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Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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Journal of Traditional Chinese Medicine 2023年第4期43卷 686-694页

作者： dong-wook kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim Suk-Yun kang Yeonhee Ryu Hwa Seung Yoo Jin Sun Lee Jin Bong Park Sang Do Lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

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Colonoscopy-induced ischemic colitis in patients without risk factors

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World Journal of Gastroenterology 2014年第13期20卷 3698-3702页

作者： Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han dong-wook kang Division of Gastroenterology Department of Internal MedicineEulji University College of MedicineEulji University HospitalDaejeon 302-779South Korea Department of radiology Eulji University College of MedicineEulji University HospitalDaejeon 302-779South Korea Department of pathology Eulji University College of MedicineEulji University HospitalDaejeon 302-779South Korea

Ischemic colitis is the most common form of intestinal *** is a condition that is commonly seen in the elderly and among individuals with risk factors for *** predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic *** colitis following colonoscopy is ***,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia.

关键词： Ischemic colitis Colonoscopy Hematochezia

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Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound

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World Journal of Gastroenterology 2010年第8期16卷 1034-1038页

作者： Sang-Woo Cha Sae Hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna Kim Min Koo Lee Hyun Young Han dong wook kang Division of Gastroenterology Department of Internal Medicine Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Surgery Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Radiology Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Pathology Eulji University College of Medicine Eulji University Hospital

Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected.

关键词： Pancreatic pseudocyst Lipids Endosonog-raphy

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In-situ electrochemical functionalization of carbon materials for high-performance Li–O2 batteries

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Journal of Energy Chemistry 2020年第9期29卷 7-13,I0001页

作者： Jungwon kang Jin Min Kim Do Youb Kim Jungdon Suk Jaekook Kim dong wook Kim Yongku kang Department of Advanced Materials Science and Engineering Mokpo National University61 dorim-ri1666 Yeongsan-roCheonggye-myeonMuan-gunJeonnamSouth Korea Center for Advanced Battery Materials Advanced Materials DivisionKorea Research Institute of Chemical Technology(KRICT)141 Gajeong-RoYuseong-GuDaejeon 305-600South Korea Department of Materials Science and Engineering Chonnam National University300 Yongbong-dongBukguGwangju 500-757South Korea

The development of effective synthetic routes is important to manifest proper nature of specific ***-situ electrochemical functionalization possesses great advantages over conventional routes,especially facile way and leading to reaching elaborate sites of functional ***,we demonstrate the preparation of functionalized carbons by in-situ electrochemical reduction in an argon atmosphere for application in low-cost,environmentally benign,and high-performance oxygen-electrodes for non-aqueous Li-O2 batteries.A Li-O2 battery with functionalized carbon shows a high discharge capacity(100 times that of pristine carbon),high power and cycling *** outstanding performance is attributed to the high O2 affinity of the functionalized carbon surface that facilitates the formation of soluble and diffusible superoxide intermediates by the reduction of the remaining O2 competing with surface growth for Li2O2 formation.

关键词： Lithium-oxygen battery High areal capacity Functionalization of carbon Electrochemistry

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Percutaneous ablation for perivascular hepatocellular carcinoma: Refining the current status based on emerging evidence and future perspectives

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World Journal of Gastroenterology 2018年第47期24卷 5331-5337页

作者： Tae wook kang Hyo Keun Lim dong Ik Cha Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHST Sungkyunkwan University

Various therapeutic modalities including radiofrequency ablation, cryoablation, microwave ablation, and irreversible electroporation have attracted attention as energy sources for effective locoregional treatment of hepatocellular carcinoma(HCC); these are accepted non-surgical treatments that provide excellent local tumor control and favorable survival. However, in contrast to surgery, tumor location is a crucial factor in the outcomes of locoregional treatment because such treatment is mainly performed using a percutaneous approach for minimal invasiveness; accordingly, it has a limited range of ablation volume. When the index tumor is near large blood vessels, the blood flow drags thermal energy away from the targeted tissue, resulting in reduced ablation volume through a socalled "heat-sink effect". This modifies the size and shape of the ablation zone considerably. In addition, serious complications including infarction or aggressive tumor recurrence can be observed during follow-up after ablation for perivascular tumors by mechanical or thermal damage. Therefore, perivascular locations of HCC adjacent to large intrahepatic vessels can affect post-treatment outcomes. In this review, we primarily focus on physical properties of perivascular tumor location, characteristics of perivascular HCC,potential complications, and clinical outcomes after various locoregional treatments; moreover, we discuss the current status and future perspectives regarding percutaneous ablation for perivascular HCC.

