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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第01期 263-271页

作者： Siyi he Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song he Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrendher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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城市轨道交通线网的规划控制问题探讨

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城市轨道交通研究 2009年第10期12卷 29-31,44页

作者：贺宁宁波市轨道交通工程建设指挥部宁波博士工程师315010

尽管城市轨道交通的规划控制在目前规划管理实务中处于一定的优先地位,但也存在一些值得商榷和进一步研究的问题。回顾和梳理了各城市线网规划控制的相关理念、技术和机制,侧重剖析规划控制的目标、对象和技术系统中的经验与问题,并从... 详细信息

尽管城市轨道交通的规划控制在目前规划管理实务中处于一定的优先地位,但也存在一些值得商榷和进一步研究的问题。回顾和梳理了各城市线网规划控制的相关理念、技术和机制,侧重剖析规划控制的目标、对象和技术系统中的经验与问题,并从基于控制的引导、阶段性分层次的梳理、技术标准与控制内容的完善等三方面提出了建议。

关键词：城市轨道交通控制性详细规划规划管理

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Synaptic Transmission of Primary Hippocampal Neurons was Enhanced after Terahertz Waves Exposure

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Biomedical and Environmental Sciences 2024年第8期37卷 926-930页

作者： Lequan Song Zhiwei he Junmiao Pan Ji dong Haoyu Wang Jing Zhang Binwei Yao XinpingXu Hui Wang Li Zhao Ruiyun Peng Beijing Institute of Radiation Medicine Beijing 100850China College of Education Hebei UniversityBaoding 071002HebeiChina

Terahertz(THz)waves,also known as T-rays,encompass frequencies ranging from 0.1 to 10 THz and possess unique properties that render them applicable in various biomedical domains,particularly in neurobiology[1].Synaptic transmission,the process through which signals propagate between neurons at synapses,is pivotal for brain function and information processing.

关键词： processing Waves render

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Fstll regulate apoptosis and autophagy process in pulmonary fibrosis

Fstll regulate apoptosis and autophagy process in pulmonary ...

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细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Xiaohe Li Yingying dong Wen ning Department of Life Science Nankai University

Idiopathic pulmonary fibrosis(IPF) is a chronic,progressive,and often fatal lung disease of unknown etiology,characterized by(myo)fibroblasts accumulation and extracellular matrix(ECM) deposition. Increased epithelial cell apoptosis but prolonged myofibroblast survival has been implicated in the development ofidiopathic pulmonary fibrosis(IPF),but the molecular pathways modulating cell

关键词： pulmonary fibrosis Fstll apoptosis autophagy bleomycin mice model

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Self-monitoring Application of Asphalt Concrete Containing Graphite and Carbon Fibers

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Journal of Wuhan University of Technology(Materials Science) 2008年第2期23卷 268-271页

作者： LIU Xiaoming WU Shaopeng LI ning GAO Bo School of Civil Engineering and Architecture Central South University Changsha 410075 China Key Laboratory of Silicate Materials Science and Engineering of Ministry of Education Wuhan University of Technology Wuhan 430070 China

The self-monitoring application of asphalt concrete containing graphite and carbon fibers using indirect tensile test and wheel rolling test were introduced. The experiment results indicate that this kind of pitch-based composite is effective for strain/stress self-monitoring. In the indirect tensile test, for a completely conductive asphalt concrete specimen, the piezoresistivity was very weak and slightly positive, which meant the resistivity increase with the increment of tensile strain at all stress/strain amplitudes, with the gage factor as high as 6. The strain self-sensing ability was superior in the case of higher graphite content. However, when the conductive concrete was embedded into common asphalt concrete specimen as a partial structure function, the piezoresistivity was positive at all stress/strain amplitudes and with the gage factor of 13, which was much higher than that of completely conductive specimen. Thus, the strain self-sensing ability was superior when conductive asphalt concrete was taken in as a partial structure function. In the wheel-rolling test, the piezoresistivity was highly positive. At any stress amplitude, the piezoresistivity was strong, with the gage factor as high as 100, which was higher for a stress amplitude of 0.7 MPa than that of 0.5 MPa.

关键词： asphalt concrete graphite carbon fibers self-monitoring piezoresistivity

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分子动力学模拟研究A1408G突变对核糖体16S rRNA片段的影响

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高等学校化学学报 2010年第9期31卷 1815-1819页

作者：董浩刘元宁吉林大学计算机科学与技术学院长春132012

利用分子动力学模拟方法,研究了原核生物核糖体小亚基中的16SrRNA片段与氨基糖苷类抗生素巴龙霉素复合物结构的柔性.结果表明,16SrRNA片段中的1408位点的腺嘌呤(A)突变为鸟嘌呤(G),改变了与tRNA中反密码子环识别相关的2个腺嘌呤A1492和A... 详细信息

利用分子动力学模拟方法,研究了原核生物核糖体小亚基中的16SrRNA片段与氨基糖苷类抗生素巴龙霉素复合物结构的柔性.结果表明,16SrRNA片段中的1408位点的腺嘌呤(A)突变为鸟嘌呤(G),改变了与tRNA中反密码子环识别相关的2个腺嘌呤A1492和A1493的空间构象,阻碍了氨基糖苷类抗生素与核糖体的结合,从而影响原核生物蛋白转录过程.模拟结果与实验测定的晶体结构相吻合,可为基于核糖体16SrRNA的药物分子设计提供较可靠的结构信息.

关键词：核糖体 16SrRNAA位点巴龙霉素分子动力学

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Composite following control for wheeled inverted pendulum vehicles based on human-robot interaction

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Science China(Information Sciences) 2019年第5期62卷 20-22页

作者： Ming YUE Yigao ning Shuzhou YU Yongshun ZHANG School of Automotive Engineering Dalian University of Technology School of Mechanical Engineering Dalian University of Technology

Dear editor,Over the past decade, wheeled mobile robots have been widely used in many fields, and for the human-following, they are required to respect the social zones when they follow humans for the purpose of company or carrying loads [1–4]. To this end, an impedance control is proposed for a human-following robot Pioneer 3AT, where the pa-

关键词： Figure WIP Composite following control for wheeled inverted pendulum vehicles based on human-robot interaction

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数控机床产业智能化发展与赛博安全问题分析

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制造技术与机床 2017年第8期 28-32页

作者：何宁对外经济贸易大学国际商学院北京100029 中国航空制造技术研究院北京100024

随着生产模式向网络化协同生产转变,数控机床的智能化发展趋势越来越明显,正逐步成为产生大数据的智能终端。由于采用国外数控系统的数控机床固有的安全漏洞、后门以及智能工厂联网后的开放性等赛博安全问题使产品信息安全面临严重威胁... 详细信息

随着生产模式向网络化协同生产转变,数控机床的智能化发展趋势越来越明显,正逐步成为产生大数据的智能终端。由于采用国外数控系统的数控机床固有的安全漏洞、后门以及智能工厂联网后的开放性等赛博安全问题使产品信息安全面临严重威胁。应采取提高综合协同防护能力、部署可信数据防护机制、深入推进实施"换脑工程"等措施来保障数控机床的自主可控和智能工厂的信息化建设。

关键词：数控机床智能化赛博安全协同防护换脑工程

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Review of risk factors,clinical manifestations,rapid diagnosis,and emergency treatment of neonatal perioperative pneumothorax

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World Journal of Clinical Cases 2022年第33期10卷 12066-12076页

作者： Xu Zhang ning Zhang Yue-Yi Ren Department of heart Center Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina Department of Clinical Laboratory Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina

Perioperative neonatal pneumothorax(NP)is rare but very *** of the surgeries and treatments in the neonatal period are time-limited or emergent,and there are often some risk factors for pneumothorax before ***,surgeons and anesthesiologists need to identify possible risk factors for pneumothorax before surgery in preterm babies,patients receiving mechanical ventilation and those with underlying lung *** clinical presentation of NP is nonspecific,and patients may rapidly develop life-threatening complications if not promptly diagnosed and *** review highlights recent progress in the identification of risk factors,clinical manifestations,diagnosis and management of NP during the perioperative period.

关键词： Neonatal Perioperative Pneumothorax Risk factors Clinical manifestations Diagnosis Management

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Reconstruction and interpretation of photon Doppler velocimetry spectrum for ejecta particles from shock-loaded sample in vacuum

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Chinese Physics B 2021年第6期30卷 419-429页

作者： Xiao-Feng Shi dong-Jun Ma Song-lin Dang Zong-Qiang Ma Hai-Quan Sun An-Min he Pei Wang Institute of Applied Physical and Computational Mathematics Beijing 100094China Jiangxi University of Applied Science Nanchang 330103China Center for Applied Physics and Technology Peking UniversityBeijing 100871China

The photon Doppler velocimetry(PDV) spectrum is investigated in an attempt to reveal the particle parameters of ejecta from shock-loaded samples in a vacuum. A GPU-accelerated Monte–Carlo algorithm, which considers the multiplescattering effects of light, is applied to reconstruct the light field of the ejecta and simulate the corresponding PDV *** influence of the velocity profile, total area mass, and particle size of the ejecta on the simulated spectra is discussed qualitatively. To facilitate a quantitative discussion, a novel theoretical optical model is proposed in which the singlescattering assumption is applied. With this model, the relationships between the particle parameters of ejecta and the peak information of the PDV spectrum are derived, enabling direct extraction of the particle parameters from the PDV *** values of the ejecta parameters estimated from the experimental spectrum are in good agreement with those measured by a piezoelectric probe.

关键词： ejecta photon Doppler velocimetry Monte–Carlo algorithm light scattering

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