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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao dou zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number violation.We propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx experiment.Besides being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological characteristics.This makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββsearches.NvDEx-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by 2025.This report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

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半地下双层浅圆仓静态储粮温度场的数值分析

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粮油食品科技 2024年第1期32卷 153-160页

作者：金立兵朱豆豆李闯吴强王宇航张为博河南工业大学土木工程学院河南郑州450001 河南工大设计研究院有限公司河南郑州450001

粮食温度是影响储粮安全的最重要因素之一,为揭示半地下双层浅圆仓的储粮温度场分布规律,本文建立了地上浅圆仓和地下仓的粮堆数学分析模型,并通过现场实验结果验证了模型的有效性。以此为基础建立了半地下双层浅圆仓数值模型,分析低温... 详细信息

粮食温度是影响储粮安全的最重要因素之一,为揭示半地下双层浅圆仓的储粮温度场分布规律,本文建立了地上浅圆仓和地下仓的粮堆数学分析模型,并通过现场实验结果验证了模型的有效性。以此为基础建立了半地下双层浅圆仓数值模型,分析低温入粮后静态储藏1年期间的粮堆温度场变化规律。结果表明:半地下双层浅圆仓地上层靠近仓壁2 m内的粮温受外界气温影响变化明显,温度范围在10.62~27.37℃,地下层粮温常年处在准低温状态,平均温度不超过地下恒温区温度17℃;入冬时地上层粮堆在距仓壁1~3 m之间会短期形成一个热量聚集区,导致近仓壁处粮堆温差较大,随后外围区温度缓慢降低,形成“热心冷皮”;仓壁的保温隔热措施可有效减小气温对粮温的影响,地上层夏季最高粮温较未做保温的地上浅圆仓低3.86℃左右。研究结果可为半地下双层浅圆仓的推广应用提供技术支持。

关键词：半地下双层浅圆仓静态储粮温度场数值分析验证

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Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui Cheng Jialiang Wei Minghui zhu Xiaodong dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so on.As Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”1.Late-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds promptly.Such modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and druggability.To enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these fields.We also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized molecules.Ultimately,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation Synthetic chemistry

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Cobalt-nanoparticle catalysts derived from zeolitic imidazolate framework@MXene composites for efficient oxidative self-coupling of benzylamines

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 95-106页

作者： Jie Chen Mingyuan Jian Deqiong Xie Kecan dou Deli Chen Weidong zhu Fumin Zhang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

In this study,we synthesize a catalyst comprising cobalt nanoparticles supported on MXene by pyrolyzing a composite in a N2 environment.Specifically,the composite comprises a bimetallic Zn/Co zeolitic imidazole framework grown in situ on the outer surface of MXene.The catalytic efficiency of the catalyst is tested for the self-coupling of 4-methoxybenzylamine to produce value-added imine,where atmospheric oxygen(1 atm)is used as the oxidant.Based on the results,the catalyst displayed impressive catalytic activity,achieving 95.4%yield of the desired imine at 383 K for 8 h.Furthermore,the catalyst showed recyclability and tolerance toward benzylamine substrates with various functional groups.The outstanding performance of the catalyst is primarily attributed to the synergetic catalytic effect between the cobalt nanoparticles and MXene support,while also benefiting from the three-dimensional porous structure.Additionally,a preliminary investigation of potential reaction mechanisms is conducted.

关键词： MXene sacrificial template oxidative self-coupling Co nanoparticles imine

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Vacancy healing for stable perovskite solar cells via bifunctional potassium tartrate

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Journal of Energy Chemistry 2024年第1期88卷 64-70,I0002页

作者： Jing dou Yue Ma Xiuxiu Niu Wentao Zhou Xueyuan Wei Jie dou Zhenhua Cui Qizhen Song Tinglu Song Huanping Zhou Cheng zhu Yang Bai Qi Chen Experimental Centre for Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationBIC-ESATSchool of Materials Science and EngineeringPeking UniversityBeijing 100871China

Perovskite solar cell has gained widespread attention as a promising technology for renewable energy.However, their commercial viability has been hampered by their long-term stability and potential Pb leakage. Herein, we demonstrate a bifunctional passivator of the potassium tartrate(PT) to address both challenges. PT minimizes the Pb leakage in perovskites and also heals cationic vacancy defects, resulting in improved device performance and stability. Benefiting from PT modification, the power conversion efficiency(PCE) is improved to 23.26% and the Pb leakage in unencapsulated films is significantly reduced to 9.79 ppm. Furthermore, the corresponding device exhibits no significant decay in PCE after tracking at the maximum power point(MPP) for 2000 h under illumination(LED source, 100 mW cm^(-2)).

