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Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

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World Journal of Gastroenterology 2016年第41期22卷 9205-9213页

作者： Hee Yeon kim Chang Wook kim Tae Yeob kim Do Seon Song dong hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang soo Lee Chang Hyeong Lee Tae Hun kim Jeong Han kim hyung joon Yim Sung Eun kim soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok kim Sang Gyune kim Jin Mo Yang joo hyun Sohn Heon Ju Lee Seung Ha park Eun Hee Choi dong joon kim Korean Acute-on-Chronic Liver Failure Study Group Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 06591South Kerea Institute of Medical Science Hanyang UniversitySeoul 04763South Kerea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Kerea Department of Internal Medicine Inje University Sanggye Paik HospitalSeoul 01757South Kerea Department of Internal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Internal Medicine Hallym University Chuncheon Sacred Heart HospitalChuncheon 24253South Kerea Department of Internal Medicine Gyeongsang National University HospitalJinju 52727South Kerea Department of Internal Medicine Catholic University of Daegu School of MedicineDaegu 42472South Kerea Department of Internal Medicine Ewha Womans University School of MedicineSeoul 07985South Kerea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Kerea Department of Internal Medicine Hallym University Sacred Heart HospitalAnyang 14068South Kerea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea Department of Internal Medicine Chungnam National UniversitySchool of MedicineDaejeon 35015South Kerea Department of Internal Medicine Soonchunhyang University College of MedicineSeoul 04401South Kerea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheon 14584South Kerea Department of Internal Medicine Hanyang University Guri HospitalGuri 11923South Kerea Department of Internal Medicine Yeungnam University College of MedicineDaegu 42415South Kerea Department of Internal Medicine Inje University Haeundae Paik-HospitalInje University College of MedicineBusan 48108South Kerea Institute of Lifestyle Medicine Yonsei University Wonju College of MedicineWonju 26426South Kerea 不详

AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic *** We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and *** Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d *** CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.

关键词： Acute-on-chronic liver failure Alcoholic hepatitis Mortality Prognosis Scoring system

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The Anti-Inflammatory Effect of Cheongseoikki-Tang Ethanol Extract on Allergic Reactions Mediated by Bone Marrow-Derived Mast Cells

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Chinese Journal of Integrative Medicine 2013年第5期19卷 380-386页

作者： joon-Ho Keum Ok-Hwa Kang Sung-Bae kim Su-hyun Mun Yun-soo Seo Ma-Ryong kim Jung-Rae Rho Young-Seob Lee Chung-Berm park Young-Guk kim Yong-II kim sin-Hee Han dong-Yeul Kwon College of Pharmacy and Wonkwang Oriental Medicines Research Institute Wonkwang UniversityJeonbuk(570-749)Republic of Korea Department of Oceanography Kunsan National UniversityKunsan(573-701)Republic of Korea National Institute of Horticultural & Herbal Science RDAEumsung(369-873)Republic of Korea

Objective： Cheongseoikki-tang （CIT, Korean）, also called Qingshu Yiqi decoction（清署益气汤）and Seisho-ekki-to （Japanese）, is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell （BMMC）-mediated allergy and inflammation mechanisms. Methods： In this study, the biological effect of Cheongseoikki-tang ethanol extract （CITE） was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myfistate 13-acetate （PMA） plus calcium ionophore A23187 （A23187）-stimulated BMMCs. These allergic mediators included intedeukin-6 （IL-6）, prostaglandin D2 （PGD2）, leukotfiene （34 （LTC4）, and β-hexosaminidase （13-hex）. Results： Our data revealed that CITE inhibited the production of IL-6, PGD2,/TC4, and 15-hex induced by PMA plus A23187 （P〈0.05）. Conclusion： These findings indicate that CITE has the potential for use in the treatment of allergy.

关键词： Cheongseoikki-tang ethanol extract bone marrow-derived mast cell allergy interleukin-6 prostaglandin D2 leukotriene C4

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Ethanol extracts of Hizikia fusiforme induce apoptosis in human prostate cancer PC3 cells via modulating a ROS-dependent pathway

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 78-86页

作者： Eun Ok Choi Hyesook Lee Cheol park Gi-Young kim Hee-Jae Cha Suhkmann kim Heui-soo kim You-Jin Jeon Hye Jin Hwang Yung hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Department of Molecular Biology College of Natural SciencesDong-eui UniversityBusan 47340Republic of Korea Laboratory of Immunobiology Department of Marine Life SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics Kosin University College of MedicineBusan 49267Republic of Korea Department of Chemistry College of Natural SciencesCenter for Proteome Biophysics and Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether ethanol extracts of Hizikia fusiforme could induce apoptosis in human prostate cancer PC3 ***:Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium *** and mitochondrial membrane potential(MMP)were measured using flow cytometry in PC3 *** damage was assessed by nuclear staining and DNA fragmentation *** of apoptosis-associated proteins were determined by Western blotting *** of caspase-3,-8,and-9 were determined by colorimetric ***,intracellular reactive oxygen species(ROS)generation was detected using a flow cytometer and fluorescence ***:Treatment of PC3 cells with ethanol extracts of Hizikia fusiforme inhibited proliferation,which was associated with induction of apoptosis,and accompanied by increased expression of Fas,Fas-ligand(Fas L),Bax and t Bid,and decreased expression of *** addition,ethanol extracts of Hizikia fusiforme reduced c-Flip expression and activated caspase-8,-9 and-3,resulting in an increase in poly(ADP-ribose)polymerase(PARP)***,in the presence of a pan-caspase inhibitor,ethanol extracts of Hizikia fusiforme-mediated growth inhibition and apoptosis were significantly *** extracts of Hizikia fusiforme also destroyed the integrity of mitochondria due to the loss of MMP,leading to cytosolic release of cytochrome ***,the levels of ROS were markedly increased by treatment with ethanol extracts of Hizikia fusiforme,which was significantly suppressed by the ROS scavenger *** investigation of whether ethanol extracts of Hizikia fusiforme-induced apoptosis was related to the generation of ROS was conducted and the results showed that N-acetyl-L-cysteine fully blocked ethanol extracts of Hizikia fusiforme-induced apoptotic events including loss of MMP,activation of caspase-3,the cytosolic release of cytochrome c and ***:E

关键词： Hizikia fusiforme Apoptosis Prostate cancer cells Caspase Reactive oxygen species

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Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)

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Cancer Communications 2019年第1期39卷 271-278页

作者： Ji-Yeon kim Seri park Seock-Ah Im Sung-Bae kim.joohyuk Sohn Keun Seok Lee Yee soo Chae Ki Hyeong Lee Jee hyun kim Young-Hyuck Im Tae-Yong kim Kyung-Hun Lee Jin-Hee Ahn Gun Min kim In Hae park soo Jung Lee Hye sook Han Se hyun kim Kyung Hae Jung Yeon Hee park Korean Cancer Study Group Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine81 Irwon-roGangnam-guSeoul 06351South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and TechnologySungkyunkwan UniversitySeoul 06351South Korea Department of Internal Medicine Seoul National University HospitalCancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Medical Oncology Department of Internal MedicineYonsei University College of MedicineSeoul 03722South Korea Center for Breast Cancer National Cancer CenterGoyang 10408South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Deparment of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC.

关键词： Metastatic breast cancer Eribulin Paclitaxel Neuropathy Quality of life Functional assessment of cancer therapy-taxane questionnaires

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Electrolyte changes after bowel preparation for colonoscopy:A randomized controlled multicenter trial

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World Journal of Gastroenterology 2015年第10期21卷 3041-3048页

作者： Kyong joo Lee Hong Jun park hyun-soo kim Kwang Ho Baik Yeon soo kim Sung Chul park hyun Il Seo Division of Gastroenterology and Hepatology Department of Internal Medicine Yonsei University Wonju College of Medicine Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital Department of Internal Medicine Kangwon National University Hospital Department of Internal Medicine Ulsan Medical University Gangneung Asan Hospital

AIM:To investigate the electrolyte changes between 2-L polyethylene glycol with ascorbic acid 20 g(PEGAsc) and 4-L PEG ***:From August 2012 to February 2013,a total of 226 patients were enrolled at four tertiary *** patients were randomly allocated to a PEG-Asc group or a 4-L *** colonoscopy,patients completed a questionnaire to assess bowel preparation-related symptoms,satisfaction,and *** assessed the bowel preparation using the Boston Bowel Preparation Scale(BBPS).In addition,blood tests,including serum electrolytes,serum osmolarity,and urine osmolarity were evaluated both before and after the ***:A total of 226 patients were *** scores were similar and the adequate bowel preparation rate(BBPS≥6)was not different between the two groups(PEG-Asc vs 4-L PEG,73.2%vs 76.3%,P=0.760).Bowel preparation-related symptoms also were not different between the two *** taste of PEG-Asc was better(41.1%vs 16.7%,P<0.001),and the willingness to undergo repeated bowel preparation was higher in the PEG-Asc group(73.2%vs 59.3%,P=0.027)than in 4-L *** were no significant changes in serum electrolytes in either ***:In this multicenter trial,bowel preparation with PEG-Asc was better than 4-L PEG in terms of patient satisfaction,with similar degrees of bowel preparation and electrolyte changes.

关键词： Colonoscopy Bowel preparation Ascorbic acid Polyet

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Aortoduodenal fistula and aortic aneurysm secondary to biliary stent-induced retroperitoneal perforation

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World Journal of Gastroenterology 2008年第19期14卷 3095-3097页

作者： Tae Hoon Lee Do hyun park Ji-Young park Suck-Ho Lee Il-Kwun Chung Hong soo kim Sang-Heum park Sun-joo kim Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of Medicine Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine

Duodenal perforations caused by biliary prostheses are not uncommon, and they are potentially life threatening and require immediate treatment. We describe an unusual case of aortic aneurysm and rupture which occurred after retroperitoneal aortoduodenal fistula formation as a rare complication caused by biliary metallic stent-related duodenal perforation. To our knowledge, this is the first report describing a lethal complication of a bleeding, aortoduodenal fistula and caused by biliary metallic stent-induced perforation.

关键词： Stents Retroperitoneal perforation Aorticaneurysm Fistula

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Ampullary adenomyoma presenting as acute recurrent pancreatitis

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World Journal of Gastroenterology 2007年第20期13卷 2892-2894页

作者： Tae-Hee Kwon Do hyun park Kwang Yeon Shim hyun-Deuk Cho Jeong Hoon park Suck-Ho Lee Il-Kwun Chung Hong-soo kim Sang-Heum park Sun-joo kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University Cheonan HospitalCheonanChoongnam 330-721Korea Division of Gastroenterology Department of PathologySoon Chun Hyang University Cheonan HospitalCheonanChoongnam 330-721Korea

Adenomyoma is a term generally applied to nodular lesions showing proliferation of both epithelial and smooth muscle components. Despite its benign nature,ampullary adenomyoma is usually presented as biliary obstruction. Most cases are misdiagnosed as carcinoma or adenoma by preoperative endoscopic or radiologic procedure. Therefore,it is frequently treated with extensive surgery. To our knowledge,this is the first reported case in English literature of adenomyoma located in the peripancreatic orifice resulting in intermittent pancreatic duct obstruction and recurrent pancreatitis diagnosed by the endoscopic piecemeal resection.

关键词： Ampulla Adenomyoma Acute recurrent pancreatitis Endoscopic resection

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Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World Journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak kim Jimin Han Myung-Hwan kim Kyu hyun Cho Im Hee Shin Gwang Ha kim Jae Seon kim Jin Bong kim Tae Nyeun kim Tae Hyeon kim Tae Hyo kim Jae Woo kim Ji Kon Ryu Young-soo Moon Jong Ho Moon Sung Jae park Chan Guk park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee dong Ki Lee Byung Seok Lee Sang soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

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A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation

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World Journal of Gastroenterology 2014年第35期20卷 12687-12690页

作者： Ji Eun kim Tae-Geun Gweon Chang dong Yeo Young-Seok Cho Gi Jun kim Jae Young kim Jong Wook kim hyunho kim Hye Won Lee Taeseok Lim Hyoju Ham hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung soo park Department of Internal Medicine Seoul St Mary’s hospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Pulmonology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine

Acute respiratory distress syndrome is a life-threatening disorder caused mainly by *** difficile infection(CDI)is a common nosocomial diarrheal *** of normal intestinal flora by antibiotics is the main risk factor for *** use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress *** microbiota transplantation is a highly effective treatment in patients with refractory *** we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation.

关键词： Clostridium difficile infection Acute respiratory distress syndrome Fecal microbiota transplantation

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Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum

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World Journal of Gastroenterology 2008年第1期14卷 136-139页

作者： Seong-Heum park Jong-Han kim Byung Wook Min Tae Jin Song Gil soo Son Seung joo kim Sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um Department of Surgery Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Internal Medicine Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Radiology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Pathology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea

Inflammatory myofibroblastic tumor （INT） of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non- clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall.

关键词： Stomach disease Stomach neoplasms Hemoperitoneum Myofibroma Granuloma Plasma cell Stomach surgery

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