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粒细胞集落刺激因子的皮肤表现

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 26-26页

作者： white J.M.L. Mufti G.J. Salisbury J.R. du vivier a.w.p. 焦婷 Department of Dermatology King' s College Hospital Denmark Hill London SE5 9RS United Kingdom Dr.

Granulocyte colony-stimulating factor (GCSF) is a recombinant human growth factor widely used in haematology. It is known to cause cutaneous vasculitis and neutrophilic dermatoses. we present three cases of Sweet’ s syndrome (SS) associated with GCSF use. Raised GCSF levels have been demonstrated in patients with SS. GCSF is the best understood mechanism by which neutrophil accumulation occurs and shows a dose-dependent effect in provoking SS.

关键词：皮肤血管炎嗜中性 Sweet 生长因子中性粒细胞

Usefulness of the Surgical Apgar Score to predict the Occurrence of Major Complications in the Early post-Operative period of Major Surgeries: Experience of Two Second-Category Hospitals in Cameroon

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Open Journal of Anesthesiology 2024年第3期14卷 51-65页

作者： Charles Emmanuel Toussaint Binam Bikoi Francis Ateba Ndongo Serge vivier Nga Nomo Édouard Léa Mekoui Ze Fidèle Binam Department of Anesthesia and Intensive Care University of Ebolowa Ebolowa Cameroon Yaounde Mother and Child Center Chantal Biya Foundation University of Garoua Garoua Cameroon Department of Anesthesia and Intensive Care Catholic University of Central Africa Yaounde Cameroon

Objective: The Surgical Apgar Score (SAS) is a tool for intraoperative stratification of the risk of serious complications in the early postoperative period. It varies from 0 to 10 points divided into three risk categories (0 to 4 high, 5 to 7 moderate, 8 to 10 low). The aim of the study was to evaluate its relevance in predicting the appearance of these complications. Material and methods: This descriptive and analytical study was carried out at the “Laquintinie” Hospital in Douala and at the Central Hospital in Yaounde, Cameroon. The main data were collected on a population of patients over 18 years old and recorded on a survey form. They consisted of variables of main interest and exposure variables. Univariate and multivariate statistical analysis using top-down logistic regression models made it possible to evaluate the association of each variable of main interest and each exposure variable. The association was significant at p Results: Of the 88 patients studied, the SAS was 3 hours. In multivariate, this link persisted only and strongly for the SAS OR (IC) 0.1 (0.1 - 0.2) and p = 000. Conclusion: The study found a specific and powerful link between the SAS score plications in the early postoperative period, in favor of its relevance in predicting them.

关键词： Early postoperative Complications Major Surgeries Surgical Apgar Score

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ARTICLE ON IATEFL

Chinese Journal of Applied Linguistics 1996年第1期19卷 133-134页

作者： Madelaine du vivier Chair IATEFL

IATEFL,the International Association of Teachers in English as a Foreign Language,is anorgamsation for all professionals involved in English Language *** has been in existencesince 1968 and has grown from a small orga... 详细信息

关键词： SIG ARTICLE ON IATEFL UK

Germinal center-dependent and-independent immune responses of tumor-infiltrating B cells in human cancers

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Cellular & Molecular Immunology 2023年第9期20卷 1040-1050页

作者： Eve playoust Romain Remark Eric vivier pierre Milpied Marseille Université CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance Innate pharma MarseilleFrance

B cells play essential roles in immunity,mainly through the production of high affinity plasma cells(pCs)and memory B(Bmem)*** affinity maturation and differentiation of B cells rely on the integration of B-cell receptor(BCR)intrinsic and extrinsic signals provided by antigen binding and the microenvironment,*** recent years,tumor infiltrating B(TIL-B)cells and pCs(TIL-pCs)have been revealed as important players in antitumor responses in human cancers,but their interplay and dynamics remain largely *** lymphoid organs,B-cell responses involve both germinal center(GC)-dependent and GC-independent pathways for Bmem cell and pC *** maturation of BCR repertoires occurs in GC reactions with specific spatiotemporal dynamics of signal integration by B *** general,the reactivation of high-affinity Bmem cells by antigens triggers GC-independent production of large numbers of pC without BCR *** B-cell dynamics in immune responses requires the integration of multiple tools and readouts such as single-cell phenotyping and RNA-seq,in situ analyses,BCR repertoire analysis,BCR specificity and affinity assays,and functional ***,we review how those tools have recently been applied to study TIL-B cells and TIL-pC in different types of solid *** assessed the published evidence for different models of TIL-B-cell dynamics involving GC-dependent or GC-independent local responses and the resulting production of antigen-specific ***,we highlight the need for more integrative B-cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies.

