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World Journal of Clinical Cases 2024年第5期12卷 913-921页

作者： Tae In Kim Sung Yong han Jonghyun lee dong Uk Kim Division of Gastroenterology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National UniversityCollege of MedicineYangsan 50612South Korea

BACKGROUND Intrahepatic duct(IHD)stones are among the most important risk factors for cholangiocarcinoma(CCC).Approximately 10%of patients with IHD stones develop CCC;however,there are limited studies regarding the effect of IHD stone removal on CCC *** To investigate the association between IHD stone removal and CCC *** We retrospectively analyzed 397 patients with IHD stones at a tertiary referral center between January 2011 and December *** CCC occurred in 36 of the 397 enrolled *** univariate analysis,chronic hepatitis B infection(11.1%vs 3.0%,P=0.03),carbohydrate antigen 19-9(CA19-9,176.00 vs 11.96 II/mL,P=0.010),stone located in left or both lobes(86.1%vs 70.1%,P=0.042),focal atrophy(52.8%vs 26.9%,P=0.001),duct stricture(47.2%vs 24.9%,P=0.004),and removal status of IHD stone(33.3%vs 63.2%,Pupper normal limit,carcinoembryonic antigen>upper normal limit,stones located in the left or both lobes,focal atrophy,and complete removal of IHD stones without recurrence were independent factors influencing CCC ***,the type of removal method was not associated with CCC *** Complete removal of IHD stones without recurrence could reduce CCC risk.

关键词： Intrahepatic bile duct stone Cholangiocarcinoma Percutaneous transhepatic cholangioscopy Endoscopic retrograde cholangiopancreatography Carbohydrate antigen 19-9

Evaluation of Auto-Ignition Characteristics of Diesel Surrogate Fuels with the Same Derived Cetane Numbers at Changed Thermodynamic Environments

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Journal of Thermal Science 2024年第4期33卷 1590-1606页

作者： ZhanG Cong GUAN Yuanhang HUANG Zhen han dong Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China College of Smart Energy Shanghai Jiao Tong UniversityShanghai200240China Shanghai Non-carbon Energy Conversion and Utilization Institute Shanghai200240China

The ignition tendency of diesel fuels is highly sensitive to ambient conditions and fuel *** this study,the ignition characteristics of different diesel surrogate fuels with the same derived cetane numbers(DCN)were measured and compared in varied thermodynamic and oxidizing *** combustion pressures,heat release rates,ignition delays,and combustion delays of the test fuels were *** experimental results showed that the diesel surrogate fuels with the same DCNs exhibit similar ignition propensity at standard DCN test ***,for the test conditions of high cetane fuels,high ambient temperatures,and suficient oxygen concentrations,surrogate fuels with the same DCN have similar ignition behaviors,and using the DCN to evaluate fuel ignition tendency is ***,for the test conditions of low cetane fuels,low ambient temperatures,and reduced oxygen concentrations,different ignition behaviors are observed for the surrogate fuels with the same DCN,so at these conditions using DCN as the evaluation index for fuel ignition tendency may lead to higher uncertainty.

关键词： diesel fuels surrogate fuels derived cetane numbers constant volume combustion chamber

Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie dong han Xiang Li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising *** ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and *** micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative ***,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing ***,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are *** also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

ZP2:the precision regulator of egg coat architecture during fertilization

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Science China(Life Sciences) 2024年第8期67卷 1779-1780页

作者： Yi dong Shigang Zhao han Zhao State Key Laboratory of Reproductive Medicine and Offspring Health Center for Reproductive MedicineInstitute of WomenChildren and Reproductive HealthShandong UniversityJinan 250012China

In a recent study published in Cell,(Nishio et al.,2024)elucidated the molecular regulatory mechanism through which organisms prevent *** process intricately involves conformational changes in the zona pellucida(ZP)*** authors present a fascinating mechanism whereby post-fertilization cleavage of the ZP subunit ZP2 triggers its oligomerization,leading to crosslinking of filaments to harden the egg coat and prevent *** also systematically analyzed the pattern of ZP filament assembly,which revealed that two protofilaments comprising type I(ZP3)and type II(ZP1/ZP2/ZP4)components interlock to form a left-handed double helix *** findings are immensely beneficial for understanding the specific role of the egg coat,providing a plethora of insights.

关键词： mechanism finding crosslinking

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A confined growth strategy to construct 3DOM SiO_(2) nanoreactor insitu embedded Co_(3)O_(4) nanoparticles catalyst for the catalytic combustion of VOCs:Superior H_(2)O and SO_(2) resistance

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Nano Research 2024年第1期17卷 207-220页

作者： Weigao han Shilin Wu Fang dong Weiliang han Yinghao Chu Linghui Su Zhicheng Tang State Key Laboratory for Oxo Synthesis and Selective Oxidation National Engineering Research Center for Fine Petrochemical IntermediatesLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Dalian 116023China College of Architecture and Environment Sichuan UniversityChengdu 610000China

SO_(2)poisoning is a common problem in the catalytic combustion of volatile organic compounds(VOCs).In this work,we took three-dimensionally ordered macroporous and mesoporous(3DOM)SiO_(2)as the nanoreactor to protect active sites from SO_(2)erosion in the catalytic combustion of ***,the confined growth of metal active nanoparticles in the multi-stage pore is also full of *** we successfully confined Co_(3)O_(4)nanoparticles(NPs)in macroporous and mesoporous ***,the precursors’growth in the pore was controlled and nanoreactors with different pore sizes were prepared by adjusting the loading amount and preparation *** is discovered that the Co_(3)O_(4)NPs confined in 3DOM SiO_(2)nanoreactor showed superior sulfur and water *** functional theory(DFT)calculations verified that the Co-Si catalyst had high SO_(2)adsorption energy(-0.48 eV),which illustrated that SO_(2)was hard to attach to the surface of the Co-Si *** SiO_(2)nanoreactor had low SO_(2)adsorption energy(-5.15 eV),which indicated that SO_(2)was easily absorbed on SiO_(2)*** illustrated that the SiO_(2)nanoreactor could protect effectively active sites from SO_(2)erosion.

关键词： zeolitic imidazolate frameworks(ZIFs) Co_(3)O_(4) benzene catalytic combustion nanoreactor sulfur and water resistance

Impact of Atmospheric Transmittance and NLTE Correction on Simulation of High Spectral Infrared Atmospheric Sounder onboard FY-3E

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Journal of Meteorological Research 2024年第2期38卷 225-234页

作者： Chenggege FANG Peiming dong Yang han Wanlin KAN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science&TechnologyNanjing 210044 donghai Laboratory Zhoushan 316021 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 CMA Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing 100081 Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041

With the launch of the first civilian early-morning orbit satellite Fengyun-3E(FY-3E),higher demands are placed on the accuracy of radiative transfer simulations for hyperspectral infrared ***,several key issues are investigated in the ***,the accuracy of the fast atmospheric transmittance model implemented in the Advanced Research and Modeling System(ARMS)has been evaluated with both the line-by-line radiative transfer model(LBLRTM)and the actual satellite *** results indicate that the biases are generally less than 0.25 K when compared to the LBLRTM,while below 1.0 K for the majority of the channels when compared to the ***,during both comparisons,significant biases are observed in certain *** accuracy of Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard FY-3E is comparable to,and even superior to that of the Cross-track Infrared Sounder(CrIS)onboard ***,apodization is a crucial step in the processing of hyperspectral data in that the apodization function is utilized as the instrument channel spectral response function to produce the satellite channel-averaged *** further explore the difference between the apodized and unapodized simulations,Sinc function is adopted in the fast transmittance *** is found that the use of Sinc function can make the simulations fit the original satellite observations *** simulating with apodized observations,the use of Sinc function exhibits larger deviations compared to the Hamming ***,a correction module is applied to minimize the impact of Non-Local Thermodynamic Equilibrium(NLTE)in the shortwave infrared *** is verified that the implementation of the NLTE correction model leads to a significant reduction in the bias between the simulation and observation for this band.

