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关于校园物质环境的小型问卷调查报告

价值工程 2012年第12期31卷 262-263页

作者：洪冬香刘晋边帅唐山科技职业技术学院唐山063001

本文通过问卷调查,分析了唐山科技职业技术学院校园环境改善带来的影响,探讨了校园物理环境会对学生行为产生怎样的影响,以及对校园物质建设的几点建议。

关键词：物理环境教育

Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation

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Chinese Journal of Chemistry 2022年第7期40卷 787-793页

作者： Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao hongbo Zhao Lizhen Liu Farong Ye Can Wang hong Shao dongxiang Xue Houchao Tao Bin Li Biao Yu Ping Wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of Medicine280 S.Chongqing RoadShanghai 200025China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200011China Shanghai Institute for Food and Drug Control NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal AntibodiesShanghai 201203China iHuman Institute ShanghaiTech UniversityHaike Road 230Shanghai 200032China State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032

Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T ***-glycosylated IL-2 has been used in clinical settings for three ***,the function of the O-glycan of native IL-2 remains ***,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram *** glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single *** evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine.

关键词： Oligosaccharide Glycoprotein Serine ligation Interleukin-2 Glycopeptides

Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

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Acta Pharmaceutica Sinica B 2016年第1期6卷 32-45页

作者： Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang dongxiang Liu Jian Cheng hong Liu CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences China Pharmaceutical University Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience Soochow University

Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds, 3a and 3b, exhibiting a potent inhibitory profile against 5-LOX with IC50 values less than 1 mu mol/L in cell-based assays. Here, we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fused ring system. Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX. In particular, compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity, but also significantly decreased infarct damage in a mouse model of cerebral ischemia. Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data. In conclusion, the excellent in vitro and in vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： 5-Lipoxygenase 5-LOX inhibitors Pyrazole derivatives Leukotrienes-related diseases In vivo Benzo-fuse heterocyle Ischemic incults Brain inflammation

Dynamic visual servoing of a small scale autonomous helicopter in uncalibrated environments

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Science China(Information Sciences) 2011年第9期54卷 1855-1867页

作者： FAN CaiZhi 1,LIU YunHui 1,2,SONG BaoQuan 1 & ZHOU dongxiang 1 1 Joint Center of Intelligent Sensing System,National University of Defense Technology,Changsha 410073,China 2 Department of Mechanical and Automation Engineering,Chinese University of hong Kong,hong Kong 1. Joint Center of Intelligent Sensing System National University of Defense Technology Changsha 410073 China2. Department of Mechanical and Automation Engineering Chinese University of Hong Kong Hong Kong China

This paper presents a novel adaptive controller for image-based visual servoing of a small autonomous helicopter to cope with uncalibrated camera parameters and unknown 3D geometry of the feature *** controller is based on the back-stepping technique,but its design has two new ***,it incorporates the visual feedback into the last step of the backstepping procedure,while existing backstepping-based methods employ the visual feedback at the early ***,the controller maps the image errors onto the actuator space via a depth-independent interaction matrix to avoid estimation the depths of the feature *** new design method makes it possible to linearly parameterize the closed-loop dynamics by the unknown camera parameters and coordinates of the feature points in the 3D space so that an adaptive algorithm can be developed to estimate the unknown parameters and coordinates *** potential functions are introduced in the controller to guarantee convergence of the image errors and to avoid trivial solutions of the estimated *** Lyapunov method is used to prove the asymptotic stability of the proposed controller based on the nonlinear dynamics of the *** have been also conducted to demonstrate the performance of the proposed method.

关键词： backstepping uncalibrated camera adaptive visual servoing autonomous helicopter

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三轴数控侧铣空间刀具半径补偿算法

机械工程学报 2007年第5期43卷 138-144页

作者：胡自化张平杨冬香徐宏湘潭大学机械工程学院湘潭411105 湘潭大学土木工程与力学学院湘潭411105

通过深入分析三轴数控侧铣加工的特点,利用几何平面投影原理,采用平面轮廓刀具半径补偿算法推导的类似方法,建立三轴数控侧铣加工的空间刀具半径补偿算法。将三轴数控侧铣加工的空间刀具半径补偿归纳为三种转接过渡类型处理,通过加工平... 详细信息

通过深入分析三轴数控侧铣加工的特点,利用几何平面投影原理,采用平面轮廓刀具半径补偿算法推导的类似方法,建立三轴数控侧铣加工的空间刀具半径补偿算法。将三轴数控侧铣加工的空间刀具半径补偿归纳为三种转接过渡类型处理,通过加工平面的投影相交求出空间两相邻程序段的过渡转接点坐标分量x、y,然后通过逆投影计算转接点的第三分量z,从而推导出各类型转接点的坐标计算公式。基于UG平台编写了三轴数控侧铣刀具补偿仿真软件,模拟和铣削加工实例结果表明所建立的三轴数控侧铣加工空间刀具半径补偿算法正确有效。基于该算法的空间刀具半径补偿G指令将可避免由于刀具磨损和刀具更换导致的三轴侧铣数控代码重生成。

关键词：三轴数控侧铣几何平面投影空间刀具半径补偿数控加工

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共享储能商业模式和定价机制研究综述

电力系统自动化 2022年第23期46卷 178-191页

作者：闫东翔陈玥香港中文大学机械与自动化工程学系中国香港999077

储能是提升电力系统灵活性以应对源荷随机波动的重要手段,但目前单用户单储能的配置与运营模式使用户面临着储能投资成本高,以及市场上可供选择的储能容量模块种类有限导致的所需储能容量定制化困难和储能设备利用率低等问题。为应对上... 详细信息

储能是提升电力系统灵活性以应对源荷随机波动的重要手段,但目前单用户单储能的配置与运营模式使用户面临着储能投资成本高,以及市场上可供选择的储能容量模块种类有限导致的所需储能容量定制化困难和储能设备利用率低等问题。为应对上述挑战,共享储能作为一种新兴商业范式受到广泛关注。文中给出了共享储能的概念,分析了其在降低用户成本、提高储能利用率、促进可再生能源消纳和提升电网运行稳定性等方面的潜力,并对共享储能的应用场景及国内外工程实践进行了详细阐述。在此基础上,根据共享储能的所有权归属不同,将共享储能的商业模式归纳为用户投资和共享公共储能、用户共享运营商投资的公共储能、用户共享自有储能3类。然后,从价格设计的角度将共享储能定价机制的相关研究归纳为3类,并总结了当前的研究进展与亟待解决的问题。最后,考虑到多共享储能运营商参与和电动汽车作为移动共享储能是2个极具潜力的应用场景,文中有针对性地对未来的研究进行了展望,并指出了所需解决的关键问题和可能的解决方案。

关键词：共享储能可再生能源商业模式定价机制容量分配博弈论

Stimulating and harnessing circularly polarized luminescence of helically assembled carbonized polymer dots via interfacial dynamics

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Aggregate 2023年第4期4卷 100-110页

作者： Jiaying Lin Rulin Liu Peixian Chen Yangfei Lv Junjie Hao Meijuan Chen dongxiang Zhang Ruikun Pan Yiwen Li Xi Zhu Tingchao He Jiaji Cheng School of Materials Science and Engineering Hubei UniversityWuhanHubeiChina College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenGuangdongChina School of Science and Engineering The Chinese University of Hong KongShenzhen Institute of Artificial Intelligence and Robotics for Society(AIRS)ShenzhenGuangdongChina Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhenGuangdongChina

Stimulating and harnessing circularly polarized luminescence(CPL)is not only a sine qua non for fundamentally unveiling chirogenesis in physical chemistry,but also a pivotal prerequisite for implementation of such phenomenon in research fields including chiral optoelectronics and ***,red-emissive carbonized polymer dots(CPDs)-based helical structures were synthesized in this work via biomolecule-tailored organic–inorganic co-assembly *** surface statesrelated chirality exhibits enhanced circular dichroism(CD)and CPL activities with anisotropic factors as high as gCD,max=5.4×10^(−3) and glum,max=1.5×10^(−2),*** obtained CPL signals can be further manipulated in an excitationdependent manner,indicating that a synergistic-competition phenomenon exists between configurational chirality and intermolecular energy-transfer dynamics,which is further supported by simulations based on density function theory(DFT).Such tunable CPL behavior triggers revolutionary designs and applications of these chiral CPDs into the realm of chirality-related biological issues and next-generation chiral optoelectronics.

关键词： carbonized polymer dots circular dichroism circularly polarized luminescence organic-inorganic coassembly synergistic-competition

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次同步振荡引起的发电机组轴系疲劳损伤

电力系统自动化 2010年第15期34卷 19-22,84页

作者：刘超蒋东翔谢小荣洪良友电力系统国家重点实验室清华大学热能工程系北京市100084 清华大学电机系北京市100084

为提高电网输送能力而被广泛采用的各种电力电子装置可能会带来电网次同步振荡风险。文中针对电网可能发生的次同步振荡现象,分析600MW汽轮发电机组轴系结构,通过机网耦合计算分析次同步振荡引起的机组轴系扭振,采用应力分析和疲劳寿命... 详细信息

为提高电网输送能力而被广泛采用的各种电力电子装置可能会带来电网次同步振荡风险。文中针对电网可能发生的次同步振荡现象,分析600MW汽轮发电机组轴系结构,通过机网耦合计算分析次同步振荡引起的机组轴系扭振,采用应力分析和疲劳寿命计算分析次同步振荡对机组轴系的疲劳损伤。研究了不同参数所引起的轴系扭振特点,重点比较次同步振荡幅值和频率对轴系疲劳损伤的影响。分析和研究结果将有助于提高机组寿命管理水平,有效评估电网波动容许值。

关键词：次同步振荡汽轮发电机组扭振疲劳损伤

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基于数据采样的弧面凸轮自适应直接插补算法

机械科学与技术 2008年第3期27卷 390-394页

作者：杨冬香胡自化徐宏孔马斌张平湘潭大学湘潭411105

针对目前弧面凸轮加工存在拟合精度与数据传输之间的矛盾,以及线性拟合破坏轮廓表面光顺性等问题,提出了一种基于数据采样的弧面凸轮自适应直接插补算法。该算法既能保证加工过程大部分时间内进给速度的恒定,而且能在曲率变化大的地方... 详细信息

针对目前弧面凸轮加工存在拟合精度与数据传输之间的矛盾,以及线性拟合破坏轮廓表面光顺性等问题,提出了一种基于数据采样的弧面凸轮自适应直接插补算法。该算法既能保证加工过程大部分时间内进给速度的恒定,而且能在曲率变化大的地方对进给速度进行自适应调整,以保证弓高误差不超出最大允许值。同时定义了相应的弧面凸轮自适应直接插补指令格式。最后基于UG开发了弧面凸轮自适应直接插补实体仿真系统,通过插补仿真实例进一步验证了该插补算法的正确性。该方法有效弥补了目前弧面凸轮线性拟合加工的缺陷,不仅能提高弧面凸轮加工过程中系统的稳定性和表面加工质量,而且使弧面分度凸轮机构定位精度和使用寿命提高,从而促进其推广和应用。

关键词：弧面凸轮自适应插补算法弓高误差插补仿真