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Research on the floating performance of a novel large caliber machine gun based on the floating principle with complicated boundary conditions

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Defence Technology（防务技术） 2019年第4期15卷 607-614页

作者： Ye Lu ke-dong zhou Lei He Jun-song Li Xue-ying Huang School of Mechanical Engineering Nanjing University of Science and Technology Nanjing 210094 Jiangsu China No.208 Research Institute of China Ordnance Industries Beijing 102202 China 63856 Unit of PLA Baicheng 137001 Jilin China

In this paper,a novel large caliber machine gun was taken as the research object to analyze the floating technique based on the principle of fixed-point constraint and secondary counter-recoil.A rigid-flexible coupling multi-body dynamic model of the large caliber machine gun with muzzle brake based on floating principle was established,in which the influence of soil and human body was taken into *** dynamic simulation was conducted and then the results were compared with the corresponding experimental data The dynamic characteristics of the machine gun with or without floating technique were analyzed to indicate the influence of floating technique upon the performance of the ***,the rigid-flexible coupling dynamic models with five different firing angles was constructed to study the influence caused by the *** results indicated that the floating mechanism could reduce the recoil effectively and improve the operational performance of this novel large caliber machine gun.

关键词： Large caliber machine gun Floating performance Dynamic analysis Firing elevation

Dauricine Inhibits IGF-I-induced HIF-1α Protein Accumulation and VEGF Expression via PI-3K/Akt/mTOR Signaling Pathway in Human Breast Cancer Cells

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Dauricine Inhibits IGF-I-induced HIF-1α Protein Accumulatio...

A low redox potential and long life organic anode material for sodium-ion batteries

2008年全国生物化学与分子生物学学术大会

作者： Xu-dong Tang ke-yuan zhou (Department of Biochemistry and Molecular Biology,Guangdong Medical College,Zhanjiang 524023)

Dauricine(Dau),a bisbenzylisoquinoline alkaloid derivative isolated from the rhizome of Menispermum dauricum DC,has been found to have anticancer ***,the effect of Dau on tumor angiogenesis is still unclear.A growing body of evidence has demonstrated that hypoxia-inducible factor(HIF)-1 and vascu- lar endothelial growth factor(VEGF)play a pivotal role in tumor *** this study,we investigated the

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang zhou Xin Huang Xing zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli dong Yonggang Wang Department of Chemistry and Shanghai key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

中药益肺活血方对慢性阻塞性肺疾病患者肺功能、炎症反应及氧化应激的影响

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中国中医基础医学杂志 2020年第8期26卷 1095-1098页

作者：董克州朱益敏江苏省第二中医院南京210000

目的:探究中药益肺活血方对慢性阻塞性肺疾病(COPD)患者肺功能、炎症反应及氧化应激的影响。方法:选择2017年9月至2019年3月在江苏省第二中医院就诊的80例COPD患者为研究对象分为对照组和观察组各40例,对照组采用常规治疗,观察组在此基... 详细信息

目的:探究中药益肺活血方对慢性阻塞性肺疾病(COPD)患者肺功能、炎症反应及氧化应激的影响。方法:选择2017年9月至2019年3月在江苏省第二中医院就诊的80例COPD患者为研究对象分为对照组和观察组各40例,对照组采用常规治疗,观察组在此基础上加用益肺活血方,比较2组的临床疗效、肺功能、炎症反应因子及氧化应激指标水平。结果:观察组总有效率明显高于对照组;治疗后观察组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC水平明显高于对照组,观察组肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-8水平明显低于对照组,观察组丙二醛(MDA)水平明显低于对照组,观察组过氧化物歧化酶(SOD)、谷胱甘肽(GSH)水平明显高于对照组。结论:中药益肺活血方对COPD患者具有较好的临床疗效,该方不仅能提高患者肺功能,还可改善机体炎症反应及氧化应激状态。

关键词：慢性阻塞性肺疾病益肺活血方肺功能炎症反应氧化应激

实时经食道三维超声心动图诊断左室流出道黏液瘤1例

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中国临床医学影像杂志 2017年第4期28卷 301-302页

作者：范苗任卫东周可孙璐中国医科大学附属盛京医院辽宁沈阳110004

病例女，55岁。1月前无明显诱因出现左侧肩胛下疼痛，为慢性钝痛，间断发作，无明显诱发和缓解因素，无胸闷胸痛，7d前出现剑突下不适及面部麻木感，伴头晕，体力尚可，饮食、睡眠正常，

关键词：心脏肿瘤粘液瘤超声心动描记术三维

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan zhou Zhijian Xie Yong He State key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian Hao Xiang zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches