检索结果-南通市图书馆

Prevention and forecasting of rock burst hazards in coal mines

在线全文

学校读者我要写书评

暂无评论

Mining Science and Technology 2009年第5期19卷 585-591页

作者： dou Lin-ming lu Cai-ping MU Zong-long GAO Ming-shi State Key Laboratory for Coal Resource and Mine Safety China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Rock bursts signify extreme behavior in coal mine strata and severely threaten the safety of the lives of miners, as well as the effectiveness and productivity of miners. In our study, an elastic-plastic-brittle model for the deformation and failure of coal/rock was established through theoretical analyses, laboratory experiments and field testing, simulation and other means, which perfectly predict sudden and delayed rock bursts. Based on electromagnetic emission (EME), acoustic emission (AE) and microseism (MS) effects in the process from deformation until impact rupture of coal-rock combination samples, a multi-parameter identification of premonitory technology was formed, largely depending on these three forms of emission. Thus a system of classification for forecasting rock bursts in space and time was established. We have presented the intensity weakening theory for rock bursts and a strong-soft-strong (3S) structural model for controlling the impact on rock surrounding roadways, with the objective of laying a theoretical foundation and establishing references for parameters for the weakening control of rock bursts. For the purpose of prevention, key technical parameters of directional hydraulic fracturing are revealed. Based on these results, as well as those from deep-hole controlled blasting in coal seams and rock, integrated control techniques were established and anti-impact hydraulic props, suitable for roadways subject to hazards from rockbursts have also been developed. These technologies have been widely used in most coal mines in China, subject to these hazards and have achieved remarkable economic and social benefits.

关键词： rock bursts elastic-plastic-brittle model multi-parameter premonitory intensity weakening strong-soft-strong (3S) structure directional hydraulic fracturing anti-impact hydraulic prop

Automatic User Goals Identification Based on Anchor Text and Click-Through Data

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2008年第4期13卷 495-500页

作者： YUAN Xiaojie dou Zhicheng ZHANG lu LIU Fang College of Information Technical Science Nankai UniversityTianjin 300071 China

Understanding the underlying goal behind a user＇s Web query has been proved to be helpful to improve the quality of search. This paper focuses on the problem of automatic identification of query types according to the goals. Four novel entropy-based features extracted from anchor data and click-through data are proposed, and a support vector machines （SVM） classifier is used to identify the user＇s goal based on these features. Experi- mental results show that the proposed entropy-based features are more effective than those reported in previous work. By combin- ing multiple features the goals for more than 97% of the queries studied can be correctly identified. Besides these, this paper reaches the following important conclusions： First, anchor-based features are more effective than click-through-based features; Second, the number of sites is more reliable than the number of links; Third, click-distribution- based features are more effective than session-based ones.

关键词： query classification user goals anchor text click-through data information retrieval

Research progress of ginger in the treatment of gastrointestinal tumors

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2023年第11期15卷 1835-1851页

作者： Guo-Qing Chen Yi Nan Shi-Cong Huang Na Ning Yu-Hua Du dou-dou lu Ya-Ting Yang Fan-Di Meng Ling Yuan College of Pharmacy Ningxia Medical CollegeYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Ethnomedicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Cancer seriously endangers human *** cancer is the most common and major malignant tumor,and its morbidity and mortality are gradually *** there are effective treatments such as radio-therapy and chemotherapy for gastrointestinal tumors,they are often accom-panied by serious side *** to the traditional Chinese medicine and food homology theory,many materials are both food and ***,food is just as capable of preventing and treating diseases as *** and food homologous herbs not only have excellent pharmacological effects and activities but also have few side *** a typical medicinal herb with both medicinal and edible uses,some components of ginger have been shown to have good efficacy and safety against cancer.A mass of evidence has also shown that ginger has anti-tumor effects on digestive tract cancers(such as gastric cancer,colorectal cancer,liver cancer,laryngeal cancer,and pancreatic cancer)through a variety of *** aim of this study is to investigate the mechanisms of action of the main components of ginger and their potential clinical applications in treating gastrointestinal tumors.

