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Analysis of risk factors for postoperative anxiety and depression in endometriosis patients with reproductive intention

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World Journal of Psychiatry 2024年第9期14卷 1364-1374页

作者： Chun-mei Wu Cai-Hua Li You-Yan Fang Huan Wu dong-mei ji Ping Zhou Yun-Xia Cao Ye He Zhao-Lian Wei Department of Obstetrics and Gynecology the First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Obstetrics and Gynecology Huaibei People's Hospital of Anhui ProvinceHuaibei 235000Anhui ProvinceChina

BACKGROUND The occurrence of postoperative depression and anxiety in patients with endomet-riosis(EMS)not only causes psychological distress,but may also harm their physical *** To explore the postoperative depression status,and its influencing factors,of EMS patients with reproductive *** A total of 321 EMS patients with reproductive intent were *** the self-rating anxiety scale and self-rating depression scale,EMS patients with anxiety or depression were distinguished.A clinical model for predicting anxiety or depression in EMS patients was constructed and evaluated using a nomogram,receiver operating characteristic curve,and calibration *** The results of the single factor analysis showed that smoking,coffee,EMS stage,chronic pelvic pain,and sexual discomfort may be related to ***,smoking,drinking,spouse,annual household income and EMS stage may be related to depression in EMS *** logistic regression illustrated that smoking,coffee,chronic pelvic pain and sexual discomfort may be inde-pendent risk factors for anxiety in EMS patients,while smoking,EMS stage(Phase III and Phase IV),spouse and high annual household income may be independent risk factors for depression in EMS ***,the models used to predict the risk of anxiety or depression in EMS patients have good predictive *** The anxiety and depression of EMS patients may be related to many *** clinical treatment,additional attention should be paid to the psychological status of EMS patients.

关键词： Endometriosis Reproductive intention Anxiety Depressed

农村初中生歧视知觉与学校适应的关系——一个链式中介模型

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山东青年政治学院学报 2024年第5期40卷 65-71页

作者：姜先朝董继林郭雅煊董及美济南大学教育与心理科学学院济南250022 沂源县第二中学山东淄博256100

为探讨农村初中生歧视知觉与学校适应的关系以及积极心理资本与孤独感在两者之间的中介作用,采用歧视知觉量表、积极心理资本量表、青少年孤独感量表和初中生学校适应量表对1097名农村初中生进行调查。结果发现:(1)农村初中生歧视知觉... 详细信息

为探讨农村初中生歧视知觉与学校适应的关系以及积极心理资本与孤独感在两者之间的中介作用,采用歧视知觉量表、积极心理资本量表、青少年孤独感量表和初中生学校适应量表对1097名农村初中生进行调查。结果发现:(1)农村初中生歧视知觉能显著负向预测学校适应;(2)积极心理资本与孤独感在农村初中生歧视知觉与学校适应关系中的链式中介作用显著,同时孤独感的单独中介作用显著;(3)农村初中生歧视知觉与学校适应关系模型具有一定的稳定性,在不同性别及是否留守初中生群体间差异不显著。

关键词：学校适应歧视知觉积极心理资本孤独感农村初中生

Effects of U0126 on growth and activation of mitogen-activated protein kinases in Aspergillus fumigatus

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Chinese Medical Journal 2013年第2期126卷 220-225页

作者： MA dong-mei ji Ya-juan YANG Fang LIU Wei WAN Zhe LI Ruo-yu Department of Dermatology Peking University First HospitalResearch Center for Medical Mycology Peking University Beijing100034 China

Background Invasive aspergillosis （IA）, which is mainly caused by Aspergillus fumigatus （A. fumigatus）, is a major cause of morbidity and mortality in immunocompromised patients. Despite considerable progress in currently available antifungals the mortality still remains high in critically ill patients. U0126 which is a highly selective inhibitor of MEK1 and MEK2 in the RAF/MEK/ERK pathway in mammalian cells has been demonstrated to have an anti-proliferative role in cancer cells. The purpose of this study was to explore the role of U0126 on growth inhibition and activation of mitogen-activated protein kinases （MAPKs） in A. fumigatus. Methods Germination percentage and hyphae growth in A. fumigatus treated with U0126 were observed and compared with untreated controls. Western blotting analysis was used to detect changes in activation of SakA, MpkA and MpkB. Results U0126 inhibited germination and hyphae growth in A. fumigatus and enhanced the phosphorylation of SakA and MpkA under oxidative stress. U0126 at 10 pmol/L did not block the activation of MpkB during nitrogen starvation stress. Conclusion U0126 shows promise as an antifungal candidate and the MAPK pathway may be a possible antifungal drug target for A. fumigatus.

关键词： Aspergillus fumigatus protein kinase inhibitors mitogen-activated protein kinases

Artemsieverolactones A—H,Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana

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Chinese Journal of Chemistry 2024年第10期42卷 1084-1092页

作者： Wei dong Xiao-Yan Huang Tian-Ze Li Yan-mei Weng Chang-An Geng ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academyof Sciences Beijing 100049China

Eight new guaiane-type sesquiterpenoid trimers,artemsieverolactones A—H,possessing unprecedented scaffolds via biocatalyzed[4+2]Diels−Alder cycloaddition reactions were identified from Artemisia *** structures were determined by comprehensive spectroscopic data,single-crystal X-ray diffraction analyses,and ECD *** terms of structure,artemsieverolactones A—H are first examples of sesquiterpenoid trimers from guaiane-type sesquiterpenoid through four different[4+2]Diels−Alder cycloaddition *** fibrosis assay suggested that five compounds exhibited activity against HSC-LX2 with IC_(50)values ranging from 37.8 to 117.1μmol/*** most active artemsieverolactone B(2)displayed significant inhibitory activity against HSC-LX2 with IC_(50)value of 37.8μmol/L,which was 3 times more active than the positive drug silybin(IC_(50),139.7μmol/L).Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen typeⅠ(ColⅠ),human hyaluronic acid(HA),and human laminin(HL)with IC_(50)values of 40.4μmol/L(Col I),55.1μmol/L(HL),47.3μmol/L(HA),which was 2 to 3-fold more potent than silybin.

关键词： Artemisia sieversiana Artemsieverolactones A-H Guaiane-type sesquiterpenoid trimers Antihepatic fibrosis Extracellular matrix Cancer NMR spectroscopy X-ray diffraction

Coordination for a Closed-loop Supply Chain with Recycling Platform Considering Dynamic Setting

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 425-451页

作者： Zehua Xiang Ting ji Lingfeng dong School of Management Zhejiang UniversityHangzhou310058China School of Business Hangzhou City UniversityHangzhou310015China Alibaba Business College Hangzhou Normal UniversityHangzhou311121China

This paper presents a dynamic closed-loop supply chain(CLSC)model,incorporating a manufacturer,a retailer,and an internet recycling platform(IRP),utilizing differential game theory while considering the forgetting effect of *** model encompasses factors such as the quality level of used products and Big Data marketing(BDM),comparing optimal equilibriums under decentralized and cooperative decision *** effectively coordinate the dynamic CLSC at each time point,we propose a revenue-sharing and cost-sharing(RSCS)combined *** addition to ensuring reasonable sharing of revenues and costs,this contract allows the manufacturer to flexibly adjust wholesale prices for final products and transfer prices for used products in order to distribute profits appropriately and achieve Pareto optimality within the CLSC ***,our results indicate that there exists a threshold for Big Data marketing efficiency;high-efficiency BDM not only facilitates increased recycling on Internet platforms but also reduces unit recycling costs for ***,when implementing the combined contract,Big Data marketing efficiency does not impact the transfer price paid by manufacturers to Internet recycling platforms.

关键词： Big Data marketing differential game closed-loop supply chain coordination internet recycling platform

Compensation temperatures and hysteresis behaviors of a graphene-like trilayer

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Communications in Theoretical Physics 2024年第5期76卷 166-179页

作者： Ying An ji Liang Wei Wang mei-mei Du Feng-ge Zhang School of Science Shenyang University of TechnologyShenyang 110870China School of Electrical Engineering Shenyang University of TechnologyShenyang 110870China

This work focuses on the ground-state phase diagram,the compensation temperatures and the critical behaviors of a ferrimagnetic graphene-like trilayer induced by crystal fields and exchange *** simulation results show that a negative decrease in crystal field or an increase in exchange coupling can increase the critical *** importantly,an M curve with double compensation temperatures can be observed,which is not predicted by the Neel *** remarkable compensation phenomenon has potential application value in the field of magnetic recording.

