检索结果-南通市图书馆

Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation

Chinese Journal of Chemistry 2022年第7期40卷 787-793页

作者： Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao Hongbo Zhao Lizhen Liu Farong Ye Can Wang Hong Shao dongxiang xue Houchao Tao Bin Li Biao Yu Ping Wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of Medicine280 S.Chongqing RoadShanghai 200025China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200011China Shanghai Institute for Food and Drug Control NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal AntibodiesShanghai 201203China iHuman Institute ShanghaiTech UniversityHaike Road 230Shanghai 200032China State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032

Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T ***-glycosylated IL-2 has been used in clinical settings for three ***,the function of the O-glycan of native IL-2 remains ***,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram *** glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single *** evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine.

关键词： Oligosaccharide Glycoprotein Serine ligation Interleukin-2 Glycopeptides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traceless specific fluorescence labeling of the smoothened receptor

Traceless specific fluorescence labeling of the smoothened r...

引用

第十一届全国化学生物学学术会议

作者： dongxiang xue Lintao Ye Yiran Wu Suwen Zhao Fei Zhao Houchao Tao iHuman Institute ShanghaiTech University

The smoothened receptor（SMO） mediates the Hedgehog（Hh） signaling pathway and plays a vital role in embryonic development and *** visualization of SMO has the potential to provide new insights into its enigmatic mechanism and associated disease *** on recent progress in structural studies of SMO,we designed and characterized a group of affinity probes to facilitate the turn-on fluorescence labeling of SMO at the ε-amine of *** chemical probes were derived from a potent SMO antagonist skeleton by conjugation of a small non-fluorescent unit,O-nitrobenzoxadiazole（O-NBD）.Optimal probes were capable of efficient and selective lighting up SMO both in micelles and in native *** importantly,the resulting labeled SMO bears a very small fluorophore that allows the recovery of the unoccupied pocket after dissociation of the residual ligand *** probes could serve as a potential tool for monitoring SMO trafficking,understanding Hh activation,and the diagnosis of tumorigenesis in the future.

关键词： Smoothened receptor turn-on fluorescence probe selective labeling structure-guided design

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于改进的双累积曲线法量化气候变化和人类活动对径流的影响

引用

Journal of Geographical Sciences 2023年第11期33卷 2237-2256页

作者：周俊菊薛东香杨岚婷刘春芳魏伟杨雪梅赵亚茹 College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China College of Earth and Environment Sciences Lanzhou UniversityLanzhou 730000China Gansu Engineering Research Center of Land Utilization and Comprehension Consolidation Lanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Gansu ProvinceLanzhou 730070China College of Social Development and Public Administration Northwest Normal UniversityLanzhou 730070China Tourism School Lanzhou University of Arts and ScienceLanzhou 730000China Institute of Geology and Geophysics CASBeijing 100029China

Quantitative assessments of the impacts of climate change and anthropogenic activities on runoff help us to better understand the mechanisms of hydrological *** study analyzed the dynamics of mountainous runoff in the upper reaches of the Shiyang River Basin(USRB)and its sub-catchments,and quantified the impacts of climate change and human activities on runoff using the improved double mass curve(IDMC)method,which comprehensively considers the effects of precipitation and evapotranspiration on runoff,instead of only considering precipitation as *** results indicated that the annual runoff depth in the USRB showed a slightly increased trend from 1961 to 2018,and sub-catchments were increased in the west and decreased in the *** seasonal distribution pattern of runoff depth in the USRB and its eight sub-catchments all showed the largest in summer,followed by autumn and spring,and the smallest in winter with an increasing *** assessment results using the IDMC method showed that the runoff change in the USRB is more significantly affected by climate change,however,considerable differences are evident in *** study further developed and improved the method of runoff attribution analysis conducted at watershed scale,and these results will contribute to the ecological protection and sustainable utilization of water resources in the USRB and similar regions.

关键词： runoff climate change land use/cover change(LUCC) improved double mass curve(IDMC) Qilian Mountains

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and photocatalytic kinetics of nano-ZnO powders by precipitation stripping process

引用

Frontiers of Chemical Science and Engineering 2008年第3期2卷 319-324页

作者： dongxiang ZHANG Hang XU Min xue Wenguo XU V TARASOV School of Chemical Engineering and the Environment Beijing Institute of TechnologyBeijing 100081China School of Science Beijing Institute of TechnologyBeijing 100081China D.I.Mendeleyev University of Chemical Technology of Russia 125190 MoscowRussia

Ultra-fine zinc oxalate powders were prepared through a precipitation stripping method with bis(2-ethylhexyl)phosphate(HDEHP)diluted by tetrachloride carbon as the extractant,and oxalic acid ethanol aqueous solution as the re-extractant and *** oxide powders were obtained by decomposing zinc oxalate powders at 450℃.The prepared zinc oxide powders were characterized by transmission electron microscope(TEM),Scanning electron microscope(SEM),Thermogravimetric analysis(TG),X-ray diffraction(XRD)and Fourier transmission infrared(FT-IR)*** photocatalytic performance of methylene blue by zinc oxide was studied based on the Langmuir model and Photo-Layer *** results show that some zinc oxide powders were micro-multipore materials with hexagonal *** particle size was around 32 *** photocatalytic process was the control step in the chemical *** photo catalytic process followed pseudo-first order kinetics and NOH concentration inside the photo-layer in different reaction condition were calculated according to the Photo-Layer model.

关键词： precipitation stripping method ZnO photocatalysis kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of age on aortic atherosclerosis

引用

Journal of Geriatric Cardiology 2013年第2期10卷 135-140页

作者： Michael A. Chen Miwa Kawakubo Patrick M. Colletti dongxiang Xu Laurie LaBree Dustin Robert Detrano Stanley P Azen Nathan D. Wong xue-Qiao Zhao Department of Medicine Division of Cardiology Harborview Medical Center/University of Washington 325 9th Avenue Box 359748 Seattle WA 98104 USA Department of Preventive Medicine Division of Biostatistics Keck School of Medicine of the University of Southern California 2001 N Soto Street SSB 201A M/C 9234 Los Angeles CA 90089-9237 USA Department of Radiology Keck School of Medicine of the University of Southern California1 1500 San Pablo Street Second Floor Imaging Los Angeles CA 90033 USA Department of Radiology University of Washington School of Medicine Box 357115 1959 Pacific Street RR-215 Seattle WA 98195-7117 USA Department of Radiological Sciences University of California Irvine School of Medicine 101 the City Drive South Route 140 Orange CA 92868 USA Department of Medicine UC Irvine School of Medicine 333 City Blvd. West Suite 400 Orange CA 92868-3298 USA

Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness ***/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×*** In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis.

关键词： Aging Aortic atherosclerosis Atherosclerotic risk factors Magnetic resonance imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于叠加频率的直流微电网改进下垂控制策略研究

引用

太阳能学报 2022年第9期43卷 461-467页

作者：薛阳黄薪操席东翔陈月钒丁子龙上海电力大学自动化工程学院上海200090

提出一种基于叠加频率的直流微电网改进下垂控制策略。首先,通过在变换器输出电压上叠加交流电压,构造交流电压频率和输出电流之间的下垂特性;同时,利用交流电压产生的无功功率调节各变换器输出电压,实现电流的精确分配;然后,通过引入... 详细信息

提出一种基于叠加频率的直流微电网改进下垂控制策略。首先,通过在变换器输出电压上叠加交流电压,构造交流电压频率和输出电流之间的下垂特性;同时,利用交流电压产生的无功功率调节各变换器输出电压,实现电流的精确分配;然后,通过引入虚拟电阻和电压二次补偿措施,实现母线电压恢复同时提高系统稳定性。该文所提控制策略无需通信网络,有效提高了微电网即插即用性能。最后,通过仿真验证了控制策略的可行性和有效性。

关键词：微电网改进下垂控制分布式发电虚拟电阻

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于与α-丙氨酸/天冬酰胺美拉德反应的低聚壳聚糖衍生物的抗氧化性能研究

引用

食品与生物技术学报 2012年第5期31卷 531-536页

作者：孙涛朱云谢晶薛斌周冬香上海海洋大学食品学院上海201306 上海海洋大学海洋科学研究院上海201306

研究低聚壳聚糖(COS)与α-丙氨酸/天冬酰胺(低聚壳聚糖的羰基与氨基的物质量比均为4:1)的美拉德反应。醇沉法提取与α-丙氨酸/天冬酰胺反应8、16h以及24h的低聚壳聚糖衍生物,分别记为:CA-8、CA-16、CA-24、CN-8、CN-16以及CN-24。对衍... 详细信息

研究低聚壳聚糖(COS)与α-丙氨酸/天冬酰胺(低聚壳聚糖的羰基与氨基的物质量比均为4:1)的美拉德反应。醇沉法提取与α-丙氨酸/天冬酰胺反应8、16h以及24h的低聚壳聚糖衍生物,分别记为:CA-8、CA-16、CA-24、CN-8、CN-16以及CN-24。对衍生物进行红外表征,并研究其对超氧阳离子O2.-、DPPH自由基的清除能力以及还原能力。结果显示:美拉德反应后低聚壳聚糖衍生物抗氧化能力得到显著提高。抗氧化能力强弱次序为CA-8>CN-8、CA-16>CN-16、CA-24>CN-24,即随着反应时间增加,低聚壳聚糖与α-丙氨酸美拉德反应的衍生物抗氧化性始终更强,表明与小分子氨基酸进行美拉德反应制得的壳聚糖衍生物具有更好的抗氧化性。

关键词：低聚壳聚糖 α-丙氨酸天冬酰胺美拉德反应抗氧化性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

壳聚糖及其衍生物的絮凝性、螯合性及抑菌性在水处理中的研究进展

引用

化工新型材料 2014年第2期42卷 171-173,176页

作者：孙涛张妮谢晶薛斌周冬香上海海洋大学食品学院上海水产品加工及贮藏工程技术研究中心上海201306

天然高分子壳聚糖及其衍生物具有无毒、易生物降解、无二次污染以及良好的生物相容性等优点,在食品、医药、化工、农业等众多领域具有极高的应用价值。综述了壳聚糖及其衍生物的絮凝性,螯合性及抑菌性在水处理方面的研究进展,为其在水... 详细信息

天然高分子壳聚糖及其衍生物具有无毒、易生物降解、无二次污染以及良好的生物相容性等优点,在食品、医药、化工、农业等众多领域具有极高的应用价值。综述了壳聚糖及其衍生物的絮凝性,螯合性及抑菌性在水处理方面的研究进展,为其在水处理中的实际应用提供参考与借鉴。

关键词：壳聚糖及其衍生物絮凝性螯合性抑菌性水处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于SBAS-InSAR技术的盘锦地区地面沉降监测

引用

工程地质学报 2018年第4期26卷 999-1007页

作者：张静冯东向綦巍周雪赵玉星辽宁省地质环境监测总站沈阳110032 辽宁省国土资源厅沈阳110032 辽宁地矿测绘院沈阳110121

近几年,盘锦地区的地面沉降问题开始受到人们的关注。为了掌握盘锦地区地面沉降现状,包括沉降中心位置、沉降区面积、沉降量、沉降速率等,选取2013-2016年覆盖研究区的19景C波段Radarsat-2 SAR数据,采用SBAS-InSAR技术提取了盘锦地区地... 详细信息

近几年,盘锦地区的地面沉降问题开始受到人们的关注。为了掌握盘锦地区地面沉降现状,包括沉降中心位置、沉降区面积、沉降量、沉降速率等,选取2013-2016年覆盖研究区的19景C波段Radarsat-2 SAR数据,采用SBAS-InSAR技术提取了盘锦地区地面沉降速率和累积沉降量。结果表明,研究区内存在两个沉降区:曙四联沉降区,面积约为43.6 km^2,最大沉降速率为-151.49 mm·a^(-1);龙王村沉降区,面积约为33.28 km2,最大沉降速率为-119.55 mm·a^(-1)。通过地表形变量时序分析,发现两个沉降区的范围随着时间不断扩大,累积沉降量不断增大。与水准监测数据进行对比后发现,两种监测方法得到的沉降区范围和沉降量大体一致,但两者间仍有差别。对研究区内油田井场分布和地下水水位降落漏斗特征与沉降区分布进行了对比分析,研究表明地面沉降与地下水开采、油气资源开采、新构造运动等多种因素具有密切关系。研究结果将为地质环境的管理、地面沉降灾害的防治及资源开发利用规划提供基础依据。

关键词：地面沉降 SBAS-InSAR 监测时间序列

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

周期性机械激励液液体系相界面层的传质特性

引用

化工学报 2000年第1期51卷 108-114页

作者：张东翔薛荣书谭世语 Tarasov V V 重庆大学化学工程系重庆400044 俄罗斯门捷列夫化工大学莫斯科125190

在改装的恒界面池中采用微分传质系数研究了无机酸和金属盐液液萃取 (反萃 )体系动态相界面的传质速度对可控界面机械激励的响应 .作用于液液体系相界面区域的机械激励不仅显著影响相间区域的扩散渗透性 ,而且明显稳定了液液体系相间区... 详细信息

在改装的恒界面池中采用微分传质系数研究了无机酸和金属盐液液萃取 (反萃 )体系动态相界面的传质速度对可控界面机械激励的响应 .作用于液液体系相界面区域的机械激励不仅显著影响相间区域的扩散渗透性 ,而且明显稳定了液液体系相间区域的传质条件 ,减小了实验误差 .微多相层的形成和发展决定相间动量与物质的传输特性 .用微多相层的概念解释了对相界面区域的激励有助于引发Marangoni表面对流及其他实验现象 .

关键词：界面现象传质萃取动力学界面激励

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：