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Lunasin protease inhibitor concentrate decreases pro-infl ammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis

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Food Science and Human Wellness 2022年第6期11卷 1508-1514页

作者： Andrea Nieto-Veloza Zhihong Wang Qixin Zhong doris d’souza Hari B.Krishnan Vermont P.dia department of Food Science University of TennesseeKnoxville 37996USA Agricultural Research Service USDAColumbia 65211USA

Lunasin protease inhibitor concentrate(LPIC)is a novel combination of soy bioactive peptide lunasin,Kunitz and Bowman-Birk protease *** reported anti-inflammatory and anticancer properties of each one of them suggest LPIC as a promising candidate for the treatment of infl ammatory-related *** objective was to assess the in vivo anti-infl ammatory properties of ***,an in vitro test was performed in lipopolysaccharide(LPS)-activated RAW264.7 murine macrophages by measuring the production of nitric oxide(NO),interleukin-6(IL-6),and tumor necrosis factorα(TNF-α)as infl ammatory *** the in vivo model,ulcerative colitis(UC)was induced in mice via oral administration of dextran sodium sulfate(dSS).LPIC treatment was performed via daily intraperitoneal injection of 50 mg/kg body *** weight,visible blood in stool and stool consistency were scored daily as macroscopic indicators of disease *** blood was evaluated by the presence of hemoglobin in stool every third *** length,caecum weight,colonic myeloperoxidase activity(MPO),presence of pro-inflammatory cytokines in blood and colon,changes in the architecture,and expression of inducible nitric oxide synthase(i NOS)in colonic tissue were *** vitro,LPIC induced production of NO and maintained cytokine levels in comparison to activated untreated *** vivo,LPIC increased colonic bleeding and did not improve macroscopic markers of the disease,but reduced colonic IL-1βand IL-6,decreased systemic circulation of TNF-α,attenuated neutrophils infi ltration and i NOS expression in colonic tissue,and diminished the damage in colonic *** results suggest that combinations of peptides in LPIC may counteract the antiinfl ammatory properties in vitro;while in vivo,LPIC can signifi cantly reduce the histopathological damage,hence is a possible therapeutic strategy to attenuate UC.

关键词： Bio-peptides Cytokines Infl ammation Protease inhibitor Ulcerative colitis

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The Pichia pastoris enzyme production platform:From combinatorial library screening to bench-top fermentation on residual cyanobacterial biomass

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Journal of Bioresources and Bioproducts 2024年第1期9卷 43-57页

作者： Korbinian Sinzinger Ulrike Obst Samed Güner Manuel döring Magdalena Haslbeck doris Schieder Volker Sieber Chair of Chemistry of Biogenic Resources Campus Straubing for Biotechnology and SustainabilityTechnical University of MunichStraubing 94315Germany Catalysis Research Center Technical University of MunichGarching 85748Germany SynBiofoundry@TUM Technical University of MunichStraubing 94315Germany School of Chemistry and Molecular Biosciences The University of QueenslandSt.Lucia 4072Australia

The demand for industrial enzymes is continually rising,fueled by the growing need to shift towards more sustainable industrial ***,making efficient enzyme production strains and identifying optimal enzyme expression conditions remains a ***,the production of the enzymes themselves comes with unavoidable impacts,e.g.,the need to utilize secondary ***,we take a more holistic view of bioprocess development and report an integrative approach that allows us to rapidly identify improved enzyme expression and secretion conditions and make use of cyanobacterial waste biomass as feed for supporting Pichia pastoris *** demonstrate these capabilities by producing a phytase secreted by *** that is grown on cyanobacterium hydrolysate and buffered glycerol-complex(BMGY)medium,with genetic expression conditions identified by high-throughput screening of a randomized se-cretion *** our best-performing strain is grown in a fed-batch fermentation on BMGY,we reach over 7000 U/mL in three days.

