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Circulating microRNA e.pre.sion and nonalcoholic fatty live. dise.se.in adole.ce.ts with se.e.e.obe.ity

World Journal of Gastroe.te.ology 2024年第4期30卷 332-345页

作者： Yi-Jie.Li Brittne. O Baume.t Nikos Stratakis Je.se.A Goodrich Hao-Tian Wu Jing-Xuan He.Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P e.ke. douglas I Walke. Damaskini Valvi Miche.e.A La Me.rill Justin R Ryde. Thomas H Inge.Todd Je.kins Ste.hanie.Sisle. Rohit Kohli Stavra A Xanthakos Andre. A Baccare.li Rob McConne.l David V Conti Lida Chatzi De.artme.t of Population and Public He.lth Scie.ce. Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barce.ona Institute.of Global He.lth Barcelona Institute of Global HealthBarcelona 08036Spain De.artme.t of e.vironme.tal He.lth Scie.ce. Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa De.artme.t of e.vironme.tal He.lth Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States De.artme.t of e.vironme.tal Me.icine.and Public He.lth Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States De.artme.t of e.vironme.tal Toxicology University of CaliforniaDavisCA 95616United States De.artme.t of Surge.y Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwe.te.n Unive.sity Fe.nbe.g School of Me.icine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and e.ide.iology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States De.artme.t of Pe.iatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States De.artme.t of Pe.iatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States De.artme.t of Gastroe.te.ology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroe.te.ology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty live. dise.se.NAFLD)is one.of the.most common chronic live. dise.se. in childre. and *** range. in se.e.ity from isolate. he.atic ste.tosis to nonalcoholic ste.tohe.atitis(NASH),whe.e.n he.atoce.lular inflammation and/or fibrosis coe.ist with *** microRNA(miRNA)le.e.s have.be.n sugge.te. to be.alte.e. in NAFLD,but the.e.te.t to which miRNA are.re.ate. to NAFLD fe.ture. re.ains *** analysis te.te. the.hypothe.is that plasma miRNAs are.significantly associate. with histological fe.ture. of NAFLD in *** To inve.tigate.the.re.ationship be.we.n plasma miRNA e.pre.sion and NAFLD fe.ture. among adole.ce.ts with *** This study include. 81 adole.ce.ts diagnose. with NAFLD and 54 adole.ce.ts without NAFLD from the.Te.n-Longitudinal Asse.sme.t of Bariatric Surge.y ***-ope.ative.core.live. biopsie. we.e.colle.te. from participants and use. to characte.ize.histological fe.ture. of *** sample. we.e.colle.te. during surge.y for miRNA profiling.A total of 843 plasma miRNAs we.e.profile. using the.HTG e.ge.e. *** e.amine. associations of plasma miRNAs and NAFLD fe.ture. using logistic re.re.sion afte. adjusting for age.se.,race.and othe. ke. *** Pathways Analysis was use. to ide.tify biological functions of miRNAs that we.e.associate. with multiple.histological fe.ture. of *** We.ide.tifie. 16 upre.ulate. plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downre.ulate. plasma miRNAs,including miR-1282 and miR-6734-5p,in adole.ce.ts with ***,52,16,15,and 9 plasma miRNAs we.e.associate. with NASH,fibrosis,ballooning de.e.e.ation,and lobular inflammation,***,16 miRNAs we.e.associate. with two or more.histological fe.ture. of *** those.miRNAs,miR-411-5p was downre.ulate. in NASH,ballooning,and fibrosis,while.miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p we.e.consiste.tly and posi

关键词： MicroRNA Nonalcoholic fatty live. dise.se Non-alcoholic ste.tohe.atitis Live. fibrosis Lobular inflammation Ballooning de.e.e.ation

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Fair Plan 10: Post-Trump Global-Warming Mitigation

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Journal of e.vironme.tal Prote.tion 2017年第8期8卷 898-913页

作者： Michae. e. Schle.inge. douglas A. Be.ke. Climate.Re.e.rch Group Department of Atmospheric Sciences University of Illinois at Urbana-Champaign Urbana IL USA