关键词： Perovskite Potassium tartrate Lead leakage Long-term stability

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译介·变异·想象:媒介环境学在中国的学术旅行——基于对何道宽、刘海龙、胡翼青的访谈

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编辑之友 2023年第5期 86-92页

作者：朱豆豆北京物资学院外国语言与文化学院北京101126

何道宽是媒介环境学派的主要译介人,刘海龙、胡翼青是国内传播学研究的学科领航人。本研究基于对三位学者的访谈,从媒介环境学的译介、学科流变及对未来的学科想象三方面考察该学派在中国的学科边界问题。该访谈实质上是对媒介环境学在... 详细信息

何道宽是媒介环境学派的主要译介人,刘海龙、胡翼青是国内传播学研究的学科领航人。本研究基于对三位学者的访谈,从媒介环境学的译介、学科流变及对未来的学科想象三方面考察该学派在中国的学科边界问题。该访谈实质上是对媒介环境学在后现代思潮下的边界“内爆”,及对传播学学科“规训”的一种回望及省思。正所谓不破不立,文章在借鉴诸多媒介研究领航人观点的基础上,提出未来汉语世界的媒介环境学研究应打破传统的将媒介作为环境的单一研究视野,发展媒介环境学的哲学观、“媒介即是膜”“媒介即中介”等多种面向的学术脉络,最终使该学派从“走进”传播学迈向“走出”传播学,进入更加广阔的跨学科领域。

关键词：媒介环境学学科之困传播学跨学科

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Luminescent metal-halide perovskites:fundamentals,synthesis,and light-emitting devices

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Science China Chemistry 2024年第6期67卷 1776-1838页

作者： Kang Wang Jeong Hui Kim Jie Yang Xiaoke Liu Yixuan dou Yuxuan Li Weijian Tao Haiyun Dong Haiming zhu Kaifeng Wu Li Na Quan Feng Gao Jianpu Wang Letian dou Yong Sheng Zhao Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Physics Linköping UniversityLinköping58183Sweden Department of Chemistry Virginia TechBlacksburgVA24060USA State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Chemistry Zhejiang UniversityHangzhou310058China Changzhou University Changzhou213164China Department of Chemistry Purdue UniversityWest LafayetteIN47907USA

Metal-halide perovskites have garnered considerable research attention as highly efficient light emitters in recent years due to their outstanding optoelectronic properties with remarkable tunability and excellent solution processabilities.Substantial advancements have been achieved in the development of novel halide perovskites,and the exploitations of these materials in lightemitting devices.This review comprehensively outlines recent breakthroughs in metal-halide perovskites,encompassing the rational design of perovskite materials with tunable light emission properties,the controllable growth of single crystal for a deeper understanding of their structure-property relationships,as well as the fundamental insights into the photophysics and carrier dynamics in perovskite systems.Additionally,it provides an overview of recent applications of perovskite materials in high-performance light-emitting diodes(LEDs)and lasers.

关键词： metal-halide perovskites perovskite luminescent materials perovskite synthesis excited-state processes perovskite light-emitting diodes perovskite lasers

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Nano friction behaviour between magnetic materials and copper considering the inter-diffusion effect

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Friction 2024年第7期12卷 1532-1547页

作者： Zilin LI Lisha dou Shiyu YANG Huajiang OUYANG Qichen zhu Xiaoyang CHEN Xin JIA Shuaiwei dou Xiaolong CUI Yudong ZHANG Jingjiang QIU Guochen QI Bangbang NIE Pan LIU Ronghan WEI School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application Zhengzhou UniversityZhengzhou 450001China Institute of Intelligent Sensing Zhengzhou UniversityZhengzhou 450001China School of Engineering University of LiverpoolLiverpool L693GHUK School of Cyber Science and Engineering&Hanwei Institute of Internet of Things Zhengzhou UniversityZhengzhou 450001China

