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Microwave synthesis and enhancement of thermoelectric performance in Hf_(x)Ti_(1-x)NiSn_(0.97)Sb_(0.03)half-Heusler bulks

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Rare Metals 2023年第11期42卷 3780-3786页

作者： Ying Lei Yu Li Run-dong wan Wen Chen Hong-Wei Zhou School of Metallurgical Engineering Anhui University of TechnologyMaxiang RoadMa’anshan243032China College of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Institute of Mineral Resources Development and Utilization Changsha Research Institute of Mining and Metallurgy Co.LtdChangsha410012China State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050China Department of Mechanical Engineering Blekinge Institute of Technology37179KarlskronaSweden

We obtained TiNiSn-based half-Heusler Hf_(x)Ti_(1-x)NiSn_(0.97)Sb_(0.03)bulks with 85%-96%relative densities via 5-min microwave synthesis and 20-min microwave sintering in sealed *** phase composition and microstructure of samples were characterized by X-ray diffractometer(XRD)and scanning electron microscopy(SEM).Thermoelectric(TE)properties were measured,i.e.,Seebeck coefficient(S),electrical resistivity(ρ),and thermal conductivity(κ)through Seebeck coefficient/resistance analysis system(S/RAs)and laser flash thermal analyzer(LFT).The results show that the nearly single phase exists after microwave *** grain sizes and the number of grain boundaries decrease with increase in Hf-doping amount due to an increase in point *** matrix grains for Hf_(0.1)Ti_(0.9)NiSn_(0.97)Sb_(0.03)are~10μ*** nanoscle pores and precipitates are present as second phases in matrix *** real composition for Hf_(0.1)Ti_(0.9)NiSn_(0.97)Sb_(0.03)matrix grain is Hf_(3.51)Ti_(28.76)-Ni_(34.76)Sn_(31.55)Sb_(1.43).The variation trends of electrical resistivity,Seebeck coefficient,power factor,and thermal conductivity were analyzed in *** maximum figure of merit(ZT)of 0.46 is obtained for Hf_(0.1)Ti_(0.9-)NiSnSn_(0.97)Sb_(0.03)at 723 *** innovation route exhibits advantages for predation of TE bulks when compared to the conventional methods,especially in terms of efficiency while it still maintains TE performance.

关键词： Half-Heusler alloys Microwave synthesis Hf doping Thermoelectric figure of merit

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Light-activated arginine-rich peptide-modified nanoparticles for deep-penetrating chemo-photo-immunotherapy of solid tumor

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Nano Research 2023年第7期16卷 9804-9814页

作者： Yonghua Gong Jinyang Zhang Yan Lu dong wan Jie Pan Guilei Ma Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy The Tianjin Key Laboratory of BiomaterialsInstitute of Biomedical EngineeringPeking Union Medical College&Chinese Academy of Medical SciencesTianjin 300192China School of Environmental and Chemical Engineering Tiangong UniversityTianjin 300387China

Poor permeation of drugs and“immune-cold”tumor microenvironment in solid tumors are the two major challenges which lead to the inefficient therapeutic efficacy for cancer ***,light-activated penetrable nanoparticles(PEGVAL&DOX&ICG@RNPs)for co-delivery of the chemotherapeutic drug doxorubicin(DOX),the photosensitizer agent indocyanine green(ICG),and the angiotensin II receptor blockers valsartan(VAL)were developed to achieve deep drug penetration and synergistic photo-chemo-immunotherapy of solid *** showed that under the first-wave of laser irradiation,the polyethylene glycol(PEG)hydrophilic layer as an“inert”surface could detach from the nanoparticles,release VAL and expose the arginine-rich peptide modified-cores that can facilitate deep drug penetration via a transcytosis *** exposed to the second-wave of laser irradiation,the synergistic chemo-photo-immunotherapy can be *** expected,in 4T1 tumorbearing mice,PEG-VAL&DOX&ICG@RNPs treatment could effectively inhibit the growth of tumors,down-regulateα-smooth muscle actin expression level of cancer-associated fibroblasts cells in tumors,induce dendritic cells(DCs)maturation,and promote intratumoral infiltration of cytotoxic T ***,combination therapy by PEG-VAL&DOX&ICG@RNPs and anti-PD-1 monoclonal antibody can elicit memory T cell response for preventing tumor recurrence and metastasis in *** work provides a promising delivery strategy to overcome the current limitations of nanomedicine for achieving more effective therapeutic index of“immune-cold”solid tumor treatment.

关键词： light-activated nanoparticles transcytosis deep penetration chemo-photo-immunotherapy solid tumor

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Intracellular and extracellular enzymatic responsive micelle for intelligent therapy of cancer

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Nano Research 2023年第2期16卷 2851-2858页

作者： dong wan Qinan Zhu Jianxin Zhang Xi Chen Fangzhou Li Yi Liu Jie Pan School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China School of Chemistry Tiangong UniversityTianjin 300387China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Recently,the incidence of cancer keeps increasing,seriously endangers human health,and has evolved into the main culprit of human *** chemotherapeutic drugs,such as paclitaxel and doxorubicin(DOX),have some disadvantages,including low therapeutic effect,poor water solubility,high toxic side effects,short blood circulation time in the body,and so *** improve the anti-tumor effect of the drug in vivo and reduce its side effects on the body,researchers have designed and developed a variety of responsive *** this work,we synthesized D-α-tocopherol polyethylene glycol 3350 succinate(TPGS3350)-Gly-Pro-Leu-Gly-Val-Arg(GPLGVR)-DOX(TPD)prodrugs in response to extracellular enzymes of matrix metalloproteinase(MMP-9)in the tumor microenvironment and FA-Asp-Glu-Val-Asp(DEVD)-DOX(FPD)prodrugs responsive to intracellular enzymes of ***,intracellular and extracellular enzyme-responsive TPD&FPD micelles with DOX(TPD&FPD&D)were successfully prepared through dialysis *** outer layer of TPGS3350 can prolong the blood circulation time of micelles in vivo,followed by accumulation of micelles at tumor tissue through enhanced permeability and retention(EPR)*** peptide of GPLGVR can be cleaved by MMP-9 enzymes to remove the outer layer of TPGS3350,exposing the targeting molecule of folate,and then the micelles are engulfed by tumor cells through folate receptor-mediated *** entering the tumor cells,the free DOX loaded in the micelles is released,which induces tumor cell apoptosis to activate caspase-3 in the cells,cutting the peptide DEVD to accelerate the intracellular release of the DOX,which further enhances cytotoxicity to improve antitumor effect.

关键词： cancer micelle peptide enzyme-responsive folate

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基于三级甲等妇幼保健院评审标准的医院后勤管理高质量发展路径探讨

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中国标准化 2024年第8期 255-260页

作者：顾苏俊袁宛东鹿冰北京市海淀区妇幼保健院

医院后勤管理是发挥服务保障效能、保障正常运转、支撑医院建设发展的重要系统。北京市海淀区妇幼保健院坚持以三级甲等妇幼保健院评审标准为牵引,突出问题导向,从实施方法入手,破除陈旧观念、完善管理制度、提升人员素养,坚持持续改进... 详细信息

医院后勤管理是发挥服务保障效能、保障正常运转、支撑医院建设发展的重要系统。北京市海淀区妇幼保健院坚持以三级甲等妇幼保健院评审标准为牵引,突出问题导向,从实施方法入手,破除陈旧观念、完善管理制度、提升人员素养,坚持持续改进,坚持改革创新,坚持精细化管理,满足人群多样化需求,建设完备的高质量的医院后勤管理体系,为医院高质量发展打下坚实的后勤保障基础。

关键词：评审医院后勤高质量发展

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Modal Parameter Identification Method of Jacket Platform Structure Based on AFDD and Optimized FBFFT

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China Ocean Engineering 2023年第3期37卷 393-407页

作者： LENG Jian-cheng MA Jin-yong FAN Zong-heng QIAN wan-dong FENG Hui-yu School of Mechanical Science and Engineering Northeast Petroleum UniversityDaqing 163318China

Offshore platforms are susceptible to structural damage due to prolonged exposure to random loads,such as wind,waves,and *** is particularly true for platforms that have been in service for an extended *** the modal parameters of offshore platforms is crucial for damage diagno sis,as it serves as a prerequisite and foundation for the ***,it holds great significance to prioritize the identification of these *** at the shortcomings of the traditional Fast Bayesian Fast Fourier Transform(FBFFT) method,this paper proposes a modal parameter identification method based on Automatic Frequency Domain Decomposition(AFDD) and optimized *** introducing the AFDD method and Powell optimization algorithm,this method can automatically identify the initial value of natural frequency and solve the objective function efficiently and *** order to verify the feasibility and effectiveness of the proposed method,it is used to identify the modal parameters of the IASC-ASCE benchmark model and the j acket platform structure model,and the Most Probable Value(MPV) of the modal parameters and their respective posterior uncertainties are successfully *** identification results of the IASC-ASCE benc hmark model are compared with the identification re sults of the MODE-ID method,which verifies the effectivene ss and accuracy of the proposed method for identifying modal *** provides a simple and feasible method for quantifying the influence of uncertain factors such as environmental parameters on the identification results,and also provide s a reference for modal parameter identification of other large structures.

关键词： jacket platform uncertain modal parameter identification FBFFT method environmental excitation AFDD method Powell optimization

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基于有限元方法的水利工程坝体稳定性监测研究

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水利科技与经济 2024年第3期30卷 152-157页

作者：雷海林张万栋张汉康温州市水利电力勘测设计院有限公司浙江温州325000 中水北方勘测设计研究有限责任公司天津300000

为了对林溪水库挡水坝进行稳定性监测,利用有限元方法,对坝体的力学性能进行计算模拟。同时,采用强度折减法,对该坝坝坡稳定性进行计算。结果表明,上游水位高程71.29m时的渗流量有限元结果为69.1m^(3)/d;当水库处于死水位时,黏土心墙逸... 详细信息

为了对林溪水库挡水坝进行稳定性监测,利用有限元方法,对坝体的力学性能进行计算模拟。同时,采用强度折减法,对该坝坝坡稳定性进行计算。结果表明,上游水位高程71.29m时的渗流量有限元结果为69.1m^(3)/d;当水库处于死水位时,黏土心墙逸出点渗透坡降为0.896,不会出现渗透破坏;3种工况下,坝坡抗滑稳定安全系数分别为1.43、1.29和1.21,均未超过限定值。研究结果可为大坝的除险加固和管理提供参考。

关键词：水利工程有限元黏土心墙土石坝稳定性监测

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医院后勤服务项目外包标准化管理研究

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中国标准化 2024年第6期 267-271页

作者：顾苏俊袁宛东鹿冰北京市海淀区妇幼保健院

医院后勤管理是医院管理工作中重要组成部分。目前,多数医院把后勤服务项目外包,借助社会专业力量,提高后勤保障质量效益,减轻医院后勤管理负担,加速实现医院后勤服务专业化。医院后勤服务项目外包,在运行当中逐步暴露出追逐利润、强压... 详细信息

医院后勤管理是医院管理工作中重要组成部分。目前,多数医院把后勤服务项目外包,借助社会专业力量,提高后勤保障质量效益,减轻医院后勤管理负担,加速实现医院后勤服务专业化。医院后勤服务项目外包,在运行当中逐步暴露出追逐利润、强压成本、管理困难等诸多风险。医院后勤服务是构成医疗卫生服务能力的重要方面,对促进医院精细化管理、保障医院正常运行、改善医疗环境起到积极推动作用。本文结合现实需求,系统总结医院后勤服务项目外包存在的风险,深入分析风险形成原因,围绕提升医院后勤服务管理部门和外包单位的融合程度,规避外包服务风险,有针对性地提出应对措施,旨在不断提高后勤服务质量,降低运行成本,提高患者就医体验,促进医院健康平稳发展。

关键词：医院后勤服务标准化外包风险应对措施

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A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery

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Bioactive Materials 2023年第7期25卷 783-795页

作者： Sunfan Li Fangzhou Li dong wan Zuqin Chen Jie Pan Xing-Jie Liang School of Chemical Engineering and Technology Tiangong UniversityTianjin300387PR China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaNo.11First North RoadZhongguancunBeijing100190PR China University of Chinese Academy of Sciences Beijing100049PR China Medical School of Chinese PLA No.28 Fuxing RoadBeijing100853PR China Department of Radiology The First Medical CentreChinese PLA General HospitalBeijingPR China Department of Radiology Chinese PAP Guangxi Corps HospitalNanningGuangxiPR China

Chemotherapy remains the mainstay of cancer treatment,benefiting millions of patients each year,but the side effects of chemotherapy drugs severely limit their clinical ***(DOX)can cause various side effects such as heart damage and treatment-related *** effective use of active and passive targeting will improve the clinical application of ***,TPGS3350 and bioactive peptides were utilized to construct a micelle-based stage-by-stage impelled efficient system(missiles)for DOX delivery(DOX missiles).By taking advantage of the EPR effect,DOX missiles are efficiently enriched at the tumor *** being cleaved by matrix metalloproteinase2(MMP2),the peptide(VRGD)targets tumor cells to facilitate uptake of the missiles by the tumor cells via receptor-mediated *** intracellular activated caspase-3-catalyzed explosion of DOX missiles further enables efficient tumor *** study provides an efficient approach for DOX delivery and toxicity reduction.

关键词： Doxorubicin Delivery Peptide Missiles Chemotherapy

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急危重症患者急性胃肠损伤的特异性生物标志物

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临床急诊杂志 2024年第5期25卷 263-268页

作者：肖慧张丽慧祝慧凤万东重庆医科大学附属第一医院重症医学科重庆400016 西南大学药学院暨中医药学院

急危重症患者往往存在急性胃肠损伤,该现象备受关注且不容忽视。急性胃肠损伤不仅发生率高,而且在多器官功能障碍综合征的发生与发展中起重要作用,其对患者病情及预后具有不可忽视的影响。本文就急危重症患者急性胃肠损伤的生物标志物... 详细信息

急危重症患者往往存在急性胃肠损伤,该现象备受关注且不容忽视。急性胃肠损伤不仅发生率高,而且在多器官功能障碍综合征的发生与发展中起重要作用,其对患者病情及预后具有不可忽视的影响。本文就急危重症患者急性胃肠损伤的生物标志物进行综述,为AGI的早期识别提供分子线索。

关键词：急性胃肠损伤生物标志物早期识别

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宫腔镜电切除术联合地屈孕酮片治疗围绝经期子宫内膜息肉致异常子宫出血的效果观察

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中国实用医刊 2024年第7期51卷 17-20页

作者：王义红朱京玲李志花董婉河南科技大学第二附属医院妇科洛阳471000

目的探讨宫腔镜电切除术联合地屈孕酮片治疗围绝经期子宫内膜息肉致异常子宫出血(AUB)的临床疗效。方法分析性研究。抽取2020年6月至2023年6月河南科技大学第二附属医院收治的82例围绝经期子宫内膜息肉致AUB患者为研究对象,采用抽签法... 详细信息

目的探讨宫腔镜电切除术联合地屈孕酮片治疗围绝经期子宫内膜息肉致异常子宫出血(AUB)的临床疗效。方法分析性研究。抽取2020年6月至2023年6月河南科技大学第二附属医院收治的82例围绝经期子宫内膜息肉致AUB患者为研究对象,采用抽签法随机分为对照组和研究组,每组41例。两组均给予常规护理,对照组予以宫腔镜电切除术治疗,研究组在对照组基础上加用地屈孕酮片治疗。比较两组患者的临床疗效,比较两组治疗前后子宫内膜厚度、月经情况和激素水平[促黄体生成素(LH)、雌二醇(E2)和促卵泡生成素(FSH)]。结果研究组总有效率(95.12%,39/41)高于对照组(75.61%,31/41),P<0.05。治疗后,两组子宫内膜厚度、月经情况均较治疗前显著改善(P<0.05),且研究组子宫内膜、月经改变情况优于对照组(P<0.05)。治疗后,两组LH、E2、FSH水平均较治疗前降低,且研究组LH、E2、FSH水平低于对照组(P<0.05)。结论宫腔镜电切除术联合地屈孕酮片治疗围绝经期子宫内膜息肉致AUB比单一应用电切除术治疗效果更好,能更好地降低子宫内膜厚度,减少月经量,降低复发率,改善激素水平。

关键词：宫腔镜地屈孕酮围绝经期子宫内膜息肉异常子宫出血

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