关键词： high spectral infrared sounding atmospheric transmittance apodization Non-Local Thermodynamic Equilibrium Fengyun-3E(FY-3E)

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

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Nano-Micro Letters 2024年第4期16卷 269-292页

作者： Moon Sung Kang Yeuni Yu Rowoon Park Hye Jin Heo Seok Hyun lee Suck Won Hong Yun Hak Kim dong‑Wook han Department of Cogno‑Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Republic of Korea Medical Research Institute School of MedicinePusan National UniversityYangsan 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsan 50612Republic of Korea Engineering Research Center for Color‑Modulated Extra‑Sensory Perception Technology Pusan National UniversityBusan 46241Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612Republic of Korea Periodontal Disease Signaling Network Research Center and Dental and Life Science Institute School of DentistryPusan National UniversityYangsan 50612Republic of Korea BIO‑IT Fusion Technology Research Institute Pusan National UniversityBusan 46241Republic of Korea Present Address:Osstem Implant Inc. Seoul 07789Republic of Korea

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient *** overcome these limitations,tissue-engineered scaffolds have emerged as a promising *** this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue *** PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and *** vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 ***,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML *** insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT ***,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast *** findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

关键词： Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing

Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials

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World Journal of Pediatrics 2024年第3期20卷 219-229页

作者： Min Seo Kim Jae han Kim Seohyun Ryu Seung Won lee dong Keon Yon Eunyoung Kim Ai Koyanagi Elena Dragioti Jae Il Shin lee Smith Samsung Advanced Institute forHealth Sciences&Technology(SAIHST) Samsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea Yonsei University Collegeof Medicine SeoulRepublicof Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulRepublic of Korea Evidence-Based Research Laboratory Department of Clinical Pharmacy and Pharmaceutical CareCollege of PharmacyChung-Ang UniversitySeoulRepublic of Korea Parc Sanitari Sant Joan de Deu/CIBERSAM/ISCIII Universitat de BarcelonaFundacio Sant Joan de Déu.Sant Boi de LlobregatBarcelonaSpain ICREA Pg.Lluis Companys 23BarcelonaSpain Pain and Rehabilitation Centre and Department of Medical and Health SciencesLinkoping University58185 LinkopingSweden Department of Pediatrics Yonsei University College of MedicineYonsei-ro 50Seodaemun-gu8044Seoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK Research Laboratory Psychology of Patients Families&Health ProfessionalsDepartment of NursingSchool of Health SciencesUniversity of IoanninaIoannina 45500Greece

Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial ***,the effective minimal antibiotic duration for AOM remains ***,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been *** We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October *** meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 *** the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day *** to amoxicillin,a shorter treatment duration was tolerable with *** Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 ***,5-day regimens would be sufficient for a modest treatment *** findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.

关键词： Amoxicillin-potassium Amoxicillin Antibacterial agents Cephalosporins Duration of therapy

Risk-Averse Two-Stage Distributionally Robust Economic Dispatch Model Under Uncertain Renewable Energy

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1514-1524页

作者： Ce Yang Weiqing Sun Jiannan Yang dong han Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Electrical Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Economics and Business Administration Chongqing UniversityChongqing 400044China

With the participation of large quantities of renewable energy in power system operations,their volatility and intermittence increases the difficulties and challenges of power system economic *** the uncertainty of renewable energy generation,based on the distributionally robust optimization method,a two-stage economic dispatch model is proposed to minimize the total operation *** this paper,it is assumed that the fluctuating of renewable power generation follows the unknown probability distribution that is restricted in an ambiguity set,which is established by utilizing the first-order moment information of available historical ***,the theory of conditional value-at-risk is introduced to transform the model into a tractable model,which we call robust counterpart *** on the stochastic dual dynamic programming method,an improved iterative algorithm is proposed to solve the robust counterpart ***,the convergence optimum can be obtained by the improved iterative algorithm,which performs a forward pass and backward pass repeatedly in each iterative ***,by comparing with other methods,the results on the modified IEEE 6-bus,118-bus,and 300-bus system show the effectiveness and advantages of the proposed model and method.

关键词： Energy and reserve co-dispatch distributionally robust conditional value-at-risk stochastic dual dynamic programming

Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： Chao Ren han Yu Yan Xu Zhao Yang dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown *** takes individual discrepancies into consideration and can handle unknown faults with incomplete *** experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL *** analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning