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A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction

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南京医科大学学报（自然科学版） 2009年第4期29卷 529-529页

作者： y.n, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. y.C. Chen, J. Lu, y. Bi, y. Zhao, C. du, y. Ma, M. Cai, y. Chen, W. y. Fok, K. L. Tsang, L. L. Li, K. Ni, y. Chung, y. W. Zhou, Z. Sha, J. Chan, H. C. Nanjing Med Univ Lab Reprod Med Dept Histol & Embryol Nanjing 210029 Peoples R China. Chinese Univ Hong Kong Epithelial Cell Biol Res Ctr Li Ka Shing Inst Hlth Sci Dept Physiol Fac Med Hong Kong Hong Kong Peoples R China. Nanjing Agr Univ Coll Anim Sci & Technol Nanjing 210095 Peoples R China. Zhejiang Acad Med Sci Dept Reprod Physiol Hangzhou 310013 Zhejiang Peoples R China.

Enantio-divergent C–H bory.ation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期 226-232页

作者： Rongrong du Senmiao Xu State Key.Laboratory.for Oxo Sy.thesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry.and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University.of Chinese Academy.of Sciences

Reported here is an iridium-cataly.ed enantio-divergent C（sp3）–H bory.ation of α-gem-dimethy. groups of trifluoromethy. ketone-derived hy.razones to construct a series of acy.lic all-carbon quaternary.stereocenters with a high level of chiral induction. Two different chiral bidentate bory. ligands from a common chiral source not only.can switch the enantioselectivity.but also are complementary.in terms of the substrate scope.

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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei du Department of Pathology.and Laboratory.Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by.OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by.analy.ing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analy.is of LLMs’current and potential impact on clinical *** ability.to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

The autophagy.ly.osome pathway.a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingy.n Meng Kang du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracy.oplasmic deposition of aggregate proteins such asα-sy.uclein in *** one of the major intracellular degradation pathway.,the autophagy.ly.osome pathway.play. an important role in eliminating these *** evidence has shown that upregulation of the autophagy.ly.osome pathway.may.contribute to the clearance ofα-sy.uclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately.linked to alterations in the autophagy.ly.osome ***,this pathway.appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly.introduce the machinery.of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy.ly.osome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy.ly.osome pathway.and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-sy.uclein

Py.optosis,ferroptosis,and autophagy.in spinal cord injury.regulatory.mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng du Wang Rongjie Lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively.controlled by.*** studies have shown that regulated cell death play. a key.role after spinal cord *** and ferroptosis are newly.discovered ty.es of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study.of spinal cord *** injury.triggers not only.cell death but also cellular survival *** signaling pathway. play.pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury.by.regulating py.optosis,ferroptosis,and ***,this review aims to comprehensively.examine the mechanisms underly.ng regulated cell deaths,the signaling pathway. that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analy.is suggests that targeting the common regulatory.signaling pathway. of different regulated cell deaths could be a promising strategy.to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory.pathway. presents a promising multi-target therapeutic strategy.for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms py.optosis regulated cell death regulatory.pathway. spinal cord injury therapeutic targets

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy.and Materials 2025年第2期32卷 402-413页

作者： Tao Zou y.nwu Dong Zhouhua Jiang Shuy.ng du y.shuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key.Laboratory.of Rolling and Automation Northeastern UniversityShenyang 110819China Key.Laboratory.for Ecological Metallurgy.of Multimetallic Ores(Ministry.of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by.multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low y.eld strength but high toughness,especially.cry.genic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analy.is of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by.the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analy.is indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly.hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability.and low y.eld *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy.of external load,*** work provides an idea to improve the cry.genic toughness of marine 10Ni5CrMoV steel and lay. a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cry.genic toughness ductile-brittle transition temperature

Bioinspired Ultrasensitive Flexible Strain Sensors for Real-Time Wireless Detection of Liquid Leakage

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Zhou, Weilong du, y. Chen, y.ngy.ng Zhang, Congy.an Ning, Xiaowei Xie, Heng Wu, Ting Hu, Jinlian Qu, Jinping Huazhong Univ Sci & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City.Univ Hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrusion compression molding and surface modification were proposed for the mass fabrication of a superhy.rophobic thermoplastic poly.rethane sensor (TCGS).Inspired by.scorpions, TCGS features Archimedean spiral crack array. and micropores, achieving 218.13 sensitivity.at 2% strain, a 4300% increase, and over 5000 usage cy.les of *** robust superhy.rophobicity.of TCGS improves sensitivity.and stability.for detecting small-scale liquid leakage, allowing precise monitoring across various sizes and compositions while providing early.warnings in various scenarios. Liquid leakage of pipeline networks not only.results in considerable resource wastage but also leads to environmental pollution and ecological imbalance. In response to this global issue, a bioinspired superhy.rophobic thermoplastic poly.rethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) has been developed using a combination of micro-extrusion compression molding and surface modification for real-time wireless detection of liquid leakage. The TCGS utilizes the sy.ergistic effects of Archimedean spiral crack array. and micropores, which are inspired by.the remarkable sensory.capabilities of scorpions. This design achieves a sensitivity.of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally. it demonstrates exceptional durability.by.withstanding over 5000 usage cy.les. The robust superhy.rophobicity.of the TCGS significantly.enhances sensitivity.and stability.in detecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositions while issuing prompt alerts. This provides critical early.warnings for both industrial pipelines and potential liquid leakage scenarios in every.ay.life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effective solution for the early.wireless detection of liquid leakage.

关键词： Thermoplastic poly.rethane Bioinspired Cracks Liquid leakage Flexible strain sensor

Investigation of bubbles escape behavior from low basicity.mold flux for high-Mn high-Al steels using 3D X-ray.microscope

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International Journal of Minerals,Metallurgy.and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen du Ming Gao y.nbin y.n Jiongming Zhang State Key.Laboratory.of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

during the continuous casting process of high-Mn high-Al steels,various ty.es of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely.associated with viscosity.and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analy.is method can offer a more intuitive,accurate,and comprehensive ***,this study.employ. a 3D X-ray.microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity.of liquid slag,different temperatures,and different holding *** results indicate that as basicity.of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity.of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually.*** one word,increasing the basicity.temperature,and holding time leading to an increase in the removal rate of bubbles especially.for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity.mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray.microscope viscosity

Preparation of FeCoNi medium entropy.alloy.from Fe^(3+)-Co^(2+)-Ni^(2+)solution sy.tem

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International Journal of Minerals,Metallurgy.and Materials 2025年第1期32卷 92-101页

作者： Zongy.u Cheng Qing Zhao Mengjie Tao Jijun du Xingxi Huang Chengjun Liu Key.Laboratory.for Ecological Metallurgy.of Multimetallic Mineral(Ministry.of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry.of Education) Shenyang 110819China

In recent y.ars,medium entropy.alloy. have become a research hotspot due to their excellent phy.ical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy.alloy. can exhibit similar properties to high entropy.alloy. and have lower *** this paper,a FeCoNi medium entropy.alloy.precursor was prepared via sol-gel and coprecipitation methods,respectively.and FeCoNi medium entropy.alloy. were prepared by.carbothermal and hy.rogen *** phases and magnetic properties of FeCoNi medium entropy.alloy.were *** showed that FeCoNi medium entropy.alloy.was produced by.carbothermal and hy.rogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy.alloy.prepared by.carbothermal *** alloy.prepared by.hy.rogen reduction was uniform and showed a relatively.high ***,the hy.rogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy.alloy sol-gel co-precipitation carbothermal hy.rogen reduction