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Scaling laws and mechanical properties of nanoporous copper

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Journal of Iron and Steel Research International 2017年第10期24卷 1041-1047页

作者： Lin-kai Guo Lei Wang dong-hui yang College of Mechanics and Materials Hohai UniversityNanjing 210098JiangsuChina

Through molecular dynamics simulations,the mechanical behavior of nanoporous copper under impact loading was investigated with relative densities ranging from 77.91% to 98.36%,focusing on deformation mechanism,the scaling laws and influence of ligament *** show that the classical Gibson-Ashby′s scaling laws should be modified for prediction of both the Young′s modulus and yield stress.A proportional relationship is established between cell wall thickness and yield stress,and new modified scaling equations are built for nanoporous copper with consideration on both relative mass density and size effects of *** size effect can be explained by larger surface area/volume ratio of samples with thinner ligament size and limited dislocation source activation due to narrow space between larger numbers of voids.

关键词： Nanoporous copper Mechanical property Molecular dynamics Scaling lawSize effect

Exploiting the Community Structure of Fraudulent Keywords for Fraud Detection in Web Search

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Journal of Computer Science & Technology 2021年第5期36卷 1167-1183页

作者： dong-hui yang Zhen-Yu Li Xiao-hui Wang Kavé Salamatian Gao-Gang Xie Network Technology Research Center Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Global Energy Interconnection Research Institute Co. Ltd.Beijing 102209China LISTIC Laboratory of Computer Science SystemsInformation and Knowledge ProcessingUniversitéSavoie Mont BlancChambéry 73011France Computer Network Information Center Chinese Academy of SciencesBeijing 100190China

Internet users heavily rely on web search engines for their intended *** major revenue of search engines is advertisements(or ads).However,the search advertising suffers from *** generate fake traffic which does not reach the intended audience,and increases the cost of the ***,it is critical to detect fraud in web *** studies solve this problem through fraudster detection(especially bots)by leveraging fraudsters'unique ***,they may fail to detect new means of fraud,such as crowdsourcing fraud,since crowd workers behave in part like normal *** this end,this paper proposes an approach to detecting fraud in web search from the perspective of fraudulent *** begin by using a unique dataset of 150 million web search logs to examine the discriminating features of fraudulent ***,we model the temporal correlation of fraudulent keywords as a graph,which reveals a very well-connected community ***,we design DFW(detection of fraudulent keywords)that mines the temporal correlations between candidate fraudulent keywords and a given list of *** particular,DFW leverages several refinements to filter out non-fraudulent keywords that co-occur with seeds *** evaluation using the search logs shows that DFW achieves high fraud detection precision(99%)and accuracy(93%).A further analysis reveals several typical temporal evolution patterns of fraudulent keywords and the co-existence of both bots and crowd workers as fraudsters for web search fraud.

关键词： community structure fraud analysis fraudulent keyword detection web search

Fabrication of AI foam without thickening process through melt-foaming method

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Journal of Iron and Steel Research International 2018年第1期25卷 90-98页

作者： dong-hui yang Jian-qing Chen Lei Wang Jing-hua Jiang Ai-bin Ma College of Mechanics and Materials Hohai UniversityNanjing 210098 Jiangsu China Suqian Research Institute of Hohai University Suqian 223814 Jiangsu China

By using calcium carbonate （CaCO3） powder as the blowing agent, Al foams with porosities of - 60 to 85% and pore size of - 1.5 mm were fabricated via melt-foaming method. Instead of adding a thickening agent to increase Al melt viscosity, a small amount of Mg ingot （5.0 wt%） was added first, and then A1 melt was foamed by adding calcium carbonate via the impellor stirring. The effect of Mg addition on the gas release behavior of calcium carbonate in the Al melt was investigated. The compression behavior of fabricated Al foams was examined. The results show that the blowing gas is possibly from the reaction between Mg and calcium carbonate, and this reaction can produce solid oxides with micrometer level size, which leads to increasing the Al melt viscosity and is beneficial for inhibiting pores coarsening. Besides, the micrometer level cracks in the cell walls make the strength of Al foam decrease.

关键词： Al foam Thickening agent Calcium carbonate Blowing gas Compression

Determination of the Absolute Configuration of Rohitukine

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Chinese Chemical Letters 2003年第7期14卷 720-723页

作者： dong hui yang Shao Qing CAI Yu Ying ZHAO Hong LIANG Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100083

The absolute configuration of rohitukine, isolated from the stem-bark of Dysoxylum binectariferum, was determined to be 5,7-dihydroxy-2-methyl-8-[4-(3S, 4R-3-hydroxy-1-methyl) -piperidinyl]-4H-1-benzopyran-4-one by X-ray crystallographic analysis on the crystal of 4-bromobenzoyl derivatives of rohitukine. At the same time, the modified Mosher method was proved to be unsuitable for determining the absolute configuration of C-3 position in rohitukine.

关键词： Dysoxylum binectariferum absolute configuration rohitukine.

Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PERK signaling pathways

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Zoological Research 2021年第4期42卷 514-524页

作者： De-Zhe Qin hui Cai Cen He dong-hui yang Jing Sun Wen-Lai He Ba-Lun Li Jin-Lian Hua Sha Peng College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China

Normal spermatogenic processes require the scrotal temperature to be lower than that of the body as excessive heat affects spermatogenesis in the testes,reduces sperm quality and quantity,and even causes *** reticulum stress(ERS)is a crucial factor in many *** several studies have linked ERS to heat stress,researchers have not yet determined which ERS signaling pathways contribute to heat-induced testicular *** activates antioxidant enzymes,scavenges free radicals,and protects the testes from inflammation;however,few studies have reported on the influence of melatonin on heat-induced testicular *** a murine model of testicular hyperthermia,we observed that heat stress causes both ERS and apoptosis in the testes,especially in the *** observations were confirmed using the mouse spermatocyte cell line GC2,where the Atf6 and Perk signaling pathways were activated during heat *** of the above genes effectively reduced spermatocyte damage caused by heat *** with melatonin alleviated heat-induced apoptosis by inhibiting the Atf6 and Perk signaling *** mitigation was dependent on the melatonin *** vivo experiments verified that melatonin treatment relieved heat-induced testicular *** conclusion,our results demonstrated that ATF6 and PERK are important mediators for heat-induced apoptosis,which can be prevented by melatonin ***,our study highlights melatonin as a potential therapeutic agent in mammals for subfertility/infertility induced by testicular hyperthermia.

关键词： Heat stress ATF6 PERK Melatonin Spermatocyte

Recent progress in porous Mg-based foam preparation approaches:effect of processing parameters on structure and mechanical property

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Journal of Iron and Steel Research International 2022年第3期29卷 371-402页

作者： Solomon-Oshioke Agbedor dong-hui yang Jing Cao Jian-qing Chen Bassiouny Saleh Chao Qiu Lei Wang Jing-hua Jiang Ai-bin Ma College of Mechanics and Materials Hohai UniversityNanjing211100JiangsuChina Suqian Research Institute of Hohai University Suqian223814JiangsuChina Ocean and Offshore Engineering Research Institute of Hohai University Nantong226019JiangsuChina

Porous metals are a class of cellular materials with lightweight and unique mechanical,electrical,thermal,physical and acoustic *** and magnesium alloy foams have exhibited excellent *** particular,open-cell Mg-based foams(porous Mg/Mg alloy foams)have been used for bioresorbable implants,CO_(2)trapping systems,filters,heat exchangers,absorbent panels and many other *** significant progress has been taken in producing porous Mg-based foams with good structure-property relations,but with a large number of different processing parameters,different mechanical properties and pore morphologies of each porous Mg-based foam,it is essential to understand the individual effects of each aspect of the ***,the present article summarized the effects of available processing parameters on the structure and mechanical properties of the porous Mg-based ***,the future perspectives to enhance the structure and properties of porous Mg/Mg alloy foams were discussed.

关键词： Porous Mg alloy Powder processing Sintering Liquid metal infiltration Mechanical property

Eleven Absorbed Constituents and 91 Metabolites of Chuanxiong Rhizoma Decoction in Rats

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 33-46页

作者： Feng Xu Lei Zhang Xin Zhao Qi-Le Zhou Guang-Xue Liu Xiu-Wei yang dong-hui yang Shao-Qing Cai Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijingChina

Objective:Chuanxiong Rhizoma(CR,the dried rhizomes of Ligusticum chuanxiong)is a well-known traditional Chinese medicine that promotes qi to activate blood,dispels wind,and relieves *** date,more than 118 constituents of CR have been isolated and ***,the in vivo mechanism of CR decoction is unclear and needs further *** addition,to clarify the effective forms of CR,it is essential to reveal the absorbed constituents and metabolites of *** and Methods:The absorbed constituents and metabolites in urine and plasma samples of rats orally administered with CR decoction were screened and characterized using a high-performance liquid chromatography with diode array detector and combined with electrospray ionization ion trap time-of-flight multistage mass spectrometry ***:In total,102 compounds,including 11 absorbed constituents(eight phthalides and three phthalic acids)and 91 metabolites(71 phthalide-related and 20 phenolic acid-related),were detected in drug-containing rat urine and plasma samples,among which 33 were new metabolites of either CR or its *** on the structures of these metabolites,six phthalides(ligustilide,senkyunolide I/H,senkyunolide J/N,and butylidenephthalide)and three phenolic acids(ferulic acid,isoferulic acid,and caffeic acid)were proposed as their *** were also deduced to be the main absorbed constituents of CR decoction,which should have closer relationships with its pharmacological effects than other ***-related metabolites were formed through the metabolic reactions of hydration,hydroxylation,cysteine conjugation,acetylcysteine conjugation,methanethiol conjugation,mercaptomethanol conjugation,glucuronidation,and sulfation,whereas the phenolic acid-related metabolites were mainly formed by glucuronidation and ***:Six phthalides and three phenolic acids were shown to be the main precursors of the metabolites of CR,and 33 compounds

关键词： Chuanxiong Rhizoma effective forms metabolites phenolic acids phthalides

Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells

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Zoological Research 2021年第1期42卷 14-27页

作者： Yu-dong Wei Xiao-Min Du dong-hui yang Fang-Lin Ma Xiu-Wei Yu Meng-Fei Zhang Na Li Sha Peng Ming-Zhi Liao Guang-Peng Li Chun-Ling Bai Wei-Shuai Liu Jin-Lian Hua College of Veterinary Medicine Northwest A&F UniversityShaanxi Centre of Stem Cells Engineering&TechnologyYanglingShaanxi 712100China College of Life Sciences Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock School of Life SciencesInner Mongolia UniversityHohhotInner Mongolia 010021China Department of Pathology Yangling Demonstration Zone HospitalYangling Shaanxi 712100China

Double sex and mab-3-related transcription factor 1(Dmrt1),which is expressed in goat male germline stem cells(mGSCs)and Sertoli cells,is one of the most conserved transcription factors involved in sex *** this study,we highlighted the role of Dmrt1 in balancing the innate immune response in goat ***1 recruited promyelocytic leukemia zinc finger(Plzf),also known as zinc finger and BTB domain-containing protein 16(Zbtb16),to repress the Toll-like receptor 4(TLR4)-dependent inflammatory signaling pathway and nuclear factor(NF)-κ*** of Dmrt1 in seminiferous tubules resulted in widespread degeneration of germ and somatic cells,while the expression of proinflammatory factors were significantly *** also demonstrated that Dmrt1 stimulated proliferation of mGSCs,but repressed apoptosis caused by the immune ***,Dmrt1 is sufficient to reduce inflammation in the testes,thereby establishing the stability of spermatogenesis and the testicular microenvironment.

关键词： Male germline stem cells(mGSCs) Goat Dmrt1 Plzf Immune response

Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility

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Zoological Research 2023年第3期44卷 505-521页

作者： Meng-Fei Zhang Shi-Cheng Wan Wen-Bo Chen dong-hui yang Wen-Qing Liu Ba-Lun Li Aili Aierken Xiao-Min Du Yun-Xiang Li Wen-Ping Wu Xin-Chun yang Yu-dong Wei Na Li Sha Peng Xue-Ling Li Guang-Peng Li Jin-Lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Center of Reproductive Medicine Amsterdam Research Institute Reproduction and DevelopmentAcademic Medical CenterUniversity of Amsterdam 1105AZAmsterdamNetherlands Key Laboratory for Mammalian Reproductive Biology and Biotechnology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia 010021China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Bacterial or viral infections,such as Brucella,mumps virus,herpes simplex virus,and Zika virus,destroy immune homeostasis of the testes,leading to spermatogenesis disorder and *** note,recent research shows that SARS-CoV-2 can infect male gonads and destroy Sertoli and Leydig cells,leading to male reproductive *** to the many side effects associated with antibiotic therapy,finding alternative treatments for inflammatory injury remains ***,we found that Dmrt1 plays an important role in regulating testicular immune *** of Dmrt1 in male mice inhibited spermatogenesis with a broad inflammatory response in seminiferous tubules and led to the loss of spermatogenic epithelial *** immunoprecipitation sequencing(ChIP-seq)and RNA sequencing(RNA-seq)revealed that Dmrt1 positively regulated the expression of Spry1,an inhibitory protein of the receptor tyrosine kinase(RTK)signaling ***,immunoprecipitation-mass spectrometry(IP-MS)and co-immunoprecipitation(Co-IP)analysis indicated that SPRY1 binds to nuclear factor kappa B1(NF-κB1)to prevent nuclear translocation of p65,inhibit activation of NF-κB signaling,prevent excessive inflammatory reaction in the testis,and protect the integrity of the blood-testis *** view of this newly identified Dmrt1-Spry1-NF-κB axis mechanism in the regulation of testicular immune homeostasis,our study opens new avenues for the prevention and treatment of male reproductive diseases in humans and livestock.

关键词： Dmrt1 Spermatogenesis Orchitis Spry1 NF-κB