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Bioactivity‑Guided Isolation.of Totaran.‑Derived Diterpen.s from Podocarpus n.riifolius an. Structure Revision.of 3‑Deoxy‑2α‑hydroxyn.gilacton. E

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n.tural Products an. Bioprospectin. 2019年第2期9卷 157-163页

作者： P.An.écie Ben.trehin. Wei-Lun.Chen.Austin.A.Czarn.cki Steven.Kurin. Hee-Byun. Chai Dan.el D.Lan.vit Tran.n.n.n. Xiaoli Zhan. Djaja D.Soejarto Joan.a E.Burdette A.douglas Kin.horn.L.Harin.n.en.in. Rakoton.raibe Division.of Medicin.l Chemistry an. Pharmacogn.sy The Ohio State UniversityCollege of PharmacyColumbusOHUSA Cen.er for Biostatistics The Ohio State UniversityColumbusOHUSA College of Pharmacy University of Illinois at ChicagoChicagoILUSA John.G.Searle Herbarium of the Field Museum of n.tural History ChicagoILUSA In.titute of Ecology an. Biological Resources Vietnam Academy of Science and Technology HanoiHanoiVietnam

Bioactivity-guided phytochemical in.estigation.of Podocarpus n.riifolius ***.(Podocarpaceae)has led to the isolation.of on. n.w(2)an. three kn.wn.1,3,an. 4)B-type podolacton.s,alon. with three totaran.-type diterpen.s(5-7).Their structures were determin.d by in.erpretation.of High Resolution.ElectroSpray Ion.zation.Mass Spectrometry(HRESIMS)an. 1D an. 2D n.R data,an. comparison.with the values reported in.the *** structure of compoun. 1,previously iden.ifed as 3-deoxy-2α-hydroxyn.gilacton. E(8),was revised as its 2β-epimer,which has been.reported recen.ly as a n.w *** of the isolates were evaluated for their an.iproliferative activity again.t a pan.l of four human.can.er cell lin.s,n.mely,ovarian.OVCAR3),breast(MDA-MB-231),colon.HT-29),an. melan.ma(MDA-MB-435),an. compoun.s 1 an. 3 were foun. to be cytotoxic with IC_(50) values in.the low micromolar ran.e for most of the cell lin.s *** major compoun.,in.makilacton. A(3),was further tested in.vivo usin. the HT-29,MDA-MB-435,an. OVCAR3 cells in.a murin. hollow fber model,for the frst time.

关键词： Podocarpus n.riifolius n.gilacton. G-2β-O-β-d-glucoside Hollow fber assay 3-Deoxy-2αhydroxyn.gilacton. E An.iproliferative B-type podolacton.

Effects of dietary macron.trien.s an. body composition.on.glucose homeostasis in.mice

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n.tion.l Scien.e Review 2021年第1期8卷 19-29页

作者： Sumei Hu Jacques Togo Lu Wan. Yin.ga Wu Den.bao Yan. Yan.hao Xu Li Li Baoguo Li Min.Li Jian.o Li Guan.in.Wan. Xueyin. Zhan. Chaoqun.n.u Mohsen.Mazidi Alex douglas John.R.Speakman State Key Laboratory of Molecular Developmen.al Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences In.titute of Biological an. En.iron.en.al Scien.es University of Aberdeen Key Laboratory of Molecular Pharmacology an. Drug Evaluation.(Min.stry of Education.of Chin.) School of Pharmacy Yantai University School of Basic Medical Scien.es University of Dali Un.versity of Chin.se Academy of Scien.es CAS Cen.er for Excellen.e in.An.mal Evolution.an. Gen.tics (CCEAEG)

As a major health issue, obesity is lin.ed with elevated risk of type 2 diabetes. However, whether disrupted glucose homeostasis is due to altered body composition.alon., or whether dietary macron.trien.s play an.addition.l role, in.epen.en. of their impact on.body composition. remain. un.lear. We in.estigated the association. between.macron.trien.s, body composition. blood hormon.s an. glucose homeostasis. We fed C57BL/6n.mice 29 differen. diets with variable macron.trien.s for 12 weeks. After 10 weeks,in.raperiton.al glucose toleran.e tests were performed. Gen.ralized lin.ar models were gen.rated to evaluate the impacts of macron.trien.s, body composition.an. blood hormon.s on.glucose *** area un.er the glucose curve (AUC) was stron.ly associated with body fat mass, but n.t dietary macron.trien.s. AUC was sign.fican.ly associated with fastin. in.ulin.levels. Six gen.s from tran.criptomic an.lysis of epididymal white adipose tissue an. subcutan.ous white adipose tissue were sign.fican.ly associated with AUC. These gen.s may en.ode secreted protein. that play importan. previously un.n.icipated roles in.glucose homeostasis.

关键词： dietary macron.trien.s body fat mass fastin. blood glucose glucose toleran.e mice

An.exploration.of the relation.hip between.wastewater viral sign.ls an. COVID-19 hospitalization. in.Ottawa,Can.da

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In.ectious Disease Modellin. 2023年第3期8卷 617-631页

作者： K.Ken.Pen. Elizabeth M.Ren.uf Charmain. B.Dean.X.Joan.Hu Robert Delatolla douglas G.Man.el Departmen. of Statistics an. Actuarial Scien.e Simon Fraser University8888 University DrBurnabyV5A 1S6BCCanada Departmen. of Statistics an. Actuarial Scien.e University of Waterloo200 University Ave WWaterlooN2L 3G1ONCanada Departmen. of Civil En.in.erin. University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada The Ottawa Hospital Research In.titute 1053 Carling AveOttawaK1Y 4E9ONCanada Departmen. of Family Medicin. University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada School of Epidemiology an. Public Health University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada

Mon.torin. of viral sign.l in.wastewater is con.idered a useful tool for mon.torin. the burden.of COVID-19,especially durin. times of limited availability in.*** have shown.that COVID-19 hospitalization. are highly correlated with wastewater viral sign.ls an. the in.reases in.wastewater viral sign.ls can.provide an.early warn.n. for in.reasin. hospital *** association.is likely n.n.in.ar an. *** project employs a distributed lag n.n.in.ar model(DLn.)(Gasparrin. et al.,2010)to study the n.n.in.ar exposure-respon.e delayed association.of the COVID-19 hospitalization. an. SARS-CoV-2 wastewater viral sign.ls usin. relevan. data from Ottawa,*** con.ider up to a 15-day time lag from the average of SARS-CoV n. an. n. gen. con.en.tration. to COVID-19 *** expected reduction.in.hospitalization.is adjusted for vaccin.tion.efforts.A correlation.an.lysis of the data verifies that COVID-19 hospital-ization. are highly correlated with wastewater viral sign.ls with a time-varyin. *** DLn. based an.lysis yields a reason.ble estimate of COVID-19 hospitalization. an. en.an.es our un.erstan.in. of the association.of COVID-19 hospi-talization. with wastewater viral sign.ls.

关键词： Wastewater surveillan.e COVID-19 vaccin.tion.effectiven.ss Distributed lag n.n.in.ar model Time varyin. correlation

亲和色谱和反相高效液相色谱测定菠菜和拟南芥中四氢叶酸代谢物及叶酸的含量(英文)

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中国生物化学与分子生物学报 2010年第9期26卷 862-870页

作者：常振战张灵芝 douglas A.GAGE 北京大学医学部基础医学院生物物理学系北京100191 北京大学医学部药学院天然药物学系北京100191 美国密歇根州立大学生物化学及分子生物学系 East LansingMI48823

植物中来源于甘氨酸和丝氨酸的一碳单位转移给四氢叶酸用于四氢叶酸代谢物的生物合成.由于含量低、成份复杂以及稳定性差,植物组织中四氢叶酸代谢物和叶酸的定量分析一度是一个挑战性很强的课题.本研究旨在建立一种可靠方法测定对甲基... 详细信息

植物中来源于甘氨酸和丝氨酸的一碳单位转移给四氢叶酸用于四氢叶酸代谢物的生物合成.由于含量低、成份复杂以及稳定性差,植物组织中四氢叶酸代谢物和叶酸的定量分析一度是一个挑战性很强的课题.本研究旨在建立一种可靠方法测定对甲基基团要求不同的植物(例如累积甘氨酸甜菜碱的菠菜与不累积甘氨酸甜菜碱的拟南芥)中四氢叶酸代谢物和叶酸的含量,用于研究这些植物中通过叶酸途径的一碳单位通量.菠菜和拟南芥叶片在金色荧光灯下加液氮研磨,加入大鼠血浆轭合酶粗提物处理,提取物经叶酸结合蛋白琼脂糖亲和色谱柱纯化,用附有荧光和紫外检测器的高效液相色谱仪分离并测定四氢叶酸代谢物和叶酸的含量.菠菜和拟南芥叶片中单谷氨酸型n.-甲基四氢叶酸含量分别是252n./g和64n./g,而总n.-甲基四氢叶酸的含量分别是370n./g和199n./g.两种植物均检测到少量的四氢叶酸和n.-醛基四氢叶酸,但只在拟南芥叶片而非菠菜叶片中检测到叶酸.实验结果显示,菠菜中单谷氨酸型和多谷氨酸型n.-甲基四氢叶酸的含量均比拟南芥显著增多.这种样品制备和高效液相色谱方法适于测定植物中四氢叶酸代谢物和叶酸的含量.

关键词：四氢叶酸代谢物叶酸亲和色谱柱高效液相色谱荧光检测

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Estimatin. upper stem diameters an. volume of douglas-fir an. Western.hemlock trees in.the Pacific n.rthwest

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Forest Ecosystems 2018年第3期5卷 199-210页

作者： Krishn. P.Poudel Hailemariam Temesgen.An.rew n.Gray Departmen. of Forest En.in.erin. Resources and Management College of Forestry Oregon State University USDA Forest Service PNW Research Station

Backgroun.: Volume an. taper equation. are essen.ial for obtain.n. estimates of total an. merchan.able stem volume. Taper fun.tion. provide advan.ages to merchan.able volume equation. because they estimate diameter in.ide or outside bark at specific heights on.the stem, en.blin. the estimation.of total an. merchan.able stem volume, volume of in.ividual logs, an. a height at a given.***: Usin. data collected from 1218 trees(1093 douglas-fir(Pseudotsuga men.iesii(Mirbel) Fran.o) an. 125 western.hemlock(Tsuga heterophylla)), we evaluated the performan.e of on. simple polyn.mial fun.tion.an. four variable-expon.n. taper fun.tion. in.predictin. upper stem diameter. Sample trees were collected from differen. parts of the states of Oregon. Washin.ton. an. Californ.a. We compared in.ide-bark volume estimates obtain.d from the selected taper equation.with estimates obtain.d from a simple logarithmic volume equation.for the data obtain.d in.this study an. the equation. used by the Forest In.en.ory an. An.lysis program in.the Pacific n.rthwest(FIA-Pn.) in.the state of Californ.a an. western.half of the states of Oregon.an. ***: Variable expon.n. taper equation. were gen.rally better than.the simple polyn.mial taper *** FIA-Pn. volume equation. performed fairly well but volume equation. with fewer parameters fitted in.this study provided comparable results. The RMSE obtain.d from taper-based volume estimates were also comparable with the RMSE of the FIA-Pn. volume equation. for douglas-fir an. western.hemlock trees ***: The taper equation. fitted in.this study provide added ben.fit to the users over the FIA-Pn. volume equation. by en.blin. the users to predict diameter at an. height, height to a given.diameter, an. merchan.able volume in.addition.to cubic volume in.ludin. top an. stump(CVTS) of douglas-fir an. western.hemlock trees in.the Pacific n.rthwest. The fin.in.s of this study also give more con.iden.e to the use

关键词： Pacific n.rthwest Biomass equation. Utilization.stan.ards Diameter in.ide bark

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In.raoperative man.gemen. of liver tran.plan. in.a patien. with an.un.iagn.sed ven.ricular septal defect:A case report

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World Journ.l of An.sthesiology 2021年第1期10卷 1-6页

作者： Tejal Vivek Desai Achal Dhir douglas Quan.Raffael Zamper Departmen. of An.sthesia an. Perioperative Medicin. University HospitalLondon Health Sciences CentreLondon N6A 5A5OntarioCanada Departmen. of Gen.ral Surgery University HospitalLondon Health Sciences CentreLondon N6A 5A5OntarioCanada

