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Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

World Journal of Gastrointestinal Oncology 2024年第3期16卷 687-698页

作者： Juan Lin Zhu-Feng Chen guo-dong guo Xin Chen Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pathology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Internal Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND The Alcian blue(AB)and periodic acid Schiff(PAS)stains are representative mucus markers in gastric signet ring cell carcinoma(SRCC).They are low-cost special staining methods used to detect acidic mucus and neutral mucus,***,the clinical importance of the special combined AB and PAS stain is *** To investigate AB expression,PAS expression and the AB-to-PAS(A/P)ratio in gastric SRCC patients and to assess patient *** Paraffin-embedded sections from 83 patients with gastric SRCC were stained with AB and PAS,and signet ring cell positivity was assessed ***-histochemical staining for Ki67,protein 53(P53)and human epidermal growth factor receptor 2(HER2)was performed *** cancer-specific survival(CSS)rate was estimated via Kaplan-Meier *** proportional hazards models were used for univariate and multivariate survival *** Kaplan-Meier survival analysis revealed that the 3-year CSS rate was significantly greater in the high-PAS-expression subgroup than in the low-PAS-expression subgroup(P0.5 group(P=0.042).Univariate Cox regression analysis revealed that the factors affecting prognosis included tumor diameter,lymph node metastasis,vessel carcinoma embolus,tumor stage,the A/P ratio and the expression of Ki67,P53 and the *** multivariate regression analysis confirmed that low PAS expression[hazard ratio(HR)=3.809,95%confidence interval(CI):1.563-9.283,P=0.003]and large tumor diameter(HR=2.761,95%CI:1.086-7.020,P=0.033)were independent risk factors for poor *** A/P>0.5 is potentially a risk factor for prognosis,and low PAS expression is an independent risk factor in the prognosis of gastric *** expression and the A/P ratio could help in predicting the clinical prognosis of patients with SRCC.

关键词： Alcian blue Periodic acid-Schiff Prognosis Gastric Signet ring cell carcinoma

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Ferrite features in simulated transition zone of EH36 shipbuilding steel submerged arc welded by CaF_(2)-SiO_(2)-MnO fluxes

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Journal of Iron and Steel Research International 2024年第4期31卷 790-796页

作者： Ming Zhong dong Hu Da-ming guo Somnath Basu Cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076MaharashtraIndia

Ferrite features in the simulated transition zone welded with CaF_(2)-SiO_(2)-MnO fluxes containing various MnO contents have been *** laser scanning microscopy has been applied to simulate the thermal cycling of the transition zone and the phase transformations during cooling have been in-situ *** has been found that the appearance temperature for ferrite side plate decreases with increasing Mn content in the weld metals caused by MnO content ***,growth rates for both ferrite side plate and acicular ferrite are significantly enhanced with a higher Mn content of weld ***,from the statistical fractions of salient microstructures,for all samples,the acicular ferrite,grain boundary ferrite,and polygonal ferrite take over more than 90%.It has also been demonstrated that with the increase in Mn content,the ferrite side plate fraction increases slightly from 5%to 10%and the acicular ferrite fraction shows a tendency of first increasing and then decreasing,which experiences the maximum with the flux containing 30 wt.%*** phenomenon is believed to be controlled by the O and Mn contents in weld metals synergistically.

关键词： Submerged arc welding Transition zone Phase transformation Microstructure

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Characteristics and stability of oxide+carbonitride in H13 steel at 1250℃

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Journal of Iron and Steel Research International 2024年第1期31卷 134-142页

作者： Xiao-lin Sun Han-jie guo Jing guo Fei Wang dong Xu Gao-yang Song Shuai Wang School of Materials Science and Engineering Hebei University of EngineeringHandan056038HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China High Temperature Materials Research Institute Central Iron and Steel Research Institute Co.Ltd.Beijing100081China Technology Innovation Center for High Quality Cold Heading Steel of Hebei Province Hebei University of EngineeringHandan056038HebeiChina

The morphology,size,quantity,and composition of complex oxide+carbonitride in H13 steel held at 1250℃for 5,10,and 15 h were *** results show that the ratio and number of complex carbonitrides with cores in H13 steel are gradually increased when holding at 1250℃compared with those in the original H13 steel,and the core size *** are one or more oxide cores in(Ti_(x),V_(1-x))(Cy,N_(1-y)),including xCaO·zAl_(2)O_(3),xCaO·yMgO·zAl_(2)O_(3),and CaO after holding at 1250℃,in addition to MgO·Al_(2)O_(3)and Al_(2)O_(3)in the original *** equilibrium temperature for(Ti_(x),V_(1-x))(Cy,N_(1-y))precipitation at the solidification front and decomposition in the solid state was theoretically analyzed,which was affected by the x value and the product of Ti and N contents in H13 ***,the composition of(Ti_(x),V_(1-x))(Cy,N_(1-y))is influenced by the oxide *** is convinced that(Ti_(x),V_(1-x))(Cy,N_(1-y))with oxide cores has a higher stability,especially for oxides with a high Al_(2)O_(3)*** treatment at high temperature facilitates a more reasonable analysis of oxide+carbonitride,and the generation mechanism of oxide+carbonitride was discussed.

关键词： Complex carbonitride Decomposition Oxide core Characteristic Stability

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Correlation between longitudinal crack occurrence and mold heat transfer in continuous casting based on process data mining

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Journal of Iron and Steel Research International 2024年第5期31卷 1139-1152页

作者： Zhi-qiang Peng Zi-bing Hou Kai Yi Kun-hui guo dong-wei guo Guang-hua Wen College of Materials Science and Engineering Chongqing UniversityChongqing400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing400044China

The correlation between the longitudinal crack occurrence and integrated heat transfer of the mold with data mining methods was ***,three kinds of support vector machine models based on principal component analysis with different input features were established to explore the effect of integrated heat transfer on the accuracy of the prediction model for the longitudinal *** results show that the accuracy was improved while features including mean and standard deviation of integrated heat transfer were ***,the difference in integrated heat transfer between defect and normal samples under the same process parameters was quantitatively *** with normal samples,the temperature difference of cooling water for defect samples decreased by 0.65%,and the temperature difference fluctuation increased by 31.1%.Finally,the literature data were used to provide support for the quantitative correlation according to defect formation mechanism.A new criterion for the prediction of longitudinal crack and a discovering method for correlation between product quality and process parameters in the manufacturing industry have been provided.

关键词： Continuous casting slab Longitudinal surface crack Heat transfer Data mining Quantitative correlation

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Interdecadal changes in the frequency of winter extreme cold events in North China during 1989–2021

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Atmospheric and Oceanic Science Letters 2024年第4期17卷 1-7页

作者： Yali Zhu Fangwu Song dong guo Nansen‐Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjingChina Carbon Neutrality Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

全球变暖背景下,极端天气气候事件的变化受到关注.本文研究发现, 1989-2021年期间,华北地区极端冷日数在2003和2013年发生了年代际变化.极端冷日数先增加后减少. 2003-2012年,西伯利亚-乌拉尔高压偏强,极地西风急流偏弱,有利于冷空气南... 详细信息

全球变暖背景下,极端天气气候事件的变化受到关注.本文研究发现, 1989-2021年期间,华北地区极端冷日数在2003和2013年发生了年代际变化.极端冷日数先增加后减少. 2003-2012年,西伯利亚-乌拉尔高压偏强,极地西风急流偏弱,有利于冷空气南下入侵华北地区,华北极端冷日数偏多.而在1989-2002年和2013-2021年,情况相反.虽然三个时段华北极端冷日的强度没有显著差异,但与其相联系的冷空气强度变得更强, 2013-2021年冷空气中心区域往西北扩张到了贝加尔湖以西地区.

关键词：华北极端冷事件西伯利亚–乌拉尔高压北大西洋涛动极地急流东亚西风急流

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