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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

A Multi-model,Large-range Flexible Strain Sensor Based on Carbonized Silk Habotai for Human Health Monitoring

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Chinese Journal of Polymer Science 2023年第8期41卷 1238-1249,I0008页

作者： Shi-dong Ma Yu-ting Wu Jian Tang Yu-Min zhang Tao Yan Zhi-Juan Pan College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China National Engineering Laboratory for Modern Silk Suzhou 215123China

In recent years,flexible strain sensors have received considerable attention owing to their excellent flexibility and ***,it is still a great challenge for them to accurately monitor multi-model deformations with high sensitivity and *** this study,the industrial insulating silk habotai was successfully converted into carbonized silk habotai(CSH)for use in strain sensors.A strain sensor created using CSH exhibited excellent sensing performance under multi-model deformations,including stretching,twist and *** maximum tensile strain was 434%.The gauge factors were 14.6 in the wide tensile range of 0%–400%with a high linearity of *** addition,the CSH strain sensor exhibited an extremely fast response time(110 ms)and could accurately detect bending(0°–180°)and torsional(0°–180°)*** durability and repeatability were observed for the multi-model ***,a new type of smart pillow was developed to accurately record head movement and breathing during *** sensor may also be used for auxiliary training in table *** proposed CSH strain sensor has shown great potential for applications in smart devices and human-machine interactions.

关键词： Carbonized silk habotai Strain sensor Smart pillow Human motions

Early Cretaceous I-type granites in the Tengchong terrane:New constraints on the late Mesozoic tectonic evolution of southwestern China

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Geoscience Frontiers 2018年第2期9卷 459-470页

作者： Yi Fang Yun-Hui zhang Shou-ting zhang Hua-Wen Cao Hao Zou Jian-Hui dong School of Geoscience and Technology Southwest Petroleum University State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology School of Earth Sciences and Resources China University of Geosciences Chengdu Center China Geological Survey School of Architecture and Civil Engineering Chengdu University

The Early Cretaceous granitoids that are widespread in the Tengchong terrane of Southwest China play a critical role in understanding the tectonic framework associated with the Tethyan oceans. In this study, we present a detailed description of zircon U-Pb ages, whole-rock geochemistry and Hf isotopes for the Laoxiangkeng pluton in the eastern Tengchong terrane and elucidate their petrogenesis and geodynamic implications. Zircon U-Pb dating of the Laoxiangkeng pluton yields ages of 114 ± 1 Ma and 115 ± 1 Ma,which imply an Early Cretaceous magmatic event. The Laoxiangkeng pluton enriched in Si and Na, is calcalkaline and metaluminous, and has the characteristics of highly fractionated I-type granites. Zircons from the pluton have calculated ε_(Hf)(t) values of-12.7 to-3.7 and two-stage model ages of 1327-1974 Ma,respectively, indicating a mixed source of partial melting of Paleo-Neoproterozoic crust-derived compositions with some inputs of mantle-derived magmas. By integrating all available data for the regional tectonic evolution of the eastern Tethys tectonic domain, we conclude that the Early Cretaceous magmatism in the Tengchong terrane was produced by the northeastward subduction of the Meso-Tethyan Bangong-Nujiang Ocean.

关键词： Zircon U-Pb dating Geochemistry I-type granite Early Cretaceous Tengchong terrane

Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3

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World Journal of Gastroenterology 2015年第6期21卷 1804-1813页

作者： ting zhang Bo Jiang Shi-Tao Zou Fen Liu dong Hua Institute of Cancer Affi-liated hospital of Jiangnan University Department of Oncology Affiliated hospital of Jiangnan University

AIM:To investigate the role of the overexpression of B7-H3 in apoptosis in colorectal cancer cell lines and the underlying molecular ***:SW620 cells that highly overexpressed B7-H3(SW620-B7-H3-EGFP)and HCT8 cells stably transfected with B7-H3 sh RNA(HCT8-sh B7-H3)were previously constructed in our *** transfected with p IRES2-EGFP were used as negative controls(SW620-NC and HCT8-NC).Real-time PCR and western blotting analysis were used to detect the m RNA and protein expressions of the apoptosis regulator proteins Bcl-2,Bcl-xl and Bax.A cell proliferation assay was used to evaluate the survival rate and drug sensitivity of the *** effect of drug resistance was detected by a cell cycle *** caspase-3western blotting was used to reflect the anti-apoptotic ability of *** blotting was also performed to determine the expression of proteins associated with the Jak2-STAT3 signaling pathway and the apoptosis regulator proteins after the treatment with AG490,a Jak2 specific inhibitor,in B7-H3 overexpressing *** data were analyzed by Graph Pad Prism 6 using a non-paired ***:Whether by overexpression in SW620cells or downregulation in HCT8,B7-H3 significantly affected the expression of anti-and pro-apoptotic proteins,at both the transcriptional and translational levels,compared with the negative control(Pting proved that B7-H3 overexpression inhibited apoptosis in colorectal cancer cell lines(Pting(Pting B7-H3 overexpressing cells with the Jak2-specific inhibitor AG490,t

关键词： B7-H3 Overexpression Colorectal cancer B-cell CLL/

A gating ultramicroporous metal-organic framework showing high adsorption selectivity,capacity and rate for xylene separation

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Science China Chemistry 2022年第8期65卷 1552-1558页

作者： Zi-Ming Ye Xue-Feng zhang De-Xuan Liu Yan-Tong Xu Chao Wang Kai Zheng dong-dong Zhou Chun-ting He Jie-Peng zhang Key Laboratory of Bioinorganic and Synthetic Chemistry(Ministry of Education) School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education/National Engineering Research Center for Carbohydrate Synthesis Jiangxi Normal UniversityNanchang 330022China 3.Guangdong Provincial Key Laboratory of New and Renewable Energy Research and DevelopmentGuangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China

Adsorptive separation of p-xylene(pX)from xylene isomers is a key process in chemical industry,but known adsorbents cannot simultaneously achieve high adsorption selectivity,capacity,and ***,we demonstrate gating ultramicropore as a solution for this *** modification of the synthetic condition gives rise to isomeric metal-organic frameworksα-[Zn(pba)](MAF-88,H2pba=4-(1H-pyrazol-4-yl)benzoic acid)andβ-[Zn(pba)](MAF-89)possessing similar pillared-column structures,porosities,and high pX capacities of 2.0 mmol g^(−1),but very different framework/pore topologies,pore sizes,and pX *** binary and ternary mixtures of liquid xylene isomers,MAF-88 with narrow one-dimensional(1D)channels shows pX selectivity of 11 and 1.6,while MAF-89 with 3D-connected quasi-discrete pores shows pX selectivity up to 221 and 46,***,differential scanning calorimetry,and time-dependent separation experiments reveal that the kinetic effects of the gating pores play more important roles than the thermodynamic effects,which is further confirmed by single-crystal X-ray diffraction and computational simulations.

关键词： metal-organic frameworks gating xylene adsorption separation

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui zhang Sonata S Y Yau Kwok-Fai So Li zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

基于摆锤法的成熟期油菜角果炸荚因素试验分析

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农机化研究 2025年第4期47卷 180-185页

作者：李港张敏魏德欣江东农业农村部南京农业机械化研究所南京210014

为了降低油菜联合收割机拨禾轮拨禾过程对角果打击造成的炸荚损失,采用摆锤法模拟拨禾轮拨禾对油菜角果冲击过程,对影响拨禾过程中的炸荚因素进行测试分析,并对角果损伤变化形式及过程进行分析。试验结果表明:摆锤冲击速度3.5 m/s、夹... 详细信息

为了降低油菜联合收割机拨禾轮拨禾过程对角果打击造成的炸荚损失,采用摆锤法模拟拨禾轮拨禾对油菜角果冲击过程,对影响拨禾过程中的炸荚因素进行测试分析,并对角果损伤变化形式及过程进行分析。试验结果表明:摆锤冲击速度3.5 m/s、夹持果柄位置距连接点2 mm是区分角果抗打击炸荚的最优参数;油菜角果炸荚不仅与冲击速度、果柄夹持位置有关,而且与油菜品种、冲击件材料类型、角果受力面、含水率、角果在植株上的分布位置等都有关系;冲击速度不超过1.5 m/s时,角果损伤以角果果柄发生塑性变形为主;冲击速度为2.5~4.5 m/s时,角果损伤以果皮破裂分离、果柄弹性变形为主。研究结果可为油菜拨禾轮设计和工作参数选择提供参考。

关键词：油菜角果炸荚率冲击拨禾轮摆锤法

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Preparation of PSFO and LPSFO nanofibers by electrospinning and their electronic transport and magnetic properties

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Chinese Physics B 2022年第5期31卷 629-635页

作者： Ying Su dong-Yang Zhu ting-ting zhang Yu-Rui zhang Wen-Peng Han Jun zhang Seeram Ramakrishna Yun-Ze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore Collaborative Innovation Center for Eco-Textiles of Shandong Province and State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China

Pr_(0.5)Sr_(0.5)FeO_(3)(PSFO)and La_(0.25)Pr_(0.25)Sr_(0.5)FeO_(3)(LPSFO)nanofibers are prepared by electrospinning followed by calcination,and their morphologies,microstructures,electronic transports,and magnetic properties are studied *** temperature-dependent resistance curves of PSFO and LPSFO nanofibers are measured in a temperature range from 300 K to 10 *** the temperature lowering,the resistance increases gradually and then decreases sharply due to the occurrence of ferromagnetic metal *** metal-insulator transition temperatures are about 110 K and 180 K for PSFO and LPSFO nanofibers,*** electronic conduction behavior above the transition temperature can be described by one-dimensional Mott’s variable-range hopping(VRH)*** hysteresis loops and the field-cooled(FC)and zero-field-cooled(ZFC)curves show that both PSFO nanofiber and LPSFO nanofiber exhibit *** the doping of La reduces the overall magnetization intensity of the material,it increases the ferromagnetic ratio of the system,which may improve the performance of LPSFO in solid oxide fuel cell.

关键词： Pr_(0.5)Sr_(0.5)FeO_(3) La_(0.25)Pr_(0.25)Sr_(0.5)FeO_(3) electrospinning electronic transport magnetic properties

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可干预因素与关节运动损伤的因果关系

中国组织工程研究 2025年第9期29卷 1953-1962页

作者：董婷婷陈天鑫李妍张晟张磊中国中医科学院望京医院骨关节四科北京市100102

背景:生活方式、代谢特征及营养摄入等干预因素与关节运动损伤的因果关系逐渐得到临床研究的重视,然而可干预因素与关节运动损伤的因果关系尚不明确。目的:运用孟德尔随机化的方法,探讨可干预因素与关节运动损伤的因果关系,为运动损伤... 详细信息

背景:生活方式、代谢特征及营养摄入等干预因素与关节运动损伤的因果关系逐渐得到临床研究的重视,然而可干预因素与关节运动损伤的因果关系尚不明确。目的:运用孟德尔随机化的方法,探讨可干预因素与关节运动损伤的因果关系,为运动损伤预防提供依据。方法:从公开数据库获取可干预因素和关节运动损伤的GWAS数据集,运用逆方差加权法、MR-Egger法、加权中位数法探讨生活方式、代谢特征、营养摄入与关节运动损伤的因果关系。敏感性分析方面,采用Cochran’s Q检验、MR-Egger回归、留一法和MR-PRESSO,以验证结果的稳定性和可靠性。结果与结论:①生活方式方面,咖啡(OR=0.29,95%CI:0.10-0.79,P=0.016)、茶消耗量(OR=0.41,95%CI=0.19-0.85,P=0.017)与足踝关节运动损伤风险下降,咖啡消耗量(OR=3.31,95%CI=1.02-10.73,P=0.046)与肩关节运动损伤风险上升具有潜在因果关系;从未吸烟(OR=0.78,95%CI=0.70-0.87,P=1.49×10^(-5))与足踝关节运动损伤风险下降具有显著因果关系。②代谢特征方面,钙水平(OR=0.88,95%CI=0.79-0.98,P=0.017)与手腕关节运动损伤风险下降具有潜在因果关系。③营养摄入方面,维生素A摄入(OR=1.08,95%CI:1.02-1.13,P=0.007)与膝关节运动损伤风险增加具有潜在因果关系。④敏感性分析方面,Cochran’s Q检验显示存在异质性(P0.05),留一法显示逐个剔除单核苷酸多态性后,结果具有稳定性。⑤此研究初步揭示生活方式、代谢特征及营养摄入等可干预因素对关节运动损伤风险的影响,为关节运动损伤的预防提供研究证据与研究方向。

关键词：孟德尔随机化关节运动损伤可干预因素生活方式代谢特征营养摄入因果关系敏感性分析