检索结果-南通市图书馆

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian zhou zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Exploring the Linear and Nonlinear Causality Between Internet Big Data and Stock Markets

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2020年第3期33卷 783-798页

作者： dong Jichang dai Wei LI Jingjing School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Economics and Management Beihang UniversityBeijing 100191China

In the era of big data,stock markets are closely connected with Internet big data from diverse *** paper makes the first attempt to compare the linkage between stock markets and various Internet big data collected from search engines,public media and social *** achieve this purpose,a big data-based causality testing framework is proposed with three steps,i.e.,data crawling,data mining and causality *** the Shanghai Stock Exchange and Shenzhen Stock Exchange as targets for stock markets,web search data,news,and microblogs as samples of Internet big data,some interesting findings can be obtained.1)There is a strong bi-directional,linear and nonlinear Granger causality between stock markets and investors'web search behaviors due to some similar trends and uncertain factors.2)News sentiments from public media have Granger causality with stock markets in a bi-directional linear way,while microblog sentiments from social media have Granger causality with stock markets in a unidirectional linear way,running from stock markets to microblog sentiments.3)News sentiments can explain the changes in stock markets better than microblog sentiments due to their *** results of this paper might provide some valuable information for both stock market investors and modelers.

关键词： Granger causality test internet big data investors'sentiment stock markets web search behavior

Excitation Wavelength Dependence of Photocatalyzed Oxidation of Methanol on TiO2(110)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2015年第4期28卷 -页

作者： Zhi-qiang Wang Qun-qing Hao Chuan-yao zhou dong-xu dai Xue-ming Yang State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Science Dalian 116023 China

Post-irradiation temperature-programmed desorption (TPD) has been used to study the photocatalyzed oxidation of methanol on TiO2(110) surface under the irradiation of 360, 380 and 400 nm light. The photocatalytic process initiated by ultraviolet light of different wavelength are similar. Methanol has been photocatalytically converted into formaldehyde, and the released hydrogen atoms transfer to the neighboring twofold coordinated oxygen to form bridging hydroxyls. The reaction rate, however, is strongly wavelength dependent. The reaction rate under 360 nm light irradiation is 4.8 times of that in the case of 400 nm exposure, consistent with a previous femtosecond time-resolved absorption measurement on TiO2 which shows the faster charge carrier recombination in the near-band-gap than the over-band-gap excitation. So far, the underlying factors which govern the excitation wavelength dependence of photocatalytic activity of TiO2 and other photocatalysts remain unclear, and future studies are needed to address this important issue.

关键词： Titanium dioxide Photocatalysis Excitation wavelength dependence Temperature-programmed desorption

Research on Alliance Decision of Dual-Channel Remanufacturing Supply Chain Considering Bidirectional Free-Riding and Cost-Sharing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第9期140卷 2913-2956页

作者： Lina dong Yeming dai School of Business Qingdao UniversityQingdaoChina

This study delves into the formation dynamics of alliances within a closed-loop supply chain(CLSC)that encom-passes a manufacturer,a retailer,and an e-commerce *** leverages Stackelberg game for this exploration,contrasting the equilibrium outcomes of a non-alliance model with those of three differentiated alliance *** non-alliance model acts as a crucial benchmark,enabling the evaluation of the motivations for various supply chain entities to engage in alliance *** analysis is centered on identifying the most effective alliance strategies and establishing a coordination within these *** thoroughly investigate the consequences of diverse alliance behaviors,bidirectional free-riding and cost-sharing,and the resultant effects on the optimal decision-making among supply chain *** findings underscore several pivotal insights:(1)The behavior of alliances within the supply chain exerts variable impacts on the optimal pricing and demand of its *** comparison to the non-alliance(D)model,the manufacturer-retailer(MR)and manufacturer-e-commerce platform(ME)alliances significantly lower both offline and online resale prices for new and remanufactured *** adjustment leads to an enhanced demand for products via the MR alliance’s offline outlets and the ME alliance’s online platforms,thereby augmenting the profits for those within the ***,retailer-e-commerce platform(ER)alliance tends to increase the optimal retail price and demand across both online and offline *** specific conditions,alliance behavior can also increase the profits of non-alliance members,and the profits derived through alliance channels also exceed those from non-alliance channels.(2)The prevalence of bidirectional free-riding behavior largely remains constant across different alliance *** these models,bidirectional free-riding typically elevates the equilibrium prices in offline channel while negatively affe

关键词： Dual-channel remanufacturing supply chain alliance remanufactured products bidirectional free-riding cost-sharing

Correction to“Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer”

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第25期28卷 3004-3005页

作者： Shuai Shao Nuo-Ming zhou dong-Qiu dai Department of Gastroenterological Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina

We have replaced the misapplied images and the revised Figure 6C is provided.