With the.e.e.tion of Donald Trump as Pre.ide.t of the.Unite. State. of Ame.ica, it appe.rs like.y that the.initiation of mitigation of human-cause. Global-Warming/Climate.Change.will be.de.aye. many ye.rs. Accordingly, he.e.we.calculate.the.e.ission Phase.ut Duration, D = Ye.- YS, whe.e.YS and Ye.are.the.Start and e.d Ye.rs of the.e.issions re.uction, for YS = 2020, 2025 and 2030, and maximum Global Warming targe.s, ΔTmax = 2.0°C, 1.9°C, 1.8°C, 1.7°C, 1.6°C and 1.5°C. The.2.0°C and 1.5°C maxima are.the.“Hard” and “Aspirational” targe.s of the.2015 Paris Climate.Agre.me.t. We.find that D de.re.se. with incre.sing YS from 2020, and with de.re.sing ΔTmax. In particular, D de.re.se. from: 1) 76 ye.rs for YS = 2020 to 53 ye.rs for YS = 2030 for ΔTmax = 2.0°C, and 2) 34 ye.rs for YS = 2020 to 7 ye.rs for YS = 2030 for ΔTmax = 1.5°C. Thus, de.aying the.initiation of the.phase.ut of gre.nhouse.gas e.issions from 2020 to 2030 make. it more.difficult to achie.e.ΔTmax = 2.0°C and impossible.to achie.e.ΔTmax = 1.5°C.

关键词： Climate Change Fair Plan Trump Mitigation

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He.icobacte. pylori re.urre.ce.afte. e.adication in Latin Ame.ica:Implications for gastric cance. pre.e.tion

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World Journal of Gastrointe.tinal Oncology 2017年第4期9卷 184-193页

作者： Juan e.Corral Robe.tino Me.a Core. W Dye.douglas R Morgan Division of Gastroe.te.ology and He.atology Mayo Clinic Division of Gastroe.te.ology Hepatologyand NutritionVanderbilt University De.artme.t of Me.icine University of Miami Miller School of Medicine

To e.timate.He.icobacte. pylori (H. pylori) re.urre.ce.rate.in Latin Ame.ica, a re.ion with a significant H. pylori pre.ale.ce.and gastric cance. burde.. Me.HODSPubMe., LILACS, Scie.O, Cochrane.database. and abstracts from re.e.ant me.tings we.e.re.ie.e.. Information colle.te. include.: Participants’ characte.istics, re.ruitme.t strate.y, diagnostic modality, tre.tme.t arms, follow-up and re.urre.ce.rate.. Re.urre.ce.was calculate. using 100-patie.ts-ye.r rate., and data we.e.poole. using a random e.fe.ts mode.. The.I2 statistic asse.se. be.we.n study he.e.oge.e.ty. Me.a-re.re.sion analyse. e.aluate. for e.fe.t modifying variable.. Re.ULTSLite.ature.se.rch yie.de. 163 article.. Twe.ve.studie. involving 4848 patie.ts from 9 countrie. me. inclusion crite.ia. Four hundre. and thirty-two re.nfe.tions we.e.re.orde. in 5487 pe.son-ye.rs of follow-up. Poole. analysis showe. a re.urre.ce.rate.of 7.9 case. pe. 100 pe.son-ye.rs (95%CI: 5.3-10.5). Me.a-re.re.sion re.e.le. that ne.the. the.antibiotic sche.a, a se.ond antibiotic course. nor the.diagnostic modality had an impact on the.obse.ve. risk of re.urre.ce. The.re.urre.ce.rate.in the.first ye.r afte. tre.tme.t, pre.ominantly re.rude.ce.ce. was 11.2 (6.1-16.4) pe. 100 patie.t ye.rs. Re.urre.ce.in subse.ue.t ye.rs, was only 6.2 (3.8-8.7). CONCLUSIONH. pylori re.urre.ce.rate. in Latin Ame.ica are.significant, and with ge.graphic variability, ye. are.acce.table.base. upon the.curre.t lite.ature.for conside.ation of large.scale.inte.ve.tion trials. Furthe. re.e.rch in Latin Ame.ica is warrante. to e.aluate.the.e.ficacy, cost-e.fe.tive.e.s, and pote.tial adve.se.outcome. of propose. e.adication programs.

关键词： Gastric cance. Re.nfe.tion Hispanic He.icobacte. pylori Latin Ame.ica

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Use.-frie.dly finite.e.e.e.t de.ign of main e.trie., barrie. pillars,and ble.de. e.trie.

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Inte.national Journal of Mining Scie.ce.and Te.hnology 2018年第1期28卷 3-10页

作者： William G.Parise.u Mark K.Larson He.the. e.Lawson douglas R.Te.arik De.artme.t of Mining e.gine.ring University of Utah Spokane.Mining Re.e.rch Division NIOSH

This contribution de.cribe. de.e.opme.t and application of a use.-frie.dly finite.e.e.e.t program,UT3PC, to addre.s thre. important proble.s in unde.ground coal mine.de.ign:(1) safe.y of main e.trie.,(2) barrie. pillar size.ne.de. for e.try prote.tion, and(3) safe.y of ble.de. e.trie. during the.advance.of an adjace.t longwall *** the.finite.e.e.e.t me.hod is by far the.most popular e.gine.ring de.ign tool of the.digital age. wide.pre.d use.by the.mining community has be.n impe.e. by the.re.ative.y high cost of and the.ne.d for le.gthy spe.ialize. training in nume.ical *** of UT3PC ove.come. the.e.impe.ime.ts in thre. e.sy ***, a mate.ial prope.tie. file.is pre.are. for the.conside.e. ***, me.h ge.e.ation is automatic through an inte.active.proce.s.A third and last ste. is simply e.e.ution of the.*** using data from se.e.al we.te.n coal mine. illustrate.the.e.se.of using the.application for analysis of main e.trie., barrie. pillars, and ble.de. e.try safe.y.

关键词： Finite e.e.e.t Coal Mine layout de.ign Main e.trie. Barrie. pillars Ble.de. e.trie.

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Ope.ator Splitting for Thre.-Phase.Flow in He.e.oge.e.us Porous Me.ia

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Communications in Computational Physics 2009年第6期6卷 72-84页

作者： e.Abre. J.douglas F.Furtado F.Pe.e.ra Instituto Nacional de.Mate.atica Pura e.Aplicada RJ 22460-320Brazil De.artme.t of Mathe.atics Purdue UniversityWest LafayetteIN 47907-1395USA De.artme.t of Mathe.atics University of WyomingLaramieWY 82071-3036USA De.artme.t of Mathe.atics and School of e.e.gy Re.ource. University of WyomingLaramieWY 82071-3036USA

We.de.cribe.an ope.ator splitting te.hnique.base. on physics rathe. than on dime.sion for the.nume.ical solution of a nonline.r syste. of partial diffe.e.tial e.uations which mode.s thre.-phase.flow through he.e.oge.e.us porous *** mode. for thre.-phase.flow conside.e. in this work take. into account capillary force.,ge.e.al re.ations for the.re.ative.pe.me.bility functions and variable.porosity and pe.me.bility *** our nume.ical proce.ure.a high re.olution,nonoscillatory,se.ond orde.,conse.vative.ce.tral diffe.e.ce.sche.e.is use. for the.approximation of the.nonline.r syste. of hype.bolic conse.vation laws mode.ing the.conve.tive.transport of the.fluid *** sche.e.is combine. with locally conse.vative.mixe. finite.e.e.e.ts for the.nume.ical solution of the.parabolic and e.liptic proble.s associate. with the.diffusive.transport of fluid phase. and the.pre.sure.ve.ocity *** nume.ical proce.ure.has be.n use. to inve.tigate.the.e.iste.ce.and stability of nonclassical shock wave.(calle. transitional or unde.compre.sive.shock wave.)in two-dime.sional he.e.oge.e.us flows,the.e.y e.te.ding pre.ious re.ults for one.dime.sional flow *** e.pe.ime.ts indicate.that the.ope.ator splitting te.hnique.discusse. he.e.le.ds to computational e.ficie.cy and accurate.nume.ical re.ults.

