Advanced strategies for combinational immunotherapy of cancer based on polymeric nanomedicines
作者机构：School of Life Science and TechnologySchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinChina State Key Laboratory for Organic Electronics and Information Display&Institute of Advanced MaterialsNanjing University of Posts&TelecommunicationsNanjingChina EMZI-UiTM Nanoparticles Colloids&Interface Industrial Research Laboratory(NANO-CORE)Centre for Chemical Engineering StudiesUniversiti Teknologi MARACawangan Pulau PinangMalaysia Department of Chemical EngineeringCenter for Intelligent Microprocess of Pharmaceutical Synthesis(CIMPS)Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Department of NeurologyThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina College of Marine Life ScienceOcean University of ChinaQingdaoChina
出 版 物：《BMEMat(BioMedical Engineering Materials)》 (生物医学工程材料（英文）)
年 卷 期：2024年第2卷第2期
页 面：7-33页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China,Grant/Award Numbers:52073071,82001240,82202316 Natural Science Foundation of Heilongjiang Province,Grant/Award Number:YQ2021H011 Original Frontier Exploration Fund of Harbin Institute of Technology,Grant/Award Number:HIT.OCEF.2022029
主 题：drug delivery immunotherapy polymer nanomedicine synergistic therapy
摘 要：Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression,long-term protection from recurrence as well as minimized side effects,the low response rate significantly limits the clinical application of immunotherapy in board types of solid *** order to improve the therapeutic efficacy,conventional therapies including radiotherapy,chemotherapy,phototherapy and chemodynamic therapy are employed to combine with immunotherapy to elicit stronger antitumor immune *** nanomedicines are frequently utilized in synergistic immunotherapy and other therapies owing to their tunable physiochemical properties,high drug loading capacity,ease of modification and low *** elaborate design and tailored properties,polymer nanomedicines can significantly enhance antitumor efficacy by enhancing tumor specificity,priming immune cells and amplifying immune responses in ***,until now,there is no review solely dedicated to the comprehensive development of polymer-based platforms for combinational immunotherapy of can***,this paper summarizes latest advances in the design,fabrication and application of polymer nanomedicines in combinational immunotherapy and traditional antitumor strategies including radiotherapy,chemotherapy,photothermal therapy,photodynamic therapy and other *** outlook on the trajectory and potential challenges of polymer nanomedicines in bridging the gap between immunotherapy and conventional therapies is also discussed.
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