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A mathematical model of synaptotagmin 7 revealing functional importance of short-term synaptic plasticity

2005年

作者： don. Dallas

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Neural Regeneration Research 2019年第4期14卷 621-631页

作者： Yao he don.Kulasiri Jingyi Liang Center for Advanced Computational Solutions (C-fACS) Lincoln UniversityChristchurch New Zealand

Synaptotagmin 7(Syt7), a presynaptic calcium sensor, has a significant role in the facilitation in shortterm synaptic plasticity: Syt7 knock out mice show a significant reduction in the facilitation. The functional importance of short-term synaptic plasticity such as facilitation is not well understood. In this study, we attempt to investigate the potential functional relationship between the short-term synaptic plasticity and postsynaptic response by developing a mathematical model that captures the responses of both wild-type and Syt7 knock-out mice. We then studied the model behaviours of wild-type and Syt7 knock-out mice in response to multiple input action potentials. These behaviors could establish functional importance of short-term plasticity in regulating the postsynaptic response and related synaptic properties. In agreement with previous modeling studies, we show that release sites are governed by non-uniform release probabilities of neurotransmitters. The structure of non-uniform release of neurotransmitters makes shortterm synaptic plasticity to act as a high-pass filter. We also propose that Syt7 may be a modulator for the long-term changes of postsynaptic response that helps to train the target frequency of the filter. We have developed a mathematical model of short-term plasticity which explains the experimental data.

关键词： synapse short-term plasticity short-term facilitation and depression mathematical model low-frequency stimulation high-frequency stimulation

Management :.a competency-based approach /.9th ed 9th ed.

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Electronictization-A Foundation for Grid Modernization

2002年

作者： hellriegel don.

Student CD-ROM to accompany.

ISBN: (纸本)0324055587

Student CD-ROM to accompany.

关键词： Management.

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Chinese Journal of Electrical Engineering 2015年第1期1卷 1-8页

作者： don.Tan IEEE Power Electronics Society New JerseyUSA

Smart grid is the flag under which the US DoE has been mobilizing efforts to modernize the *** is the first step towards a smart modern *** is a process that transforms the grid from electrical and electromechanical(EE)to electronic,electrical and electromechanical(EEE),laying down the very basic foundation for the modern *** things grid connected(ATGC)has five groups of essential hardware:1)Grid interface(smart)inverters;2)Hardware for flexible AC transmissions;3)Intelligent electronic power transformers(grid scale);4)Solid-state circuit breaker,current limiters,smart fuses and sensors;and 5)Multi-port bidirectional power&control *** and deployment of ATGC will be a grassroots drive to transform the grid from an old passive technology to a new active technology based on electronic power transmission,distribution,processing and *** modernization represents a win-win-win situation for the environment(Government),consumers,and grid owners/operators.

关键词： Grid modernization electronictization fractal grid structure energy system resiliency fault management fault isolation renewable energy integration all things grid connected

Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

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Neural Regeneration Research 2021年第4期16卷 700-706页

作者： Piyush Bhardwaj don.Kulasiri Sandhya Samarasinghe Centre of Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsible for the recruitment of Nav channels into the structure of AIS through interactions with ankyrin-G(AnkG).In this study,a series of computational experiments are performed to understand the role of AIS proteins casein kinase 2 and AnkG on Nav channel recruitment into the *** computational simulation results using Virtual cell software indicate that Nav channels with all serine sites available for phosphorylation bind to AnkG with strong *** the low initial concentration of AnkG and casein kinase 2,the concentration of Nav channels reduces significantly,suggesting the importance of casein kinase 2 and AnkG in the recruitment of Nav channels.

关键词： Alzheimer’s disease ankyrin-G axon initial segment casein kinase-2 microtubules voltage-gated potassium channel voltage-gated sodium channel

Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders

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Neural Regeneration Research 2021年第6期16卷 1150-1157页

作者： Raheel Khan don.Kulasiri Sandhya Samarasinghe Centre for Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and ***^2+- dependent kinases and phosphatases are responsible for controlling neuronal processing;balance is achieved through *** molecular mechanisms of learning and memory,kinases generally modulate positively while phosphatases modulate *** review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural *** also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.

