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The diagnostic value of tenascin-C in acute aortic syndrome

Journal of Geriatric Cardiology 2024年第3期21卷 359-368页

作者： Ming MA Wei CHEN Hai-Long CAO Jun PAN Qing ZHOU Xin-Long TANG dong-jin wang Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina Department of Thoracic surgery Kunshan Hospital of Traditional Chinese MedicineJiangsuChina

OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases ***-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular *** elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains *** We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back *** to discriminate AAS from acute coronary syndrome(ACS)were compared and *** From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50–5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of *** the 166 AAS patients,the peaked level of TN-C was at acute stage(P=0.012),then a slight of decrease was observed at subacute *** area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for *** a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and *** The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and ***-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain diseases.

关键词： acute cardiovascular elevated

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A Review on Particle Reinforced Mg Matrix Composites Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 391-400页

作者： Zhiyuan Liu Li jin Jian Zeng Fulin wang Fenghua wang Shuai dong Jie dong National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper provides a comprehensive review of research progress in particle-reinforced Mg matrix composites prepared via powder *** article discusses different strategies,such as micro-sized,nano-sized particles,and multi-particle hybridization,which has been employed to enhance the performance of the *** addition,a range of preparation techniques that optimize the dispersion of the reinforcing particles are *** paper also highlights how the different configurations between the reinforcements and matrix alloy impact the composites’***,the article outlines the prospects of particles reinforced Mg matrix composites fabricated via powder metallurgy and recommends modification methods that could be explored to further develop these materials for various applications.

关键词： Magnesium matrix composites Reinforcing particle Powder metallurgy Mechanical properties Configuration

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Cancer cachexia:Focus on cachexia factors and inter-organ communication

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Chinese Medical Journal 2024年第1期137卷 44-62页

作者： Yongfei wang Zikai dong Ziyi An Weilin jin The First Clinical Medical College of Lanzhou University LanzhouGansu 730000China Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhouGansu 730000China

Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia *** cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer *** cachexia factors are also a potential target for the diagnosis and *** pathogenesis of cachexia is unclear and no clear effective treatment is ***,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently *** the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and *** review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia *** summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.

关键词： Cancer cachexia Cancer cachexia factors Inter-organ communication Tumor ecosystem Tumor microenvironment

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Theoretical and experimental investigations on single-atom catalysis:Pt1/FeOx for water-gas shift reaction Shan-Fei wang1,§,Yangyang Li2,3,§,Haiyan wang1,jin-Xia Liang1(✉),Chun Zhu1

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Nano Research 2024年第9期17卷 8627-8637页

作者： Shan-Fei wang Yangyang Li Haiyan wang jin-Xia Liang Chun Zhu Botao Qiao School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Oxide-supported metal single-atom catalysts(SACs)have exhibited excellent catalytic performance for water-gas shift(WGS)***,we report the single-atom catalyst Pt1/FeOx exhibits excellent medium temperature catalytic performance for WGS reactions by the density functional theory(DFT)calculations and experimental *** calculations indicate that H_(2)O molecules are easily dissociated at oxygen vacancies,and the formed*OH and*O are adsorbed on Pt1 single atoms and the adjacent O atoms,*** studying four possible reaction mechanisms,it is found that the optimal WGS reaction pathway is proceeded along the carboxyl mechanism(pathway III),in which the formation of*COOH intermediates can promote the stability of Pt1/FeOx SAC and the easier occurrence of WGS *** energy barrier of the rate-determining step during the entire reaction cycle is only 1.16 eV,showing the high activity for the medium temperature WGS reaction on Pt1/FeOx SAC,which was verified by experimental ***,the calculated turnover frequencies(TOFs)of CO_(2)and H_(2)formation on Pt1/FeOx at 610 K(337℃)can reach up to 1.14×10^(-3)s^(-1)·site^(-1)through carboxyl *** this work,we further expand the application potential of Pt1/FeOx SAC in WGS reaction.

关键词： water-gas shift(WGS)reaction single-atom catalyst(SAC) density functional theory(DFT) thermocatalysis

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Tuning mechanical and electrical performances of B_(4)C-TiB_(2)ceramics in a two-step spark plasma sintering process

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Journal of Advanced Ceramics 2024年第4期13卷 518-528页

作者： Jun Zhao Xingshuo Zhang Zongning Ma dong wang Xing jin Songlin Ran Advanced Ceramics Research Center School of Materials Science and EngineeringAnhui University of TechnologyMaanshan 243002China Anhui Engineering Research Center for High Efficiency Intelligent Photovoltaic Module Chaohu UniversityHefei 238024China

B_(4)C–TiB_(2)is an advanced electrically conductive ceramic with excellent mechanical and electrical discharge machinable *** is challenging and rewarding to achieve highly conductive and hard B_(4)C–TiB_(2)composites at a minimum content of conductive TiB2 that has inferior hardness but double specific gravity of the B_(4)C matrix.A novel strategy was used to construct conductive networks in B_(4)C‒15 vol%TiB2 composite ceramics with B_(4)C,TiC,and amorphous B as raw materials by a two-step spark plasma sintering *** influences of particle size matching between B_(4)C and TiC on the conducting of the strategy and the microstructure were discussed based on the selective matrix grain growth *** mechanical and electrical properties were also systematically *** B_(4)C–15 vol%TiB2 composite ceramic prepared from 10.29µm B_(4)C and 0.05µm TiC powders exhibited a perfect three-dimensional interconnected conductive network with a maximum electrical conductivity of 4.25×10^(4)S/m,together with excellent mechanical properties including flexural strength,Vickers hardness,and fracture toughness of 691±58 MPa,30.30±0.61 GPa,and 5.75±0.32 MPa·m^(1/2),respectively,while the composite obtained from 3.12µm B_(4)C and 0.8µm TiC powders had the best mechanical properties including flexural strength,Vickers hardness,and fracture toughness of 827±35 MPa,32.01±0.51 GPa,and 6.45±0.22 MPa·m^(1/2),together with a decent electrical conductivity of 0.65×10^(4)S/m.

关键词： B_(4)C-TiB_(2) mechanical properties electrical conductivity conductive network

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Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： jin Tang Mingxuan Feng dong wang Liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

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Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression

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China Ocean Engineering 2024年第2期38卷 313-325页

作者： dong Wen-bo ZHOU Li DING Shi-feng wang Ai-ming CAI jin-yan School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of *** the Arctic,merchant ships with low ice class often navigate in channels opened up by *** in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large *** ship may get stuck if steered into ice fields off the *** this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable *** this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point *** first stage employs the image segmentation method to extract channel *** the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression *** training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel *** evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.

关键词： ice channel ship navigation identification image segmentation corner point regression

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Investigation of the block toppling evolution of a layered model slope by centrifuge test and discrete element modeling

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 112-122页

作者： Leilei jin Hongkai dong Fei Ye Yufeng Wei Jianfeng Liu Changkui wang State Key Laboratory of Hydraulic and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China

Primary toppling usually occurs in layered rock slopes with large anti-dip *** this paper,the block toppling evolution was explored using a large-scale centrifuge *** block column in the layered model slope was made of cement *** artificial cracks perpendicular to the block column were *** gages,displacement gages,and high-speed camera measurements were employed to monitor the deformation and failure processes of the model *** centrifuge test results show that the block toppling evolution can be divided into seven stages,*** compression,formation of major tensile crack,reverse bending of the block column,closure of major tensile crack,strong bending of the block column,formation of failure zone,and complete *** toppling is characterized by sudden large deformation and occurs in *** wedge-shaped cracks in the model incline towards the *** observations show that block toppling is mainly caused by bending failure rather than by shear *** tensile strength also plays a key factor in the evolution of block *** simulation results from discrete element method(DEM)is in line with the testing *** stress exists at the backside of rock column during toppling *** concentration results in the fragmented rock column and its degree is the most significant at the slope toe.

关键词： Block toppling Centrifuge Anti-dip slope Failure mechanism Discrete element method

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Improving the Accuracy of Vegetation Index Retrieval for Biomass by Combining Ground-UAV Hyperspectral Data-A New Method for Inner Mongolia Typical Grasslands

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 387-411页

作者： Ruochen wang Jianjun dong Lishan jin Yuyan Sun Taogetao Baoyin Xiumei wang The College of Resources and Environmental Engineering Inner Mongolia University of TechnologyHohhot010000China The College of Ecology and Environment Inner Mongolia UniversityHohhot010000China Key Laboratory of Environmental Pollution Control and Remediation at Universities of Inner Mongolia Autonomous Region Inner Mongolia University of TechnologyHohhot010000China

Grassland biomass is an important parameter of grassland *** complexity of the grassland canopy vegetation spectrum makes the long-term assessment of grassland growth a *** studies have explored the original spectral information of typical grasslands in Inner Mongolia and examined the influence of spectral information on aboveground biomass(AGB)*** order to improve the accuracy of vegetation index inversion of grassland AGB,this study combined ground and Unmanned Aerial Vehicle(UAV)remote sensing technology and screened sensitive bands through ground hyperspectral data transformation and correlation *** narrow band vegetation indices were calculated,and ground and airborne hyperspectral inversion models were ***,the accuracy of the model was *** results showed that:(1)The vegetation indices constructed based on the ASD FieldSpec 4 and the UAV were significantly correlated with the dry and fresh weight of AGB.(2)The comparison between measured R^(2) with the prediction R^(2) indicated that the accuracy of the model was the best when using the Soil-Adjusted Vegetation Index(SAVI)as the independent variable in the analysis of AGB(fresh weight/dry weight)and four narrow-band vegetation *** SAVI vegetation index showed better applicability for biomass monitoring in typical grassland areas of Inner Mongolia.(3)The obtained ground and airborne hyperspectral data with the optimal vegetation index suggested that the dry weight of AGB has the best fitting effect with airborne hyperspectral data,where y=17.962e^(4.672x),the fitting R^(2) was 0.542,the prediction R^(2)was 0.424,and RMSE and REE were 57.03 and 0.65,***,established vegetation indices by screening sensitive bands through hyperspectral feature analysis can significantly improve the inversion accuracy of typical grassland biomass in Inner *** with ground monitoring,airborne hyperspectral monitoring better reflec

关键词： Aboveground biomass inversion model vegetation index unmanned aerial vehicle typical grassland

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Numerical simulation of melt flow and temperature field during DC casting 2024 aluminium alloy under different casting conditions

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China Foundry 2024年第4期21卷 387-396页

作者： jin-chuan wang Yu-bo Zuo Qing-feng Zhu jing Li Rui wang Xu-dong Liu Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Engineering Research Center of Advanced Materials Preparing Technology Ministry of EducationShenyang 110819China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Casting speed,casting temperature and secondary cooling water flow rate are the main process parameters affecting the DC casting *** parameters significantly influence the flow and temperature fields during casting,which are crucial for the quality of the ingot and can determine the success or failure of the casting *** simulation,with the advantages of low cost,rapid execution,and visualized results,is an important method to study and optimize the DC casting *** the present work,a simulation model of DC casting 2024 aluminum alloy was established,and the reliability of the model was ***,the influence of casting parameters on flow field and temperature field was studied in detail by numerical simulation *** show that with the increase of casting speed,the melt flow becomes faster,the depths of slurry zone and mushy zone increase,and the variation of slurry zone depth is greater than that of mushy *** an increase in casting temperature,the melt flow rate increases,the depth of the slurry zone becomes shallower,and the depth of the mushy zone experiences only minor *** simulation results further indicate that the increase of the flow rate of the secondary cooling water slightly reduces the depths of both slurry and mushy zone.

关键词： aluminium DC casting flow field temperature field numerical simulation

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