关键词： Ginger Medicine and food homology Gastrointestinal cancer Molecular mechanism Tumor

18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription 3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第27期29卷 4317-4333页

作者： Yi Yang Yi Nan Yu-Hua Du Shi-Cong Huang dou-dou lu Jun-Fei Zhang Xia Li Yan Chen Lei Zhang Ling Yuan Ningxia Medical University Yinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Gastric cancer(GC)is one of the most common cancer types worldwide,and its prevention and treatment methods have garnered much *** the active ingredient of licorice,18β-glycyrrhetinic acid(18β-GRA)has a variety of pharmacological *** aim of this study was to explore the effective target of 18β-GRA in the treatment of GC,in order to provide effective ideas for the clinical prevention and treatment of *** To investigate the mechanism of 18β-GRA in inhibiting cell proliferation and promoting autophagy flux in GC *** Whole transcriptomic analyses were used to analyze and screen differentially expressed microRNAs(miRNAs)in GC cells after 18β-GRA ***-transfected GC cells and the Cell Counting Kit-8 were used to detect cell proliferation ability,cell colony formation ability was detected by the clone formation assay,and flow cytometry was used to detect the cell cycle and apoptosis.A nude mouse transplantation tumor model of GC cells was constructed to verify the effect of miR-328-3p overexpression on the tumorigenicity of GC *** tissue morphology was observed by hematoxylin and eosin staining,and microtubule-associated protein light chain 3(LC3)expression was detected by ***,STRING,and miRWalk databases were used to predict the relationship between miR-328-3p and signal transducer and activator of transcription 3(STAT3)-related *** of STAT3 mRNA and miR-328-3p was detected by quantitative polymerase chain reaction(qPCR)and the expression levels of STAT3,phosphorylated STAT3(p-STAT3),and LC3 were detected by western blot *** targeted relationship between miR-328-3p and STAT3 was detected using the dual-luciferase reporter gene *** cells were infected with monomeric red fluorescent protein-green fluorescent protein-LC3 adenovirus double ***3 was labeled and autophagy flow was observed under a confocal laser *** The expression

关键词： 18β-glycyrrhetinic acid miR-328-3p Signal transducer and activator of transcription 3 Cell proliferation Autophagy flow

Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第11期14卷 1672-1692页

作者： Fan-Di Meng Ling Yuan Duo-Jie Xu Meng-Ying Che Shao-Zhang Hou dou-dou lu Wen-Jing Liu Yi Nan Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Ethnomedicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Ningxia Key Laboratory of Craniocerebral Diseases Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic nephropathy(DN)stands as the most prevalent chronic microvascular complication of diabetes *** 50%of DN patients progress to end-stage renal disease,posing a substantial health *** To employ network pharmacology and molecular docking methods to predict the mechanism by which glycyrrhetinic acid(GA)treats DN,subsequently validating these predictions through experimental *** The study initially identified GA targets using Pharm Mapper and the TCMSP *** relevant to DN were obtained from the Genecards,OMIM,and TTD *** Venny database facilitated the acquisition of intersecting targets between GA and *** String database was used to construct a protein interaction network,while DAVID database was used to conducted Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis and Gene Ontology(GO)*** docking experiments were performed using Autodock software with selected *** validation was conducted using renal proximal tubular cells(HK-2)as the study subjects.A hyperglycemic environment was simulated using glucose solution,and the effect of GA on cell viability was assessed through the cell counting kit-8 *** cytometry was employed to detect cell cycle and apoptosis,and protein immunoblot(western blot)was used to measure the expression of proteins of the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway and insulin resistance pathway,including insulin receptor(INSR),PI3K,p-PI3K,AKT,p-AKT,and glycogen synthase kinase-3(GSK3).RESULTS A total of 186 intersecting targets between GA and DN were identified,which were associated with 144 KEGGrelated enrichment pathways,375 GO biological process entries,45 GO cellular component entries,and 112 GO cellular function *** docking demonstrated strong binding of GA to mitogen-activated protein kinase(MAPK)-1,SRC,PIK3R1,HSP90AA1,CASPASE9,HARS,KRAS,and *** vitro experiment

关键词： Network pharmacology Molecular docking Diabetic nephropathy Glycyrrhetinic acid Mechanism of action

18β-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第23期29卷 3622-3644页

作者： Xia Li Xiao-Ling Ma Yi Nan Yu-Hua Du Yi Yang dou-dou lu Jun-Fei Zhang Yan Chen Lei Zhang Yang Niu Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Hui Ethnic Medicine Modernization of Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Gastric cancer(GC)is a common gastrointestinal malignancy *** on cancer-related mortality,the current prevention and treatment strategies for GC still show poor clinical ***,it is important to find effective drug treatment *** To explore the molecular mechanism of 18β-glycyrrhetinic acid(18β-GRA)regulating the miR-345-5p/TGM2 signaling pathway to inhibit the proliferation of GC *** CCK-8 assay was used to determine the effect of 18β-GRA on the survival rate of GES-1 cells and AGS and HGC-27 *** cycle and apoptosis were detected by flow cytometry,cell migration was detected by a wound healing assay,the effect of 18β-GRA on subcutaneous tumor growth in BALB/c nude mice was investigated,and the cell autophagy level was determined by MDC *** proteomic analysis was used to detect the differentially expressed autophagy-related proteins in GC cells after 18β-GRA intervention,and then the protein-protein interaction was predicted using STRING(https://***/).MicroRNAs(miRNAs)transcriptome analysis was used to detect the miRNA differential expression profile,and use miRBase(https://***/)and TargetScan(https://***/)to predict the miRNA and complementary binding *** real-time polymerase chain reaction was used to detect the expression level of miRNA in 18β-GRA treated cells,and western blot was used to detect the expression of autophagy related ***,the effect of miR-345-5p on GC cells was verified by mir-345-5p *** 18β-GRA could inhibit GC cells viability,promote cell apoptosis,block cell cycle,reduce cell wound healing ability,and inhibit the GC cells growth in *** staining results showed that 18β-GRA could promote autophagy in GC *** TMT proteomic analysis and miRNAs transcriptome analysis,it was concluded that 18β-GRA could down-regulate TGM2 expression and up-regulate miR-345-5p expression in GC ***,we

关键词： 18β-glycyrrhetinic acid Gastric cancer MiR-345-5p TGM2 Proliferation Autophagy

Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-Ying Che Ling Yuan Jiao Min Duo-Jie Xu dou-dou lu Wen-Jing Liu Kai-Li Wang Yan-Yan Wang Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： dou-dou lu Ling Yuan Zhao-Zhao Wang Jian-Jun Zhao Yu-Hua Du Na Ning Guo-Qing Chen Shi-Cong Huang Yi Yang Zhe Zhang Yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 ***,the mechanism of its anti-gastric cancer and regulate immunity are still remains *** To explore the mechanism of YGS anti-gastric cancer and immune *** Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric ***,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub *** the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were ***,molecular docking was used to verify the binding ability of YGS active ingredient and hub *** Firstly,obtained 55 common targets of gastric cancer and *** Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub *** 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer ***,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic *** YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

养老旅游者与目的地居民的情感凝聚对重游意愿的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

旅游科学 2016年第5期30卷 63-73页

作者：窦璐济南大学商学院山东济南250002

本文以养老旅游者安全感知为中介变量,构建了养老旅游者与目的地居民的情感凝聚对重游意愿的影响机制模型;并以哈尔滨赴海南的养老旅游者为例,运用结构方程模型进行实证研究。研究表明:养老旅游者与目的地居民的情感凝聚的3个维度均显... 详细信息

本文以养老旅游者安全感知为中介变量,构建了养老旅游者与目的地居民的情感凝聚对重游意愿的影响机制模型;并以哈尔滨赴海南的养老旅游者为例,运用结构方程模型进行实证研究。研究表明:养老旅游者与目的地居民的情感凝聚的3个维度均显著地正向影响养老旅游者安全感知,影响程度大小依次为养老旅游者与目的地居民的情感亲密性、养老旅游者感知的受欢迎程度、养老旅游者对目的地居民的认同感;养老旅游者与目的地居民的情感凝聚通过养老旅游者安全感知的完全中介作用间接影响重游意愿。

关键词：养老旅游者目的地居民情感凝聚重游意愿