Review of the genetic basis of emotion dysregulation in children and adolescents
Review of the genetic basis of emotion dysregulation in children and adolescents作者机构：Division of Child and Adolescent PsychiatryCincinnati Children’s Hospital Medical Center Department of Psychiatry and Behavioral NeuroscienceUniversity of Cincinnati College of Medicine Division of Biostatistics and EpidemiologyCincinnati Children’s Hospital Medical Center
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2015年第5卷第1期
页 面：112-117页
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：Supported by Oxley Foundation(Lin PI and Barzman D) Center for Clinical and Translational Science and Training(Barzman D) American Physician Institute(Geise C)
主 题：Gene Emotion regulation Adolescents Children 5-HTTLPR polymorphism
摘 要：Previous evidence suggests that emotion dysregulation may have different biological correlates between adults and children/adolescents. Although the role of genetic factors has been extensively studied in adult-onset emotion dysregulation, the genetic basis for pediatriconset emotion dysregulation remains elusive. The current review article presents a summary of previous studies that have suggested a few genetic variants associated with pediatric emotion dysregulation. Among these candidate loci, many prior studies have been focused on serotonin transporter promoter gene polymorphism 5-HTTLPR. Certain alleles of the 5-HTTLPR gene polymorphism have been found to be associated with traits associated with emotion dysregulation, such as aggression, affect reactivity, and insecure attachment. Additionally, genetic variants involving dopamine and neurophysiological biomarkers like the COMT Val158Met(rs460) and dopamine receptor D2/ ankyrin repeat and kinase domain containing one polymorphisms may play a role in emotion dysregulation. Inconsistent findings have been noted, possibly due to the heterogeneity in study designs and characteristics of different populations. Further research on the role of genetic predetermination of emotion dysregulation in children and adolescents is warranted.
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