关键词： graphene-like trilayer mixed-spin Ising model magnetization double compensation temperatures triple-loop hysteresis monte Carlo

Multiple factors influencing high-purity indium electrolytic refining

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Chinese Journal of Chemical Engineering 2024年第7期71卷 148-160页

作者： Hong-Qiang Fan Fei Li Hong-Xing Zheng Wu-ji Pan mei-Zhen Wu Yashar Behnamian Ju-Bo Peng dong-Hai Lin State Key Laboratory of Advanced Special Steel&School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials Shanghai UniversityShanghai 200444China Research&Development Center Yunnan Tin Group(Holding)Limited CompanyKunming 650032China Department of Chemical and Materials Engineering University of AlbertaEdmonton T6G 2V4AlbertaCanada School of Energy and Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China

The effects of various contaminants in the electrolytic refinement of indium were investigated using a glow discharge mass spectrometer(GDMS).The effects of several factors such as the indium ion(In3+)concentration,the sodium chloride(NaCl)concentration,the current density,the gelatin concentration,the pH,and the electrode distance,were *** variations in impurity levels concerning gelatin concentration were *** the gelatin and In3+concentration were moderately positively correlated with the Pb *** Sb concentration was associated positively with the NaCl concentration,while the Ti concentration had an adverse correlation with the NaCl *** Bi element content was positively linked to the electrode *** the current density increased,Cu,Pb,and Bi impurities initially rose and then eventually ***,a critical current density of 45 A·m^(-2) was identified in this behavior.

关键词： High-purity indium Electrolysis Multiple factors Electrochemistry Purification

In-vitro Developmental Potential of Single Blastomeres Derived from Day 3 Discarded Human Embryos

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Journal of Reproduction and Contraception 2010年第1期21卷 1-8页

作者： dong-mei ji Yi-juan SUN Ai-jun ZHANG Xiao-wei LU Zhi-hong NIU Yun FENG Reproductive Medical Center Ruijin Hospital Shanghai Jiao Tong University of Medicine Shanghai 200025 China

Objective To investigate whether isolated blastomeres of discarded human embryos could develop into blastocysts cultured in vitro without zona pellucida. Methods Total discarded 60 embryos, which were not suitable for transplanting or freezing, were collected from 21 patients. Of 60 embryos, 10, 8, 24, 12, and 4 embryos were at 2-, 3-, 4-, 5- and 6-cell stage, respectively. These embryos were split by 0.5% protease combined with mechanical method. The resulting single blastomere was cultured individually, evaluated daily and counted blastocyst development. Pluripotency of inner cell mass （ICM） of the blastocyst was analyzed by the expression of alkaline phosphatase（AKP）. Results A total of 229 single blastomeres were isolated from 60 embryos. Defining the day when the embryos were split as the first day （d 1）. The majority of the blastomere- derived embryos followed the normal pattern of development with compaction on d 3 and cavitationon d 4 and developed into small blastocysts on d 5. Rates of division, compaction, cavity and expansion of single blastomeres from 4-cell embryos were higher than those in other groups （P 〈O.05）, and AKP was expressed in ICM. Conclusion Some of the blastomeres from discarded human embryo are flexible and able to develop into blastocysts, the potential was related to their donor embryos closely. They seem to follow development pattern of their donor embryos. The blastomere- derived blastocysts have smaller size and fewer cells compared with regular in vitro cultured human embryos. However, AKP expression showed ICM cells with pluripotency. We believe that the value of single blastomere of discarded embryos will be further confirmed in the future.

关键词： discarded embryo single blastomere in-vitro development

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： Sai ji Min Li mei Liang Zhenning Zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as *** a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected *** goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most ***,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering *** paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with *** parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite ***,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding