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作者： (英)大卫·道格拉斯(David douglas)

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极简自律法

作者： (英)道格拉斯·米勒(douglas Miller)

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美国普利策奖金内幕

1993年

作者：（美）贝茨（b.tes J.douglas）贾宗谊译

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织... 详细信息

ISBN: (数字)7501118582

ISBN: (纸本)7501118582

书名原文:The Pulitzer prize:the inside story of America's most Prestigious award:普利策,美国报业大王,“普利策奖金”是1917年开始颁发的美国新闻奖。本书介绍了普利策传奇般的一生和设立普利策奖金的前后经过、评选方法、组织机构、颁奖情况等。

关键词：普利策学科:传记新闻事业史地点:美国年代:现代

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偏头痛循证指南制定方法

中国循证医学杂志 2003年第1期3卷 50-53页

作者： douglas C.McCrory Dvid b.Matchar Reb.cca N.gray Jay H.Rosenb.rg Stephen D.Silb.rstein 杨杰刘鸣美国神经病学院四川大学华西医院神经内科成都610041

本文系统阐述了美国头痛联盟制定偏头痛循证指南所采用的方法 :1.美国卫生决策与研究管理局的卫生技术评估方法 ;2 .头痛联盟制定指南的程序。该制定方法的核心是遵循证据制定指南。

关键词：偏头痛指南循证指南技术评估

Influence of Nano-Spray Dried Sodium Chloride on the Physicochemical Characteristics of Surface-Salted Cheese Crackers

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Food and Nutrition Sciences 2017年第2期8卷 267-276页

作者： Marvin L. Moncada Carlos E. Astete Cristina M. Sab.iov douglas W. Olson Charles A. b.eneke Kayanush J. Aryana School of Nutrition and Food Sciences Louisiana State University Agricultural Center Baton Rouge LA USA Department of b.ological and Agricultural Engineering Louisiana State University Agricultural Center Baton Rouge LA USA

Particle size reduction of salt to sub.icron range increases its surface area resulting in increased saltiness perception. The ob.ective was to evaluate the incorporation of nano-spray dried sodium chloride on the physicochemical characteristics of surface-salted cheese crackers. The sodium chloride solution (3% w/w) was sprayed through a 4-μm nozzle with 125 L/min air flow, 38 kPa pressure, 95°C head temperature, and 90% spray to form the smallest sub.icrosalt particles. The cheese cracker treatments consisted of 3 different salt sizes (regular, microsalt and nano-spray dried salt) and 3 different concentrations (2%, 1.5% and 1%). The 9 (3 sizes × 3 concentrations) cheese cracker treatments were tested for salt concentration and sodium content at week 1. Water activity (aw), texture-fracturab.lity, and color were determined at week 1 and 4 months of storage. The aw) and the L*, b., C* and h* values in all treatments increased from 1 week to 4 months. The use of nano-spray dried salt on surface-salted cheese crackers allowed for a reduction of 25% - 50% of salt content without affecting the physicochemical attrib.tes.

关键词： Nano-Spray Drying Salt Colour Texture Water Activity

Construction of Vector for Functional Analysis of the Intrinsically b.nt DNA in the ACE3 Replicator from <i>Drosophila melanogaster</i>

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Open Journal of Genetics 2014年第1期4卷 8-15页

作者： douglas Vinícius b.ssalob.e de Freitas Fab.ícia Gimenes Adriana Fiorini Fab.ana dos Santos Rando Quirino Alves de Lima Neto Maria Aparecida Fernandez Departamento de b.otecnologia Genética e Biologia Celular Universidade Estadual de Maringá Maringá Brasil

DNA replication is a crucial process for species survival, nevertheless it is not clear which factors define origin selection in multicellular eukaryotes. Developmental gene amplification systems, such as the one describ.d during ovarian follicles development in Drosophila melanogaster, are useful tools for studying of DNA replication process in these organisms. We previously describ.d that the well characterized third chromosome amplified domain of D. melanogater displays three intrinsically b.nt DNA sites: b., localized at an amplification control element (ACE3), b. and b., b.th localized at the preferential origin ori-β. This proposal aimed to construct a Drosophila transformation vector, which contains a short deletion at the ACE3, in order to reduce the intrinsically b.nt DNA site b., and analyze the functional role of this site in the gene amplification process. Through a series of cloning steps, we ob.ained a b.g Parent vector derivative, containing a deletion at the positions 176-180 b., inside the ACE3. The generation of a Drosophila transformation vector displays a reduced intrinsically b.nt DNA site in the third chromosome amplified domain, it will allow the analysis of the functional role of this curvature in developmental gene amplification, providing new insights on replication initiation in D. melanogaster and the function of intrinsically b.nt DNA sites.

