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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan dong Jia-huan qin Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

A NOVEL PHOTO-INITIATING SYSTEM FOR ATOM TRANSFER RADICAL POLYMERIZATION OF STYRENE

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Chinese Journal of Polymer Science 2001年第5期19卷 441-445页

作者： shu-hui qin dong-qi qin kun-yuan qiu Department of Polymer Science and Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871, China 北京大学北京

A novel photo-induced initiating system, 2,2-dimethoxy-2-phenylacetophenone (DMPA)/ferric tri(NN-diethyldithiocarbamate) [Fe(DC)(3)], was developed and used for the atom transfer radical polymerization (ATRP) of styrene in toluene. The polymerization proceeds with DMPA as photo-initiator, Fe(DC)(3) as catalyst and DC as a reversible transfer group, while the halogen and ligands are free. Well-defined PSt was prepared and the polymerization mechanism revealed by end group analysis belongs to a reverse ATRP. Block copolymer was prepared by using thus obtained PSt as macroinitiator and Fe(DC)(2) as catalyst under UV light irradiation via a conventional ATRP process.

关键词： photo atom transfer radical polymerization living radical polymerization well-defined polystyrene block copolymer

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新引发体系引发MMA活性自由基聚合

高等学校化学学报 2001年第5期22卷 866-868页

作者：秦东奇钦曙辉丘坤元北京大学化学与分子工程学院高分子科学与工程系北京100871

Living radical polymerization of methyl methacrylate was investigated using a new initiation system, i. e. DCDPS/Fe(DC)3, in which diethyl 2,3-dicyano-2,3-diphenyl-succinate(DCDPS) is a hexa-substituted ethane thermal iniferter and ferric tri(diethyldithiocarbamate)(Fe(DC)3) is a ligand-free catalyst. The polymerization was successfully controlled in bulk at 95 ℃, PMMA with high molecular weight and quite narrow polydispersities(Mw/Mn=1.20～1.29) were obtained. End group analysis by 1H NMR spectroscopy shows that the resulting PMMA is ω-functionalized by a DC group.

关键词：活性自由基聚合引发体系 2,3-二氰基-2,3-二苯基丁二酸二乙酯甲基丙烯酸甲酯

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新型引发体系引发MMA“活性”自由基聚合

高等学校化学学报 2000年第4期21卷 650-652页

作者：秦东奇钦曙辉丘坤元北京大学化学与分子工程学院高分子科学与工程系北京100871

Living" radical polymerization of methyl methacrylate was investigated using a new initiating system, i.e. DCDPS/FeCl 3/PPh 3, in which diethyl 2,3 dicyano 2,3 diphenyl succinate(DCDPS) is a hexa substituted ethane thermal iniferter. The polymerization mechanism belongs to a reverse ATRP process. The polymerization was closely controlled in bulk at 75 ℃, polymethyl methacrylate(PMMA) with a high molecular weight and quite narrow polydispersity ( M w/ M n=1 20—1 29) was obtained. End group analysis by 1H NMR spectroscopy shows that the resulting PMMA is ω functionalized by a chlorine atom, which is also confirmed by the chain extension reaction in the presence of CuCl/bipy catalyst via a conventional ATRP process. [WT5HZ]

关键词： ATRP 自由基聚合甲基丙烯酸甲酯

Construction of CoNi_(2)S_(4) nanocubes interlinked by few-layer Ti_(3)C_(2)T_(x) MXene with high performance for asymmetric supercapacitors

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Rare Metals 2022年第12期41卷 4116-4126页

作者： Ji-qiu qi Meng-yuan Huang Chen-Ya Ruan dong-dong Zhu Lei Zhu Fu-Xiang Wei Yan-Wei Sui qing-kun Meng Jiangsu Province Engineering Laboratory of High Efficient Energy Storage Technology and Equipments School of Materials Science and PhysicsChina University of Mining and TechnologyXuzhou 221116China Key Laboratory of Air-Driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000China