关键词： Alzheimer’s disease autism spectrum disorder CaMKII calcineurin longterm depression long-term potentiation protein kinase A protein phosphatase 1 protein dephosphorylation protein phosphorylation

Approximate equivalence in von Neumann algebras

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Science China Mathematics 2005年第2期48卷 239-247页

作者： DING Huiru don.Hadwin Department of Mathematics University of New HampshireDurhamNH03824USA Department of MathematicsUniversity of New HampshireDurhamNH03824USA

One formulation of D. Voiculescu's theorem on approximate unitary equivalence is that two unital representations π and ρ of a separable C*-algebra are approximately unitarily equivalent if and only if rank οπ = rank ορ. We study the analog when the ranges of π and ρ are contained in a von Neumann algebra R, the unitaries inducing the approximate equivalence must come from R, and 'rank' is replaced with 'R -rank' (defined as the Murray-von Neumann equivalence of the range projection).

关键词： approximate equivalence, R-rank.

CFD investigation of dense phase pneumatic conveying at a pipeline enlargement

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Particuology 2012年第2期10卷 176-183页

作者： don.McGlinchey Andrew Cowell Ryan Crowe School of Engineering and Computing Glasgow Caledonian University Glasgow Scotland UK

The practice of stepping a conveying line is not new and there are many examples in industry; however, the details of the flow behaviour at the step have not been extensively studied. Three step geometries were modelled： an ＇abrupt＇ step and two ＇gradual＇ step-up geometries from a pipe bore of 75-100 ram. The flow behaviour of a single plug of material passing through these geometries was investigated using the ＇Eulerian＇ CFD model from Fluent. Solids volume fractions were recorded at 0.01 s time steps at several point locations, and visualised throughout the pipe.

关键词： Pneumatic conveyingStepped pipelinePlug flowCFD

Theory of phonon-modulated electron spin relaxation time based on the projection reduction method

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Chinese Physics B 2014年第8期23卷 436-443页

作者： Nam Lyong Kang Sang don.Choi Department of Applied Nanoscience Pusan National University Department of Physics Kyungpook National University

This paper introduces a new method for a formula for electron spin relaxation time of a system of electrons interacting with phonons through phonon-modulated spin-orbit coupling using the projection-reduction method. The phonon absorption and emission processes as well as the photon absorption and emission processes in all electron transition processes can be explained in an organized manner, and the result can be represented in a diagram that can provide intuition for the quantum dynamics of electrons in a solid. The temperature （T） dependence of electron spin relaxation times （T1） in silicon is T1 ∝ T-1.07 at low temperatures and T1 ∝ T-3.3 at high temperatures for acoustic deformation constant Pad = 1.4 × 10^7 eV and optical deformation constant Pod = 4.0 × 10^17 eV/m. This means that electrons are scattered by the acoustic deformation phonons at low temperatures and optical deformation phonons at high temperatures, respectively. The magnetic field （B） dependence of the relaxation times is T1 ∝ B-2.7 at 100 K and T1 ∝ B-2.3 at 150 K, which nearly agree with the result of Yafet, T1 ∝ B-3.0- B -2.5.

关键词： electron spin resonance spin-orbit coupling projection-reduction method phonon scattering

The effects of indigenous prescribed fire on riparian vegetation in central California

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Ecological Processes 2013年第1期2卷 245-253页

作者： don.L Hankins Department of Geography and Planning California State University-ChicoChicoCAUSA

Introduction:Fire has a long history,but little documented role,as a process in riparian *** millennia California Indians have applied fire to riparian ecosystems for a variety of purposes,but the effects of such fires on riparian vegetation are poorly known outside of traditional knowledge structures of indigenous ***:This study involved the seasonal application of fire based on traditional ecological knowledge versus alternate burn methods to assess fire effects on riparian vegetation in central ***:While the annual variation amongst treatments was not significant,the results of this study suggest that fall burns support higher overall richness and native species richness;spring burns yield a decrease in overall richness,but an increase in native species richness;and summer burns contribute to an initial decline in overall and native species *** evenness indices of treatments increase most with spring and summer ***:These findings are key to understanding the seasonal role of fire in managing native species in areas prone to non-native or other invasive *** research demonstrates the application of traditional ecological knowledge to facilitate an understanding of how prescribed fire could aid in the management and conservation of riparian ecosystems.

关键词： Riparian California Indian Fire Indigenous Traditional ecological knowledge