关键词： Protein secretion Phytase Cyanobacterial biomass Fed-batch fermentation Pichia pastoris

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Long-lived lunar volcanism sustained by precession-driven core-mantle friction

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National Science Review 2024年第2期11卷 114-123页

作者： Shuoran Yu Xiao Xiao Shengxia Gong Nicola Tosi Jun Huang doris Breuer Long Xiao dongdong Ni State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Planetary Science Institute State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences CAS Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Institute of Planetary Research German Aerospace Centre(DLR)

Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ～3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ～3.0 Ga. Besides, core-mantle friction tends to suppress the secular cooling of the lunar core and is unlikely to be an energy source for the long-lived lunar core dynamo. Our model also favours the transition of the Cassini state before the end of the lunar magma ocean phase(～4.2 Ga), which implies a decreasing lunar obliquity over time after the solidification of the lunar magma ocean. Such a trend of lunar obliquity evolution may allow volcanically released water to be buried in the lunar regolith of the polar regions. As a consequence, local water ice could be more abundant than previously thought when considering only its accumulation caused by solar wind and comet spreading.

关键词： Moon precession orbit volcanism

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Mechanical upper bowel obstruction caused by a large trichobezoar in a young woman: A very unusual case report

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World Journal of Clinical Cases 2024年第4期12卷 777-781页

作者： Magdalena Scherrer Peter Kornprat Robert Sucher Johanna Muehlsteiner doris Wagner department of Surgery Division for GeneralVisceral and Transplantation SurgeryMedical University of GrazGraz 8036Austria department of Surgery Clinic RohrbachRohrbach 4150Austria

BACKGROUNd Bezoars usually compile human fibers and debris.A special form of bezoar in case of psychologically altered individuals is the *** consists of voluntarily swallowed hair bulks and is normally removed via *** leading to ileus have rarely been *** SUMMARY A 24-year-old female patient presented to the emergency room with abdominal pain,nausea,and vomiting for 3 *** previous medical and psychiatric history was *** analysis showed iron deficiency anemia,leukocytosis,and elevated liver *** abdominal CT scan revealed a dense structure in the patients’stomach which turned out to be a huge trichobezoar completely obstructing the *** trichobezoar had to be removed *** her postoperative course,a subcutaneous seroma *** a single puncture,the rest of the recovery process was unremarkable,and the patient recovered *** A mechanical bowel obstruction is a potentially life-threatening event for every *** our case a young female was suffering from severe symptoms of an obstruction which might have resulted in serious harm without successful surgical management.

关键词： Rapunzel syndrome Hair ingestion Gastroscopy Bezoar Case report

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Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2024年第13期30卷 1899-1910页

作者： Ante Tonkic Marko Kumric Ivna Akrapovic Olic doris Rusic Piero Marin Zivkovic daniela Supe domic Zeljko Sundov Ivan Males Josko Bozic Biology of Neoplasms University of Split School of MedicineSplit 21000Croatia department of Pathophysiology University of Split School of MedicineSplit 21000Croatia department of Gastroenterology University Hospital of SplitSplit 21000Croatia department of Pharmacy University of Split School of MedicineSplit 21000Croatia department of Medical Laboratory diagnostics University Hospital of SplitSplit 21000Croatia department of Health Studies University of SplitSplit 21000Croatia department of Internal Medicine University of Split School of MedicineSplit 21000Croatia department of Surgery University Hospital of SplitSplit 21000Croatia

BACKGROUNd Population of patients with inflammatory bowel disease(IBd)is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and ***-differentiation factor-15(GdF-15)is often overexpressed under stress conditions,such as inflammation,malignancies,heart failure,myocardial ischemia,and many *** To explore the association between GdF-15 and IBd as serum concentrations of GdF-15 were shown to be an independent predictor of poor outcomes in multiple *** additional aim was to determine possible associations between GdF-15 and multiple clinical,anthropometric and laboratory parameters in patients with *** This cross-sectional study included 90 adult patients diagnosed with IBd,encompassing both Crohn’s disease(Cd)and ulcerative colitis(UC),and 67 healthy age-and sex-matched *** patients underwent an extensive workup,including colonoscopy with subsequent histopathological *** activity was assessed by two independent gastroenterology consultants specialized in IBd,employing well-established clinical and endoscopic scoring ***-15 serum concentrations were determined following an overnight fasting,using electrochemiluminescence *** In patients with IBd,serum GdF-15 concentrations were significantly higher in comparison to the healthy controls[800(512-1154)pg/mL vs 412(407-424)pg/mL,Pdifference in GdF-15 was found between patients with Cd and UC[807(554-1451)pg/mL vs 790(509-956)pg/mL,P=0.324].Moreover,multiple linear regression analysis showed that GdF-15 levels predict Cd and UC severity independent of age,sex,and C-reactive protein levels(P=0.016 and P=0.049,respectively).Finally,an association between GdF-15 and indices of anemia was ***,negative correlations were found between GdF-15 and serum iron levels(r=-0.248,P=0.021),as well as GdF-15 and hemoglobin(r=-0.351,P=0.021).Accordingly,in comparison to I

