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Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

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Neural Regeneration Research 2015年第6期10卷 989-995页

作者： Yi-ke Li Juan-mei Yang Yi-bo Huang dong-dong ren Fang-lu Chi Department of Otology and Skull Base Surgery Eye Ear Nose & Throat HospitalFudan University Shanghai Auditory Medical Center Key Laboratory of Hearing Science Ministry of Health Department of Hearing and Speech Sciences Vanderbilt University

The morphological changes that occur in the taste buds after denervation are not well under- stood in rats, especially in the contralateral tongue epithelium. In this study, we investigated the time course of morphological changes in the taste buds following unilateral nerve transection. The role of the trigeminal component of the lingual nerve in maintaining the structural integrity of the taste buds was also examined. Twenty-four Sprague-Dawley rats were randomly divided into three groups： control, unilateral chorda tympani nerve transection and unilateral chorda tympani nerve transection ＋ lingual nerve transection. Rats were allowed up to 42 days of re- covery before being euthanized. The taste buds were visualized using a cytokeratin 8 antibody. Taste bud counts, volumes and taste receptor cell numbers were quantified and compared among groups. No significant difference was detected between the chorda tympani nerve transection and chorda tympani nerve transection ＋ lingual nerve transection groups. Taste bud counts, volumes and taste receptor cell numbers on the ipsilateral side all decreased significantly compared with control. On the contralateral side, the number of taste buds remained unchanged over time, but they were larger, and taste receptor cells were more numerous postoperatively. There was no evidence for a role of the trigeminal branch of the lingual nerve in maintaining the structural integrity of the anterior taste buds.

关键词： nerve regeneration gustation cytokeratin tongue epithelium immunohistochemistry taste bud trigeminal nerve disorder NSFC grants neural regeneration

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Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae

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Neural Regeneration Research 2017年第12期12卷 2092-2099页

作者： Wen-wei Luo Zhao Han dong-dong ren Xin-wei Wang Fang-lu Chi Juan-mei Yang Department of Otolaryngology Eye & ENT Hospital of Fudan University Research Institute of Otolaryngology Fudan University

Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1 overexpression has mainly focused on the rat lesser epithelial ridge and induces ectopic hair cell regeneration. The sensory region of rat cochlea is difficult to transfect, thus new hair cells are rarely produced in situ in rat cochlear explants. After culturing rat cochleae in medium containing 10% fetal bovine serum, adenovirus successfully infected the sensory region as the width of the supporting cell area was significantly increased. Adenovirus encoding Atoh1 infected the sensory region and induced hair cell formation in situ. Combined application of the Notch inhibitor DAPT and Atoh1 increased the Atoh1 expression level and decreased hes1 and hes5 levels, further promoting hair cell generation. Our results demonstrate that DAPT enhances Atoh1 activity to promote hair cell regeneration in rat cochlear sensory epithelium in vitro.

关键词： nerve regeneration Atoh 1 DAPT. transdifferentiation gamma secretase inhibitor cochlea sensory epithelium fetal bovine serum hair cell supporting cell hair cell regeneration neural regeneration

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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雌激素水平对绝经后女性急性心肌梗死发生的影响研究

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临床心血管病杂志 2017年第2期33卷 153-156页

作者：董海秋董梅任法新青岛大学医学院附属医院烟台毓璜顶医院心血管内科山东烟台264000

目的:本研究探讨内源性雌激素水平对绝经后女性急性心肌梗死(AMI)发生的影响。方法:本研究共计纳入30例绝经后女性AMI患者(AMI组)和60例健康绝经后女性(对照组)。所有患者均检测内源性性激素水平(包括血雌酮、雌二醇、雄烯二醇和睾酮水... 详细信息

目的:本研究探讨内源性雌激素水平对绝经后女性急性心肌梗死(AMI)发生的影响。方法:本研究共计纳入30例绝经后女性AMI患者(AMI组)和60例健康绝经后女性(对照组)。所有患者均检测内源性性激素水平(包括血雌酮、雌二醇、雄烯二醇和睾酮水平)。多因素Logistic回归分析性激素水平与AMI发生风险的关系。结果:与对照组相比,AMI组的血雌酮、雌二醇、雄烯二醇和睾酮水平明显升高(P<0.05),而性激素结合球蛋白(SHBG)水平却减低(P<0.05)。单因素Logistic回归分析显示,雌酮、雌二醇、睾酮、臀腰比、体质指数、糖尿病和高血压均与AMI发生呈正相关(P<0.05)。校正这些因素后,雌二醇[比值比(OR)4.75,95%可信区间(CI):1.07~21.10,P<0.05]和腰臀比(OR=6.46,95%CI:1.09~38.39,P<0.05)仍和AMI呈正相关。结论:高雌二醇水平与绝经后女性AMI的发生呈正相关,提示内源性高雌激素可能是绝经后女性AMI发生的独立危险因素。

关键词：雌激素急性心肌梗死急性应激脂肪组织绝经后女性

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颏部位置对面部侧貌唇突度的影响

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上海口腔医学 2008年第6期17卷 598-602页

作者：苏盈盈王春玲刘东旭董仁萍李红山东大学口腔医院正畸科山东济南250012

目的:探讨颏部位置对侧貌唇突度的影响。方法:选取具有标准中国人面型的成年男性1名,描绘其头颅侧位片的侧貌轮廓,制作成剪影图作为标准侧貌,利用图像处理技术对标准侧貌的面突角进行变动,获得5张具有不同颏部位置(颏部位置正常、后缩5... 详细信息

目的:探讨颏部位置对侧貌唇突度的影响。方法:选取具有标准中国人面型的成年男性1名,描绘其头颅侧位片的侧貌轮廓,制作成剪影图作为标准侧貌,利用图像处理技术对标准侧貌的面突角进行变动,获得5张具有不同颏部位置(颏部位置正常、后缩5°、后缩10°、前突5°、前突10°)的剪影图。在此基础上,以E线为参考线,将各剪影图的上、下唇分别后移1mm和前移1mm各4次,每张剪影图分别得到9幅具有不同唇突度的侧貌图。选择180名大学生对侧貌图进行审美评价,从9种面型中选出最喜爱的3种。应用SPSS13.0软件包对评价结果进行统计学分析。结果:颏部位置正常时相对后缩的唇突度最受欢迎,最受欢迎的3种面型与其他面型的得分相比,差异有统计学意义(P<0.05);随着颏部位置的后缩,人群倾向于喜爱略微前突的唇部位置;而随着颏部位置的前突,人们则倾向于喜爱更加后缩的唇部突度。结论:颏部位置对美观侧貌的唇突度有显著影响,颏部位置不同,唇突度的审美标准亦不同。对不同错类型的临界拔牙患者进行矫治设计时,应考虑颏部位置对唇突度的影响。

关键词：颏部位置唇突度侧貌面突角

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骨性Ⅲ类偏颌患者颌面硬组织的三维形态测量分析

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上海口腔医学 2010年第1期19卷 6-10页

作者：潘爽王春玲刘东旭董仁萍韩敏山东大学口腔医院正畸科山东省口腔生物医学重点实验室山东济南250012

目的:利用三维CT重建技术分析骨性Ⅲ类偏颌患者颌面部硬组织的对称性,研究造成颏部偏斜的主要骨性因素。方法:选择女性成人骨性Ⅲ类偏颌患者41例,根据颏点偏斜程度,将其分为实验组(偏斜超过4mm)和对照组(偏斜不足4mm)。三维CT成像后,测... 详细信息

目的:利用三维CT重建技术分析骨性Ⅲ类偏颌患者颌面部硬组织的对称性,研究造成颏部偏斜的主要骨性因素。方法:选择女性成人骨性Ⅲ类偏颌患者41例,根据颏点偏斜程度,将其分为实验组(偏斜超过4mm)和对照组(偏斜不足4mm)。三维CT成像后,测量并分析2组间及组内两侧的中面部、下颌骨结构的对称性差异。采用SPSS13.0软件包对数据进行配对t检验和Pearson相关分析。结果:⑴实验组偏斜侧U3及U6的垂直向位置显著高于对侧(P<0.01);2组间比较,上颌两侧牙槽高度之差具有统计学意义(P<0.01)。⑵实验组偏斜侧长度显著小于对侧及对照组偏斜侧(P<0.01),下颌角向上旋转(P<0.01);对侧明显向前、内侧倾斜(P<0.01),下颌角位置偏前、内侧(P<0.05)。⑶颏点偏斜与偏斜侧高度、两侧升支高度差异等骨性因素明显相关。结论:与偏斜侧相比,对侧升支生长过多,向前、内侧倾斜是导致骨性Ⅲ类偏颌患者颏部偏斜的主要骨性因素。

关键词：骨性Ⅲ类偏颌颏点偏斜三维CT重建技术

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Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： dong ZHAO Wenjing ren School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan ren Fei Zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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