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Chinese Journal of Chemistry 2021年第11期39卷 2973-2982页

作者： Jiang-Chun Wei Yu-Ning Gao dong-dong wang Xiao-Yu Zhang San-Peng Fan Te-Ri-Gen Bao Xiao-Xu Gao Gao-Sheng Hu An-Hua wang Jing-Ming Jia School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning110016 China

Four previously undescribed ent-abietane diterpenoids(1—4),along with eleven known analogues(5—15),were isolated from the roots of wild Euphorbia *** gross structures were determined via extensive spectroscopic data,and the absolute configurations were elucidated by means of single-crystal X-ray diffraction analysis,Rh2(OCOCF3)4-induced CD spectrum and ECD *** cervical carcinoma inhibition activities counteract HeLa cells were screened by MTT assay,and the structure-activity relationships were further *** results demonstrated that 2(IC50 value at 3.75μmol/L)was more potent than *** underlying mechanism study revealed that 2 could distinctly induce apoptosis accompanied by increasing reactive oxygen species(ROS)production,Ca^(2+)influx and decreasing mitochondrial membrane ***,signal pathways including MAPKs/AKT might play a significant role in 2-induced cervical cancer cells death.

关键词： Euphorbia fischeriana Diterpenoids Structure elucidation Biological activity Anti-tumor

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

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Neural Regeneration Research 2022年第10期17卷 2293-2299页

作者： Meng-Yu Lai Jie Li Xi-Xi Zhang Wei Wu Zhi-Ping Li Zhi-Xin Sun Meng-Yang Zhao dong-Ming Yang dong-dong wang Wen Li De-Ming Zhao Xiang-Mei Zhou Li-Feng Yang National Animal Transmissible Spongiform Encephalopathy Laboratory College of Veterinary MedicineChina Agricultural UniversityBeijingChina

Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss,axonal degeneration,and mitochondrial *** degeneration is an early hallmark of neurodegeneration and is triggered by *** found that depletion or dysfunctional mutation of SARM1 protected against NAD+loss,axonal degeneration,and mitochondrial functional disorder induced by the neurotoxic peptide ***+supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective ***+supplementation in PrP106-126-incubated N2a cells,SARM1 depletion,and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell *** results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP^(106-126) are partially dependent on SARM1 NADase *** pathway has potential as a therapeutic target in the early stages of prion disease.

关键词： axonal degeneration mitochondrial dysfunction NAD+metabolism NADase neurodegenerative disease prion disease SARM1 sterile alpha and TIR motif-containing 1

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan dong Wenzheng An Zihu wang dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： wang Shuang MU Lin LI Xue XIE Jun dong Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer

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World Journal of Gastroenterology 2001年第4期7卷 522-526页

作者： Dian-Chun Fang Shi-Ming Yang Xiao-dong Zhou dong-Xu wang Yuan-Hui Luo Department of Gastroenterology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China Southwest Hospital Third Military Medical University Chongqing 400038China. fangdianchun@***

AIM: To correlate the length of the telomere to microsatellite instability (MSI) and loss of heterozygosity (LOH) of APC, MCC and DCC genes in gastric carcinomas. METHODS: Telomeric restriction fragment (TRF) length of gastric cancer was measured with Southern blot. LOH of APC, MCC and DCC genes, microsatellite instability (MSI) and frameshift mutation of hMSH6, TGF-betaRII and BAX genes were analyzed by PCR-based methods. RESULTS: Sixty-eight cases of sporadic gastric carcinoma were studied for MSI using five microsatellite markers. MSI in at least one locus was detected in 17 (25%) of 68 tumors analyzed. Frameshift mutations of hMSH6, TGF-betaRII and BAX were detected in 2,6 and 3 of gastric carcinomas respectively showing high MSI (> or = 2 loci, n = 8), but none was found in those showing low MSI (only one locus, n = 9) or MSS (tumor lacking MSI or stable, n = 51). Thirty-five cases, including all high MSI and low MSI, were studied for TRF. The mean TRF length was not correlated with clinicopathological parameters. No association was observed between TRF length and MSI or frameshift mutation. On the contrary, LOH at the DCC locus was related to telomere shortening (P<0.01). This tendency was also observed in APC and MCC genes, although there was no statistical significance. CONCLUSION: The development of gastric cancer can arise through two different genetic pathways. In high MSI gastric cancers, defective mismatch repair allows mutations to accumulate and generate the high MSI phenotype. In gastric cancers showing either low MSI or MSS, multiple deletions may represent the LOH pathway. Telomere erosion is independent of high MSI phenotype but related to the LOH pathway in gastric cancer.

关键词： Adult Aged DNA, Neoplasm Female Frameshift Mutation Humans Loss of Heterozygosity Male Microsatellite Repeats Middle Aged Research Support, Non-U.S. Gov't Stomach Neoplasms Telomere

Follistatin Like 5 ( FSTL5) inhibits epithelial to mesenchymal transition in hepatocellular carcinoma

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Chinese Medical Journal 2020年第15期133卷 1798-1804页

作者： Deng-Yong Zhang Jia-Sheng Lei Wan-Liang Sun dong-dong wang Zheng Lu Department of General Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233000China

Background:Epithelial to mesenchymal transition(EMT)is a key process in determining distant metastasis and intra-hepatic dissemination of hepatocellular carcinoma(HCC).Follistatin(FST)family members are considered to be an attractive therapeutic targets and prognostic indicators in *** a derivative of FST,Follistatin Like 5(FSTL5)may play a similar role in HCC *** study aimed to investigate the expression and function of FSTL5 in HCC and its role in ***:FSTL5,E-cadherin and vimentin in HCC,and paracancerous tissues were detected by *** of FSTL5 expression with overall survival was *** proliferation and invasion of HCC cell lines SK-Hep1 and MHCC-LM3 were analyzed by cell counting kit-8 and Transwell *** expression of FSTL5,E-cadherin,and vimentin in HCC cells was examined by polymerase chain reaction and Western blot analysis.T-test was used to analyze the difference in proliferation and invasion ability between *** Spearman rank correlation test was used to detect the correlation between the expression of FSTL5 and E-cadherin or ***:The expression of FSTL5 in HCC was lower than that in paracancerous tissues(9.97%vs.82.55%,χ2=340.15,P<0.001).Patients with high FSTL5 expression had a better prognosis(χ2=8.22,P=0.004)and smaller tumor diameter(χ2=45.52,P<0.001),less lymph node metastasis(χ2=5.58,P=0.02),earlier tumor node metastasis stage(χ2=11.29,P=0.001),a reduced number of tumors(χ2=5.05,P=0.02),lower alpha-fetoprotein value(χ2=24.36,P<0.001),more probability of hepatitis carrying(χ2=40.9,P<0.001),and better liver function grade(χ2=5.21,P=0.02).Immunohistochemistry showed that FSTL5 expression in HCC tissues was positively correlated with E-cadherin expression(r=0.38,P<0.001)and negatively correlated with vimentin expression(r=-0.385,P<0.001).Furthermore,over-expression of FSTL5 up-regulated the expression of E-cadherin and down-regulated the expression of vimentin in SK-Hep1(neg

关键词： Hepatocellular carcinoma Follistatin-related protein Epithelial to mesenchymal transition Prognosis Disease-free survival

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang dong Liang Lei Yang Zegao wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Choroid Plexus Papilloma of the Fourth Ventricle Developing Postoperative Intracranial and Rectal Hemorrhage Three Times： A Case Report

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Clinical oncology and cancer researeh 2010年第1期7卷 60-63页

作者： Heng-zhu ZHANG Lei SHE Lin YANG Xian ZHANG Lun dong Xiao-dong wang Lin-hai SHEN Jian LI Department of Neurosurgery Clinical MedicalCollege of Yangzhou University Yangzhou225001 Jiangsu Province China.

Introduction Choroid plexus papilloma （CPP） is a relatively rare, slow-growing benign tumor （WHO level I）. Recently, an adult patient with fourth ventricle choroid plexus papilloma received surgery via a suboc- cipital midline approach in our hospital. It has been rare in clinical practice to see postoperative hemorrhage occurring in the same patient 3 times. The causes of the hemorrhage were analyzed based on literature regarding postoperative hemorrhage in choroid plexus papilloma and in intracranial tumors. The case involved in our study is described and detailed in the following.

关键词： choroid plexus papilloma antineoplasticprotocols operative complications.

Remedial dosing recommendations for sirolimus delayed or missed dosages caused by poor medication compliance in pediatric tuberous sclerosis complex patients

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Remedial dosing recommendations for sirolimus delayed or mis...

Drug-drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics

2023年度全国临床药理学学术论坛

作者： Xiao Chen dong-dong wang School of Nursing Xuzhou Medical University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy & School of Pharmacy Xuzhou Medical University

Background:Delayed or missed dosages caused by poor medication compliance significantly affect the treatment of diseases in *** present study aimed to investigate the influence of delayed or missed dosages on sirolimus pharmacokinetics(PK) in pediatric tuberous sclerosis complex(TSC) patients and to recommend remedial dosages for nonadherent ***:Sirolimus population PK model in pediatric TSC patients was used for assessing the influence from different nonadherence scenarios and recommending optimally remedial dosages based on Monte Carlo *** nonadherent scenarios were simulated in this study including delayed 2h,4h,6h,8h,10h,12h,14h,16h,18h,20h,22h,23.5h and missed one *** dosing strategies contained 10%-200% of scheduled ***:The optimally remedial dosage was that with the maximum probability to return the individual therapeutic *** delayed or missed sirolimus dosages in pediatric TSC patients,when the delayed time were 0-8h,8-10h,10-18h,18-22.7h,22.7-24h,70%,60%,40%,30%,20% scheduled dosages were recommended to take *** one dosage was missed,120% scheduled dosages were recommended at the next ***:It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation,meanwhile the present study provided a potential solution for delayed or missed dosages in clinical practice.

关键词： remedial dosing recommendations sirolimus delayed or missed dosages poor medication compliance pediatric tuberous sclerosis complex

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Drug-drug interaction and initial dosage optimization of ari...