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免疫球蛋白辅助益生菌对轮状病毒肠炎婴幼儿病程、细菌感染率及S IgA水平的影响

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世界华人消化杂志 2017年第27期25卷 2486-2490页

作者：刘冬王金珠天津市宁河区医院儿科天津市301500

目的研究免疫球蛋白辅助益生菌对轮状病毒肠炎婴幼儿病程、细菌感染率及分泌性IgA(secretory IgA,SIgA)水平的影响.方法选择2015-01/2016-12在天津市宁河区医院治疗的轮状病毒肠炎患儿120例.用随机数表法分为对照组和观察组,每组各60例... 详细信息

目的研究免疫球蛋白辅助益生菌对轮状病毒肠炎婴幼儿病程、细菌感染率及分泌性IgA(secretory IgA,SIgA)水平的影响.方法选择2015-01/2016-12在天津市宁河区医院治疗的轮状病毒肠炎患儿120例.用随机数表法分为对照组和观察组,每组各60例,对照组患儿给予常规治疗联合酪酸梭菌活菌散治疗,观察组患儿在对照组的基础上加用免疫球蛋白治疗.比较2组患儿的病程、腹泻次数、细菌感染率及SIgA水平等.结果观察组患儿治疗3、5、7和9 d的腹泻次数分别为5.62次±1.38次、3.49次±0.87次、2.25次±0.74次和1.27次±0.51次,平均病程为4.15 d±0.93 d,均低于对照组,差异有统计学意义(P0.05),治疗后观察组患儿的SIgA水平高于对照组(4.25±0.39 vs 2.84±0.35),轮状病毒含量(0.13±0.03 vs 0.52±0.09)、白介素-6(15.02±3.62 vs 19.47±4.02)和肿瘤坏死因子-α(2.47±0.62 vs 3.26±0.71)水平低于对照组(P0.05),治疗后观察组患儿的CD3^+(67.51±12.95 vs 59.15±10.83)、CD4^+(36.95±6.51 vs 32.71±5.29)和CD4^+/CD8^+(1.47±0.38 vs 1.21±0.27)水平高于对照组,CD8^+(23.16±3.01 vs 28.03±3.64)水平低于对照组,差异有统计学意义(P<0.05).观察组患儿有4例发生细菌感染,发生率为6.67%,对照组患儿有12例发生细菌感染,发生率为20.00%,差异有统计学意义(χ~2=4.615,P<0.05).结论免疫球蛋白辅助益生菌可以明显改善轮状病毒肠炎婴幼儿的免疫功能,提高SIgA水平,明显缓解临床症状,有益于肠道内轮状病毒的清除,缩短病程,值得在临床推广.

关键词：免疫球蛋白酪酸梭菌活菌散轮状病毒肠炎分泌性IgA

Physiological significance of probability plasticity

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Physiological significance of probability plasticity

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jian-dong YU,jin-Hui wang The State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences

Short-term plasticity in synaptic transmission is believed to control the efficiency of signal communication among the neurons,one of key processes in neural *** better understand the mechanisms underlying synaptic transmission,we conduct paired-recordings between neocortical regular-spiking pyramidal neurons(RS) and a specific subtype of inhibitory interneuron("GIN cells":low threshold-spiking,somatostatin-expressing,EGFP-labeled interneurons in the GIN line of transgenic mice) in brain *** from glutamatergic unitary synapses on pyramidal neurons and GABAergic interneurons are mainly *** both the net amplitude of synchronous release and the amplitude of asynchronous release of each EPSC are *** suggests the quantum size underlying short-term facilitation is not *** contrast,the probabilities of synchronous and asynchronous release of each EPSC are both increased ***,the release probabilities are relative increased when we augment the facilitation by changing the firing frequency of presynaptic *** results indicate the short-term facilitation can be explained by the increasing of release *** examine the role of presynaptic Cal in synaptic release probability and facilitation, we reduced Ca levels by infusing BAPTA(a Ca chelator) into presynaptic *** reduction of presynaptic Ca level significantly blocks synaptic vesicle release,and makes synaptic facilitation *** elevation of presynaptic Ca by adenophostin increases synaptic release probability,but attenuates synaptic *** integrated current pulses mathematically based on different release probability and found that high probability can improve both spike capacity and timing *** conclusion,the elevation of release probability is the main mechanism of short-term facilitation,and it can improve the spike programming.

关键词： short-term plasticity probability plasticity calcium quantum size

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi wang Mengke Zhao dong Fu Meina wang Chao Han Zhongyue Lv Liang wang jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

基于妙思V6.5连续出版物管理系统的中文期刊规范管理策略

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农业图书情报学刊 2013年第4期25卷 174-177页

作者：靳东旺南阳理工学院图书馆河南南阳473004

妙思V6.5连续出版物管理系统的应用,使图书馆期刊工作的现代化水平得到了明显提升,但当前期刊的不规范出版现象给期刊管理工作带来了一定的困扰。结合妙思V6.5连续出版物管理系统,从期刊订购、录入、验收、分编、下架及阅览管理等环节入... 详细信息

妙思V6.5连续出版物管理系统的应用,使图书馆期刊工作的现代化水平得到了明显提升,但当前期刊的不规范出版现象给期刊管理工作带来了一定的困扰。结合妙思V6.5连续出版物管理系统,从期刊订购、录入、验收、分编、下架及阅览管理等环节入手,对期刊的规范化管理提出了建议,旨在与图书馆界同仁进行沟通、交流,以促进期刊管理工作的规范发展。

关键词：中文期刊妙思V6 5 规范管理

个性化信息服务:高校图书馆服务创新的新举措

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农业图书情报学刊 2008年第8期20卷 193-196页

作者：靳东旺南阳理工学院图书馆河南南阳473004

个性化信息服务是高校图书馆服务创新的新举措。分析了个性化信息服务的涵义,介绍了高校图书馆开展个性化信息服务的优势,阐述了高校图书馆开展个性化信息服务的措施和方法及注意的问题。

关键词：高校图书馆服务创新个性化信息服务

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi jin Suyu wang Yujia Yao Qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen wang Kai Rong Shanlei Chang Youxing Fang Shaojun dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

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环中环结构谐振腔中的耦合谐振透明特性研究

物理学报 2009年第11期58卷 7672-7679页

作者：王楠掌蕴东王金芳田赫王号张学楠张敬袁萍哈尔滨工业大学光电子技术研究所哈尔滨150080

在考虑耦合器插入损耗的情况下,理论分析了环中环结构谐振腔的耦合谐振透明效应.利用迭代法推导了整个结构的透过系数和有效相移,从而得到考虑了插入损耗的该结构的色散.研究表明,整个结构的有效相移,群速度和带宽,可通过耦合器的插入... 详细信息

在考虑耦合器插入损耗的情况下,理论分析了环中环结构谐振腔的耦合谐振透明效应.利用迭代法推导了整个结构的透过系数和有效相移,从而得到考虑了插入损耗的该结构的色散.研究表明,整个结构的有效相移,群速度和带宽,可通过耦合器的插入损耗、环中环结构中环与环周长之间的倍数以及环的个数来控制,这在旋转传感、光学时延线、光缓存、滤波等方面的应用有重要意义.

关键词：环中环结构耦合谐振透明色散慢光