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High-efficiency somatic embryogenesis and morphohistology and histochemistry of somatic embryo development in Larix leptolepis Gordon

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Forestry Studies in China 2007年第3期9卷 182-188页

作者： Wang Xiao-xiong Lu Long-dou Hao Huai-qing Teng Nian-jun Chen Tong Guo Yi-ming Yang Ying-gen Guo Zhong-chen Lin Jin-xing Key Laboratory of Photosynthesis and Molecular Environmental Physiology Institute of Botany the Chinese Academy of Sciences Beijing 100093 P. R. China College of Life Sciences Henan Normal University Xinxiang 453007 P. R. China

A high-efficiency somatic embryogenesis protocol of Japanese larch （Larix leptolepis Gordon） has been established in our investigation. Calli were induced from immature zygotic embryos of female cones ofL. leptolepis and then subcultured regularly on to a modified Gupta and Durzan （DCR） basal medium for 5 years. Embryogenic tissues showed distinct morphological changes dur- ing somatic embryo development when they were transferred to a maturation medium supplemented with abscisic acid （ABA） com- pared with the morphology in a medium lacking ABA. Histological observations indicated that polyembryony was a characteristic feature during early embryogeny and somatic embryos at later stages showed normal histodifferentiation. In addition, histochemical analysis revealed that abundant starch granules and proteins accumulated in mature embryos, indicating that they played important roles in the development and regeneration of normal plantlets from somatic embryos on hormone-free germination media

关键词： Larix leptolepis Gordon abscisic acid (ABA) histochemistry morphohistology polyembryony

基于FPGA的细粒度并行CYK算法加速器设计与实现

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计算机学报 2010年第5期33卷 797-812页

作者：夏飞窦勇宋健雷国庆国防科学技术大学计算机学院中国人民解放军61785部队

基于随机上下文无关文法(SCFG)理论模型进行RNA二级结构预测是目前采用计算方法研究RNA二级结构的一种重要途径.由于基于SCFG模型的标准结构预测算法(Coche-Younger-Kasami,CYK)巨大的时空复杂度,对CYK算法进行加速成为计算生物学领域... 详细信息

基于随机上下文无关文法(SCFG)理论模型进行RNA二级结构预测是目前采用计算方法研究RNA二级结构的一种重要途径.由于基于SCFG模型的标准结构预测算法(Coche-Younger-Kasami,CYK)巨大的时空复杂度,对CYK算法进行加速成为计算生物学领域一个极具挑战性的热点问题.CYK的并行性能受限于算法多维度、非一致性的数据依赖关系和较低的计算/通信比,现有的基于通用微处理器结构的大规模并行处理方案不能获得令人满意的加速效果,并且大规模并行计算机系统硬件设备的购置、使用、日常维护的成本高昂,其适用性受到诸多限制.文中在深入分析CYK算法计算特征的基础上,基于FPGA平台提出并实现了一种细粒度的并行CYK算法.设计采用了对三维动态规划矩阵"按区域分割"和"逐层按列并行处理"的计算策略实现了多个处理单元间的负载均衡;采用数据预取、滑动窗口和数据传递流水线实现处理单元间的数据重用,有效解决了计算和通信间的平衡问题;设计了一种类似脉动阵列(systolic-like array)结构的主从多PE并行计算阵列,并在目前最大规模的FPGA芯片(Xilinx XC5VLX330)上成功集成了16个处理单元(processing elements),实验结果表明作者提出的CYK算法加速器结构具备良好的可扩展性.当RNA序列长度为959bps,CM模型状态数为3145时,与运行在Intel双核E5200 2.5GHzCPU、2.0GB主存通用计算上的Infernal-1.0软件相比,可获得超过14倍的加速效果.配置一个FP-GA算法加速器的通用计算平台的综合处理性能与包含20个Intel-Xeon CPU的PC集群相当,而硬件成本仅为后者的20%,系统功耗不到后者的10%.

