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Science China Chemistry 2024年第1期67卷 408-414页

作者： Suting Xie Xinyu Zhao dongxiao Wang Huawei Yang Lixia Yang Liangjiu bai Donglei Wei Wenxiang Wang Ying Liang Hou Chen Shaojun Guo College of Chemistry and Materials Science Ludong UniversityYantai 264025China College of Materials Science and Engineering Peking UniversityBeijing 100871China

Photocatalytic aerobic oxidation desulfurization(PAODS)is a promising and sustainable alternative to conventional,energyintensive desulfurization techniques for petroleum products.However,its development is greatly plagued by the low capability in generating highly reactive oxygen species and sluggish kinetics of sulfide oxidation of reported photocatalysts.Here we report a class of MoO_(x)nanocluster decorated on ultrathin Mo-doped TiO_(2)nanosheet(MoO_(x)/MoTiO)catalyst for efficiently facilitating the photocatalytic aerobic oxidation of sulfides.We demonstrate that MoO_(x)/MoTiO can not only promote the generation of highly reactive singlet oxygen(^(1)O_(2))but also enhance the aerobic conversion of sulfides,which leads to a record dibenzothiophene oxidation activity of 3.90 mmol g^(-1)h^(-1).The multiple experimental characterizations and density functional theory calculations collectively reveal that the doped-Mo sites can interact with the photogenerated excitons,enabling directly energy transfer generation of^(1)O_(2)through a new exciton modulation mechanism,and the coordination unsaturated MoO_(x)clusters play the role of co-catalyst to enhance the separation of charge carriers,and effectively catalyze the reaction between sulfides and1O_(2)to form sulfones.

关键词： titanium dioxide photocatalytic aerobic oxidation desulfurization dibenzothiophene singlet oxygen

Photodegradation of hydroxyfluorenes in ice and water: A comparison of kinetics, effects of water constituents, and phototransformation by-products

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Journal of Environmental Sciences 2023年第2期124卷 139-145页

作者： Linke Ge Shengkai Cao Crispin Halsall Junfeng Niu dongxiao bai Guangkai He Peng Zhang Hongrui Ma School of Environmental Science and Engineering Shaanxi University of Science&TechnologyXi’an 710021China Lancaster Environment Centre Lancaster UniversityLancaster LA14YQUK State Environmental Protection Key Laboratory of Coastal Ecosystem National Marine Environmental Monitoring CenterDalian 116023China

The photochemical behavior of organic pollutants in ice is poorly studied in comparison to aqueous photochemistry.Here we report a detailed comparison of ice and aqueous photodegradation of two representative OH-PAHs,2-hydroxyfluorene(2-OHFL)and 9-hydroxyfluorene(9-OHFL),which are newly recognized contaminants in the wider environment including colder regions.Interestingly,their photodegradation kinetics were clearly influenced by whether they reside in ice or water.Under the same simulated solar irradiation(λ>290 nm),OHFLs photodegraded faster in ice than in equivalent aqueous solutions and this was attributed to the specific concentration effect caused by freezing.Furthermore,the presence of dissolved constituents in ice also influenced photodegradation with 2-OHFL phototransforming the fastest in‘seawater’ice(k=(11.4±1.0)×10^(−2) min^(−1))followed by‘pure-water’ice((8.7±0.4)×10^(−2) min^(−1))and‘freshwater’ice((8.0±0.7)×10^(−2) min^(−1)).The presence of dissolved constituents(specifically Cl^(−),NO_(3)^(−),Fe(Ⅲ)and humic acid)influences the phototransformation kinetics,either enhancing or suppressing phototransformation,but this is based on the quantity of the constituent present in the matrixes,the specific OHFL isomer and the matrix type(e.g.,ice or aqueous solution).Careful derivation of key photointermediates was undertaken in both ice and water samples using tandem mass spectrometry.Ice phototransformation exhibited fewer by-products and‘simpler’pathways giving rise to a range of hydroxylated fluorenes and hydroxylated fluorenones in ice.These results are of importance when considering the fate of PAHs and OH-PAHs in cold regions and their persistence in sunlit ice.

关键词： Ice photochemistry Hydroxyfluorene Photodegradation Kinetics Water constituents Intermediates

基于变桨与襟翼协同的降载特性研究及机理分析

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动力工程学报 2024年第7期44卷 1068-1074页

作者：白冬晓王冰李寅生王万成河海大学能源与电气学院南京211100

研究了尾缘襟翼长度、偏转角和攻角对翼型降载特性的影响,并分析其影响机理。结果表明:变桨与尾缘襟翼的协同控制可有效实现挥舞方向上的降载;尾缘襟翼长度越大,尾缘偏转角越小,攻角越远离临界值,降载性能越佳;偏转角增大会导致临界攻... 详细信息

研究了尾缘襟翼长度、偏转角和攻角对翼型降载特性的影响,并分析其影响机理。结果表明:变桨与尾缘襟翼的协同控制可有效实现挥舞方向上的降载;尾缘襟翼长度越大,尾缘偏转角越小,攻角越远离临界值,降载性能越佳;偏转角增大会导致临界攻角位置前移;为实现快速降载,在正偏转角、大攻角下优先选择尾缘控制,其他情况下均优先选择变桨控制;降载特性与翼型及翼缝流体分布密切相关,压差越小,降载性能越好。

关键词：法向力系数静压尾缘襟翼长度襟翼偏转角攻角

Space advanced technology demonstration satellite

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Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU dongxiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen bai XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

马甲子干预实验性结肠炎相关结直肠癌前期病变的网络药理学及实验研究

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中药药理与临床 2024年第3期40卷 65-74页

作者：赵欢胡竟一白筱璐雷玲吴瑕林雪燕牛圆圆陈雨慧余悦李东晓徐超群成都中医药大学药学院成都610041 四川省中医药科学院中药材品质及创新中药研究四川省重点实验室/中药新药创制与质量评价川渝共建重点实验室成都610041

目的:研究马甲子(Paliurus ramosissimus,PR)对结肠炎相关结直肠癌(colitis-associated colorectal cancer,CAC)前期病变的干预作用,探索作用机制。方法:采用基因功能注解(GO)、基因数据库(KEGG)富集分析和分子对接等方法,分析马甲子提... 详细信息

目的:研究马甲子(Paliurus ramosissimus,PR)对结肠炎相关结直肠癌(colitis-associated colorectal cancer,CAC)前期病变的干预作用,探索作用机制。方法:采用基因功能注解(GO)、基因数据库(KEGG)富集分析和分子对接等方法,分析马甲子提取物中主要药效成分白桦脂酸干预CAC前期病变的潜在靶点和通路;采用腹腔注射氧化偶氮甲烷(Azoxymethane,AOM)及经饮水摄入葡聚糖硫酸钠(Dextran sulfate sodium,DSS)对小鼠进行循环处理方式,建立实验性CAC前期病变小鼠模型,连续42 d灌胃给予马甲子提取物205、820 mg/kg,观察其对小鼠模型疾病活动指数(DAI)、结直肠组织病理等的影响,ELISA法检测血清中癌胚抗原(CEA)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)含量,q RT-PCR法检测结直肠组织中信号转导和转录激活子3(Stat3)m RNA表达。结果:网络药理学研究筛选出157个白桦脂酸干预CAC的潜在作用靶点,对激素的反应、跨膜受体蛋白酪氨酸激酶信号通路、细胞迁移的正向调节、等874个生物过程,激酶结合、蛋白激酶活性等75个分子功能,膜筏、谷氨酸能突触等37个细胞组分,涉及的主要通路有癌症通路、癌症中的蛋白聚糖、脂质和动脉粥样硬化、前列腺癌、JAK-STAT信号通路;白桦脂酸与IL-1β、STAT3等靶点亲和力均<-5 kcal/mol。与正常对照组比较,模型对照组小鼠死亡率明显增高(P<0.05),脾脏指数及组织病理评分显著升高(P<0.01),异型增生等提示癌前病变,血清中CEA、IL-1β、TNF-α含量显著升高(P<0.01),Stat3 m RNA的表达显著上调(P<0.01);与模型对照组比较,马甲子提取物820 mg/kg组组织病理评分明显降低(P<0.05),血清中CEA、IL-1β、TNF-α含量显著降低(P<0.01),Stat3 m RNA的表达显著下调(P<0.01)。结论:马甲子提取物经口给药可抑制AOM/DSS所致实验性CAC癌前病变,其作用机制与炎症抑制及下调STAT3等有关。

关键词：马甲子白桦脂酸结肠炎相关结直肠癌网络药理学分子对接癌胚抗原信号转导和转录激活子3

肠道菌群联合血清肿瘤相关物质在鉴别诊断近端结肠癌中的应用

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中华检验医学杂志 2024年第4期47卷 444-450页

作者：黄天臣韩晓东张勇李衎郭志朋李磊武亚超王雁军白东晓肖建安赵江曼周福有李维丽安阳市肿瘤医院普外科安阳455000 上海宝藤生物医药科技股份有限公司上海201204

目的探索不同部位结直肠癌肠道菌群的差异以及特征菌联合肿瘤标志物在近端结肠癌中的鉴别效能。方法病例对照研究。选取2019年5月至2022年7月在安阳市肿瘤医院普外科确诊的结直肠癌(CRC)85例和结直肠腺瘤(CRA)患者8例,根据原发部位CRC... 详细信息

目的探索不同部位结直肠癌肠道菌群的差异以及特征菌联合肿瘤标志物在近端结肠癌中的鉴别效能。方法病例对照研究。选取2019年5月至2022年7月在安阳市肿瘤医院普外科确诊的结直肠癌(CRC)85例和结直肠腺瘤(CRA)患者8例,根据原发部位CRC又分为近端结肠癌组(PC)22例、远端结肠癌组(DC)15例和直肠癌组(RC)48例。肠道准备前采集患者血液和粪便样本分别进行肿瘤标志物检测和16S rDNA基因测序。采用SPSS(27.0.1)软件进行单因素方差分析、Mann-WhitneyU检验、Kruskal-WallisH检验或χ^(2)检验比较组间差异,并利用SPSS对肿瘤标志物、特征菌分别进行单独和联合绘制鉴别PC的受试者工作特征(ROC)曲线。结果PC组、DC组、RC组和CRA组进行组间比较,糖类抗原125(CA125)、CA72-4以及血清肿瘤相关物质(TAM)差异有统计学意义(F=3.543,P<0.05;F=3.596,P<0.05;F=5.787,P<0.01)。其中PC组的CA125水平和CA72-4水平高于RC组[PC组比RC组,(36.84±6.30)kU/L比(12.73±4.21)kU/L,P<0.01;PC组比RC组,(45.56±10.86)kU/L比(3.30±7.63)kU/L,P<0.01],PC组的TAM水平高于RC组和CRA组[PC组比RC组,(124.84±5.19)U/ml比(102.44±3.63)U/ml,P<0.001;PC组比CRA组,(124.84±5.19)U/ml比(95.39±8.42)U/ml,P<0.01]。LEfSe分析显示PC组的特征菌包括拟杆菌科、奈瑟菌科、梭菌科和螺旋体科等。TAM联合拟杆菌科鉴别诊断PC的曲线下面积最大,为0.845(95%CI 0.747~0.944),敏感度为0.857,特异度为0.815。结论不同部位CRC以及CRA间的肠道菌群组成具有异质性,肠道菌群联合肿瘤标志物在区分近端结肠癌中具有良好的鉴别效能。

关键词：结直肠肿瘤肠道菌群敏感性与特异性肿瘤标记生物学

r＇ranscriptome assembly strategies for ）recision medicine

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Frontiers of Electrical and Electronic Engineering in China 2017年第4期5卷 280-290页

作者： Lu Wang Lipi Acharya Changxin bai dongxiao Zhu Department of Computer Science Wayne State University Detroit MI 48202 USA DOW AgroSciences lndianapolis IN 46268 USA

Background： Precision medicine approach holds great promise to tailored diagnosis, treatment and prevention. Individuals can be vastly different in their genomic information and genetic mechanisms hence having unique transcriptomic signatures. The development of precision medicine has demanded moving beyond DNA sequencing （DNA-Seq） to much more pointed RNA-sequencing （R_NA-Seq） [Cell, 2017, 168： 584--599]. Results： Here we conduct a brief survey on the recent methodology development of transcriptome assembly approach using RNA-Seq. Conclusions： Since transcriptomes in human disease are highly complex, dynamic and diverse, transcriptome assembly is playing an increasingly important role in precision medicine research to dissect the molecular mechanisms of the human diseases.

关键词： precision medicine transcriptome assembly RNA-Seq de novo De Bruijn

Effectiveness of external Sanjierupi Gao on mastalgia caused by mammary gland hyperplasia: a placebo controlled trial

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Journal of Traditional Chinese Medicine 2013年第5期33卷 603-607页

作者： Yingyi Fan Xiaohua Pei Zhaolan Liu Zhongyuan Xia dongxiao Zhang Afeng Song Duo Liu Surgical Department of the Third Hospital Affiliated to Beijing University of Traditional Chinese Medicine Centre for Evidence-based Chinese Medicine Beijing University of Chinese Medicine Surgical Department of TCM in Sino-Japanese Friendship Hospital Mammary Department of Dongfang Hospital under Beijing University of Traditional Chinese Medicine Surgical Department of the First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Surgical Department of Hubei Provincial Hospital of Traditional Chinese Medicine

OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study enrolled 260 patients with mammary gland hyperplasia from five hospitals.Patients were randomly and equally divided in-to a Sanjierupi Gao treatment group and a placebo control group.An adhesive plaster was applied to the most painful area on either breast for 7 h a day.Treatment lasted for two menstrual cycles without application during menstruation.Mastalgia was used as the main index of curative effect.The change before and after treatment in days of mastalgia,the time to alleviate pain,pain extent,and severe pain scores were observed.RESULTS:Compared to the control group,the treatment group had significantly fewer days of mastalgia(P<0.01),a significantly lower severe pain score(P<0.01),and significantly less subjective pain and tenderness(P<0.05 and P<0.01,respectively).Three days before the follow-up visit,the pain score in the treatment group was significantly lower than that in the control group(P<0.05).A non-parametric test was used to compare the time to alleviate mastalgia between the two groups and found no statistical difference(Z=0.313,P=0.754).CONCLUSION:Application of Sanjierupi Gao can decrease mastalgia duration in patients with mammary gland hyperplasia during menstruation and alleviate the extent of mastalgia.The time to alleviate pain is psychologically influenced.

关键词：乳腺增生对照试验持续时间月经期间非参数检验对照组月经周期疼痛

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冰雪中有机污染物的环境光化学行为

中国科学：化学 2022年第1期52卷 1-14页

作者：白东晓葛林科张蓬曹胜凯马宏瑞陕西科技大学环境科学与工程学院西安710021

冰雪是一类重要且普遍的环境介质,冰雪环境光化学是一门新兴的学科,相关研究方兴未艾.冰雪中有机污染物的光化学行为被广泛关注,其转化动力学、影响因素、转化产物等研究水平持续提升,模型化合物的种类数量和复杂程度也在增加.本文通过... 详细信息

冰雪是一类重要且普遍的环境介质,冰雪环境光化学是一门新兴的学科,相关研究方兴未艾.冰雪中有机污染物的光化学行为被广泛关注,其转化动力学、影响因素、转化产物等研究水平持续提升,模型化合物的种类数量和复杂程度也在增加.本文通过总结冰雪环境光化学最新进展,介绍了冰雪中典型有机污染物的光化学转化动力学与反应路径,评述了溶解性物质和冰雪物理性状对光降解动力学的影响与作用机制,讨论了冰雪环境光化学对寒冷地区污染物归趋和风险的指示意义,最后对冰雪环境中有机污染物的光化学行为研究进行了展望.

关键词：冰雪环境光化学有机污染物光降解影响因素寒冷地区

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抗生素不同解离形态在水环境中的光化学行为

中国科学：化学 2022年第12期52卷 2183-2200页

作者：葛林科杨妍曹胜凯白东晓尉小旋张蓬马宏瑞陕西科技大学环境科学与工程学院西安710021 浙江师范大学地理与环境科学学院金华321004

表层水体中存在众多可解离的有机污染物,揭示其不同解离形态的环境光化学行为,对于污染物的环境持久性和风险评价具有重要意义.抗生素是在水环境中广泛存在的新型有机污染物,其中氟喹诺酮类(FQs)、磺胺类(SAs)、四环素类(TCs)等抗生素... 详细信息

表层水体中存在众多可解离的有机污染物,揭示其不同解离形态的环境光化学行为,对于污染物的环境持久性和风险评价具有重要意义.抗生素是在水环境中广泛存在的新型有机污染物,其中氟喹诺酮类(FQs)、磺胺类(SAs)、四环素类(TCs)等抗生素因分子结构中含有羧基、羟基和/或氨基等可电离基团,在水中以多种解离形态共存而备受关注.抗生素的多种解离形态不仅以不同的丰度共存于环境表层水体中,而且不同的解离形态表现出相异的环境光化学转化行为和风险.本文总结了水环境中可解离抗生素光化学行为研究的最新进展,介绍了pH值对直接和间接光解动力学的影响,着重评述了抗生素不同解离形态的光化学反应动力学、转化产物和路径,讨论了可解离抗生素光化学转化的环境半减期和风险,最后对抗生素不同解离形态的光化学行为研究进行了展望.

关键词：抗生素解离形态光化学转化 pH 光解动力学产物