera were also estimated by an isoelectric focusing-immunoblotting assay. RESULTS： The tumor ST6Gal I activity was negatively correlated with serum msAfP percentage （r = -0.53, P = 0.019）. Both decreased tumor ST6Gal I activity and increased serum msAfP percentage were associated with poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal I activity （P = 0.028）, increased serum msAfP percentage （P = 0.034） and poor tumor cell differentiation （P = 0.031）were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAfP percentage （P = 0.022） and tumor cell differentiation status （P = 0.048） were independent prognostic indicators for patient overall survival. CONCLUSION： Our results indicate that the presence of msAfP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAfP are potential prognostic markers for patients with operable HCC.

关键词： Alpha-fetoprotein Beta-galactoside alpha-2,6-sialyltransferase Hepatocellular carcinoma Patientsurvival Cell differentiation

金融行为监管局和审慎监管局的设立:不仅仅是结构转变?

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公司法律评论 2014年第1期 242-257页

作者：薛晟(译) Helen Marshall Christopher Leonard Rosemarie paul Ezra Zahabi Chris poon Cecile Chastre Jessica Howlett 不详

引言2013年是加强监管的一年。在一系列政策颁布之后,2013年内金融监管的格局发生了巨大的变化。英国撤销了金融服务管理局,设立了审慎监管局和金融行为监管局。在本次合规专员公告中,我们研究得出,新监管机构的设立将对金融监管方式产... 详细信息

引言2013年是加强监管的一年。在一系列政策颁布之后,2013年内金融监管的格局发生了巨大的变化。英国撤销了金融服务管理局,设立了审慎监管局和金融行为监管局。在本次合规专员公告中,我们研究得出,新监管机构的设立将对金融监管方式产生重要影响。监管部门似乎决定建立新的监管形式.

关键词：金融英国影响专员利益合规监管监管局

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复杂功能超高层建筑的结构设计挑战

建筑结构 2011年第7期41卷 I0023-I0029页

作者： Dennis poon paul Lew Ling-En Hsiao Yi Zhu paul fu Steve Zuo Thomton Tomasetti Inc. 美国宋腾添玛沙帝工程顾问公司

复杂超高层建筑结构设计最严峻的挑战是结构本身承受的巨大内力、结构达到预期性能目标所需的大量材料，以及在地震及风荷载作用引起的巨大构件连接内力下仍能达到良好延性的构件连接方式。这些巨大内力、位移和材料必须受到施工条件的... 详细信息

复杂超高层建筑结构设计最严峻的挑战是结构本身承受的巨大内力、结构达到预期性能目标所需的大量材料，以及在地震及风荷载作用引起的巨大构件连接内力下仍能达到良好延性的构件连接方式。这些巨大内力、位移和材料必须受到施工条件的限制，设计者必须找到能够充分利用现有施工条件的解决方案。为了达到预期的性能目标，塔楼的巨大位移必须控制在幕墙体系、其他非结构构件以及人体反应所能接受的范围内。本文将讨论超高层结构设计中的各种问题，以及通过现有的分析工具来应对各种设计挑战。另外将讨论超高层结构在现实存在的施工技术限制下如何保证施工的可行性。综合性超高层建筑中存在的楼面功能多变性使这些设计挑战更加严峻。通过Thornton Tomasetti公司（简称TT）以前完成和现在正在设计中的一些超高层结构设计项目来叙述如何应对各种挑战。

关键词：超高层传力路径材料抗侧力体系延性节点