检索结果-南通市图书馆

Petroleum Science 2022年第1期19卷 329-338页

作者： zhi-dong li Qing-lin Cheng You-Wang Chen Jiang-dong Wei li-li Lv Hao Wu Yang liu Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing 163318China PetroChina Planning&Engineering Institute(CPPEI) Beijing 100000China

Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of differential pressure produced by natural gas *** using the exergy analysis theory,the black box-gray box hierarchical exergy analysis models of three differential pressure power generation technologies are established ***,the“black box”analysis models of main energy consuming equipment are established,and then the“gray box”analysis model of the total system is *** on the calculation results of exergy analysis indexes,the weak energy consumption equipment in the whole power generation process is accurately *** a gas field in southwest China as an example,the comprehensive energy consumption evaluation of the three power generation technologies is carried out,and the technology with the best energy consumption condition among the three technologies is ***,the rationalization improvement measures are put forward from improving the air tightness,replacing the deflector and reducing the flow loss.

关键词： Expansion differential pressure power generation Black box-gray box hierarchy Exergy analysis method Weak link of energy consumption

Identification of the 2-tridecanone cis-acting element in the promoter of cytochrome P450 CYP6B7 in Helicoverpa armigera

在线全文

学校读者我要写书评

暂无评论

Insect Science 2018年第6期25卷 959-968页

作者： li Xu dong-zhi li Yuan-Yuan Luo Jian-Ying Qin li-Hong Qiu College of Science China Agricultural UniversityBeijingChina

The expression level of cytochrome P450 genes in insects can be induced by plant allelochemicals,which is important for insects to adapt to host *** P450CYP6B 7has been reported to be involved in pyethroid insecticide resistance in Heli- coverpa armigera,and its transcription level was induced by some ***,the regulatory mechanism of the induced expression of CYP6B7remains unknown,although it is very important for understanding the detoxification mechanism to allelochemicals in host *** objective of the present study was to investigate the eis-acting ele- ment in the promoter of CYP6B7 mediating the inducible up-regulation of CYP6B7in *** by *** promoter region of CYP6B7was cloned by genome walking technique and analyzed by transient transfeetion *** 5'deletion of the promoter region of CYP6B7revealed that the relative luciferase activity of construct -320/+232could be significantly induced by *** stepwise deletion between -320 and -238 bp found that construct -292/+232 could also be significantly induced by 2-tridecanone,but the adjacent construct -256/+232could not,suggesting the essential role of the sequence between -292 and --257 bp for 2-tridecanone induction. Nucleotide mutations between -292 and -281 bp had no influence on the induction ef- fect by 2-tridecanone,but nucleotide mutations between -280 and -257 bp significantly decreased the induction *** results demonstrated that the cis-acting element for 2-trideeanone induction was between -280 and -257 bp in the promoter of CYP6B7.

关键词： cis-acting element cytochrome P450 CYP6B7 Helicoverpa armigera induction 2-tridecanone

PEG-grafted PVA Membrane and Its Blood Compatibility

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第6期27卷 1078-1082页

作者： JIN Gu YAO Qi-zhi dong li-quan MA Feng Department of Chemistry University of Science and Technology of China Hefei 230026 P. R. China

Preparation and blood compatibility of different shape polyvinyl alcohol（PVA） membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene（PTFE） capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol（mPEG） was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

关键词： Polyvinyl alcohol(PVA) Polyethylene glycol(PEG) Membrane Platelet Adhesion

Design,synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第12期19卷 1395-1397页

作者： Hua Wang Qi dong You zhi Yu li Yi Quan Zou Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Be17402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor ceils are comparable to that of topotecan, one of topoisomerase I inhibitors.

关键词： Quinolone derivatives Synthesis Antitumor

前置胎盘合并胎盘植入组织中HMGB1蛋白、EphA5蛋白、VEGF表达水平及临床意义

在线全文

学校读者我要写书评

暂无评论

临床和实验医学杂志 2024年第13期23卷 1415-1419页

作者：王同娜董智力渠爱华高瑞雪衡水市第二人民医院妇产科河北衡水053000

目的探讨前置胎盘合并胎盘植入组织中高迁移率族蛋白B1(HMGB1)蛋白、促红细胞生成素产生肝细胞受体A5(EphA5)蛋白、血管内皮生长因子(VEGF)表达水平及临床意义。方法回顾性选取2021年1月至2023年12月衡水市第二人民医院收治的前置胎盘... 详细信息

目的探讨前置胎盘合并胎盘植入组织中高迁移率族蛋白B1(HMGB1)蛋白、促红细胞生成素产生肝细胞受体A5(EphA5)蛋白、血管内皮生长因子(VEGF)表达水平及临床意义。方法回顾性选取2021年1月至2023年12月衡水市第二人民医院收治的前置胎盘合并胎盘植入患者60例作为病例组,并选取同期健康产妇60名作为对照组,比较两组临床资料(年龄、体重指数、孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置)及胎盘组织中HMGB1蛋白、EphA5蛋白、VEGF表达水平,并对前置胎盘合并胎盘植入的危险因素进行多因素Logistic回归分析,同时采用受试者工作特征(ROC)曲线分析HMGB1蛋白、EphA5蛋白、VEGF对前置胎盘合并胎盘植入的预测价值。结果病例组患者年龄、体重指数与对照组比较,差异均无统计学意义(P>0.05);病例组患者孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置与对照组比较,差异均有统计学意义(P<0.05)。病例组患者胎盘组织HMGB1蛋白、VEGF水平分别为1.35±0.34、0.90±0.24,均高于对照组(1.12±0.36、0.60±0.19),胎盘组织EphA5蛋白水平为0.75±0.26,低于对照组(2.05±0.66),差异均有统计学意义(P<0.05)。经二元Logistic回归分析显示,孕周、孕次、产次、既往剖宫产次数、剖宫产间隔时间、既往流产次数、前置胎盘类型、胎盘主体位置、HMGB1蛋白、EphA5蛋白、VEGF均是前置胎盘合并胎盘植入的独立影响因素(P<0.05)。ROC曲线分析显示,胎盘组织HMGB1蛋白、EphA5蛋白、VEGF、三者联合预测前置胎盘合并胎盘植入的曲线下面积(AUC)分别为0.817、0.814、0.764、0.956,且三者联合的敏感度为78.30%,特异度为100.00%。结论前置胎盘合并胎盘植入组织中可见HMGB1蛋白、VEGF表达升高,EphA5蛋白表达降低,前置胎盘合并胎盘植入影响因素较多,而胎盘组织HMGB1蛋白、EphA5蛋白、VEGF是前置胎盘合并胎盘植入的危险因素,3种指标联合对前置胎盘合并胎盘植入具有较高的预测价值。

关键词：前置胎盘高迁移率族蛋白类血管内皮生长因子类胎盘植入肝细胞受体A5蛋白

Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： Yan-li Xin zhi-ying Gao Bo Tian Qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

连续函数式曲线光滑法（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第4期19卷 304-314页

作者： Yu-fei WU liang HE zhi-dong li School of Engineering RMIT University Carlton Victoria 3053 Australia Guangzhou Metro Design and Research Institute Co. Ltd. Guangzhou 510010 China Department of Architecture and Civil Engineering City University of Hong Kong Kowloon Hong Kong China

目的:用连续函数实现无限接近原始非连续曲线的光滑。创新点:首次提出用一个连续函数替代原来由任意多非连续区域函数构成的函数。该方法可视为一种新的函数光滑算法。方法:1.通过引入特殊的区域变量,并用该区域变量替代原函数自变量的... 详细信息

目的:用连续函数实现无限接近原始非连续曲线的光滑。创新点:首次提出用一个连续函数替代原来由任意多非连续区域函数构成的函数。该方法可视为一种新的函数光滑算法。方法:1.通过引入特殊的区域变量,并用该区域变量替代原函数自变量的方法,将区域函数改造成在该区域无限接近原函数而在区域外取值常数的函数。2.把所有的区域函数相乘得到一个连续函数的方程。结论:1.由任意多非连续区域函数构成的函数可以改造成一个连续函数。2.该连续函数在原非连续边界的光滑程度可以由各个边界上独立的参数按需调整。3.该方法产生的连续函数没有摆动现象,其形状与原始区域函数无限接近。该方程在数学上是连续的,同时无限接近原始非连续函数,包括原来在边界上函数值的非连续。

关键词：曲线光滑区域变量区域函数连续函数

liquid-phase epitaxial layer by layer brushing fabrication of metalorganic frameworks films

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5698-5704页

作者： li-Mei Chang Rui Zhai zhi-Zhou Ma Jian-dong Huang zhi-Gang Gu Jian Zhang College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

Development of metal-organic framework(MOF)films is of great importance to expand their ***,we report a facile and universal method of liquid-phase epitaxial(LPE)layer by layer(LBL)brushing approach for fabricating MOF films on various substrates in a high-throughput *** MOF films preparation method offers a great prospective to cost-effectively construct films with short preparation time and little reagent ***,this LBL brushing approach has been implemented successfully to assemble various MOF films,including HKUST-1,zeolitic imidazolate framework-8(ZIF-8),Cu(bdc),and Cu_(2)(L)_(2)P(L=bdc,ndc,and cam;P=dabco and bipy).Afterwards,the classic MOF HKUST-1 and ZIF-8 films were grown on sensor chip electrode and porous fiber support for good volatile organic compounds(VOCs)selective sensing and water purification *** study demonstrates that this LBL brushing preparation method can be employed to synthesize various MOF films with a variety of characteristics to realize their sensing and separation applications.

关键词： metal-organic framework porous materials layer by layer fabrication film

Design,synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第5期21卷 554-557页

作者： Bao liu,Qi dong You,zhi Yu li Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives(12a-l) were *** cytotoxicity of 12 new compounds was evaluated in AGS,HepG2 and HT-29 cell *** results showed that compounds 12g, 12h,12i,12k and 12l displayed more potent cytotoxic activities than Bosutinib,compound 12l exhibited the most potent antitumor activity among the tested compounds.

关键词： 3-Quinolinecarbonitrile derivatives Synthesis Antitumor

Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第8期42卷 1185-1197页

作者： zhi-Ying Zhao Hao Jiang Xiao-dong li Xu-dong Zhang Xing Su Mei-Shuai Zou School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external *** polyurethane microcellular elastomers(PUMEs)can absorb energy through cell collapse and molecular chain *** this study,PUMEs with different densities were investigated by scanning electron microscopy,dynamic mechanical analysis and dynamic compression *** exhibited significant im pact resistance and the maximum peak stress attenuation ratio reached 73.33%.The protective equipment was made by PUME with the optimal density of 600 kg/m^(3),and then the acceleration sensing device installed with the same protective equipment fell from a height of 3,5 and 10 m to evaluate the energy-absorbing property and reusability of *** results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%,with a maximum deviation of 9%between actual test and simulation,and shortened the impact time of first landing by 57.39%.In addition,the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance