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Single-Molecule Protein Fingerprinting with Photonic Hexagonal Boron Nitride Nanopores

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Accounts of Materials Research 2023年第4期4卷 307-310页

作者： dong hoon shin Xiliang Yang Sabina Caneva Department of Precision and Microsystems Engineering Delft University of Technology2628 CD DelftThe Netherlands

Reading biomolecular signatures and understanding their role in health and disease is one of the greatest scientific challenges in modern *** this information is not only foundational for biology but also a cornerstone for next generation molecular *** calls for novel methods that can capture the presence and identity of low-abundance compounds at the individual molecule *** its inception in the 1980s,nanopore sequencing has become an essential part of the single-molecule sensing toolkit,proving that long,labelfree reads of DNA can be achieved at low cost and high throughput.1 Despite their huge success in genome sequencing,reading the linear sequence of proteins is a considerably more complex task that requires differentiating 20 different amino acids(as opposed to the 4 DNA bases),as well as their modifications,during real-time *** the time-dependent electrical current traces to determine entire amino acid sequences over long reads is as yet an unaccomplished milestone.

关键词： corners pores bases

Induction of vascular endothelial growth factor receptor expression in human umbilical vein endothelial cells after repeated bevacizumab treatment in vitro

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1064-1068页

作者： Ji Eun Lee Jin Young Kim Jae Ho Jung dong hoon shin Sung Who Park Department of Ophthalmology School of MedicinePusan National University Medical Research Institute Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Pathology School of MedicinePusan National University

AIM： To investigate the mechanism underlying the loss of responsiveness to anti-vascular endothelial growth factor（VEGF） treatment after repeated injections for choroidal neovascularization, VEGF and VEGF receptor（VEGFR） expressions were evaluated following repeated bevacizumab treatments in hypoxic human umbilical vein endothelial cells（HUVECs） in ***： HUVECs were incubated under hypoxic conditions in two media of different bevacizumab concentrations（1.0 or 2.5 mg/m L） for 17 h, and then in a new medium without bevacizumab for 7h. This procedure was repeated twice more. A culture with an identical volume of excipients served as the control. Cytotoxicity and cell proliferation were assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and Ki-67 assays, respectively. Levels of VEGF and VEGFR were assessed using enzyme-linked immunosorbent assay and Western blot ***： Cytotoxic effects were not reported for either bevacizumab concentration. Cell proliferation was not reduced after anti-VEGF treatments. VEGF level after single treatment was significantly higher than that of the control and after repeated treatments. Phosphorylated VEGFR-2 expression increased significantly after singleand repeated bevacizumab treatments compared with the control. The 1.0 mg/m L bevacizumab induced significantly higher expressions of VEGFR-2 than the 2.5 mg/m L in single and repeated treatment ***： Bevacizumab treatment of HUVECs elevated VEGFR expression in both single and repeated treatments, indicating a mechanism for the reduced efficacy of anti-VEGF therapy in ocular neovascular disorders.

关键词： vascular endothelial growth factor vascular endothelial growth factor receptor choroidal neovascularization bevacizumab repeated treatments

Enhancement of mechanical and tribological performance of Ti-6Al-4V alloy by laser surface alloying with Inconel 625 and SiC precursor materials

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Friction 2024年第9期12卷 2089-2107页

作者： Hao-Ran CHENG Ki-hoon shin Hong Seok KIM Department of Mechanical Engineering Graduate School of Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

This study focused on producing metal matrix composite(MMC)coatings on Ti–6Al–4V alloy through laser surface alloying using a novel combination of Inconel 625 and SiC precursor *** ratios of alloying powders were examined to evaluate surface properties such as microhardness,wear resistance,and friction coefficient,along with analyzing the phase composition and microstructure of the *** in situ synthesized MMC coatings exhibited the presence ofα-Ti,NiTi,NiTi_(2),and TiC ***,Ti_(5)Si_(3)andα-Ti/Ti_(5)Si_(3)eutectic structures were observed when the SiC content exceeded 20%.In comparison to the titanium substrate,the MMC coating significantly enhanced microhardness by over threefold and reduced wear by 95%.However,it was crucial to carefully select the appropriate combination of alloying powders to avoid a substantial decrease in friction performance and excessive formation of *** a comparative analysis of experimental results,the optimal precursor material composition was identified as 85%Inconel 625 and 15%*** study demonstrated the effective utilization of Inconel 625 and SiC alloying materials to enhance the surface properties of titanium alloys,thereby expanding their application in challenging environments.

