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特克斯河上游湿地镰叶锦鸡儿群落植物多样性及区系分析

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伊犁师范学院学报（自然科学版） 2017年第1期11卷 44-49,84页

作者：赵玉董芳慧刘影贾娜尔.阿汗伊犁师范学院生物与地理科学学院新疆伊宁835000 伊犁师范学院化学与环境科学学院新疆伊宁835000 伊犁哈萨克自治州文化体育广播影视局新疆伊宁835000

特克斯河上游湿地镰叶锦鸡儿群落内共有植物76种,分布在33科56属中.在群落植物组成成分中,含有3种以上的科有5科,分别是菊科、豆科、毛莨科、杨柳科和蔷薇科,共计32种,占总科数的15.2%,总种数的42.1%;在属的分布区类型中显示,群落内种... 详细信息

特克斯河上游湿地镰叶锦鸡儿群落内共有植物76种,分布在33科56属中.在群落植物组成成分中,含有3种以上的科有5科,分别是菊科、豆科、毛莨科、杨柳科和蔷薇科,共计32种,占总科数的15.2%,总种数的42.1%;在属的分布区类型中显示,群落内种子植物属的地理成分包含9个分布区类型,11个变型.温带分布型也占有绝对的优势,共有31属,占总属数的55.3%,表现出显著的温带性质.研究区域没有中国特有属物种,新疆特有种15种,占总种数的19.7%.特克斯河上游湿地锦鸡儿群落植物资源利用价值多集中在药用、食用、饲用及添加剂等方面,具有较好的开发利用前景.

关键词：特克斯河湿地植物植物区系生物多样性资源利用

井-地电位成像技术及其在孤东八区剩余油分布研究中的应用

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石油大学学报（自然科学版） 2004年第2期28卷 31-37页

作者：谭河清沈金松周超董辉房锡业张福莱胜利油田有限公司孤东采油厂地质研究所石油大学盆地与油藏研究中心石油天然气成藏机理教育部重点实验室北京102249 胜利油田有限公司孤岛采油厂孤二管理区山东东营257231 山东胜利职业学院山东东营257061 胜利油田有限公司测井分公司山东东营257062

利用传输线理论讨论了套管供大电流时井眼、套管内和套管外水泥环及地层中的电流分布。介绍了井地电位测量技术的方法及原理 ,重点分析了井地电位测量数据的成像方法。利用井地电位测量技术取得了孤东油田八区 2 6 J9井区的野外实测电... 详细信息

利用传输线理论讨论了套管供大电流时井眼、套管内和套管外水泥环及地层中的电流分布。介绍了井地电位测量技术的方法及原理 ,重点分析了井地电位测量数据的成像方法。利用井地电位测量技术取得了孤东油田八区 2 6 J9井区的野外实测电位数据。用数值模拟和反演成像方法对实测电位数据进行了处理 ,得到了 2 6 J9井区目的层的电阻率和剩余油饱和度分布。对本区构造、岩性及反演得到的电阻率数据分析可知 ,近南北方向有一条渗透性较好的优势通道 ,注水水洗及聚合物驱较为充分 ,剩余油饱和度相对较低 ;在高渗透带的两侧非均质性严重 ,水洗不充分 ,这是今后注聚合物封堵和调整挖潜应考虑的因素。与测试、生产动态和其他开发地质资料对比表明 ,井地电位测量资料的结果与其他监测资料吻合较好 ,剩余油平面分布和层间分布与智能测试结果一致。

关键词：井-地电位测量技术剩余油成像技术孤东油田传输线理论电流分布电流密度

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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新生儿真菌性败血症临床特点分析

中国新生儿科杂志 2013年第3期28卷 155-158页

作者：董慧芳徐豪魏琛徐发林郑州大学第三附属医院新生儿科 450052 郑州大学第三附属医院检验科 450052

目的探讨新生儿真菌性败血症的临床特点,以提高该疾病的诊治水平。方法选择2009—2011年我院新生儿重症监护病房收治的新生儿真菌性败血症病例,对患儿的一般状况、发病时间、首发症状、血培养结果、感染指标进行回顾性分析,比较治疗前... 详细信息

目的探讨新生儿真菌性败血症的临床特点,以提高该疾病的诊治水平。方法选择2009—2011年我院新生儿重症监护病房收治的新生儿真菌性败血症病例,对患儿的一般状况、发病时间、首发症状、血培养结果、感染指标进行回顾性分析,比较治疗前与治疗中、治疗后血白细胞、血小板、C反应蛋白的变化情况。结果新生儿真菌性败血症的病原菌以白色念珠菌为主,发病日龄为生后5～29天,平均(11.5±9.9)天;频繁呼吸暂停、反应差、喂养不耐受、少动、发热是新生儿真菌性败血症的常见首发症状;多数患儿出现血小板减少、C反应蛋白增高,抗真菌治疗3天后多数患儿血小板可恢复正常,治疗1周后CRP可恢复正常,而WBC变化不明显,治疗前与治疗中、治疗后比较差异无统计学意义;应用氟康唑治疗新生儿念珠菌性败血症可取得满意疗效。结论新生儿真菌性败血症的临床表现缺乏特异性,对有高危因素的新生儿应高度警惕真菌感染的可能性,早期发现、及时治疗是治疗成功的关键。

关键词：败血症真菌婴儿新生临床分析

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： fang JIANG Tian MAO Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo fang fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

足月新生儿呼吸窘迫综合征危险因素及肺表面活性物质疗效评估

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中国循证儿科杂志 2012年第5期7卷 393-396页

作者：董慧芳吉玲白琼丹庄方莉徐发林郑州大学第三附属医院新生儿科郑州450052

目的探讨足月新生儿呼吸窘迫综合征(RDS)的危险因素,观察肺表面活性物质(PS)的疗效,为足月儿RDS的防治提供依据。方法选取2007年1月至2011年12月郑州大学第三附属医院NICU收治的足月儿RDS为RDS组,以同期入院的非RDS足月儿为对照组,对两... 详细信息

目的探讨足月新生儿呼吸窘迫综合征(RDS)的危险因素,观察肺表面活性物质(PS)的疗效,为足月儿RDS的防治提供依据。方法选取2007年1月至2011年12月郑州大学第三附属医院NICU收治的足月儿RDS为RDS组,以同期入院的非RDS足月儿为对照组,对两组性别、胎龄、分娩方式、宫内窘迫、出生窒息、母亲妊高症、糖尿病、胎膜早破进行单因素方差分析和Logistic多因素回归分析;并以RDS组中是否给予PS治疗分为应用PS亚组和未应用PS亚组,评估PS的疗效。结果 RDS组和对照组各106例进入分析。①RDS组发病时间为生后5min至18h,平均(4.9±3.4)h,其中生后6h内发病87例(82.1%),～12h16例(15.1%),>12h3例(2.8%);X线胸片分级Ⅰ级28例(26.4%),Ⅱ级36例(34.0%),Ⅲ级23例(21.7%),Ⅳ级19例(17.9%);②Logistic回归分析显示男性(OR=10.35,95%CI:1.94～15.26)、胎龄0.05)。结论男性、胎龄<39周、剖宫产尤其是无医学指征的择期剖宫产、出生窒息是足月儿RDS的危险因素,PS治疗足月儿RDS疗效较好。

关键词：呼吸窘迫综合征足月儿危险因素肺表面活性物质