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Growth-differentiation factor-15 Anemia Extraintestinal manifestations

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Effect of different Rates and Mixtures of Solid Household Waste and Faecal Sludge-Based Composts on Soil Fertility and Productivity of Sunflower (Helianthus annuus L.) in dschang, West Cameroon

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Open Journal of Soil Science 2024年第7期14卷 448-470页

作者： Romary Ngnipa Tchinda Rodrigue Emmanuel Kenne Primus Azinwi Tamfuh Jovanie Gladys Kenfack doris Temgoua Zombou désiré Évariste Moundjeu Tsafack Richard Tanwi Ghogomu Emile Temgoua dieudonné Bitom Oyono department of Environmental Sciences of the Higher Institute of Agriculture Wood Water and the Environment of the University of Bertoua Blabo Cameroon department of Soil Science Soil Analysis and Environmental Chemistry Research Unit Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon department of Mining and Mineral Engineering National Higher Polytechnic Institute University of Bamenda Bambili Cameroon department of Animal Biology Faculty of Sciences University of Dschang Dschang Cameroon department of Earth Sciences University of Yaounde 1 Yaounde Cameroon

The unbalanced and inadequate use of fertilizers is one of the causes of soil degradation. Combined with the ever-increasing population, it is necessary to find sustainable agricultural production alternatives. The present work aims to determine the effect of different rates and mixtutes of organic amendments on soil fertility and the performance of Sunflower (Helianthus annuus L.). In the field, treatments consisted of solid household waste and faecal sludge in the ratios of 3/5 (V1), and a mixture of faecal sludge and household waste in the ratio of 3/5 with 900 worms (V2). At the end of the composting process, V1, V2 composts and the poultry manure (PM) were applied at rates of 4, 5 and 6 t∙ha−1 in a randomized complete block design with three replications. Soil samples were collected before and after the experiment and analyzed. The main results revealed that at the end of the composting process, there was a progressive improvement in the physico-chemical properties of V1 and V2 composts. In particular, the C/N ratio, phosphorus (P) and total nitrogen (TN) initially at 16.49 ± 0.42 (V1, V2), 21.06 ± 0.07 mg∙kg−1 (V1, V2), 0.76% ± 0.08% (V1, V2) respectively, increased after 60 days to 12.40 ± 0.41 (V1), 9.74 ± 0.28 (V2) for C/N, 21.94 ± 0.63 mg∙kg−1 (V1) and 22.04 ± 0.04 mg∙kg−1 (V2) for P, 0.96% ± 0.0% (V1) and 1.22 ± 0.04 (V2) for TN. The application of 6 t∙ha−1of PM had the greatest influence on the diameter and weight of the flower heads (27.16 ± 4.01 t∙ha−1 and 230.83 ± 2.64 t∙ha−1), while 4 t∙ha−1 of V2 gave the tallest sunflower plants (110.07 ± 73.28 cm) as well as the diameter at the crown (19.30 ± 9.07 cm). However, CEC was most influenced by 4 t∙ha−1 of V1, while 4 t∙ha−1 of PM had the greatest effect on organic carbon and phosphorus. However, 5 t∙ha−1 of PM showed the highest sunflower production and yield (1.67 ± 0.21 t∙ha−1). The combination with 900 earthworms is recommended for composting and 5 t∙ha−1 of PM is recommended to obtain a better sunfl

关键词： Sunflower Faecal Sludge Household Waste Compost Soil Fertility

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Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa

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Infectious diseases of Poverty 2024年第1期13卷 93-94页

作者： Shuchao Wang Roland Suluku Mohamed B.Jalloh Ahmed F.Samba Baogui Jiang Yubiao Xie doris Harding Mengyao Zhang Foday Sahr Mahmud E.Sesay James S.Squire Mohamed A.Vandi Moinina N.Kallon Shoufeng Zhang Rongliang Hu Yuee Zhao Zhiqiang Mi Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun China department of Animal Sciences School of Agriculture and Food Sciences Njala University Njala Sierra Leone department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Ministry of Agriculture and Food Sciences Freetown Sierra Leone Beijing Institute of Microbiology and Epidemiology Beijing China Ministry of Health and Sanitation Freetown Sierra Leone Beijing Institute of Biotechnology Beijing China

