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Pd cluster decorated free standing flexible cathode for high performance Li-oxygen batteries

Nano Research 2024年第4期17卷 2678-2686页

作者： Liang Guo Guoliang zhang Ruonan Yang dongmei zhang Xiuqi zhang Han Yu Xia Li Feng Dang Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

As a promising candidate for the next generation energy storage system,rechargeable lithium-oxygen batteries(LOBs)still face substantial challenges caused by insulating discharge products that preclude their practical *** highly efficient cathode catalysts capable of facilitating formation/decomposition of discharge products is considered as an essential approach towards high performance ***,Pd decorated Te nanowires(Pd@Te NWs)were synthesized as advanced catalyst in LOBs to maximize Pd utilization and achieve synergistic effect,in which Pd clusters were uniformly grown on Te substrate though regulating the Pd:Te ***,Pd@Te nanowires assembled into an interpenetrating network-like structure by vacuum filtration and employed as flexible cathode,enabling LOBs achieved an ultralong 190 cycles stability and a superior specific capacity of 3.35 mAh·cm^(-2).Experimental studies and density functional theory(DFT)calculations reveal the excellent catalytic ability of Pd@Te and synergistic catalytic mechanism of Pd and Te,in which uniform electron distribution,extensive electron exchange,and large adsorption distance between Pd cluster and discharge products promote homogeneous adsorption/desorption of discharge products,while the high adsorption energy of Te substrate for Li species reduces the initial dynamical energy barrier during discharging *** current work provides viable strategy to design composite catalysts for flexible cathode of LOBs with synergistic catalytic effects.

关键词： flexible lithium-oxygen batteries Pd@Te synergistic catalysis cathode catalysts density functional theory(DFT)calculation

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Selective nickel-electrocatalyzed benzylic C-H oxygenation of functionalized alkyl arenes

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Chinese Chemical Letters 2024年第2期35卷 396-401页

作者： Shunyao Tang Siyi Wang dongmei zhang Xinxing zhang Guang Yang Yanwei Wang Youai Qiu State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education)Renewable Energy Conversion and Storage Center (RECAST)Frontiers Science Center for New Organic MatterNankai UniversityTianjin 300071China

Herein, a site-selective paired electrochemical C–H oxidation of functionalized alkyl arenes promoted by nickel catalyst is disclosed. A Ni(Ⅱ)-dioxygen species formed in situ efficiently enable the oxidation process under mild conditions with a broad substrate scope with excellent functional group compatibilities,such as free carboxylic acid, aldehyde, halogen(including aryl iodide), amide and amino acid. The use of the nickel catalyst in combination with water provides a safe, green and economical method for oxidation of a range of molecules varying in complexity and drug derivatives, demonstrating its potential application in organic synthesis and the pharmaceutical industry. Reaction outcomes and mechanistic studies revealed the key role of the in situ Ni(Ⅱ)-dioxygen species for the subsequent oxidation of C(sp^(3))–H bonds,and short-lived reactive intermediates(aryl radical cation) was rapidly captured by the combination of a bipolar ultramicroelectrode(BUME) with nano-electrospray ionization mass spectrometry.

关键词： Electrochemical C-H oxidation Functionalized alkyl arenes Paired nickel-electrocatalysis H_(2)O oxidation Ketones

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Development and Quality Improvement of Lianqingshan Scenic Spot in Tengzhou City

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Journal of Landscape Research 2024年第1期16卷 91-95页

作者： zhang dongmei WANG Yifan School of Tourism Taishan UniversityTai’anShandong 271000China

Since the 21st century,China’s overall national strength has increased *** the rapid development of the tourism industry,people have an increasingly strong demand for ***,tourists’satisfaction to Lianqingshan Scenic Spot was surveyed,and then the types of tourism resources,current development situation and problems in the scenic spot were ***,some countermeasures and suggestions for its development and quality improvement were put *** is found that based on the environmental quality,safety and service quality of Lianqingshan Scenic Spot,the basic situation of the development of the scenic spot was investigated,and the comprehensive satisfaction of each item is 3.30,3.24 and *** tourists of the scenic spot is mainly from Tengzhou City and its surrounding cities,and the popularity of the scenic spot is relatively *** management personnel of the scenic spot needs to increase the tourist flow by improving its *** problems of the scenic spot include low popularity,poor environmental quality,low safety of tourists,poor operating condition of catering industry and service quality of service personnel.

关键词： Lianqingshan Scenic Spot Problems Countermeasures

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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu dongmei zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

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Telomere-to-telomere genome of the allotetraploid legume Sesbania cannabina reveals transposon-driven subgenome divergence and mechanisms of alkaline stress tolerance

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Science China(Life Sciences) 2024年第1期67卷 149-160页

作者： Haofei Luo Xiaofei Wang Changqing You Xuedan Wu Duofeng Pan Zhiyao Lv Tong Li dongmei zhang Zhongbao Shen Xiaodong zhang Guodao Liu Kaixuan He Qingtong Ye Yajun Jia Qinghua Zhao Xian Deng Xiaofeng Cao Xianwei Song Gai Huang State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Lab Sanya 572025China University of Chinese Academy of Sciences Beijing 100049China Institute of Forage and Grassland Sciences Heilongjiang Academy of Agricultural SciencesHarbin 150086China Shandong Academy of Agricultural Sciences Jinan 250100China National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land Dongying 257345China Shandong Green Manure Ecological Technology Co. LtdDongying 257345China State Key Laboratory of Tropical Crop Breeding Chinese Academy of Tropical Agricultural SciencesHaikou 571101China

Alkaline soils pose an increasing problem for agriculture worldwide,but using stress-tolerant plants as green manure can improve marginal ***,we show that the legume Sesbania cannabina is very tolerant to alkaline conditions and,when used as a green manure,substantially improves alkaline *** understand genome evolution and the mechanisms of stress tolerance in this allotetraploid legume,we generated the first telomere-to-telomere genome assembly of *** spanning~2,087 *** assembly included all centromeric regions,which contain centromeric satellite repeats,and complete chromosome ends with telomeric *** genome analysis distinguished A and B subgenomes,which diverged approximately 7.9 million years *** genomic analysis revealed that the chromosome homoeologs underwent large-scale inversion events(>10 Mb)and a significant,transposon-driven size expansion of the chromosome 5A *** further identified four specific alkali-induced phosphate transporter genes in ***;these may function in alkali tolerance by relieving the deficiency in available phosphorus in alkaline *** work highlights the significance of *** as a green tool to improve marginal lands and sheds light on subgenome evolution and adaptation to alkaline soils.

关键词： Sesbania cannabina alkaline stress telomere-to-telomere genome legume green manure phosphate transporter allotetraploid

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基于几何约束的倾斜影像特征匹配方法

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西南交通大学学报 2024年第2期59卷 353-360页

作者：韦春桃张冬梅重庆交通大学土木工程学院重庆400074

针对倾斜影像视角变换较大、重复纹理导致匹配数量少、匹配精度不高的问题,提出一种适用于倾斜影像的特征点、线分级匹配方法.首先,用直线提取(检测)算法(LSD)获取影像直线特征,并将直线特征以一定约束进行直线组对,构建直线对区域与改... 详细信息

针对倾斜影像视角变换较大、重复纹理导致匹配数量少、匹配精度不高的问题,提出一种适用于倾斜影像的特征点、线分级匹配方法.首先,用直线提取(检测)算法(LSD)获取影像直线特征,并将直线特征以一定约束进行直线组对,构建直线对区域与改进的SIFT(scale-invariant feature transform)特征描述符进行匹配,使用RANSAC算法剔除误匹配,获得初始匹配结果后再进行核线约束;然后,利用已获得直线对区域进行影像局部纠正,在纠正后的局部影像上采用SIFT匹配并反算回原始影像,利用得到的同名点全局纠正倾斜影像,并进行特征点匹配与采用基于方格的运动统计算法(GMS)剔除误匹配,仍将匹配结果反算回原始影像上;最后,将仿射尺度不变特征变化结果与点拓展匹配结果进行合并,得到最终匹配结果.试验结果表明:本文方法匹配正确率与经典的仿射不变匹算法(ASIFT)的正确率相差不大,但匹配数量却是ASIFT算法的1倍~3倍.

关键词：倾斜影像直线特征核线约束点拓展匹配全局纠正

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美国大学参与国家实验室管理的动因、途径与趋势

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高等工程教育研究 2024年第1期 196-200页

作者：张冬梅厦门大学教育研究院/教师发展中心

美国大学参与国家实验室管理的积极行为,主要由依托大学力量建设国家实验室的国家战略、大学对国家实验室资源和平台的需要、国家实验室与大学具有一致知识创新使命等内外动因促成。成为承包商是美国大学参与国家实验室管理的主要途径,... 详细信息

美国大学参与国家实验室管理的积极行为,主要由依托大学力量建设国家实验室的国家战略、大学对国家实验室资源和平台的需要、国家实验室与大学具有一致知识创新使命等内外动因促成。成为承包商是美国大学参与国家实验室管理的主要途径,存在大学独立运营国家实验室和大学参与成立有限责任公司共同管理国家实验室两种模式。21世纪以来,美国大学参与管理国家实验室呈现出管理资格从固定承包转向动态竞标、参与方式从独立管理逐渐转向大学成立公司合作管理、内部管理结构从单一主体走向多元主体、运营模式从大学管理转向公司治理等趋势。其优势是企业管理经验丰富有助于提高实验室运营效益;合作运营避免单一管理者过度吸纳实验室资源;扩大企业参与有助于技术转让;有限责任公司有助于提高管理灵活性等。

关键词：国家实验室美国大学参与管理

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Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao dongmei zhang Wencai Ye Minfeng Chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

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国内外结核病临床在研疫苗最新研究进展

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中国血吸虫病防治杂志 2024年第2期36卷 201-206,218页

作者：周方斌张逸龙张冬梅海军军医大学海军医学系热带病学教研室上海200433

结核病是全球最大的传染病杀手之一,接种疫苗是预防结核病最理想的方法,但此前广泛用于预防结核病的卡介苗保护效果存在局限性,亟需开发新型结核病疫苗。目前,国内外已有包括减毒疫苗、灭活疫苗、亚单位疫苗及病毒载体疫苗等在内的15种... 详细信息

结核病是全球最大的传染病杀手之一,接种疫苗是预防结核病最理想的方法,但此前广泛用于预防结核病的卡介苗保护效果存在局限性,亟需开发新型结核病疫苗。目前,国内外已有包括减毒疫苗、灭活疫苗、亚单位疫苗及病毒载体疫苗等在内的15种新型结核病疫苗进入临床试验阶段,为最终实现“终结结核病流行目标”带来了曙光。本文就国内外临床在研结核病疫苗的最新研究进展作一综述,以期为后续结核病防治提供参考。

关键词：结核病结核分枝杆菌疫苗临床试验

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基于多重分形的改进GRU滑坡位移预测模型

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浙江大学学报（工学版） 2024年第7期58卷 1407-1416页

作者：徐满张冬梅余想李江吴益平中国地质大学(武汉)计算机学院湖北武汉430074 湖北省自然资源厅信息中心湖北武汉430071 中国地质大学(武汉)工程学院湖北武汉430074

门控机制设计难以学习序列变化趋势,导致传统记忆网络模型对滑坡位移非平稳跃变段预测效果较差.基于多重分形改进门控循环单元(GRU),通过量化序列的变化特征来动态更新门控权重,引入循环神经网络单元的状态融合策略以学习数据的长程相... 详细信息

门控机制设计难以学习序列变化趋势,导致传统记忆网络模型对滑坡位移非平稳跃变段预测效果较差.基于多重分形改进门控循环单元(GRU),通过量化序列的变化特征来动态更新门控权重,引入循环神经网络单元的状态融合策略以学习数据的长程相关性特征.采用变分模态分解算法将滑坡累积位移分解成趋势项、周期项及随机项,利用改进GRU进行位移分量的训练和预测.选取三峡库区白水河滑坡监测点ZG93、ZG118进行仿真实验.实验结果表明,相比传统预测模型,新模型的滑坡位移形变趋势特征学习能力更强,预测精度更高.

关键词：滑坡累积位移多重分形门控循环单元(GRU) 变分模态分解循环神经网络

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