关键词： antibody tertiary lymphoid structure plasma cell germinal center cancer

Targeting natural killer cells in solid tumors

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Cellular & Molecular Immunology 2019年第5期16卷 415-422页

作者： Guillaume Habif Adeline Crinier pascale Andre Eric vivier Emilie Narni-Mancinelli Innate pharma MarseilleFrance Aix Marseille Universite INSERMCNRSCentre d’Immunologie de Marseille-LuminyMarseilleFrance Service d’Immunologie Marseille ImmunopoleHopital de la TimoneAssistance Publique-Hopitaux de MarseilleMarseilleFrance

Natural killer(NK)cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and *** lines of evidence suggest that NK cells play an important role in anti-tumor *** therapies against hematological malignacies make use of the immune properties of NK cells,such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell ***,knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so *** pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells(ILC1s)and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity,at least in ***,we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions,including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment.

关键词： killer tumors lymphoid

Reply to ‘Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia’

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Cellular & Molecular Immunology 2021年第5期18卷 1350-1352页

作者： Adeline Crinier Bertrand Escalière Emilie Narni-Mancinelli Eric vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance ApHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Innate pharma Research Laboratories Innate PharmaMarseilleFrance

we thank Melsen et *** their interest in our *** remarks allow us to clarify key aspects of our work on human bone marrow NK cell biology.1 Our study reports the unsupervised single-cell analysis of NK cells from eight healthy donors and eight acute myeloid leukemia(AML)patients.1 First,we detected an adaptive NK cell subset that correlated with the cytomegalovirus(CMV)positivity status of the donors.

关键词： myeloid acute

Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells

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Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-...

Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

第十三届全国免疫学学术大会

作者： Eric vivier Innate pharma Research Laboratories Innate Pharma Aix Marseille Univ CNRS INSERM APHM CIML H?pital de la Timone ImmunologieMarseille-Immunopole

Immuno-oncology, including checkpoint inhibitors targeting the pD-1/pD-L1 (pD-x) axis in particular, has revolutionized cancer treatment. However, only a subset of patients responds to these immunotherapies, and the development of drug resistance is frequent. Here, we report that the blocking of the inhibitory NKG2A receptor enhances tumor immunity by promoting both Natural Killer (NK) and CD8+T-cell effector functions in mice and humans. Monalizumab, a humanized

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Cellular & Molecular Immunology 2021年第11期18卷 1290-1304页

作者： Adeline Crinier pierre-Yves dumas Bertrand Escalière Christelle piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic pierre Milpied Émilie Narni-Mancinelli Éric vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance CHU Bordeaux Service d’Hématologie Clinique et de Thérapie CellulaireBordeauxFrance Bordeaux University BordeauxFrance Institut National de la Santéet de la Recherche Médicale U1035BordeauxFrance ApHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Établissement Français du Sang Nouvelle Aquitaine BordeauxFrance Innate pharma Research Laboratories Innate PharmaMarseilleFrance

Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor *** human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and *** the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone *** analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological *** profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell *** marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate.

关键词： NK cells scRNASeq AML

Roger vivier 以慢取胜,在独特中延续性感

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明日风尚 2010年第9期 128-131页

作者：吕安婕 Sharon Chiu 郑玮 Roger vivier

来自法国的鞋包品牌Roger vivier,视艺术为其创作灵感的主要来源。这份品牌精神,不单只呈现在Roger vivier的精品世界中,在全球仅有的八间店铺中,每家无不在设计装潢上讲究得"拒人千里"。而其每个城市只有一间店铺的以慢制胜的市场哲学... 详细信息

来自法国的鞋包品牌Roger vivier,视艺术为其创作灵感的主要来源。这份品牌精神,不单只呈现在Roger vivier的精品世界中,在全球仅有的八间店铺中,每家无不在设计装潢上讲究得"拒人千里"。而其每个城市只有一间店铺的以慢制胜的市场哲学,仿佛也带着那么点不以为然的头巾气。难道真如品牌设计总监Bruno Frisoni说的"我们只是一个小品牌,仍在发展阶段"?

关键词：设计总监 Bruno 创作灵感 Roger vivier 发展阶段巴黎人高级定制时尚界鞋履