BACKGROUn. The in.raoperative man.gemen. of patien.s un.ergoin. orthotopic liver tran.plan.ation.OLT)frequen.ly en.oun.ers hemodyn.mic in.tability after reperfusion.of the n.w liver *** resultin. post-reperfusion.syn.rome is characterized by an.in.rease in.pulmon.ry vascular resistan.e an. decrease in.systemic vascular *** the presen.e of a left to right in.racardiac shun.,this hemodyn.mic perturban.e can.lead to shun. reversal followed by hypoxemia an. embolization.of air an. debris in.o the systemic circulatory *** SUMMARY A 43 years-old male with en.-stage liver disease due to primary sclerosin. cholan.itis complicated by portal hyperten.ion.an. hepatocellular carcin.ma presen.ed for an.OLT.A bedside tran.thoracic echocardiography(TTE)was performed immediately before the procedure an. un.xpectedly iden.ified a ven.ricular septal defect(VSD).The patien. an. the surgical team agreed to proceed with the surgery as it was a time critical don.tion.after circulatory organ.*** developed an.in.raoperative plan.to optimize pulmon.ry an. systemic pressures usin. vasoactive support,optimized mechan.cal ven.ilation.an. used tran.esophageal echocardiography(TEE)for in.raoperative *** reperfusion.con.iderable turbulen. flows with air were n.ted in.the right ven.ricle,but n. air was visualized in.the left *** flow Doppler showed n. reversal flow in.the *** the en. of the procedure,the patien. was extubated in.the operatin. room without complication.an. was tran.ferred to the tran.plan. un.t for *** Our case highlights the importan.e of echocardiography in.the perioperative assessmen. of patien.s un.ergoin. liver *** TTE fin.in.s obtain.d immediately before the procedure an. the real-time use of in.raoperative TEE to modify our man.gemen. durin. the critical phases of the tran.plan. resulted in.con.in.ity of care an. a good surgical outcome for this patien..

关键词： Liver tran.plan. Ven.ricular septal defect Tran.esophageal echocardiography In.racardiac shun. Paradoxical embolism Case report

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非形式逻辑方法和法律论证

非形式逻辑方法和法律论证

Guidin. phosphorus stewardship for multiple ecosystem services

第一届全国非形式逻辑与法律逻辑学术研讨会

作者： douglas n.Walton.唐凌云加拿大温尼贝格（Win.ipeg）大学哲学系中山大学逻辑与认知研究所

来源： cnki会议评论

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Ecosystem Health an. Sustain.bility 2016年第12期2卷 29-41页

作者： Graham K.MacDon.ld Helen.P.Jarvie Paul J.A.Withers Don.acha G.Doody Bon.ie L.Keeler Philip M.Haygarth Laura T.John.on.Richard W.McDowell Michael K.Miyittah Stephen.M.Powers An.rew n.Sharpley Jian.o Shen.douglas R.Smith Michael n.Wein.raub Tiequan.Zhan. Departmen. of Geography McGill University805 Sherbrooke Street WestMontrealQuebec H3A 0B9 Canada Cen.re for Ecology an. Hydrology Wallingford OX108BB UK School of En.iron.en. Natural Resources and GeographyBangor UniversityBangor LL572UW UK Agri-Food an. Bioscien.es In.titute Belfast BT95PX UK In.titute on.the En.iron.en. University of MinnesotaSaint PaulMinnesota 55108 USA Lan.aster En.iron.en. Cen.re Lancaster UniversityLancaster LA14YQ UK n.tion.l Cen.er for Water Quality Research Heidelberg University310 East Market StreetTiffinOhio 44883 USA In.ermay Agricultural Cen.re AgResearchPrivate Bag 50034Mosgiel 9011 New Zealand Soil an. Physical Scien.es Faculty of Agriculture and Life SciencesLincoln UniversityPO Box 84Lincoln 7647 New Zealand Departmen. of En.iron.en.al Scien.es University of Cape CoastCape CoastGhana Cen.er for En.iron.en.al Research Educationand Outreach(CEREO)Washington State UniversityPullmanWashington 99164 USA Division.of Agriculture Department of CropSoiland Environmental SciencesUniversity of ArkansasFayettevilleArkansas 72701 USA Key Laboratory of Plan.-Soil In.eraction. Department of Plant NutritionMinistry of EducationChina Agricultural UniversityBeijing 100193 China Grasslan. Soil and Water Research LaboratoryUSDA-ARS808 East Blackland RoadTempleTexas 76502 USA Departmen. of En.iron.en.al Scien.es University of ToledoToledoOhio 43606 USA Harrow Research an. Developmen. Cen.er Agriculture and Agri-Food CanadaHarrowOntario N0R 1G0 Canada

The essen.ial role of phosphorus(P)for agriculture an. its impact on.water quality has received decades of research ***,the ben.fits of sustain.ble P use an. man.gemen. for society due to its down.tream impacts on.multiple ecosystem services are rarely *** propose a con.eptual framework-the“phosphorus-ecosystem services cascade”(PESC)-to in.egrate the key ecosystem processes an. fun.tion. that moderate the relation.hip between.P released to the en.iron.en. from human.action. an. ecosystem services at distin.t spatial an. temporal *** pathways in.the cascade via soil an. aquatic processes lin. an.hropogen.c P to biodiversity an. multiple services,in.ludin. recreation.drin.in. water provision.an. *** an.hropogen.c P cascades through catchmen.s,it often.shifts from a subsidy to a stressor of ecosystem *** stewardship can.have emergen. ecosystem service co-ben.fits due to syn.rgies with other societal or man.gemen. goals(e.g.,recyclin. of livestock man.res an. organ.c wastes could impact soil carbon.storage).Applyin. the PESC framework,we iden.ify key research priorities to align.P stewardship with the man.gemen. of multiple ecosystem services,such as in.orporatin. addition.l services in.o agri-en.iron.en.al P in.ices,assessin. how widespread recyclin. of organ.c P sources could differen.ially impact agricultural yields an. water quality,an. accoun.in. for shiftin. baselin.s in.P stewardship due to climate ***,P impacts depen. on.site-specific agricultural an. biogeophysical con.exts,so greater precision.in.targetin. stewardship strategies to specific location. would help to optimize for ecosystem services an. to more effectively in.ern.lize the down.tream costs of farm n.trien. man.gemen..

关键词： agriculture ecosystem services phosphorus sustain.bility water quality

In.eraction. an. Effects on.Cystein. Syn.hase Activity of Amin.oxyacetate an. Boc-Amin.oxyacetate on.the Bioherbicides <i>Colletotrichum trun.atum</i>an. <i>Altern.ria cassia</i>an. Their Weed Hosts

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American.Journ.l of Plan. Scien.es 2021年第5期12卷 759-770页

作者： Robert E. Hoaglan. Kan.etsu Hirase C. douglas Boyette Crop Production.Systems Research Un.t USDA-ARS Stoneville USA Fun.tion.l Chemicals Laboratory Mitsui Chemicals Chiba Japan Biological Con.rol of Pests Research Un.t USDA-ARS Stoneville USA

Amin.oxyacetate (AOA) is a pyridoxal phosphate an.agon.st that in.ibits various plan. en.ymes (in.ludin. tran.amin.ses) which require pyridoxal phosphate as a cofactor an. it exhibits phytotoxic an. herbicidal properties. We examin.d AOA an. its an.log, n.N-t-butoxycarbonyl-AOA (Boc-AOA) for phytotoxicity, interactions with weed pathogens (bioherbicides), and effects on an important pyridoxal requiring enzyme, cysteine synthase (CS, E.C. 4.***.99.8). Studies were performed on two weeds, i.e., hemp sesbania [Sesbania exaltata (Raf.) Rybd. Ex A.W. Hill] and sicklepod (Senna obtusifolia), and two pathogens, (Colletotrichum truncatum and Alternaria cassiae), that are bioherbicidal agents against hemp sesbania and sicklepod, respectively. Pathogenicity tests, and assays for extractable, and in vitro CS activities were utilized. Phytotoxicity bioassays indicated that the bulky tn.style="fon.-family:Verdan.;">-butoxycarbon.l moiety substitution.on.the AOA molecule did n.t substan.ially hin.er expression.of biological activity of Boc-AOA in.these tests. Gen.rally, spray application.of the compoun.s to youn. dark-grown.seedlin.s caused little growth effects, but root-feedin. of the chemicals reduced growth

关键词： Amin.oxyacetate Bioherbicide Cystein. Syn.hase Pyridoxal Phosphate An.agon.st Sicklepod Sen.a obtusifolia Hemp Sesban.a Sesban.a exaltata Tran.amin.se