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Journal of Int.grat.ve Plant.Biology 2014年第1期56卷 75-87页

作者： Braulio J.Sot.-Cerda Scot. Duguid Helen Booker Gordon rowland Axel Diederichsen Sylvie Clout.er Depart.ent.of Plant.Science University of Manitoba 66 Dafoe Road Cereal Research Cent.r Agriculture and Agri-Food Canada 195 Dafoe Road Morden Research St.t.on Agriculture and Agri-Food Canada 101 Route 100 Unit 100 Morden Depart.ent.of Plant.Sciences College of Agriculture and Bioresources University of Saskatchewan 51 Campus Drive Plant.Gene Resources of Canada Agriculture and Agri-Food Canada 107 Science Place

t.e ext.eme climat. of t.e Canadian Prairies poses a major chal enge t. improve yield. Alt.ough it.is possible t. breed for yield per se, focusing on yield-relat.d t.ait. could be advant.geous because of t.eir simpler genet.c archit.ct.re. t.e Canadian flax core col ect.on of 390 accessions was genot.ped wit. 464 simple sequence repeat.markers, and phenot.pic dat. for nine agronomic t.ait. including yield, bol s per area, 1,000 seed weight. seeds per bol , st.rt.of flowering, end of flowering, plant.height. plant.branching, and lodging col ect.d from up t. eight.environment. was used for associat.on mapping. Based on a mixed model （principal component.analysis （PCA） t.kinship mat.ix （K））, 12 significant.marker-t.ait.associat.ons for six agronomic t.ait. were ident.-fied. Most.of t.e associat.ons were st.ble across environment. as revealed by mult.variat. analyses. St.t.st.cal simulat.on for five markers associat.d wit. 1000 seed weight.indicat.d t.at.t.e favorable al eles have addit.ve effect.. None of t.e modern cult.vars carried t.e five favorable al eles and t.e maximum number of four observed in any accessions was most.y in＆amp;nbsp;breeding lines. Our result. confirmed t.e complex genet.c archit.ct.re of yield-relat.d t.ait. and t.e inherent.difficult.es associat.d wit. t.eir ident.ficat.on while il ust.at.ng t.e pot.nt.al for improvement.t.rough marker-assist.d select.on.

关键词： Linum usit.t.ssimum marker-assist.d select.on

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Chromosomal localizat.on of a t.ndemly repeat.d DNA sequence in t.ifolium repens L

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Cell Research 1996年第1期6卷 39-46页

作者： ZHU JM NW ELLISON RE rowland (t.e Hort.cult.re and Food Research Inst.t.t. of NewZealand, M Albert.Research Cent.e, Privat. Bag 92169, Auckland, New Zealand.)(New Zcaland Past.ral Agricult.re Research Inst.t.t., Grasslands Research Cent.e, Privat. Bag 11 t.e Hort.cult.re and Food Research Inst.t.t. of New Zealand Mt Albert Research Centre Private Bag 92169 Auckland New Zealand

A karyot.pe of t.ifolium repens const.uct.d from mit.t.c cells revealed 13 pairs of met.cent.ic and 3 pairs of submet.cent.ic chromosomes including a pair of sat.llit.s locat.d at.t.e end of t.e short.arm of chromosome 16.C-bands were ident.fied around t.e cent.omeric regions of 8 pairs of chromosomes. A 350 bp t.ndemly repeat.d DNA sequence from t. repens labelled wit. digoxygenin hybridized t. t.e proximal cent.omeric regions of 12 chromosome pairs. Some correlat.on bet.een t.e dist.ibut.on of t.e repeat.sequence and t.e dist.ibut.on of C-banding was demonst.at.d.

关键词： t.ndem repeat in sit. hybridizat.on digoxygenin-labelled probe C-banding karyot.pe

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工业菌株的改良:合理筛选与遗传重组技术

国外医药(抗生素分册) 1985年第6期 405-412页

作者： R.t.rowland ,蒋鎏

工业菌株的改良涉及到对主要商业发酵产物生产菌的改良或开发,以达到降低成本的目的.通常采用提高菌种产量的方法,也有按要求去操纵菌种的某些特性,如深层培养的菌体形态,或使之能利用廉价原料等.产黄青霉菌产量比原种提高五百倍左右,并

关键词：真菌菌株链霉菌科放线菌目内酞胺类抗生素单基因原生质体融合技术细胞融合技术菌株改良终产物抑制作用菌种改良质粒基因载体抗生素耐药产黄青霉菌双倍体青霉素抗菌素类似物同型物遗传重组

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临床药动学

Hesit.nt.adopt.rs:COVID-19 vaccine hesit.ncy among diverse vaccinat.d adult. in t.e Unit.d St.t.s

丛书名：临床医学高级研究修书系

1999年

作者：（英）（M.罗兰）Malcolm rowland （美）（t.N.托泽）t.omas N.t.zer原彭彬主译

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Infect.ous Medicine 2023年第2期2卷 89-95页

作者： Sharon Reece Sheena CarlLee Aaron J.Scot. Don E.Willis Bret. rowland Krist.n Larsen Ijanae Holman-Allgood Pearl A.McElfish College of Medicine University of Arkansas for Medical Sciences NorthwestFayettevilleAR 72703USA Office of Communit. Healt. and Research University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA College of Medicine University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA

Background:Despit. t.e Unit.d St.t.s(US)having an abundant.supply of COVID-19 vaccines,vaccinat.on rat.s lag behind ot.er high-income count.ies,suggest.ng t.at.vaccine hesit.ncy and at.it.des play a great.r role in public healt. measures t.an pure supply and *** t.e acknowledgment.t.at.vaccinat.on at.it.des and st.t.s may or may not.be correlat.d,t.is st.dy examined COVID-19 vaccine hesit.ncy among vaccinat.d US adult. by asking:(1)What.is t.e prevalence of COVID-19 vaccine hesit.ncy among t.e vaccinat.d?(2)Does COVID-19 vaccine hesit.ncy vary across sociodemographic charact.rist.cs?(3)Does COVID-19 vaccine hesit.ncy vary by healt.care access and influenza vaccinat.on over t.e past.5 years?Met.ods:Dat. were collect.d t.rough an online survey of 2022 US adult. wit. a final analyt.c sample of 1383 vaccinat.d ***:Overall,48.8%of vaccinat.d adult. report.d some level of hesit.ncy,while a slight.majorit. report.d t.ey were“not.at.all hesit.nt..Younger respondent.,women,and Black and American Indian or Alaska Nat.ve part.cipant. had great.r adjust.d odds of being more hesit.nt.t.wards receiving t.e COVID-19 ***-dent. who had a primary care physician had great.r adjust.d odds t.an t.ose who did not.have a primary care physician of being more hesit.nt.t.wards receiving t.e COVID-19 ***:t.is is t.e first.populat.on-based nat.onal sample st.dy examining COVID-19 vaccine hesit.ncy among vaccinat.d individuals from subgroups of dist.nct.ve backgrounds in order t. inform t.rget.d st.at.gies for reducing vaccine *** can assist.in effort. t. increase vaccinat.on rat.s and also decrease vaccine hesit.ncy at.t.e nat.onal level.

关键词： COVID-19 vaccine Vaccine hesit.ncy Hesit.nt.adopt.rs US adult.

Higher t.pe 1 Int.rferon Levels in Plasma of Asympt.mat.c HIV-2 t.an in HIV-1 Individuals

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Advances in Infect.ous Diseases 2016年第1期6卷 15-23页

作者： Samuel V. Nuvor Hilt.n Whit.le Sarah rowland-Jones Assan Jaye MRC Laborat.ries Fajara Banjul The Gambia School of Medical Sciences University of Cape Coast Cape Coast Ghana London School of Hygiene & t.opical Medicine London UK MRC Human Immunology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Oxford UK Hospit.l A. le Dant.c Laboratoire de Bacteriologie Virologie (LBV) Universite Cheikh Anta Diop (UCAD) Dakar Senegal

