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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psy.h.atric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psy.h.atric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

STRUCTURE, MAGNETISM AND MAGNETORESISTANCE OF ANNEALED Co/Cu DISCONTINUOUS MULTILAyERS

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Acta Metallurgica Sinica(English Letters) 1997年第6期10卷 465-473页

作者： yan, S.S. Lou, J.X. Zhang, L. Zhang, R.Z. Zhang, y.M. Liu, y.h. Mei, L.M. huang, J. Shandong Univ Jinan China

Co/Cu discontinuous multilayers were prepared by rf-sputtering method under high sputtering power and then annealed at various temperatures in a high vacuum. The structural, magnetic and transport properties were strongly influenced by the annealing temperature. The annealed samples obviously became discontinuous multilayers. A maximum magnetoresistance ratio of 5.6% was obtained under a relatively low saturation field of about 400 (10/4π) A/m at the optimum annealing temperature of 450°C. When the annealing temperature was increased, the resistivity decreased, and the coercive force and the saturation field increased. The magnetoresistance ratio also depended on the thickness of Co and Cu layers. The magnetic and transport properties were explained on the basis of the discontinuous multilayered structure.

关键词： Copper Magnetic properties Multilayers Sputtering Transport properties

Catalytic nucleation of a meta-stable δ phase in phase-seeded undercooled Fe75Ni25 melts

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Progress in Natural Science:Materials International 2012年第3期22卷 258-262页

作者： y.Z. Chen, X.h. Shi, F. Liu, G.C. yang, y.h. Zhou State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, China State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi’an Shaanxi 710072 China

Undercooled Fe75Ni25 melts were phase-seeded by a high purity iron. It was found that above a critical undercooling, △Tc 135 K, a metastable δ phase (b.c.c) solidifies from the iron-seeded melts instead of a thermodynamically stable γ phase (f.c.c). While undercooling of the melt (△T) is below △Tc, solidification of the γ phase prevails in the iron-seeded melts. For the undercooled melts subjected to spontaneous nucleation, the γ phase always solidifies. After solidification, the as-solidified γ phase transforms completely to martensite; whereas the as-solidified metastable δ phase partially transforms to the γ phase, and then to martensite. The untransformed δ phase retains as a-ferrite particles in the microstructures. Based on the classical nucleation theory, catalytic nucleation of the metastable δ phase in the phase-seeded undercooled Fe75Ni25 melts was analyzed. It was quantitatively demonstrated that when △T>△Tc, the formation of the δ phase can be ascribed to a better catalytic effect of the iron on its nucleation than that on the nucleation of the γ phase.

关键词： Iron-nickel alloy Rapid solidification Microstructure Nucleation Undercooling

Analyzing the Photodetachment Cross Section of h^(-) in Parallel Electric and Magnetic Fields

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Chinese Physics Letters 1996年第11期13卷 817-820页

作者： yANG Guang-can du Meng-li Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

We studied the photodetachment of h^(-) in the presence of parallel electric and magnetic *** system is an important model that demonstrates the effects of closed-orbits and their bifurcations on the quantum *** Poisson's summation formula,we have obtained a reduction formula that represents the cross section a sum of *** reduction formula is valid *** compare it with the predication from the closed-orbit theory.

关键词： theory spectra uniformly

Effects of Growth Temperature on Structural and Electrical Properties of Li-N-h Codoped ZnO

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Journal of Materials Science & Technology 2013年第2期29卷 154-156页

作者： y.F. Lu Z.Z. ye L.P. Zhu y.J. Zeng J.y. huang B.h. Zhao State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Effects of growth temperature on the structural and electrical properties of Li-N-h codoped ZnO thin films grown by DC reactive magnetron sputtering were investigated. Scanning electron microscopy and X-ray diffraction results showed that increasing growth temperature could improve the crystalline quality. But hall measurement results showed that growth temperature had a nonlinear influence on the electrical property. The variation of electrical properties with the growth temperature was found to be related to the activated concentration of N in ZnO and the evaporation of Li during the growth process, derived from the hall measurement and the second ion mass spectroscopy measurement.

关键词： ZnO Codoped Growth temperature Structural property Electrical property

Magnetic properties and magnetocaloric effects in(ho_(1-x)y_x)_5Pd_2 compounds

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Chinese Physics B 2019年第5期28卷 293-299页

作者： X F Wu C P Guo G Cheng C R Li J Wang y S du G h Rao Z M du School of Materials Science and Engineering University of Science and Technology Beijing School of Materials Science and Engineering Guilin University of Electronic Technology Guangxi Key Laboratory of Information Materials

The crystal structure, magnetic and magnetocaloric properties of(ho_(1-x) y_(0.5))_5 Pd_2 compounds are investigated. All the compounds crystallize in a cubic Dy_5 Pd_2-type structure with the space group Fd3 m and undergo a second order transition from spin glass(SG) state to paramagnetic(PM) state. The spin glass transition temperatures T_g decrease from 26 K for x = 0 to 13 K for x = 0.5. In the PM region, the reciprocal susceptibilities for all the compounds obey the Curie–Weiss law. The paramagnetic Curie temperatures(θp) for ho_5 Pd_2,(ho_(0.75) y_(0.25)_5 Pd_2, and(ho_(0.5) y_(0.5))_5 Pd_2 are determined to be 32 K, 30 K, and 22 K, respectively, and the corresponding effective magnetic moments(μeff) are10.8 μB/ho, 10.3 μB/RE, and 7.5 μB/RE, respectively. Magnetocaloric effect(MCE) is anticipated according to the Maxwell relation, based on the isothermal magnetization curves. For a magnetic field change of 0–5 T, the maximum values of the isothermal magnetic entropy change-?SMof the(ho_(1-x)y_x)_5 Pd_2(x = 0, 0.25, and 0.5) compounds are determined to be 11.5 J·kg^(-1)·K^(-1), 11.1 J·kg^(-1)·K^(-1), and 8.9 K J·kg^(-1)·K^(-1), with corresponding refrigerant capacity values of 382.3 J·kg^(-1), 336.2 J·kg^(-1), and 242.5 J·kg^(-1), respectively.

关键词： (ho1-xyx)5Pd2 compounds magnetic transition magnetocaloric effect

The effects of rises in external K^+ on the hyperpolarization-activated cation current I_h in rat dorsal root ganglion neurons

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Science China Chemistry 2009年第8期52卷 1258-1263页

作者： du ZhengQing WU WenJie ZhOU yuFen Department of Environmental Science Shanxi University of Finance and EconomicsTaiyuan 030006China

The effects of rises in external K+(Kext) were examined on the hyperpolarization-activated cation current(Ih) in rat dorsal root ganglion neurons using the whole-cell patch clamp *** results showed that Kext increased Ih in a certain concentration and voltage-dependent *** the basal Kext level(4 mmol/L),Ih had a maximal amplitude of 1085 ± 340 pA which was enhanced by ～45% and ～92% at 8 and 16 mmol/L Kext,*** midpoint activation voltage was significantly shifted from -98 mV in the hyperpolarizing direction by 8 and 12 mV at 8 and 16 mmol/L Kext,respectively with alteration of the activation course of *** short time constants of activation became longer with the increasing amplitude of the command potential upon rises in *** long time constants became *** reversal potentials were shifted in the positive direction without significant alterations upon rises in *** to the functional role of Ih,Kext increased Ih,resulting in an enhanced neuronal excitability,which might produce activation potential abnormality and perhaps neuropathic pain involved.

关键词： hyperpolarization-activated inward current external potassium dorsal root ganglion neurons patch clamp

Bioinspired Ultra-Low Adhesive Energy Interface for Continuous 3D Printing: Reducing Curing Induced Adhesion

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Research 2018年第1期2018卷 194-200页

作者： L.Wu ZDong h.du CLi N.X.Fang y.Song Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesZhongguancun North First Street 2100190 BeijingChina CAS Key Laboratory of Bio-inspired Materials and Interfacial Sciences Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Additive manufacturing based on liquid resin curing is one of the most promising methods to construct delicate ***,precision and speed are limited by the vertical adhesion of in situ cured resin at the curing *** overcome the unavoidable adhesion and to develop a general curing interface,we propose a slippery surface taking inspiration of the peristome surface of the pitcher *** surface shows ultra-low adhesive energy at the curing interface due to the inhibition of the direct contact between the cured resin and the solid surface,which also increases the reflling speed of liquid *** ultra-low adhesive energy interface is efective for continuous 3D printing and provides insights into the physical mechanisms in reducing vertical solid-solid interfacial adhesion.

关键词： curing resin interface