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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Protective effects of naringenin eye drops on N-methylN-nitrosourea-induced photoreceptor cell death in rats

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 391-396页

作者： Jun-Li lin Yan-dong Wang Yan Ma Chun-mei Zhong mei-Rong Zhu Wen-Pei Chen Bao-Qin lin School of Chinese Materia Medica Guangzhou University of Chinese Medicine Zhongshan Ophthalmic Center Sun Yat-Sen University Zhuhai United Laboratories Co. Ltd

AIM:To investigate the effects of naringenin eye drops on N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell death in ***:Photoreceptor cell death was induced by single intraperitoneal injection of MNU(60 mg/kg)in *** eyes of all animals were instilled with one drop of vehicle,0.5% or 1.0% naringenin eye drops three times per day from 7d before to 17d after MNU *** of naringenin on MNU-induced photoreceptor cell death were evaluated by electrophysiological and histological ***:Flash electroretinography (FERG)and oscillatory potentials (OPs) recordings showed that the vehicle control group had remarkable reduction of amplitudes and prolongation of latency *** and OPs responses were significantly reversed in MNUinduced rats treated with 0.5%or 1.0% naringenin eye drops compared with the vehicle *** retinal morphological results showed that naringenin dosedependently preserved the outer nuclear layer,outer retina and total ***:These results indicate that topical treatment with naringenin eye drops prevented retinal neurons from MNU-induced structural and functional damages.

关键词： naringenin N-methyl-N-nitrosourea photoreceptor cell death retinitis pigmentosa

Magnetic correction to the anomalous magnetic moment of electrons

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Communications in Theoretical Physics 2022年第5期74卷 75-85页

作者： Fan lin mei Huang School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

We investigate the leading order correction of anomalous magnetic moment(AMM) to electrons in a weak magnetic field and find that the magnetic correction is negative and magnetic field dependent, indicating a magnetic catalysis effect for the electron gas. In the laboratory, to measure the g-2, the magnitude of the magnetic field B is several T, and correspondingly the magnetic correction to the AMM of electron/muon is around 10^(-34)/10^(-42), therefore the magnetic correction can be safely neglected in the current measurement. However, when the magnitude of the magnetic field strength is comparable with the electron mass, the magnetic correction of the electron’s AMM will become considerable. This general magnetic correction to the charged fermion’s AMM can be extended to study quantum chromodynamic matter under a strong magnetic field.

关键词： anomalous magnetic moment magnetic correction magnetic field

Endpoint Estimates for Marcinkiewicz Integrals on Weighted Weak Hardy Spaces

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Acta Mathematica Sinica,English Series 2015年第3期31卷 430-444页

作者： Yan lin mei XU School of Sciences China University of Mining and Technology

In this paper, we obtain the（W Hω^1, W Lω^1） type estimate for the Marcinkiewicz integral and the（W H1 b,ω, W L1ω） type estimate for the commutator generated by a BMO function and the Marcinkiewicz integral, w... 详细信息

关键词： μΩ boundedness kernel inequality logarithmic satisfying endpoint maximal Lebesgue proof

Corrosion resistance and superhydrophobicity of one-step polypropylene coating on anodized AZ31 Mg alloy

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Journal of Magnesium and Alloys 2021年第4期9卷 1452-1466页

作者： Zhao-Qi Zhang Li Wang mei-Qi Zeng Rong-Chang Zeng Cun-Guo lin Zhen-lin Wang dong-Chu Chen Qiang Zhang Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400065China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China

Superhydrophobic coatings have been considerably used in corrosion and its protection of metallic *** the comprehensive performance(hydrophobicity,bonding strength,and corrosion resistance,etc.)of the top coating may be highly dependent on the physical and chemical properties of the primer or under ***,an integrated superhydrophobic polypropylene(PP)coating was fabricated on the micro-arc oxidized Mg substrate via one-step *** morphologies and chemical compositions of the composite coating were examined through Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),and field-emission scanning electron microscopy(FESEM)together with X-ray photoelectron spectroscopy(XPS).The surface wettability of the coating was determined by contact angle and sliding *** corrosion-resistant performance was evaluated via electrochemical and immersion *** results showed that the hybrid coating possessed micron-scaled granular structure on the surface with a high water contact angle of 167.2±0.8°and a low water sliding angle of 2.7±0.5°.The corrosion resistance of superhydrophobic coating was obviously enhanced with a low corrosion current density of 8.76×10^(−9)A/cm^(2),and the coating still maintained integrity after 248 h of immersion in 3.5wt%NaCl aqueous *** MAO coating provides better adhesion of PP to the ***,the superhydrophobic coating exhibited superior bonding strength,corrosion resistance and durability.

关键词： Magnesium alloy Corrosion resistance Superhydrophobicity Bonding strength Polymer coating

Poly(vinyl alcohol)/GO-MMT Nanocomposites: Preparation, Structure and Properties

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Chinese Journal of Polymer Science 2015年第2期33卷 329-338页

作者： Muhammad Raheel Kun Yao Jiang Gong 陈学成 dong-tao Liu Yi-chao lin dong-mei Cui Muhammad Siddiq 唐涛 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Chemistry Quaid-i-Azam University

A facile, efficient and environment friendly method is established to prepare poly（vinyl alcohol）（PVA） based graphene oxide-montmorillonite（GO-MMT） nanocomposites in aqueous media. GO-MMT nanohybrid is obtained by the combination of GO and MMT in water without any reducing or stabilizing agents. The formation of GO-MMT nanohybrid is due to the hydrogen bonding and crosslinking effects. The sodium ions within MMT sheets act as crosslinkers between GO sheets and MMT platelets. The resultant nanocomposites are characterized by means of X-ray diffraction（XRD）, scanning electron microscopy（SEM）, differential scanning calorimetry（DSC）, thermogravimetric analysis（TGA） and mechanical testing. Compared to that of pure PVA, PVA nanocomposites show enhanced thermal stabilities and mechanical properties, which results from strong interfacial adhesion of the nanoadditives in PVA matrix. The further increase in the tensile strength and modulus results from strong interaction between PVA chains and layered GO-MMT as well as good mechanical properties of GO-MMT hybrid, compared to PVA/GO and PVA/MMT nanocompsoites.

关键词： Clay Graphene oxide Nanocomposites Poly(vinyl alcohol)

Serum Spondin-2 expression,tumor invasion,and antitumor immune response in patients with cervical cancer

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World Journal of Clinical Cases 2022年第36期10卷 13304-13312页

作者： ling-Li Zhang Song lin Yan Zhang dong-mei Yao Xin Du Department of Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Surgery Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Women’s Health Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina

BACKGROUND Cervical cancer is a gynecological malignancy common in middle-aged and older patients,with a high mortality ***-2 is an extracellular matrix protein that involved in innate and acquired immune ***,we investigated the relationship between serum Spondin-2 expression,tumor invasion and infiltration,and immune response in patients with cervical cancer and provided a theoretical basis for clinical *** To investigate the relationship between serum Spondin-2 expression and cervical cancer-related *** Overall,147 patients with cervical cancer who were admitted to our institution between January 2019 and August 2019 were assigned to the cervical cancer group,and 92 patients with benign uterine lesions and 86 healthy individuals were assigned to the benign and control groups,*** each group,serum Spondin-2 expression was measured,and the receiver operating characteristic(ROC)curve was *** with cervical cancer were classified into high or low Spondin-2 groups depending on the Spondin-2 threshold value used for diagnosing cervical ***’s clinical data were collected to compare the clinicopathologic characteristics,immune cytokine levels,and prognosis of patients with varying Spondin-2 expression *** The expression level of serum Spondin-2 was significantly higher in the cervical cancer group than in the benign and control groups(P<0.05).According to the ROC curve,the cutoff value of Spondin-2 used in the diagnosis of cervical carcinoma was 25.68±7.11μg/*** proportion of patients with Federation of Gynecology and Obstetrics stage III,nerve invasion,vascular invasion,and lymph node metastasis was higher in the high Spondin-2 group than in the low Spondin-2 group(P<0.05).Interleukin-5(IL-5)and IL-4 Levels were higher in the high Spondin-2 group than in the low Spondin-2 *** contrast,IL-2 and tumor necrosis factor-αlevels were lower in the high Spondin-2 group than in th

关键词： Cervical cancer Spondin-2 Invasion and infiltration Immune response Prognosis Malignant tumor

Repeated morphine treatment influences operant and spatial learning differentially

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Neuroscience Bulletin 2006年第3期22卷 137-143页

作者： mei-Na WANG Zhi-Fang dong Jun CAO lin XU Key Laboratory of Animal Models and Human Disease Mechanisms Laboratory of Learning and Memory Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 and Graduate School of Chinese Academy of Sciences Beijing 100039 China Mental Health Institute the 2^nd Xiangya Hospital of Central South University Changsha 410011 China

Objective To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially. Methods Animals were chronically treated with morphine or subjected to morphine withdrawal. Then, they were subjected to two kinds of learning: operant conditioning and spatial learning. Results The acquisition of both simple appetitive and cued operant learning was impaired after repeated morphine treatment. Withdrawal for 5 weeks alleviated the impairments. Single morphine exposure disrupted the retrieval of operant memory but had no effect on rats after 5-week withdrawal. Contrarily, neither chronic morphine exposure nor 5-week withdrawal influenced spatial learning task of the Morris water maze. Nevertheless, the retrieval of spatial memory was impaired by repeated morphine exposure but not by 5-week withdrawal. Conclusion These observations suggest that repeated morphine exposure can influence different types of learning at different aspects, implicating that the formation of opiate addiction may usurp memory mechanisms differentially.

关键词： morphine addiction withdrawal conditioning spatial learning

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun Jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement