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Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines

BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 7-33页

作者： Kaisheng You Qi Wang Mohamed Syazwan Osman dongpyo kim Qian Li Chao Feng Lei Wang Kuikun Yang School of Life Science and Technology School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinChina State Key Laboratory for Organic Electronics and Information Display&Institute of Advanced Materials Nanjing University of Posts&TelecommunicationsNanjingChina EMZI-UiTM Nanoparticles Colloids&Interface Industrial Research Laboratory(NANO-CORE) Centre for Chemical Engineering StudiesUniversiti Teknologi MARACawangan Pulau PinangMalaysia Department of Chemical Engineering Center for Intelligent Microprocess of Pharmaceutical Synthesis(CIMPS)Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Department of Neurology The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina College of Marine Life Science Ocean University of ChinaQingdaoChina

Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression,long-term protection from recurrence as well as minimized side effects,the low response rate significantly limits the clinical application of immunotherapy in board types of solid *** order to improve the therapeutic efficacy,conventional therapies including radiotherapy,chemotherapy,phototherapy and chemodynamic therapy are employed to combine with immunotherapy to elicit stronger antitumor immune *** nanomedicines are frequently utilized in synergistic immunotherapy and other therapies owing to their tunable physiochemical properties,high drug loading capacity,ease of modification and low *** elaborate design and tailored properties,polymer nanomedicines can significantly enhance antitumor efficacy by enhancing tumor specificity,priming immune cells and amplifying immune responses in ***,until now,there is no review solely dedicated to the comprehensive development of polymer-based platforms for combinational immunotherapy of can***,this paper summarizes latest advances in the design,fabrication and application of polymer nanomedicines in combinational immunotherapy and traditional antitumor strategies including radiotherapy,chemotherapy,photothermal therapy,photodynamic therapy and other *** outlook on the trajectory and potential challenges of polymer nanomedicines in bridging the gap between immunotherapy and conventional therapies is also discussed.

关键词： drug delivery immunotherapy polymer nanomedicine synergistic therapy

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Synthesis of Ordered Mesoporous SiC Via Templating Inorganic Polymer

Synthesis of Ordered Mesoporous SiC Via Templating Inorganic...

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中国空间科学学会空间材料专业委员会2009学术交流会

作者： dongpyo kim Department of Fine Chemical Engineering and Chemistry Chungnam National University

＜正＞1 INTRODUCTION Recently,nanostructured materials have been discovered and an explosive growth of research in this area has drawn more and more *** which,the successful fabrication of ordered nanostructured SiC,such as ordered tubular SiC assemblies,three dimensionally ordered macroporous（3DOM） SiC,porous SiC with special morphologies and 3D ordered SiC sphere assemblies,etc.,has expanded the range of periodic porous materials

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Cell-type continuous electromagnetic radiation system generating millimeter waves for active denial system applications

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Defence Technology（防务技术） 2022年第10期18卷 1895-1913页

作者： Sun-Hong Min Ohjoon Kwon Matlabjon Sattorov Seontae kim In-Keun Baek Seunghyuk Park Ranjan Kumar Barik Anirban Bera dongpyo Hong Seonmyeong kim Bong Hwan Hong Chawon Park Sukhwal Ma Minho kim Kyo Chul Lee Yong Jin Lee Han Byul Kwon Young Joon Yoo Sang Yoon Park Gun-Sik Park Korea Institute of Radiological and Medical Sciences(KIRAMS) Seoul01812South Korea Institute for Basic Science Center for Axion and Precision Physics ResearchDaejeon34141South Korea Center for THz-Driven Biomedical Systems Department of Physics and AstronomyCollege of Natural SciencesSeoul National UniversitySeoul08826South Korea Center for Applied Electromagnetic Research Advanced Institute of Convergence TechnologySuwonGyeonggi-do16229South Korea R&D Department Seoul-TeracomInc.Suwon16229South Korea Mechatronics R&D Center Samsung Electronics Co.Ltd.Hwasung18448South Korea Hanwha Corporation Gumi730-030South Korea Council of Scientific and Industrial Research Central Electronics Engineering Research InstitutePilani333031India Home Economics Education/Biosystems and Biomedical Sciences Korea UniversitySeoul02841South Korea Current affiliation of Seontae kim:Young IN ACE 1 F60Anyangcheondong-roDongan-guAnyang-siGyeonggi-do14042South Korea.

The cell-type continuous electromagnetic radiation system is a demonstration device capable of generating high-power millimeter electromagnetic waves of a specific wavelength and observing their effects on living *** irradiates a biological sample placed in a 30×30×50 cm^(3)cell with electromagnetic waves in the 3.15-mm-wavelength region(with an output of≥1 W)and analyzes the temperature change of the sample.A vacuum electronic device-based coupled-cavity backward-wave oscillator converts the electron energy of the electron beam into radiofrequency(RF)energy and radiates it to the target through an antenna,increasing the temperature through the absorption of RF energy in the *** system causes pain and ultimately reduces combat power.A cell-type continuous electromagnetic radiation system consisting of four parts—an electromagnetic-wave generator,a highvoltage power supply,a test cell,and a system controller—generates an RF signal of≥1 W in a continuous waveform at a 95-GHz center frequency,as well as a chemical solution with a dielectric constant similar to that of the skin of a living *** increase of 5°C lasting approximately 10 s was confirmed through an experiment.

关键词： Millimeter waves Terahertz waves Coupled-cavity backward wave oscillator(CCBWO) Cell-type continuous electromagnetic radiation Active denial system(ADS) Directed-energy weapon(DEW)

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Cell-type continuous electromagnetic radiation system generating millimeter waves for active denial system applications

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Defence technology 2022年第10期

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