关键词： titanium alloy Inconel 625 SiC ceramic laser surface alloying metal matrix composite(MMC)

Rosai-Dorfman disease in the spleen of a pediatric patient:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6032-6040页

作者： Hwaseong Ryu Jae-Yeon Hwang Yong-Woo Kim Tae-Un Kim Joo-Yeon Jang Su-Eun Park Eu-Jeen Yang dong-hoon shin Department of Radiology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Pediatrics Pusan National University Children’s HospitalYangsan 50612South Korea Department of Pathology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND Rosai–Dorfman disease(RDD)is a rare histiocytic proliferation of unknown etiology commonly found in children and *** common manifestation of RDD is massive and painless bilateral cervical lymphadenopathy with extranodal *** extranodal involvement in RDD is common,the spleen is an infrequent site of *** SUMMARY We report a 10-mo-old female infant with RDD presenting multiple splenic masses without cervical *** had fever,and blood tests showed leukocytosis,anemia,and elevated erythrocyte sedimentation rate and Creactive ***,computed tomography,and magnetic resonance images demonstrated multiple splenic *** antibiotic therapy,her symptoms were not *** underwent diagnostic splenectomy and was discharged with *** In pediatric patients with refractory infectious symptoms or hematological abnormalities,clinicians should suspect RDD,even in patients without significant lymphadenopathy.

关键词： Rosai–Dorfman disease Sinus histiocytosis with massive lymphadenopathy Ultrasonography Computed tomography Magnetic resonance imaging Case report

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim dong hoon shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

4-1BB-4-1BBL cis-interaction contributes to the survival of selfreactive CD8^(+)T cell

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Cellular & Molecular Immunology 2023年第9期20卷 1077-1080页

作者： Eunjung Cho Rohit Singh Chungyong Han Seon-Hee Kim Kwang H.Kim Bo-Mi Park dong hoon shin Seongeun Han Young H.Kim Byoung S.Kwon Ki Taek Nam Beom K.Choi Immuno-oncology Branch Division of Rare and Refractory CancerNational Cancer CenterGoyang 10408Republic of Korea Severance Biomedical Science Institute Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulRepublic of Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408Republic of Korea Department of Biomedical Laboratory Science Catholic Kwandong UniversityGangneung 25601Republic of Korea Biomedicine Production Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea Anticancer Resistance Branch Division of Rare and Refractory CancerResearch InstituteNational Cancer CenterGoyang 10408Republic of Korea Eutilex Co. Ltd.Geumcheon-guSeoul 08594Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA Innobationbio Co. Ltd.Mapo-guSeoul 03929Republic of Korea

4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of... 详细信息

关键词： interaction activation knowledge

Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： Young Jae Park Jaeho Shim Joo Song Lee Kyu Seung Lee Ji-Yeon Kim Kang Bok Ko Sang-Youp Yim Seongjun Kim hoon-Kyu shin donghee Park Yong Ju Yun dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

Atomically Adjustable Rhodium Catalyst Synthesis with Outstanding Mass Activity via Surface-Li mi ted Cation Exchange

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Energy & Environmental Materials 2024年第2期7卷 83-92页

作者： Hak Hyeon Lee dong Su Kim Swagotom Sarker Ji hoon Choi Ho Seong Lee Hyung Koun Cho Department of Advanced Materials Science&Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-doSeoul 16419Korea Department of Advanced Materials Science&Engineering Kyungpook National University80Daehak-roBuk-guDaegu 41566Korea

Rh has been widely studied as a catalyst for the promising hydrazine oxidation reaction that can replace oxygen evolution reactions for boosting hydrogen production from hydrazine-containing *** Rh being expensive,only a few studies have examined its electrocatalytic mass ***,surface-limited cation exchange and electrochemical activation processes are designed to remarkably enhance the mass activity of *** atoms were readily replaced at the Ni sites on the surface of NiOOH electrodes by cation exchange,and the resulting RhOOH compounds were activated by the electrochemical reduction *** cation exchange-derived Rh catalysts exhibited particle sizes not exceeding 2 nm without agglomeration,indicating a decrease in the number of inactive inner Rh ***,an improved mass activity of 30 A mg_(Rh)^(-1)was achieved at 0.4 V versus reversible hydrogen ***,the two-electrode system employing the same CE-derived Rh electrodes achieved overall hydrazine splitting over 36 h at a stable low *** proposed surface-limited CE process is an effective method for reducing inactive atoms of expensive noble metal catalysts.

关键词： cation exchange synthesis electrochemical metallization hydrazine oxidation reaction mass activity rhodium catalyst

Evaluation of Seepage Behavior of Concrete Faced Gravel Fill Dam

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Evaluation of Seepage Behavior of Concrete Faced Gravel Fill...