关键词： Hepatocellular carcinoma Perivascular Radiofrequency ablation Liver Cryoablation Microwave ablation Irreversible electroporation

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Simple reactor for the synthesis of silver nanoparticles with the assistance of ethanol by gas-liquid discharge plasma

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Plasma Science and Technology 2019年第4期21卷 34-43页

作者： Pan LU dong-wook KIM dong-Wha PARK Department of Chemistry and Chemical Engineering Inha University100 Inha-Ro.Michuhol-guIncheon 22212Republic of Korea Regional Innovation Center for Environmental Technology of Thermal Plasma(RIC-ETTP: Inha University100 Inha-RoMichuhol-gu.Incheon 22212.Republic of Korea

Atmospheric pressure plasma technology is gaining increasing importance because it is a simple and tunable synthesis process for the production of metallic *** addition to the development of the power supply,improving the reactor is also one of the main strategies to enhanee the *** this study,a simple reactor for the gas-liquid discharge plasma induced by argon gas was applied to synthesize silver nanopailicles from silver nitrate(AgNO3)in *** AC power supply with a peak voltage of 3.5 kV was *** frequency and on-time were set to 50 kHz and 2.5“s,*** oscilloscope showed that the rising time was approximately 2“*** ethanol was used as the source for the reactive reducing *** more additional comp on ents existed in the solution during the discharge and neither of the electrodes was in contact with the treated *** temperature in creased by 10°C within 1 min without a cooling *** was the main impurity and was expected to be produced from the decomposition of the organics under the *** elevated temperature decreased the organic by-products by evaporation and could also decrease the production of *** electron microscopy showed that the spherical silver nanoparticles with a size of approximately 10 nm were synthesized with a crystal structure and that a low concentration of ethanol prefers the production of the mono-dispersed colloid.

关键词： silver nanoparticles synthesis nonthermal plasma ethanol reduction gas-liquid discharge

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Electrochemical Performance and ex situ Analysis of ZnMn2O4 Nanowires as Anode Materials for Lithium Rechargeable Batteries

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Nano Research 2011年第5期4卷 505-510页

作者： Sung-wook Kim Hyun-wook Lee Pandurangan Muralidharan dong-Hwa Seo Won-Sub Yoon Do Kyung Kim Kisuk kang Research Institute of Advanced Materials Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology 335 Gwahangno Yuseong-gu Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Seoul National University 599 Kwanak-ro Kwanak-gu Seoul 151-742 Republic of Korea

One-dimensional ZnMn2O4 nanowires have been prepared and investigated as anode materials in Li rechargeable batteries. The highly crystalline ZnMn2O4 nanowires about 15 nm in width and 500 nm in length showed a high specific capacity of about 650 mAh.g-1 at a current rate of 100 mA.g-1 after 40 cycles. They also exhibited high power capability at elevated current rates, i.e., 450 and 350 mAh.g 1 at current rates of 500 and 1000 mA.g 1, respectively. Formation of Mn3O4 and ZnO phases was identified by ex situ X-ray diffraction （XRD） and transmission electron microscopy （TEM） studies after the initial discharge-charge cycle, which indicates that the ZnMn2O4 phase was converted to a nanocomposite of Mn3O4 and ZnO phases immediately after the electrochemical conversion reaction.

关键词： Energy storage lithium rechargeable battery anode ZnMn204 nanowire

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Network Traffic Synthesis and Simulation Framework for Cybersecurity Exercise Systems

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Computers, Materials & Continua 2024年第9期80卷 3637-3653页

作者： dong-wook Kim Gun-Yoon Sin Kwangsoo Kim Jaesik kang Sun-Young Im Myung-Mook Han Department of AI Software Gachon UniversitySeongnam-Si13120Republic of Korea School of Computer Engineering&Applied Mathematics Hankyong National UniversityPyeongtaek-Si17738Republic of Korea Cyber ElectronicWarfare Research and Development LIG Nex1Seongnam-Si13488Republic of Korea

In the rapidly evolving field of cybersecurity,the challenge of providing realistic exercise scenarios that accurately mimic real-world threats has become increasingly *** methods often fall short in capturing the dynamic and complex nature of modern cyber *** address this gap,we propose a comprehensive framework designed to create authentic network environments tailored for cybersecurity exercise *** framework leverages advanced simulation techniques to generate scenarios that mirror actual network conditions faced by professionals in the *** cornerstone of our approach is the use of a conditional tabular generative adversarial network(CTGAN),a sophisticated tool that synthesizes realistic synthetic network traffic by learning fromreal data *** technology allows us to handle technical components and sensitive information with high fidelity,ensuring that the synthetic data maintains statistical characteristics similar to those observed in real network *** meticulously analyzing the data collected from various network layers and translating these into structured tabular formats,our framework can generate network traffic that closely resembles that found in actual *** integral part of our process involves deploying this synthetic data within a simulated network environment,structured on software-defined networking(SDN)principles,to test and refine the traffic *** simulation not only facilitates a direct comparison between the synthetic and real traffic but also enables us to identify discrepancies and refine the accuracy of our *** initial findings indicate an error rate of approximately 29.28%between the synthetic and real traffic data,highlighting areas for further improvement and *** providing a diverse array of network scenarios through our framework,we aim to enhance the exercise systems used by cybersecurity *** not only improves their ability to r

关键词： Cybersecurity exercise synthetic network traffic generative adversarial network traffic generation software-defined networking

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SnO_(2)/Graphene Composite with High Lithium Storage Capability for Lithium Rechargeable Batteries

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Nano Research 2010年第11期3卷 813-821页

作者： Haegyeom Kim Sung-wook Kim Young-Uk Park Hyeokjo Gwon dong-Hwa Seo Yuhee Kim Kisuk kang Graduate School of Energy EnvironmentWaterand SustainabilityKorea Advanced Instituteof Science and Technology(KAIST)335 GwahangnoYuseong-guDaejeon 305-701Republic of Korea Department of Materials Science and Engineering KAIST335 GwahangnoYuseong-guDaejeon 305-701Republic of Korea KAIST Institute for Eco-energy NanocenturyKAIST335 GwahangnoYuseong-guDaejeon 305-701Republic of Korea Korea Institute of Science and Technology(KIST) 39-1 Hawolgok-dongWolsong-gil 5Seongbuk-guSeoul 136-791Republic of Korea

SnO_(2)/graphene nanocomposites have been fabricated by a simple chemical *** the fabrication process,the control of surface charge causes echinoid-like SnO_(2)nanoparticles to be formed and uniformly decorated on the *** electrostatic attraction between a graphene nanosheet(GNS)and the echinoid-like SnO_(2)particles under controlled pH creates a unique nanostructure in which extremely small SnO_(2)particles are uniformly dispersed on the *** SnO_(2)/graphene nanocomposite has been shown to perform as a high capacity anode with good cycling behavior in lithium rechargeable *** anode retained a reversible capacity of 634 mA·h·g^(–1)with a coulombic efficiency of 98%after 50 *** high reversibility can be attributed to the mechanical buffering by the GNS against the large volume change of SnO_(2)during delithiation/lithiation ***,the power capability is significantly enhanced due to the nanostructure,which enables facile electron transport through the GNS and fast delithiation/lithiation reactions within the echinoid-like nano-SnO_(2).The route suggested here for the fabrication of SnO_(2)/graphene hybrid materials is a simple economical route for the preparation of other graphene-based hybrid materials which can be employed in many different fields.

关键词： Graphene SnO_(2) surface charge nanocomposite rechargeable batteries lithium

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Liquid-Liquid Phase Transition as a New Means of Protein Targeting in Chloroplasts

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Molecular Plant 2020年第5期13卷 679-681页

作者： dong wook Lee Inhwan Hwang Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju 61186Korea Department of Bioenergy Science and Technology Chonnam National UniversityGwangju 61186Korea Division of Integrative Biosciences and Biotechnology Pohang University of Science and TechnologyPohang 37673Korea Department of Life Sciences Pohang University of Science and TechnologyPohang 37673t Korea

The chloroplast is a unique organelle in that it possesses an intra-organellar membrane-enclosed structure called thylakoid,which is central to ***,the timely expression and correct localization of thylakoid proteins are of utmost importance to plant growth and development(Lee et al.,2017;New et al.,2018).Biogenesis of thylakoid proteins is highly complex;they are encoded by two different genomes,nuclear and chloroplast genomes,and translated in the cytosol and chloroplasts,***-encoded thylakoid proteins are first imported into the stroma of chloroplasts before they are targeted to *** the stroma,multiple sorting mechanisms exist to ensure import or insertion of thylakoid luminal or membrane proteins,respectively(Lee et al.,2017).Approximately 50%of thylakoid luminal proteins are imported through the cpTAT(chloroplast twin-arginine translocation)pathway,which is also present in bacteria and plant mitochondria(Cline,2015;Schafer et al.f 2020).

关键词： al. Transition insertion

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