关键词： Correction

Species composition and minimum sampling area of a riparian mixed broadleaved-Korean pine forest in Changbai Mountain Nature Reserve

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2011年第3期22卷 471-474页

作者： dai Fang-zhou XU dong DENG Hong-bing Institute of Urban Environment Chinese Academy of Sciences Xia- men 361021 China Graduate University of the Chinese Academy ofSciences Beijing 100049 China Shenyang Normal University Shen-yang 110036 China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Science Beijing 100085 China）. Phone：＋86 10 62849112

Riparian areas are unique although often small component of the overall watershed landscape. The structure of riparian forests along Erdaobai River on the north slope of Changbai Mountain were investigated by using field data collected from eight sampling transects perpendicular to the Erdaobai River channel. Two kinds of species-area saturation curves were used to examine the relationship between species number and minimum sampling area. The results showed that riparian gymnosperms accounted for a high proportion of all gymnosperms in the Changbai Mountain Nature Reserve while riparian ferns and angiosperms accounted for a relatively low proportion. The average minimum sampling areas of riparian forest that included 60%, 80%, and 90% of the community species pool were about 85, 185, and 328 m 2 , respectively; while those for nonriparian forest were about 275, 390, and 514 m 2 , correspondingly.

关键词： mixed broadleaved-Korean pine forest minimum sampling area ecosystem management Changbai Mountain

Regulating the formation ability and mechanical properties of high-entropy transition metal carbides by carbon stoichiometry

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第26期121卷 181-189页

作者： Juntao Song Guiqing Chen Huimin Xiang Fuzhi dai Shun dong Wenbo Han Xinghong Zhang Yanchun zhou Science and Technology on Advanced Composite in Special Environments Laboratory Harbin Institute of TechnologyHarbin150080China Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyBeijing100076China

Tremendous efforts have been dedicated to promote the formation ability of high-entropy transition metal ***,the majority of methods for the synthesis of high-entropy transition metal carbides still face the challenges of high temperature,low efficiency,additional longtime post-treatment and uncontrollable *** cope with these challenges,high-entropy transition metal carbides with regulatable carbon stoichiometry(HE TMC)were designed and synthesized,achieving improved ability for single phase solid solutions formation,promoting of sintering and controllable mechanical *** typical composition series,i.e.,easily synthesized(ZrHfTaNb)C(ZHTNC)and difficultly synthesized(Zr_(0.25)Hf_(0.25)Ta_(0.25)Ti_(0.25))C(ZHTTC)are selected to demonstrate the promoting formation ability of single phase solid solutions from carbon stoichiometry *** phase high-entropy ZHTTC,which has been proven difficult in forming a single phase solid solution,can be prepared with the decrease of C/TM ratio under 2000℃;while the high-entropy ZHTNC,which has been proven easy in forming a single phase solid solution,can be synthesized at lower temperatures with the decrease of C/TM *** synergistic effect of entropy stabilization and reduced chemical bond strength gaining from carbon stoichiometry deviations is responsible for the formation of single phase solid solutions and the promoted sintering of HE *** example,the relative density of bulk(ZrHfTaNb)C(SPS-ZHTNC)increases from 90.98%to 94.25%with decreasing the C/TM atomic ratio from 0.9 to *** importantly,the room temperature flexural strength,fracture toughness and brittleness index of SPS-ZHTNCcan be tuned in the range of 384 MPa–419 MPa,4.41 MPam–4.73 MPamand 3.679μm–4.083μm,***,the HE TMCprepared by adjusting the ratio of carbon to refractory transition metal oxides have great potential for achieving low temperature synthesis,promoted sintering and tunable properties.

关键词： Carbon stoichiometry High-entropy ceramics Transition metal carbide Low temperature synthesis Tunable mechanical properties

A distribution prior model for airplane segmentation without exact template

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2020年第1期31卷 56-63页

作者： dai Ming zhou Zhiheng GUO Yongfan School of Electronics and Information Engineering South China University of Technology

In many practical applications of image segmentation problems,employing prior information can greatly improve segmentation *** paper continues to study one kind of prior information,called prior *** this research,there is no exact template of the object;instead only several samples are *** proposed method,called the parametric distribution prior model,extends our previous model by adding the training procedure to learn the prior distribution of the *** this paper establishes the energy function of the active contour model(ACM)with consideration of this parametric form of prior ***,during the process of segmenting,the template can update itself while the contour *** are performed on the airplane data *** results demonstrate the potential of the proposed method that with the information of prior distribution,the segmentation effect and speed can be both improved efficaciously.

关键词： image segmentation active contour model(ACM) prior distribution level set method

Secrets of high thermal emission of transition metal disilicides TMSi_(2)(TM=Ta,Mo)

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第30期89卷 114-121页

作者： Huimin Xiang Fuzhi dai Yanchun zhou Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials and Processing TechnologyBeijing 100076China

TMSi_(2)(TM=Ta,Mo)are extensively used as thermal emissivity agents in high emission coatings due to their well-known"high"emissivity in infrared ***,there is a paucity of the high temperature(HT)emissivity property of these two ***,room temperature(RT)spectrometer measurements have demonstrated that the emittance in infrared range of two silicides was considerably ***,providing critical HT data and satisfactory elucidation on the emission incompatibility of TMSi_(2)is eagerly *** this contribution,combining first principles calculations and Drude model,the reflectance spectra of TMSi_(2)were predicted at both RT and *** with spectrometer measurements,the intrinsic emittance of silicides was relatively low in the entire investigated *** explain the incompatible emission behavior,two simplified models including the majority of high emissivity coating,SiO_(2),were ***,with SiO_(2)considered in simulations,no matter covered on the surface or blended in the composites,the emittance of the TMSi_(2)enhanced *** theoretical results demonstrate the non-negligible significance of oxides on the high temperature performance of silicides and provide the guidelines for improving the emission performance of silicides and searching for potential high emissivity agents.

关键词： Disilicide Optical properties Thermal emission First-principles calculations Drude model