Background Anthrax,a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis,remains a major global public health concern,especially in countries with limited *** Leone,a West African country historically plagued by anthrax,has almost been out of report on this disease in recent *** this study,we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the *** The causative agent of the animal outbreak in Port Loko district,Sierra Leone,between March and May 2022 was identified using the nanopore sequencing technique.A nationwide active surveillance was implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-specific symptoms in *** cases were subsequently verified using quantitative polymerase chain ***-genome sequencing was accomplished by combining long-read and short-read sequencing *** phylogenetic analysis was performed based on the full-chromosome single nucleotide *** The outbreak in Port Loko district,Sierra Leone,led to the death of 233 animals between March 26th and May 16th,*** ruled out the initial suspicion of Anaplasma species and successfully identified *** as the causative agent of the *** a result of the government's prompt response,out of the 49 suspected human cases identifed during the one-year active surveillance,only 6 human cases tested positive,all within the frst month after the official declaration of the *** phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the ***.153 clade within the TransEuroAsian group of *** We successfully identifed a large-scale anthrax outbreak in Sierra *** causative isolate of ***,BaSL2022,phylogenetically bridged other lineages in ***.153 clade and neighboring genetic groups,***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus anthracis Sierra Leone Phylogeny Single nucleotide polymorphism

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FROM YOUR Editor

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空中英语教室（高级版．彭蒙惠英语） 2024年第6期 1-1页

作者： doris Brougham 不详

dearreaders,Where is the most beautiful place you have been to?Over the years,I have traveled to more than 35 countries,playing my trumpet on tours with our professional choir,Heavenly Melody.I have seen many beautiful sights,but a sight that truly took my breath away was actually under the *** was when I went scuba diving off the coast of Sipadan,Malaysia.

关键词： beautiful travel sights

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On the principles of Parsimony and Self-consistency for the emergence of intelligence

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Frontiers of Information Technology & Electronic Engineering 2022年第9期23卷 1298-1323页

作者： Yi MA doris TSAO Heung-Yeung SHUM Electrical Engineering and Computer Science department University of CaliforniaBerkeleyCA94720USA department of Molecular&Cell Biology and Howard Hughes Medical Institute University of CaliforniaBerkeleyCA94720USA International digital Economy Academy Shenzhen518045China

Ten years into the revival of deep networks and artificial intelligence,we propose a theoretical framework that sheds light on understanding deep networks within a bigger picture of intelligence in *** introduce two fundamental principles,Parsimony and Self-consistency,which address two fundamental questions regarding intelligence:what to learn and how to learn,*** believe the two principles serve as the cornerstone for the emergence of intelligence,artificial or *** they have rich classical roots,we argue that they can be stated anew in entirely measurable and computable *** specifically,the two principles lead to an effective and efficient computational framework,compressive closed-loop transcription,which unifies and explains the evolution of modern deep networks and most practices of artificial *** we use mainly visual data modeling as an example,we believe the two principles will unify understanding of broad families of autonomous intelligent systems and provide a framework for understanding the brain.

关键词： Intelligence Parsimony Self-consistency Rate reduction deep networks Closed-loop transcription

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F4ESS-a framework for interdisciplinary data-driven earth system science

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International Journal of digital Earth 2023年第1期16卷 3973-3986页

作者： doris dransch daniel Eggert Mike Sips Remote sensing and Geoinformatics Helmholtz Center Potsdam–German Research Center for GeosciencePotsdamGermany Geography department Humboldt-University at BerlinBerlinGermany

Earth system science is an interdisciplinary effort to understand the fundamentals and interactions of environmental *** research is challenging since it demands the integration of scientific schemes and practices from different research fields into a collaborative work *** paper introduces the framework F4ESS that supports this integration.F4ESS provides methods and technologies that facilitate the development of integrative work environments for Earth system science.F4ESS enables scientists a)to outline structured and summarized descriptions of scientific procedures to facilitate communication and synthesis,b)to combine a large variety of distributed data analysis software into seamless data analysis chains and workflows,c)to visually combine and interactively explore the manifold spatiotemporal data and results to support understanding and knowledge *** F4ESS methods and technologies are generic and can be applied in various scientific *** discuss F4EsS in the context of the interdisciplinary investigation of flood events.

关键词： Earth system science interdisciplinary research scientific workflows integration

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