Copper,permalloy,cobalt,and silicon are the materials that have been widely utilised in magnetic devices.When the size of interest is down to the nanoscale,the inter-diffusion between certain materials becomes influential.This paper studies the nanoscale friction characteristics between frictional pairs with and without inter-diffusion properties through the atomic force microscope.The distinct evolution features of nanoscale friction force when inter-diffusion is involved are discovered experimentally,which is also confirmed through theoretical analysis.Firstly,through the thin film deposition method,four pairs of contact materials(Cu–Ni_(81)Fe_(19),Si–Ni_(81)Fe_(19),Cu–Co,Cu–Si)are designed for friction tests,in which diffusion occurs at the interface of Cu–Ni_(81)Fe_(19)pair.Then,the effects of sliding velocity and loading force on the nano friction of each pair are measured.It is found that regardless of the diffusion phenomenon:(1)the adhesion force values exhibit a notable correlation to the values of the friction force;(2)the friction force in all four material pairs consistently increases with the growth of the normal loading force,although the growth rate may differ.In terms of the sliding velocity effect,the friction forces of immiscible materials(Si–Ni_(81)Fe_(19),Cu–Co,and Cu–Si)are found to increase with the increasing sliding velocity.However,the friction force of Cu–Ni_(81)Fe_(19),decreases with the increasing sliding velocity.Furthermore,a compositive friction model considering both the velocity and the normal force effect was proposed,which shows good agreement with the experimental results and explains the nano friction behaviour of both miscible and immiscible metals.

关键词： atomic force microscope friction force normal load sliding velocity

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Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 304-310页

作者： Yuan-Zhang zhu Zhi-Zhi dou Wen-Ying Wang Qing-Yue Ma Wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang Wen-Juan Luo Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To observe the therapeutic effect of conbercept on diabetic macular edema(DME)complicated with diabetic nephropathy(DN).METHODS:In this retrospective study,54 patients(54 eyes)that diagnosed as DME from January 2017 to October 2021 were collected.The patients were divided into two groups:DME patients with DN(25 eyes),and DME patients without DN(29 eyes).General conditions were collected before treatment,laboratory tests include fasting blood glucose,HbA1c,microalbumin/creatinine,serum creatinine.Optical coherence tomography(OCT)was used to check the ellipsoidal zone(EZ)and external limiting membrane(ELM)integrity.Central macular thickness(CMT),best corrected visual acuity(BCVA),and retinal hyperreflective foci(HF)as well as numbers of injections were recorded.RESULTS:There were significant differences between fasting blood glucose,HbA1c,serum creatinine,urinary microalbumin/creatinine,and estimated glomerular filtration rate(eGFR)between the two groups(all P<0.05).EZ and ELM continuity in the DME+DN group was worse than that in the DME group(P<0.05).BCVA(logMAR)in the DME group was significantly better than that in the DME+DN group at the same time points during treatment(all P<0.05).CMT and HF values were significantly higher in the DME+DN group than that in the DME group at the all time points(all P<0.05)and significantly decreased in both groups with time during treatment.At 6mo after treatment,the mean number of injections in the DME+DN and DME group was 4.84±0.94 and 3.79±0.86,respectively.CONCLUSION:Conbercept has a significant effect in short-term treatment of DME patients with or without DN,and can significantly ameliorate BCVA,CMT and the number of HF,treatment efficacy of DME patients without DN is better than that of DME patients with DN.

关键词： conbercept diabetic nephropathy diabetic macular edema optical coherence tomography

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Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： Hui-Hui LIU Meng ZHANG Yuan-Lin GUO Cheng-Gang zhu Na-Qiong WU Ying GAO Rui-Xia XU Jie QIAN Ke-Fei dou Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are unavailable.Therefore,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with AMI.METHODS In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were enrolled.On admission,ABG,SHR,and GG were assessed and all participants were classified according to their quartiles.Kaplan-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term follow-up.RESULTS During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were recorded.Kaplan-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and GG.After adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term CVM.Additionally,we observed similar associations of these acute glycemic parameters with 30-day CVM.CONCLUSIONS Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

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