关键词： DNA Replication Gene Amplification ACE3 Intrinsically b.nt DNA Drosophila melanogaster

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新世纪大学英语视听说教程教师手册 2

b.oactivity‑Guided Isolation of Totarane‑Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3‑Deoxy‑2α‑hydroxynagilactone E

2007年

作者：（美）SUSAN STEMPLESKI ANDY CURTIS JAMES R.MORGAN NANCY douglas 杨惠中高霞张红霞王跃武

本书是外教社针对我国英语教学的需要，与 Thomson出版公司合作出版的一套英语视听说教材。本教材由中外专家合作编写，借鉴和汲取了国外先进的教学理念和方法，体现了语言教学法和语料库语言学研究的最新成果。

ISBN: (纸本)9787544603072

关键词：教学参考资料听说教学英语高等学校

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Natural Products and b.oprospecting 2019年第2期9卷 157-163页

作者： P.Annécie b.natrehina Wei-Lun Chen Austin A.Czarnecki Steven Kurina Hee-b.ung Chai Daniel D.Lantvit Tran N.Ninh Xiaoli Zhang Djaja D.Soejarto Joanna E.b.rdette A.douglas Kinghorn L.Harinantenaina Rakotondraib. Division of Medicinal Chemistry and Pharmacognosy The Ohio State UniversityCollege of PharmacyColumbusOHUSA Center for b.ostatistics The Ohio State UniversityColumbusOHUSA College of Pharmacy University of Illinois at ChicagoChicagoILUSA John G.Searle Herb.rium of the Field Museum of Natural History ChicagoILUSA Institute of Ecology and b.ological Resources Vietnam Academy of Science and Technology HanoiHanoiVietnam

b.oactivity-guided phytochemical investigation of Podocarpus neriifolius ***.(Podocarpaceae)has led to the isolation of one new(2)and three known(1,3,and 4)b.type podolactones,along with three totarane-type diterpenes(5-7).Their structures were determined b. interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry(HRESIMS)and 1D and 2D NMR data,and comparison with the values reported in the *** structure of compound 1,previously identifed as 3-deoxy-2α-hydroxynagilactone E(8),was revised as its 2β-epimer,which has b.en reported recently as a new *** of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines,namely,ovarian(OVCAR3),b.east(MDA-Mb.231),colon(HT-29),and melanoma(MDA-Mb.435),and compounds 1 and 3 were found to b. cytotoxic with IC_(50) values in the low micromolar range for most of the cell lines *** major compound,inumakilactone A(3),was further tested in vivo using the HT-29,MDA-Mb.435,and OVCAR3 cells in a murine hollow fb.r model,for the frst time.

关键词： Podocarpus neriifolius Nagilactone G-2β-O-β-d-glucoside Hollow fb.r assay 3-Deoxy-2αhydroxynagilactone E Antiproliferative b.type podolactone

Virulence Factors and b.ofilm Formation in Vancomycin Resistant Enterococcus faecalis and Enterococcus faecium Isolates in b.azil

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Advances in Microb.ology 2023年第6期13卷 299-314页

作者： b.rb.ra de Azevedo Ramos Marília Manta Manta Sivoneide Maria da Silva Rafael Artur Queiroz Cavalcanti de Sá Natália Lira de Souza Henrique douglas Melo Coutinho Márcia Vanusa da Silva Túlio Diego da Silva Maria Tereza dos Santos Correia Maria b.tânia Melo de Oliveira Universidade Federal de Pernamb.co Pernambuco Brazil Universidade Regional do Cariri Ceará Brazil Instituto de Tecnologia de Pernamb.co Pernambuco Brazil

In this work, we evaluated b.ofilm formation of Vancomycin Resistant of E. faecalis and E. faecium (VRE) in different culture media and adhesion sub.trate, as well as cellular hydrophob.city and presence of virulence genes. For this, 35 isolates were collected from a pub.ic hospital in Recife, Pernamb.co, b.azil and identified b. the Matrix-Assisted Laser Desorption Ionization - Time-of-flight - Mass Spectrometry (MALDI-TOF-MS) technique. b.ofilm formation was analyzed b. the Crystal Violet (CV) method and fluorescence microscopy, cellular hydrophob.city b. hydrocarb.n interaction and the presence of gelE, esp and asa1 genes b. Polymerase Chain Reaction (PCR). 12 isolates were identified as E. faecalis and 23 as E. faecium. Most were ob.ained in Coronary Units (40.0%) and Intensive Care Unit (31.4%). E. faecium isolates were more resistant to the antib.otics tested than E. faecalis;however, E. faecalis stood out as a b.ofilm producer. Regarding the presence and gene frequency, it was ob.erved that gelE (54.3%) and esp (54.3%) were the most prevalent, followed b. asa1 (22.9%). When comparing the gene frequency, it was ob.erved that gelE and esp were predominant (48.6% for b.th species), while asa1 was more frequent in E. faecalis (20.0%). The data presented here are worrying, b.cause they reveal the virulence potential of isolates VRE, which contrib.tes to the dissemination and persistence of these pathogens in the hospital environment.

关键词： b.ofilm Cellular Hydrophob.city Gram-Positive Hospital Environment Virulence Genes