关键词： Ope.ator splitting thre.-phase.flow he.e.oge.e.us porous me.ia ce.tral diffe.e.cing sche.e. mixe. finite.e.e.e.ts

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Patte.ns of host ce.l inhe.itance.in the.bacte.ial symbiosis of white.lie.

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Inse.t Scie.ce 2020年第5期27卷 938-946页

作者： Xiao-Rui Xu Na-Na Li Xi-Yu Bao Ange.a e.douglas Jun-Bo Luan Liaoning Ke. Laboratory of e.onomic and Applie. e.tomology College of Plant ProtectionShenyang Agricutural UniversityShenyangChina De.artme.t of e.tomology Cornell UniversitIthacaNYUSA De.artme.t of Mole.ular Biology and Ge.e.ics Cormell UniversitylthacaNYUSA

White.lie. posse.s bacte.ial symbionts Candidatus Portie.a ale.rodidium that are.house. in spe.ialize. ce.ls calle. bacte.iocyte. and are.faithfully transmitte. via the.ovary to inse.t *** one.white.ly spe.ie. studie. pre.iously,Be.isia tabaci Me.MI,transmission is me.iate. by somatic inhe.itance.of bacte.iocyte.,with a single.bacte.iocyte.transfe.re. to e.ch oocyte.and pe.sisting through e.bryoge.e.is to the.ne.t ***,we.inve.tigate.the.mode.of bacte.iocyte.transmission in two whie.ly spe.ie.,*** Me.,the.siste. spe.ie. of Me.M1,and the.phyloge.e.ically distant spe.ie. Triale.rode. *** analysis supporte. by microscopical studie. de.onstrate. that *** Me. bacte.iocyte. are.ge.e.ically diffe.e.t from othe. somatic ce.ls and pe.sist through e.bryoge.e.is,as for Me.MI,but *** bacte.iocyte. are.ge.e.ically ide.tical to othe. somatic ce.ls of the.inse.t,like.y me.iate. by the.de.radation of mate.nal bacte.iocyte. in the.*** two alte.native.mode. of transmission provide.a first de.onstration among inse.t symbiose. that the.ce.lular proce.se. unde.lying ve.tical transmission of bacte.ial symbionts can dive.sify among re.ate. host spe.ie. associate. with a single.line.ge.of symbiotic bacte.ia.

关键词： bacte.iocyte inhe.itance somatic ce.ls symbiont transmission white.ly

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Inte.actions and e.fe.ts on Cyste.ne.Synthase.Activity of Aminooxyace.ate.and Boc-Aminooxyace.ate.on the.Biohe.bicide. <i>Colle.otrichum truncatum</i>and <i>Alte.naria cassia</i>and The.r We.d Hosts

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Ame.ican Journal of Plant Scie.ce. 2021年第5期12卷 759-770页

作者： Robe.t e. Hoagland Kange.su Hirase.C. douglas Boye.te Crop Production Syste.s Re.e.rch Unit USDA-ARS Stoneville USA Functional Che.icals Laboratory Mitsui Chemicals Chiba Japan Biological Control of Pe.ts Re.e.rch Unit USDA-ARS Stoneville USA

Aminooxyace.ate.(AOA) is a pyridoxal phosphate.antagonist that inhibits various plant e.zyme. (including transaminase.) which re.uire.pyridoxal phosphate.as a cofactor and it e.hibits phytotoxic and he.bicidal prope.tie.. We.e.amine. AOA and its analog, N-t-butoxycarbonyl-AOA (Boc-AOA) for phytotoxicity, interactions with weed pathogens (bioherbicides), and effects on an important pyridoxal requiring enzyme, cysteine synthase (CS, E.C. 4.***.99.8). Studies were performed on two weeds, i.e., hemp sesbania [Sesbania exaltata (Raf.) Rybd. Ex A.W. Hill] and sicklepod (Senna obtusifolia), and two pathogens, (Colletotrichum truncatum and Alternaria cassiae), that are bioherbicidal agents against hemp sesbania and sicklepod, respectively. Pathogenicity tests, and assays for extractable, and in vitro CS activities were utilized. Phytotoxicity bioassays indicated that the bulky te."font-family:Ve.dana;">-butoxycarbonyl moie.y substitution on the.AOA mole.ule.did not substantially hinde. e.pre.sion of biological activity of Boc-AOA in the.e.te.ts. Ge.e.ally, spray application of the.compounds to young dark-grown se.dlings cause. little.growth e.fe.ts, but root-fe.ding of the.che.icals re.uce. growth

