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World Journal of Clinical Cases 2024年第36期12卷 6935-6938页

作者： dong-hua liu Xiao-Ming dong Wen-Jie Long The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Geriatrics The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

Coronary heart disease and type 2 diabetes mellitus(T2DM)often co-occur,presenting substantial health risks,particularly following acute myocardial infarction(AMI).While percutaneous coronary intervention(PCI)is a prevalent treatment,complications such as microvascular dysfunction may lead to heart failure,necessitating additional *** editorial examines the emerging roles of sacubitril/valsartan and sodium-glucose co-transporter 2 inhibitors in managing *** research investigates the combined effects of dapag-liflozin and telmisartan on myocardial microperfusion in post-AMI heart failure patients with *** findings suggest that this combination enhances myo-cardial microcirculation,improves cardiac function,and achieves better glycemic control,with a reduced incidence of major adverse cardiovascular *** ongoing challenges,the integration of dapagliflozin and sacubitril/valsartan re-presents a significant advancement in post-AMI *** investigation in larger cohorts and more diverse patient populations is required to confirm its long-term clinical outcomes.

关键词： Heart failure Type 2 diabetes mellitus Dapagliflozin Sacubitril Cardiovascular outcomes

Molecular mechanism of Mimenghua Granules in treating dry eye

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Medical Data Mining 2021年第4期4卷 33-41页

作者： dong-hua liu Peng-Fei Jiang Pei liu Chen Ou Jun Peng Hou-Pan Song Qing-hua Peng Hunan University of Chinese Medicine Changsha 410208China First Affiliated Hospital of Hunan University of Chinese Medicine Changsha 410007China

Objective:To explore the molecular mechanism of Mimenghua Granules in treating dry eye based on network pharmacology and bioinformatics ***:Screening and prediction of possible blood-inducing active ingredients and action target of Mimenghua Granules through Traditional Chinese Medicine Systems Pharmacology database and analysis platform;mining dry eye-related diseases through disease gene database,gene target;use the functional protein combined network database STRING to draw the component-target and disease-target PPI networks,and extract the intersection of these two networks;use DAVID database analysis to screen key targets and analyze the mechanism of ***:A total of 593 active ingredients related to Mimenghua Granules were retrieved from the Traditional Chinese Medicine Systems Pharmacology database,and 59 blood active ingredients were obtained by screening based on pharmacokinetic parameters,and 680 targets related to these ingredients were retrieved;from disease genes,the database searches for 47 genes directly related to dry eye;3 key genes(ICAM1,IFNG,and IL-6)were obtained after the intersection of the component target and disease target PPI network;these genes are mainly involved in natural killer cell-mediated cytotoxicity,Jak-STAT signaling pathway,and Cytokine-cytokine receptor ***:The mechanism of Mimenghua Granules in treating dry eye is related to the interaction of cytotoxic pathway,Jak-STAT signal pathway,and *** key gene targets are ICAM1,IFNG,and IL-6.

关键词： Mimenghua Granules Buddlejae Flos Lycii Fructus Chrysanthemi Flos Dry eye Network pharmacology Bioinformatics

Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction

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Chinese Medical Journal 2009年第15期122卷 1738-1742页

作者： LI dong-bao hua Qi liu Zhi LI Jing XU Li-qing WANG Shan JIN Wei-ying Department of Cardiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Background Inflammatory mechanisms had played an important role in the occurrence and prognosis of acute myocardial infarction, inflammatory mediators was associated with adverse outcomes of acute myocardial infarction. This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, neutrophil count and high-sensitivity C-reactive protein are predictive of angiographic morphologic features that indicate thrombus formation in the infarct-related artery. Methods This retrospective study included 182 consecutive patients with acute myocardial infarction and ST-segment elevation. Patients were assigned to a thrombus-formation group （n=77） and a non-thrombus-formation group （n=-106）. All patients had a Killip＇s classification 〈3 and onset 〈12 hours prior to presentation. All the cases were going to undergo coronary angiography, including primary percutaneous coronary intervention, simple coronary angiography, or thrombolysis in a coronary artery （or arteries） or coronary artery bypass graft（s）. Blood samples for measurement of high-sensitivity C-reactive protein and for routine blood laboratory studies were collected prior to coronary angiography. Results The levels of high-sensitivity C-reactive protein, total leukocyte counts, neutrophil counts, and neutrophil/ lymphocyte ratios were substantially higher in the thrombus-formation group than in the non-thrombus-formation group patients （for each, P 〈0.05）. Stepwise Logistic regression analyses identified high-sensitivity C-reactive protein, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery （for each, P 〈0.05）. Conclusions In patients with acute myocardial infarction levels of high-sensitivity C-reactive protein are predictors to higher neutrophil counts, neutrophil/lymphocyte ratio, and ndicate thrombus formation

关键词： acute myocardial infarction thrombosis neutrophil percutaneous coronary intervention C-reactive protein

Upregulation of 14-3-3γ is induced by a synergistic effect of multiple factors during ischemia in astrocytes

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Upregulation of 14-3-3γ is induced by a synergistic effect ...

Research on variable camber wing driven bv ultrasonic motors

中国神经科学学会第十届全国学术会议

作者： Ymg PANG Yan dong hua-dong liu Ann Yuen Kwan WONG Greg VATCHER Xiao-Qian CHEN Jian-Guo CHEN Albert Cheung Hoi YU Neuroscience Research Institute Department of Neurobiology Key Laboratory for Neuroscience (Peking University) Ministry of Education Key Laboratory for Neuroscience (Peking University) Ministry of Public Health Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Department of Pathophysiology the Key Laboratory of Neurological Diseases the Ministry of Education and Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Department of Cell Biology and Genetics College of Life Sciences Peking University Key Laboratory for Cell Proliferation and Differentiation Ministry of Education State Key Laboratory for Bio-membrane and Membrane Bio-engineering Laboratory ofTranslattonal Medicine Institute of Systems Biomedicine Peking University

14-3-3γ is a multifunctional acidic protein that is induced by ischemia in neural cells,including astrocytes,and has a neuroprotective *** ischemia,a lack of oxygen（hypoxia） and glucose,and an accumulation of toxins,*** order to elucidate which ischemia components caused the damage to astrocytes and the induction of the protective protein 14-3-3γ,we examined the effects of hypoxia,glucose deprivation,and the accumulation of toxins,separately,and compared the degree of damage to ischemia *** caused a rapid upregulation of 14-3-3γthat occurred within 1 to 4 *** alone elevated 14-3-3γ expression,while glucose deprivation did not cause a detectable change in the 14-3-3γ mRNA and protein *** changes of toxic metabolites barely affected14-3-3γ gene and protein expression in the time course *** addition,comparing the activation of the ERK1/2,Akt,P38 and JNK signaling pathways under ischemia and hypoxia in astrocytes revealed mat ischemia activated all four pathways,while hypoxia had little effect on any of *** also observed how glutamate（Glu） and arachidonic acid（AA）,the main toxic substances released by neural cells during ischemia injury,affected the expression of the14-3-3 protein *** all members of the 14-3-3 family,β and γ were up-regulated rapidly after 3 hr of treatment with G1u or AA,while η and ε increased until 6 hr and ζ increased after *** results demonstrated that the three components of ischemia played diverse roles in the regulation of 14-3-3Y) that different isoforms of the 14-3-3family showed disparate responses to Glu and AA treatments,and that the JNK/c-Jun/AP-1 signaling pathway was involved in 14-3-3γ up-regulation.

关键词： 14-3-3γ hypoxia ischemia glutamate arachidonic acid

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Research on variable camber wing driven bv ultrasonic motors

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

2011年全国压电和声波理论及器件应用研讨会

作者： Wei-dong liu hua ZHU~* State Key Laboratory of Mechanics and Control for Mechanical Structures,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,CHINA

＜正＞Taking the Advantages of ultrasonic motors such as high torque,small size,light weight,self-locking and rapid response,a kind of variable camber wing driven by ultrasonic motors is designed in this *** morphing wing is suitable for small UAV of low Mach number because it is able to obtain a good aerodynamic efficiency. Parallelogram linkage driven by ultrasonic motor is designed and applied to the variable camber wing to drive the trailing *** layout of the mechanism is adopted and continuous deformations can be produced,so

关键词： Variable camber wing Ultrasonic motor aerodynamic efficiency morph

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe Zhao Peng liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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High-resolution imaging through dynamic scattering media: Iterative optimization based on polarimetric characteristics

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Science China Technological Sciences 2025年第1期 82-84页

作者： Meng XIANG Kai DENG Tianyu WANG Jinpeng liu Xue dong Teli XI Fei liu Xiaopeng SHAO School of Optoelectronic Engineering Xidian University Xi'an Key Laboratory of Computational Imaging National Key Laboratory of Infrared Detection Technologies

High-resolution imaging through randomly dynamic scattered fields and highly scattered walls is an extensively sought-after capability with potential applications in various fields such as underwater imaging, biomedical imaging, and seeing through fog. Numerous methods have been proposed to unscramble object information from degraded scattered images, resulting in considerable improvements in image contrast in degraded scenarios [1].

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-Lan Xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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六旋翼无人机的飞行力学建模研究

飞行力学 2016年第6期34卷 10-14页

作者：辛冀董圣华刘毅陈仁良中航工业直升机设计研究所总体气动室江西景德镇333001 南京航空航天大学航空宇航学院江苏南京210016

为开展六旋翼无人机的全机飞行力学建模研究,针对六旋翼无人机的前飞和非定常飞行要求,引入了动量叶素理论和动态入流理论对旋翼气动力进行分析。根据无人机的变转速控制方式,增加了旋翼转速变化对机身运动的影响项,推导了使六旋翼总需... 详细信息

为开展六旋翼无人机的全机飞行力学建模研究,针对六旋翼无人机的前飞和非定常飞行要求,引入了动量叶素理论和动态入流理论对旋翼气动力进行分析。根据无人机的变转速控制方式,增加了旋翼转速变化对机身运动的影响项,推导了使六旋翼总需用功率最小的拉力分配优化方法,建立了六旋翼无人机的飞行力学模型。气动力计算结果表明,新建立的旋翼气动力计算方法精度高于现有的比例系数法。

关键词：六旋翼无人机飞行力学模型飞行模态

对全国女子排球联赛部分中、小城市主场现场观众的调查

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体育科学 2004年第11期24卷 17-18页

作者：屈东华刘红史友宽河南大学体育学院河南开封475001

采用问卷调查、专家访谈和数理统计等研究方法 ,对 2 0 0 3年全国女排联赛河南、湖南、江苏主场现场观众进行了调查。结果表明 ,男性观众明显多于女性 ;观众学历层次较高 ;观众人数随年龄增大依次递减 ;学生、工人、干部和教师占据观众... 详细信息

采用问卷调查、专家访谈和数理统计等研究方法 ,对 2 0 0 3年全国女排联赛河南、湖南、江苏主场现场观众进行了调查。结果表明 ,男性观众明显多于女性 ;观众学历层次较高 ;观众人数随年龄增大依次递减 ;学生、工人、干部和教师占据观众群的绝大部分 ;个人购票的观众相对较少 ;促使观众到现场观看比赛的最主要的原因是“家乡荣誉感驱使”。

关键词：排球女子联赛主场调研中国