A number of cyt.kines are secret.d during HIV infect.on t.at.enhances bot. innat. and adapt.ve immune responses. Int.rferon-α/β/γ, IL-12, IL-15 and IL-18 have been found t. cont.ibut. t. t.e development. mat.rat.on, different.at.on and funct.on of NK and ot.er immune cells. t.e levels of IFN-α/β/γ, IL-12, IL-15 and IL-18 were compared in t.e plasma of 90 HIV-1 infect.d and 90 HIV-2 infect.d subject. by ELISA or Cyt.met.ic Beads Array assays. t.e HIV-infect.d subject. were st.at.fied according t. CD4+ t.cell count. int. t.ree groups: >500, 200 - 500 and t. 30 subject. in each group. Cyt.kine levels were also det.rmined in t.e plasma of 50 HIV uninfect.d blood bank donors. Among t.e cyt.kines t.st.d, IFN-α was found t. be significant.y increased in HIV-2 infect.d compared t. HIV-1 infect.d subject. at.high CD4+ t.cell count. (p = 0.001). t.e levels of IFN-β were seen t. differ bet.een t.e t.o infect.ons in pat.ent. from t.e cat.gory of medium CD4+ t.cell count.: t.is was significant.y increased in HIV-2 infect.d pat.ent. (p t. uninfect.d cont.ols (p = 0.001). t.e levels of IFN-γ were similar at.all t.e CD4+ t.cell cat.gories except.for an increase in HIV-2 infect.d pat.ent. at.low CD4+ t.cell count. (p = 0.02). t.e levels of t.ese cyt.kines were similar in all HIV-1 subject.. Also, t.e level of IL-12p70 was similar bet.een t.e t.o infect.ons but.significant.y higher in HIV-2 at.low compared t. medium CD4+ t.cells cat.gories (p = 0.047). Similar t. IFN-γ and IL-12p70, t.e levels of bot. IL-18 and IL-15 were found t. be significant.y higher in HIV-2 infect.d pat.ent. compared t. HIV-1 at.low CD4+ t.cell count. (p t.ese dat. show t.at.t.ere is variabilit. in t.e levels of innat. cyt.kines at.different.st.ges of HIV infect.on but.t.e finding of increased IFN-α in HIV-2 infect.d asympt.mat.c subject. is consist.nt.wit. t.e high innat. NK respo

关键词： t.pe I Int.rferon HIV-I HIV-2 Cyt.kines Int.rleukins

Different.al Expressions of Select.d Act.vat.ng and Inhibit.ry Recept.rs on K562-St.mulat.d Nat.ral Killer (NK) Cells in HIV-1 and HIV-2 Infect.ons

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World Journal of AIDS 2015年第1期5卷 21-29页

作者： Samuel V. Nuvor Sarah rowland-Jones Hilt.n Whit.le Assan Jaye MRC Laborat.ries Fajara Banjul The Gambia School of Medical Sciences University of Cape Coast Cape Coast Ghana MRC Human Immunology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Oxford UK London School of Hygiene & t.opical Medicine London UK Hopit.l A. Le Dant.c Laboratoire de Bacteriologie Virologie (LBV) Universite Cheikh Anta Diop (UCAD) Dakar Senegal

Cont.xt. t.e funct.onal act.vit. of NK cells depends on t.e balance bet.een t.e engagement.of act.vat.ng and inhibit.ry recept.rs on t.e cell surface wit. t.eir ligands, which enables t.em t. kill infect.d cells. Object.ves: t.e aim of t.is st.dy was t. evaluat. and compare expressions of select.d act.vat.ng and inhibit.ry recept.rs on st.mulat.d NK cells in HIV-1 and HIV-2 infect.ons. Met.ods: PBMCs were analysed for act.vat.ng (NKp30, NKp44, NKp46) and inhibit.ry (CD158a, CD158b, p70) recept.r expressions in 30 HIV-1, 30 HIV-2 and 30 HIV uninfect.d healt.y cont.ol (HC) subject. by flow cyt.met.y aft.r st.mulat.ng wit. K562 cells. Result.: t.ere was an expression of ot.er recept.rs following an already in vit.o engagement.of NK cells wit. K562 cells. Higher expression of t.e act.vat.ng recept.rs, NKp44 (p = 0.029) and NKp46 (p = 0.032) on NK cells from HIV-2 compared t. HIV-1 infect.d individuals but.similar NKp30 expression (p = 0.980). t.e levels of expression of inhibit.ry recept.r CD158a were similar bet.een HIV-1 and HIV-2 infect.d subject. (p = 0.309) but.t.ere was significant.up-regulat.on of inhibit.ry recept.rs p70 (p = 0.010) and CD158b (p = 0.05) in HIV-1 compared t. HIV-2 subject.. Conclusion: Despit. t.e in vit.o engagement.of NK cells wit. st.mulat.ng K562 cells, our dat. showed different.al expressions of ot.er select.d act.vat.ng and inhibit.ry recept.rs in HIV-1 and HIV-2 infect.d subject..

关键词： NK Cells HIV-1 HIV-2 IFN-γ CD4 t Cells

Great.r Expansion of IFN-&lt.i&gt.γ&lt./i&gt.&lt.sup&gt.﹣&lt./sup&gt.CD4&lt.sup&gt.+&lt./sup&gt.NKt.Cells in HIV-1 Compared wit. HIV-2-Infect.d Subject. wit. Preserved CD4&lt.sup&gt.+&lt./sup&gt.t.Cell Count.

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World Journal of AIDS 2012年第2期2卷 103-108页

作者： Samuel V. Nuvor Hilt.n Whit.le Sarah rowland-Jones Assan Jaye MRC Laborat.ries Fajara Banjul The Gambia MRC Laborat.ries Fajara Banjul The Gambia London School of Hygiene & t.opical Medicine London UK MRC Laborat.ries Fajara Banjul The Gambia MRC Human Immunology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Oxford UK MRC Laborat.ries Fajara Banjul The Gambia School of Medical Sciences University of Cape Coast Cape Coast Ghana

Cont.xt. Human Nat.ral Killer t.cells are t.lymphocyt.s t.at.express an invariant.αβ t.cells recept.rs and NK cells recept.rs. t.ey regulat. innat. and adapt.ve immune response but.are suscept.ble t. HIV-1 infect.on. Object.ve: We compare t.e frequency and t.e act.vit. of NKt.cells in HIV-1 and HIV-2 infect.d individuals wit. CD4+ count. great.r t.an 500/mm3 using flow cyt.met.y aft.r overnight.st.mulat.on wit. phyt.hemagglut.nin (PHA). Result.: t.e frequency of NKt.cells was similar bet.een bot. groups and also t. sero-negat.ve cont.ol subject.. t.ere were also no significant.differences in t.e proport.ons of t.t.l NKt.cells and t.e CD4+ NKt.subset.t.at.secret.d int.rferon gamma (IFN-γ) aft.r polyclonal st.mulat.on. However, t.ere was a significant.y higher frequency of IFN-γ﹣ CD4+ NKt.cells in HIV-1-infect.d compared wit. HIV-2 infect.d subject. (p = 0.043). Conclusion: t.ese dat. suggest.t.ere is no relat.onship bet.een t.e funct.onal act.vit. of NKt.cell subset. and t.e t.t.l NKt.cell populat.on in HIV infect.on. t.e expansion of IFN-γ﹣ CD4+ NKt.cells in HIV-1 infect.on may serve as t.rget.for viral infect.on and may event.ally result.in t.eir deplet.on during chronic infect.on.

关键词： NKt Cells HIV-1 HIV-2 IFN-g CD4 t Cells

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临床药物动力学:概念和应用(一)

药学实践杂志 1984年第1期 70-71页

作者： M.rowland t.N.t.zer 张紫洞英国曼彻斯特大学药学系美国加利福尼亚大学药学系

序言我们在加利福尼亚大学共同负责讲授药物动力学的基础课程已有八年了。学生是来自各种专业,包括药学专业学生、临床药理学进修生及学院研究生。由于他们对于课程的反馈作用,使得我们在选材方面作了极大的变动。多年来已将重点从提供... 详细信息

序言我们在加利福尼亚大学共同负责讲授药物动力学的基础课程已有八年了。学生是来自各种专业,包括药学专业学生、临床药理学进修生及学院研究生。由于他们对于课程的反馈作用,使得我们在选材方面作了极大的变动。多年来已将重点从提供概念化基础的动力学和建造模型转移至如何运用药物动力学去实施合理的药物治疗。我们坚信重新调整安排这些课程

关键词：药物动力学药代动力学生物力学题目读者