关键词： Aminooxyace.ate Biohe.bicide Cyste.ne.Synthase Pyridoxal Phosphate.Antagonist Sickle.od Se.na obtusifolia He.p Se.bania Se.bania e.altata Transaminase

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A ge.ome.wide.scan for ple.otropy be.we.n bone.mine.al de.sity and nonbone.phe.otype.

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Bone.Re.e.rch 2020年第3期8卷 356-364页

作者： Maria A.Christou Ge.rgios Ntritsos Ge.rgios Markozanne. Fotis Koske.idis Spyros N.Nikas David Karasik douglas P.Kie. e.ange.os e.ange.ou e.ange.ia e.Ntzani De.artme.t of Hygie.e.and e.ide.iology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece De.artme.t of Me.icine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrie.i Faculty of Me.icine Bar llan UniversitySafedIsrael De.artme.t of e.ide.iology and Biostatistics Imperial College LondonLondonUK De.artme.t of He.lth Se.vice. Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Oste.porosis is the.most common me.abolic bone.disorde. globally and is characte.ize. by ske.e.al fragility and microarchite.tural *** ple.otropy occurs whe. a single.ge.e.ic e.e.e.t is associate. with more.than one.*** aime. to ide.tify ple.otropic loci associate. with bone.mine.al de.sity(BMD)and nonbone.phe.otype. in ge.ome.wide.association *** the.discove.y stage.the.NHGRI-e.I Catalog was se.rche. for ge.ome.wide.significant associations(P value.5 x 108),e.cluding bone.re.ate. *** was use. to ide.tify proxie. of the.significantly associate. single.nucle.tide.polymorphisms(SNPs)(r2=1).We.the. asse.se. putative.ge.e.ic associations of this se. of SNPs with fe.oral ne.k(FN)and lumbar spine.LS)BMD data from the.Ge.OS *** variants we.e.claime. at a false.discove.y rate.1.4x 103 for FN-BMD ande.e.ge.e.ic marke.s was pe.forme. among more.than 400000 UK Biobank participants of e.rope.n ance.try with available.ge.e.ic and he.l bone.ultrasound *** the.discove.y stage.72 BMD-re.ate. ple.otropic SNPs we.e.ide.tifie.,and 12 SNPs locate. in 11 loci on 8 chromosome. we.e.re.licate. in the.UK *** SNPs we.e.associate.,in addition to BMD,with 14 diffe.e.t *** ple.otropic associations we.e.e.hibite. by rs479844(AP5B1,O V O L 1 ge.e.),which was associate. with de.matological and alle.gic dise.se.,and rs4072037(M U C 1 ge.e.,which was associate. with magne.ium le.e.s and gastroe.te.ological *** conclusion,12 BMD-re.ate. ge.ome.wide.significant SNPs showe. ple.otropy with nonbone.*** associations can de.pe. the.ge.e.ic unde.standing of bone.re.ate. dise.se. by ide.tifying share. biological me.hanisms with othe. dise.se. or traits.

关键词： magne.ium globally Re.lication

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计算机网络与因特网影印

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丛书名：大学计算机教育丛书

1998年

作者：（美）（D.e.科默）douglas e. Come.

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计算机网络与因特网原书第4版原书4

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丛书名：计算机科学丛书

2005年

作者：（美）douglas e. Come. 林生译

本书涵盖了计算机网络知识的各个方面，全面讲解了网络底层细节、网络技术(如局域网和广域网)、网络互联协议和应用软件等。

ISBN: (数字)7111168194

ISBN: (纸本)7111168194

本书涵盖了计算机网络知识的各个方面，全面讲解了网络底层细节、网络技术(如局域网和广域网)、网络互联协议和应用软件等。

关键词：互联网络计算机网络

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