Both MXene and zeolitic imidazolate framework(ZIF)derivatives are tend to agglomerate during the compound process,which adversely affects their electrochemical *** alleviate this phenomenon,fewlayer MXene was stripped by mechanical method,and electrostatic self-assembly with ZIF-67 in the presence of cationic ***,CoNi_(2)S_(4)/MXene composite was synthesized by the facile hydrothermal ***_(2)S_(4)well retained the cube frame structure of the ZIF-67 with the sagging outer frame and rough *** the composite,CoNi_(2)S_(4)nanocubes were interlinked by MXene nanosheets,which can effectively improve the structural stability and make full use of the active ***_(2)S_(4)/MXene composite electrode exhibits an outperforming specific capacitance(751 C·g^(-1)at 1 A·g^(-1)),far higher than that of pure CoNi2S4(600 C·g^(-1)at 1 A·g^(-1)).An asymmetric supercapacitor(CoNi_(2)S_(4)/MXene//reduced graphene oxide(RGO))assembling delivers high energy density of 33.8 Wh·kg^(-1)and excellent cycling *** study indicates the potential of MXene/ZIF derivatives in the application of supercapacitor.

关键词： Cubic frame structure Few-layer MXene ZIF-67 Asymmetric supercapacitor

Relationship among the secretion of extracellular polymeric substances, heat resistance, and bioleaching ability of Metallosphaera sedula

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1504-1511页

作者： Run-lan Yu Zhen-hua Liu Zhao-jing Yu Xue-ling Wu Li Shen yuan-dong Liu Jiao-kun Li Wen-qing qin Guan-zhou qiu Wei-min Zeng School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Biometallurgy of Ministry of Education Central South UniversityChangsha 410083China

This paper describes the investigation of the secretion of extracellular polymeric substances(EPS)by an extremely thermoacidophilic archaea,Metallosphaera sedula(***),during the bioleaching of pyrite under different temperatures and discusses the relationship among the EPS secretion,its heat resistance,and its ability to bioleach *** investigation results indicate that the amount of extracellular proteins is significantly higher than the amount of extracellular polysaccharides in the extracted EPS whether free cells or attached cells;these results are quite different from the behavior of mesophilic Acidithiobacillus *** the growth of *** is inhibited at 80℃,the bioleaching ability of *** is only slightly lower than that at the optimum growth temperature of 72℃ because of the heat resistance mechanism based on EPS *** secretion of more extracellular proteins is an important heat resistance mechanism of ***.

关键词： bioleaching extracellular polymeric substances(EPS) heat resistance Metallosphaera sedula

In situ mitigation strategies for field emission-induced cavity faults using low-level radiofrequency system

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Nuclear Science and Techniques 2022年第11期33卷 46-60页

作者： Feng qiu yuan He An-dong Wu Zhen-Long Zhu Guo-dong Jiang Tian-Cai Jiang Zheng Gao qi Chen Zong-Heng Xue Jin-Ying Ma Cheng-Ye Xu Zi-qin Yang Gui-Rong Huang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

In the Chinese ADS front-end demo superconducting radiofrequency linac(CAFe)at the Institute of Modern Physics,a burst-noise signal-triggered cavity fault frequently appears during beam *** events are characterized by a rapid burst noise in the cavity pick-up,which may lead to an unexpected low-level radiofrequency(LLRF)response that eventually causes a cavity *** eliminate the undesirable reaction of the LLRF control loop,we propose a method that uses a burstnoise detection and processing algorithm integrated into the LLRF feedback *** algorithm can prevent undesired regulations in LLRF *** analysis revealed that some burst-noise events did not exhibit measurable energy *** contrast,the other events were accompanied by a rapid loss of cavity stored energy and exhibited similarities to the‘‘E-quench’’phenomena reported in other laboratories.A particle-in-cell simulation indicated that the suspected E-quench phenomenon may be related to a plasma formation process inside the ***,the LLRF algorithm is robust to the two different types of burst-noise events and can significantly mitigate the corresponding cavity faults in CAFe beam commissioning.

关键词： Field emission Flashover E-quench Superconducting LLRF CAFe Plasma formation

Intranasal Immunization Using CTA1-DD as a Mucosal Adjuvant for an Inactivated Influenza Vaccine

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Biomedical and Environmental Sciences 2019年第7期32卷 531-540页

作者： FAN Xue Ting WANG Yun Long SU qiu dong qiu Feng YI Yao JIA Zhi yuan WANG Da Yan qin kun ZOU Ye Ning BI Sheng Li SHEN Li Ping National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Henan Bioengineering Research Center Zhengzhou 4500466 Henan China Sinovac Biotech Co. Ltd. Beijing 100085 China

Objective To evaluate the effect of intranasal immunization with CTA1-DD as mucosal adjuvant combined with H3N2 split vaccine. Methods Mice were immunized intranasally with PBS(negative control), or H3N2 split vaccine(3 μg/mouse) alone, or CTA1-DD(5 μg/mouse) alone, or H3N2 split vaccine(3 μg/mouse) plus CTA1-DD(5 μg/mouse). Positive control mice were immunized intramuscularly with H3N2 split vaccine(3 μg/mouse) and alum adjuvant. All the mice were immunized twice, two weeks apart. Then sera and mucosal lavages were collected. The specific HI titers, IgM, IgG, IgA, and IgG subtypes were examined by ELISA. IFN-γ and IL-4 were test by ELISpot. In addition, two weeks after the last immunization, surivival after H3N2 virus lethal challenge was measured. Results H3N2 split vaccine formulated with CTA1-DD could elicit higher Ig M, Ig G and hemagglutination inhibition titers in sera. Furthermore, using CTA1-DD as adjuvant significantly improved mucosal secretory Ig A titers in bronchoalveolar lavages and vaginal lavages. Meanwhile this mucosal adjuvant could enhance Th-1-type responses and induce protective hemagglutination inhibition titers. Notably, the addition of CTA1-DD to split vaccine provided 100% protection against lethal infection by the H3N2 virus. Conclusion CTA1-DD could promote mucosal, humoral and cell-mediated immune responses, which supports the further development of CTA1-DD as a mucosal adjuvant for mucosal vaccines.

关键词： Adjuvants H3N2 Influenza Mucosal immunization Split vaccine

经额定位联合颅内压监测下微创手术治疗基底节区脑出血的疗效观察

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海南医学 2024年第3期35卷 339-344页

作者：覃成箭张坤源郑传华邓显东罗中彬燕鹏梁洪岖吕浩罗起胜右江民族医学院附属医院神经外科广西百色533000 平昌县第二人民医院神经外科四川巴中636400

目的探讨经额简易定位软通道联合颅内压监测下微创手术治疗椭圆形基底节区脑出血的效果。方法回顾性分析2019年1月至2021年12月右江民族医学院附属医院神经外科在简易定位后经额软通道微创手术治疗的70例椭圆形基底节区脑出血患者的临... 详细信息

目的探讨经额简易定位软通道联合颅内压监测下微创手术治疗椭圆形基底节区脑出血的效果。方法回顾性分析2019年1月至2021年12月右江民族医学院附属医院神经外科在简易定位后经额软通道微创手术治疗的70例椭圆形基底节区脑出血患者的临床资料,根据术前是否行颅内压(ICP)监测传感器置入术将其分为监测组26例和对照组44例,比较两组患者的一般资料、血肿清除率、术后甘露醇使用时间、术后住院时间、术后出血率、术后颅内感染率、术后1个月格拉斯哥预后分级(GOS)评分、预后良好率、术后3个月改良Rankin量表(mRS)评分等指标之间的差异。结果两组患者的年龄、性别、出血量、是否中线移位、是否破入脑室等一般资料比较差异均无统计学意义(P>0.05);监测组患者的血肿清除率为(58.72±13.61)%,明显高于对照组的(50.58±15.50)%,差异有统计学意义(P0.05);监测组患者术后1个月的GOS评分为(3.96±0.96)分,明显高于对照组的(3.39±1.08)分,预后良好率为69.23%,明显高于对照组的38.64%,差异均有统计学意义(P<0.05);监测组患者术后3个月的mRS评分为(0.88±1.18)分,明显低于对照组的(2.39±1.40)分,差异有统计学意义(P<0.05)。结论在经额简易定位软通道联合颅内压监测下进行椭圆形基底节区脑出血微创手术治疗,血肿清除率较高,能有效改善患者的预后。

关键词：经额简易定位软通道有创颅内压监测微创椭圆形基底节区脑出血疗效