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Comparative Study of Ascorbic Acid and Tocopherol Concentrations in Hydroponic- and Soil-Grown Lettuces

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Food and Nutrition Sciences 2013年第10期4卷 1047-1053页

作者： drew N. Buchanan Stanley T. Omaye Agriculture Nutrition and Veterinary Sciences Department University of Nevada Reno USA.

Hydroponically-grown produce may be a way of helping to feed the world a variety of fruits and vegetables, regardless of soil quality, space availability or climate. The objective of this study was to determine whether hydroponicallygrown lettuce contains as much ascorbic acid and tocopherol as soil-grown lettuce. We analyzed four varieties of lettuce, including: Waldmann’s Dark Green, Red Lollo Antago, Red Romaine Annapolis, and Butterleaf. The tocopherol content of hydroponically-grown Waldmann’s Dark Green, Red Lollo Antago, and Red Romaine Annapolis was 229%, 497% and 492% higher, respectively, compared to their soil-grown counterpart. The ascorbic acid content of hydroponically-grown Waldmann’s Dark Green, Red Lollo Antago, and Red Romaine Annapolis was 93%, 171% and 216% higher, respectively, compared to their soil-grown counterparts. Hydroponically grown lettuce varieties are significantly higher in both ascorbic acid and tocopherol content than their soil-grown counterparts, and hydroponic gardening is a viable option for producing nutritious fruits and vegetables.

关键词： Hydroponic Lettuce Ascorbic Acid Tocopherol Leafy Vegetables

Improved Anticancer Effects on Various Cancers with Combinations of Chemotherapeutic Drugs or Vitamin C and D-Fraction

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Journal of Cancer Therapy 2013年第4期4卷 843-850页

作者： Sensuke Konno Bobby Alexander drew Freilich Muhammad Choudhury Department of Urology New York Medical College Valhalla USA

Although chemotherapy is one of several therapeutic options for cancer patients, the outcomes have been less satisfactory with palpable side effects in many cases. To help improve the efficacy of chemotherapy, we examined whether D-fraction (DF), a bioactive mushroom extract, would potentiate anticancer effects of those drugs in vitro. Seven types of cancer cell lines, including breast, lung, stomach, colon, prostate, bladder, and kidney cancers, were tested with various chemotherapeutic drugs and their combinations with DF. Compared to individual drugs alone, combinations of those drugs and DF have indeed improved anticancer activity, resulting in the significant (p 0.05) cell viability reduction in all cancer cells. As vitamin C (VC) has been insinuated to potentiate bioactivity of DF, combination of DF (300 μg/ml) and VC (200 μM) was also examined. Such studies showed that DF/VC combination led to the drastic (≥90%) viability reductions in 6 cancer cells and the 70% reduction in 1 cancer cell type. These results were superior to those from combinations of drugs and DF. To assess if such a profound cell viability reduction by DF/VC combination might be attributed to apoptosis, this possibility was tested by Western blots. Analyses revealed that anti-apoptotic bcl-2 was down-regulated while pro-apoptotic Bax was up-regulated with DF/VC combination, indicating induction of apoptosis. It is plausible that DF/VC combination may induce apoptosis, resulting in the severe cell viability reduction. Therefore, DF may have a great potential as an adjuvant agent that can be combined with chemotherapeutic drugs or with VC for the improved treatment of various human malignancies.

关键词： D-Fraction Vitamin C Chemotherapy Apoptosis Human Cancers Maitake

Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach

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Bioactive Materials 2024年第4期34卷 125-137页

作者： Rachel E.Young Katherine M.Nelson Samuel I.Hofbauer Tara Vijayakumar Mohamad-Gabriel Alameh drew Weissman Charalampos Papachristou Jason P.Gleghorn Rachel S.Riley Department of Biomedical Engineering Henry M.Rowan College of EngineeringRowan University201 Mullica Hill RdGlassboroNJ 08028United States School of Translational Biomedical Engineering&Sciences Virtua College of Medicine&Life Sciences of Rowan University201 Mullica Hill RdGlassboroNJ 08028United States Department of Chemical and Biomolecular Engineering College of EngineeringUniversity of Delaware150 Academy StreetNewarkDE 19716United States Cooper Medical School of Rowan University Rowan University401 BroadwayCamdenNJ 08103United States Perelman School of Medicine University of Pennsylvania3400 Civic Center BlvdPhiladelphiaPA 19104United States Department of Mathematics College of Science&MathematicsRowan University201 Mullica Hill RdGlassboroNJ 08028United States Department of Biomedical Engineering College of EngineeringUniversity of Delaware590 Avenue 1743NewarkDE 19713United States

Ionizable lipid nanoparticles(LNPs)have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement *** enhance mRNA stability,circulation time,cellular uptake,and preferential delivery to specific tissues compared to mRNA with no carrier ***,LNPs are only in the beginning stages of development for safe and effective mRNA delivery to the placenta to treat placental ***,we develop LNPs that enable high levels of mRNA delivery to trophoblasts in vitro and to the placenta in vivo with no *** conducted a Design of Experiments to explore how LNP composition,including the type and molar ratio of each lipid component,drives trophoblast and placental *** data revealed that utilizing C12-200 as the ionizable lipid and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)as the phospholipid in the LNP design yields high transfection efficiency in *** of lipid molar composition as a design parameter in LNPs displayed a strong correlation between apparent pKa and poly(ethylene)glycol(PEG)content,as a reduction in PEG molar amount increases apparent ***,we present one LNP platform that exhibits the highest delivery of placental growth factor mRNA to the placenta in pregnant mice,resulting in synthesis and secretion of a potentially therapeutic ***,our high-performing LNPs have no toxicity to both the pregnant mice and *** results demonstrate the feasibility of LNPs as a platform for mRNA delivery to the placenta,and our top LNP formulations may provide a therapeutic platform to treat diseases that originate from placental dysfunction during pregnancy.

关键词： Lipid nanoparticles(LNPs) Drug delivery Nucleic acids Placental growth factor(PlGF) Placenta Pregnancy Preeclampsia

Detail in contemporary retail design

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Novell TCP/IP与IntranetWare使用指南

2012年

作者： drew Plunkett and Olga Reid.

ISBN: (纸本)9781856697415

Good retail design must attract and keep customers, support a brand or stores image, showcase the product, and work as a functional shopping environment. This book features 44 of the best recent examples of retail design from around the world, and examines the details within the larger decorative schemes. Most retail interiors have a comparatively short life, and economic realities influence choice of materials and methods of construction; while these will mainly be necessarily modest, style or a sense of luxury are effectively achieved by the creative consideration of detail. Projects range from specialist boutiques to branded high street chain stores, from fashion retailers to eateries, and include de*ive text, colour photographs, floor plans, sections and construction and decorative details. A bonus CD-ROM contains all the drawings as printed in the book, in both EPS and DWG (generic CAD) formats.

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To be Heard, Speaking Softly: Building Resistance to Attitude Change

1998年

作者：（美）（D.海伍德）drew Heywood 陈骞等译

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To be Heard, Speaking Softly: Building Resistance to Attitud...

Evaluating a school based childhood obesity intervention for posture and comfort

2016战略管理国际会议

作者： David Gadiuta Roger Marshall drew Franklin Department of Marketing AdvertisingRetailing and Sales (MARS)Auckland University of Technology

Although there are several attitude resistance techniques, attitude inoculation most effectively serves the purpose of withstanding attacks from conflicting arguments. Inoculation treatment methods are comparable to that of medical vaccination, where a patient is exposed to a small, weakened dose of a pathogen. In this case, the pathogen is simply a counter-argument offered against an advertisement claim aimed at attitude change. These techniques are typically tested within a political domain, rarely in a commercial context. In this research the effects of inoculation treatments are investigated. We find that strong counter-arguments initially have a strong impact on an existing attitude, but their effect quickly dissipates. However, weaker counter-arguments, although initially not as effective as strong, are shown to be more influential over a longer period of time. Attention is also given to potential moderators of this main effect.

关键词： attitude change attitude immunization inoculation health marketing

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Health 2013年第8期5卷 54-60页

作者： Mark Benden Adam Pickens Eva Shipp Jase Perry drew Schneider Texas A & M Health Science Center College Station USA

Background: Research shows that students who are more active throughout the day have fewer reports of body part discomfort and greater energy expenditure needed to combat childhood obesity. Many factors may contribute to the overall health of the child, including the postures that are required to complete assigned tasks at their school workstations. Decreasing sedentary behaviors in children through the use of standing desks at school has been shown to increase calorie expenditure and may be a viable approach to the energy imbalance typical of modern children. The objective of this research was to quantify and analyze sub-optimal postures and self-reported discomfort of students during the use of traditional seated and stand-biased desks to determine whether any unintended consequences of the intervention were present. Methods: A postural analysis based on the Portable Ergonomic Observation (PEO) method was used to assess the posture of 42 elementary school students as they worked at their assigned workstation (either standing or seated). Two classrooms contained stand-biased workstations (15 students) and two classrooms had traditional seated workstations (27 students). Each student was assessed three times at 10 minutes, for a total of 30 minutes of observations each. The percent of time spent in preferred versus non-preferred postures was then computed. Student body part discomfort surveys were used to assess the discomfort of students between the two groups. The relationship between type of workstation and percent time in non-preferred postures and body discomfort was examined using Wilcoxon ranksum tests and Fisher’s exact tests, respectively. The significance level was p ≤ 0.05 for all of the two-sided tests. Results: No significant difference was found between the two groups and time spent in non-preferred postures and body discomfort, children using stand-biased workstations reported less discomfort overall. Stand-biased desks presented no additional ergonom

关键词： Childhood Obesity Elementary Health Ergonomics Stand-Biased Posture

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Windows 2000网络服务

Molecular phylogeny and taxonomy of Phlomoides(Lamiaceae subfamily Lamioideae)in China:Insights from molecular and morphological data

2002年

作者：（美）drew Heywood 王奇睿陈文飞译

本书介绍了Windows 2000网络服务的基础知识，路由和远程访问服务，Windows 2000网络服务的安全问题，Windows 2000网络服务与非Windows环境的协作等内容。

ISBN: (数字)7115102716

ISBN: (纸本)7115102716

本书介绍了Windows 2000网络服务的基础知识，路由和远程访问服务，Windows 2000网络服务的安全问题，Windows 2000网络服务与非Windows环境的协作等内容。

关键词：窗口软件网络服务器

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Plant Diversity 2024年第4期46卷 462-475页

作者： Yue Zhao Ya-Ping Chen Bryan T.drew Fei Zhao Maryam Almasi Orzimat T.Turginov Jin-Fei Xiao Abdul G.Karimi Yasaman Salmaki Xiang-Qin Yu Chun-Lei Xiang CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010000Inner MongoliaChina Department of Biology University of Nebraska at KearneyKearneyNE 68849USA CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chinese Academy of SciencesChengdu Institute of BiologyChengdu 610042SichuanChina Center of Excellence in Phylogeny of Living Organisms Department of Plant ScienceCollege of ScienceUniversity of TehranP.O.Box 14155-6455TehranIran Institute of Botany Academy of Sciences of the Republic of UzbekistanTashkent 100047Uzbekistan Faculty of Biology Department of Botany and Plant PhysiologyNational University of Uzbekistan named after Mirzo UlugbekTashkent 100174Uzbekistan Faculty of Pharmacy Kabul University1006 KabulAfghanistan

Phlomoides,with 150-170 species,is the second largest and perhaps most taxonomically challenging genus within the subfamily Lamioideae(Lamiaceae).With about 60 species,China is one of three major biodiversity centers of *** some Phlomoides species from China have been included in previous molecular phylogenetic studies,a robust and broad phylogeny of this lineage has yet to be ***,given the myriad new additions to the genus,the existing infrageneric classification needs to be evaluated and ***,we combine molecular and morphological data to investigate relationships within Phlomoides,with a focus on Chinese *** observed that plastid DNA sequences can resolve relationships within Phlomoides better than nuclear ribosomal internal and external transcribed spacer regions(nrITS and nrETS).Molecular phylogenetic analyses confirm the monophyly of Phlomoides,but most previously defined infrageneric groups are not *** addition,morphological analysis demonstrates the significant taxonomic value of eight characters to the *** on our molecular phylogenetic analyses and morphological data,we establish a novel section Notochaete within Phlomoides,and propose three new combinations as well as three new *** study presents the first molecular phylogenetic analyses of Phlomoides in which taxa representative of the entire genus are included,and highlights the phylogenetic and taxonomic value of several morphological characters from species of Phlomoides from *** study suggests that a taxonomic revision and reclassification for the entire genus is necessary in the future.

关键词： Lamioideae Molecular phylogenetics Morphology Phlomideae Taxonomy