关键词：生物信息学 RNA 二级结构预测 SCFG模型并行CYK算法 FPGA 硬件加速器

Analysis of long-term outcomes and application of the tumor regression grading system in the therapeutic assessment of resectable limited-disease small cell lung cancer

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Oncology and Translational Medicine 2016年第5期2卷 227-233页

作者： Shuonan Xu Jianfei Zhu Yawei dou Wei Tian Yun Dai Xianghui Luo Hongtao Wang department of Thoracic Surgery Shaanxi Provincial People’s HospitalXi'an 710000China Medical College of Yan’an University Xi'an 716000China The Third Affiliated Hospital of the School of Medicine Xi’an Jiao Tong University Xi'an 710000China

Objective The present study attempted to evaluate the value of neoadjuvant chemotherapy in limiteddisease small cell lung cancer(LD-SCLC),and to identify the predictive value of the tumor regression grading(TRG) system in LD-SCLC treatment-response and *** The records of patients with LD-SCLC(p-Stage I–IIIa) who underwent definitive radical resection at Shaanxi Provincial People's Hospital between March 1,2000 and March 31,2014 were retrospectively *** compared the disease-free survival(DFS) and overall survival(OS) rates between Group A patients(patients who underwent surgery combined with pre-and post-operative chemotherapy) and Group B patients(patients who underwent surgery combined with adjuvant chemotherapy only) using the Kaplan-Meier method and the Mantel-Cox *** specimens of patients who received neoadjuvant chemotherapy were reassessed according to the TRG *** The median DFS for 27 patients was 16.267 months and the median OS was 81.167 months(1-year OS,74.07%;3-year OS,22.22%;5-year OS,14.81%).Thirteen patients received neoadjuvant chemotherapy,and their specimens were reassessed by TRG(pathological complete remission,3/13,23.08%).Patients in group A had a longer OS than those in group B(mean,93.782 months versus 42.322 months,P = 0.025),although there was no significant difference in DFS between the two groups(median 20.100 months versus 14.667 months,P = 0.551).Statistical analysis revealed that TRG Grade(G) 0(mean,61.222 months) was associated with better OS than G1-2(mean,31.213 months)(P = 0.311).Conclusion Our study indicated that neoadjuvant chemotherapy combined with surgical resection may represent a feasible treatment method for patients with *** TRG system may be a valuable prediction tool to assess neoadjuvant chemotherapeutic efficacy,especially in patients with G0 disease as determined by TRG;these patients may attain an improved survival benefit with neoadjuvant chemotherapy.

关键词： small cell lung cancer tumor regression grading neoadjuvant chemotherapy

Multi-scale validation strategy for satellite albedo products and its uncertainty analysis

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Science China Earth Sciences 2015年第1期58卷 573-588页

作者： PENG JingJing LIU Qiang WEN JianGuang LIU QinHuo TANG Yong WANG LiZhao dou BaoCheng YOU DongQin SUN ChangKui ZHAO XiaoJie FENG YouBin SHI Jian State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences College of Global Change and Earth System Science Beijing Normal University

Coarse-resolution satellite albedo products are important for climate change and energy balance research because of their capability to characterize the spatiotemporal patterns of land surface parameters at both the regional and global scales. The accuracy of coarse-resolution products is usually assessed via comparison with in situ measurements. The key issue in the comparison of remote sensing observations with in situ measurements is scaling and uncertainty. This paper presents a strategy for validating 1-km-resolution remote sensing albedo products using field measurements and high-resolution remote sensing observations. Field measurements were collected to calibrate the high-resolution(30 m) albedo products derived from HJ-1a/b images. Then, the calibrated high-resolution albedo maps were resampled(i.e., upscaled) to assess the accuracy of the coarse-resolution albedo products. The samples of field measurements and high-resolution pixels are based on an uncertainty analysis. Two types of coarse-resolution albedo datasets, from global land surface satellite(GLASS) and moderate-resolution imaging spectroradiometer(MODIS), are validated over the middle reaches of the Heihe River in China. The results indicate that the upscaled HJ(Huan Jing means environment in Chinese and this refers to a satellite constellation designed for environment and disaster monitoring by China) albedo, which was calibrated using field measurements, can provide accurate reference values for validating coarse-resolution satellite albedo products. However, the uncertainties in the upscaled HJ albedo should be estimated, and pixels with large uncertainties should be excluded from the validation process.

关键词： MCD43B3 GLASS02 uncertainty analysis validation remote sensing albedo

H_(2)O_(2)-responsive multifunctional nanocomposite for the inhibition of amyloid-βand Tau aggregation in Alzheimer's disease

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BMEMat(BioMedical Engineering Materials) 2023年第1期1卷 91-99页

作者： Luying Qiao Yang Shen Shiyu Zhang Man Wang Guanglei Lv Qingqing dou Chunxia Li Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity ScienceShandong UniversityQingdaoChina School of Environmental Science and Engineering Shandong UniversityQingdaoChina Center for Biotechnology and Biomedical Engineering Yiwu Research Institute of Fudan UniversityYiwuChina Institute of Material Research&Engineering Agency for ScienceTechnology and Research(A^(*)STAR)SingaporeSingapore

Amyloid-β(Aβ)and Tau proteins are the main components of Aβplaques and neurofibrillary tangles in Alzheimer's disease(AD),and their abnormal ag-gregation is closely related to the pathogenesis of *** production of reactive oxygen species(ROS)and the aggregation of Aβand Tau form a vi-cious circle,which leads to the aggravation of ***,inhibiting the aggregation of Aβand Tau or scavenging ROS is not able to effectively reverse the progression of ***,we prepared a H_(2)O_(2) responsive multifunctional nanocomposite UCNPs@mSiO_(2)-MB@AuNPs(abbreviated as USMA)to inhibit the aggregation of Aβand *** this system,USMA could respond to H_(2)O_(2) to detach gold nanoparticles(AuNPs)and lead to the release of meth-ylene blue(MB)from mesoporous silica(mSiO_(2)),where AuNPs and MB can inhibit Aβand Tau aggregation,***,USMA could consume H_(2)O_(2) by reacting with ***,upconversion lumines-cence of UCNPs can be used to track USMA and monitor MB release,which could provide information on the content of MB in the lesion ***-tantly,the USMA can effectively reduce the cytotoxicity induced by Aβand Tau *** work opens up a possibility to improve therapeutic ef-ficacy for the treatment of AD.

关键词： Alzheimer's disease Amyloid-β Tau upconversion nanoparticles

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临床异种器官移植十大问题的思考

器官移植 2022年第4期13卷 411-416页

作者：窦科峰张玄空军军医大学西京医院肝胆外科西安710032

供者短缺是影响器官移植发展的一大难题,而异种器官移植可能是解决这一难题的有效途径。随着基因编辑技术的发展以及新型免疫抑制剂的研发,异种器官移植领域取得了许多突破性的进展,但大多数研究目前仍处于临床前阶段。近期,世界首例基... 详细信息

供者短缺是影响器官移植发展的一大难题,而异种器官移植可能是解决这一难题的有效途径。随着基因编辑技术的发展以及新型免疫抑制剂的研发,异种器官移植领域取得了许多突破性的进展,但大多数研究目前仍处于临床前阶段。近期,世界首例基因编辑猪到人心脏移植的成功极大地鼓舞了科研工作者。但临床异种器官移植仍面临很多重要问题,包括克服排斥反应、控制炎症反应、调节凝血紊乱、提高移植物生理相容性、重视种间感染风险、优化免疫抑制方案、筛选供体基因编辑类型、选择适宜受者人群、完善异种移植指南、明确大众认可度等,本文就以上十大问题进行总结,以期为促进异种器官移植的临床应用提供参考。

关键词：异种移植基因编辑排斥反应炎症反应凝血紊乱生理相容性种间感染免疫抑制方案

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面向大尺度战场的飞行机动建模仿真技术

系统仿真学报 2021年第3期33卷 613-621页

作者：初阳刘志窦林涛江苏自动化研究所江苏连云港222061

为满足智能对抗博弈系统对体系仿真加速能力的要求,分析了大尺度战场空间大规模空中兵力仿真建模方法,结合体系对抗对飞机、导弹等空中飞行器建模逼真性、实时性、准确性的需求,在原有空中飞行器运动模型的基础上,通过约减变量、简化参... 详细信息

为满足智能对抗博弈系统对体系仿真加速能力的要求,分析了大尺度战场空间大规模空中兵力仿真建模方法,结合体系对抗对飞机、导弹等空中飞行器建模逼真性、实时性、准确性的需求,在原有空中飞行器运动模型的基础上,通过约减变量、简化参数、等效计算等方法,推导出了一种快速飞行机动仿真建模方法,能够实现对飞行器轨迹、姿态的正确建模,符合一般飞行物理规律,满足体系对抗建模仿真和智能博弈对抗的需求,同时大大提升了仿真模型解算效率,计算机仿真结果证明该方法的正确性。

关键词：飞行仿真体系建模仿真伪六自由度大尺度战场

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圆锥空腔内涡破裂现象的数值模拟

排灌机械工程学报 2014年第10期32卷 829-834页

作者：窦华书肖美娜浙江理工大学机械与自动控制学院浙江杭州310018

采用三维非定常的Navier-Stokes方程对底面驱动的密闭圆锥室内旋转层流流动中的涡破裂现象进行了数值模拟,分析了雷诺数和几何结构对圆锥空腔内涡破裂现象的发展规律的影响.利用有限体积法离散控制方程和SIMPLE算法实施计算,计算网格采... 详细信息

采用三维非定常的Navier-Stokes方程对底面驱动的密闭圆锥室内旋转层流流动中的涡破裂现象进行了数值模拟,分析了雷诺数和几何结构对圆锥空腔内涡破裂现象的发展规律的影响.利用有限体积法离散控制方程和SIMPLE算法实施计算,计算网格采用非结构化网格.根据数值模拟结果得出了圆锥室内涡破裂现象的发展特性.研究结果表明:当达到一定雷诺数时,圆锥室内中心轴线附近会出现一个低压的涡破裂区域,并伴随着局部流体回流;在所研究的雷诺数范围内,随雷诺数的增加,涡破裂气泡的尺寸先增大后减小直至消失,涡破裂气泡的位置沿中心轴向远离驱动面的方向移动;对于相同高径比的圆锥室,涡破裂现象出现和消失时的临界位置不随圆锥室几何形状的变化而变化;由涡破裂现象出现时的临界雷诺数的大小可知,圆锥室模型相对于圆柱室模型抑制了涡破裂现象的产生,且顶面直径最大时的圆锥室(H1/H=0)的抑制效果最好.

关键词：涡破裂圆锥空腔失稳数值模拟加权平均

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子宫动脉栓塞治疗子宫肌瘤的并发症及防治

实用放射学杂志 2002年第9期18卷 792-794页

作者：窦永充孔健曹满瑞深圳市人民医院暨南大学医学院附属二院放射科深圳市人民医院暨南大学医学院附属二院放射科广东深圳518021

目的　总结子宫动脉栓塞治疗子宫肌瘤的并发症及防治经验。方法　自 1996年以来 ,使用子宫动脉栓塞治疗子宫肌瘤10 3例 ,除栓塞后综合征外 ,有 16例 18例次出现术后并发症。结果　除栓塞后综合征外 ,其它并发症包括 :动脉破裂 6例 ,子... 详细信息

目的　总结子宫动脉栓塞治疗子宫肌瘤的并发症及防治经验。方法　自 1996年以来 ,使用子宫动脉栓塞治疗子宫肌瘤10 3例 ,除栓塞后综合征外 ,有 16例 18例次出现术后并发症。结果　除栓塞后综合征外 ,其它并发症包括 :动脉破裂 6例 ,子宫动脉痉挛 6例 ,肌瘤脱落 3例 ,停经 1例 ,膀胱误栓 1例 ,宫腔感染 1例。栓塞后综合征以对症治疗为主。动脉破裂后使用栓塞治疗未出现严重并发症。动脉痉挛使用解痉治疗 4例有效 ,1例出现假性栓塞 ,1例使用明胶海绵栓塞子宫动脉主干。脱落的肌瘤取出后采用止血、抗炎治疗 ,恢复正常。膀胱误栓使用对症治疗后无后遗症。宫腔感染采用子宫全切术后恢复正常。结论　正确处理术后并发症有利于提高治疗效果

关键词：子宫肌瘤栓塞治疗性并发症