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Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system

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Asian Journal of Pharmaceutical Sciences 2017年第3期12卷 279-284页

作者： Sushilkumar A.Jadhav Valentina Brunella dominique Scalarone Gloria Berlier Department of Chemistry and NIS Research Centre University of Torino

Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.

关键词： Porous silica nanoparticles Thermoresponsive polymer Drug delivery system Ibuprofen Drug loading Drug release profile

Why interleukin-10 supplementation does not work in Crohn's disease patients

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World Journal of Gastroenterology 2013年第25期19卷 3931-3941页

作者： Gareth J Marlow dominique van Gent Lynnette R Ferguson Discipline of Nutrition Faculty of Medical and Health Sciences The University of Auckland Auckland 1142 New Zealand Gareth J Marlow Lynnette R Ferguson Nutrigenomics New Zealand The University of Auckland

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in "Westernised" countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit.

关键词： Inflammatory bowel disease Crohn’s disease Interleukin-10 Recombinant human interleukin-10

Attitudes toward forest diversity and forest ecosystem services—a cross-cultural comparison between China and Switzerland

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Journal of Plant Ecology 2014年第1期7卷 1-9页

作者： Petra Lindemann-Matthies dominique Keller Xuefei Li Bernhard Schmid Institute of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 190CH-8057 ZurichSwitzerland Institute of Biology Karlsruhe University of EducationBismarckstrasse 10D-76060 KarlsruheGermany

Aims Despite the current interest in services provided by ecosystems and the role of biodiversity,the relationship among human attitudes,biodiversity and ecosystem services has hardly been ***,few studies have examined attitudes toward nature in cross-cultural *** study investigates the attitudes of Chinese and Swiss people,both environmental experts and laypersons,toward forest biodiversity and ecosystem *** Overall,640 people in China and Switzerland were interviewed with the help of a standardized *** each country,the study population was equally divided into an urban(80 city dwellers and 80 environmental science students)and a rural(80 forest visitors and 80 farmers)study *** 15-minute interviews took place in the cities of Beijing and Zurich and in the rural forested areas of Dujiangyan,Sichuan Province and Lake Sempach,canton *** toward forest biodiversity were investigated with the help of color photographs that depicted both monocultures and speciesrich forests typical for China and *** toward ecosystem services were investigated with the help of 13 statements on provisioning,regulating,cultural and supporting services of *** Findings On average,Chinese participants showed no strong preferences for biodiversity,whereas the Swiss clearly preferred species-rich forests over ***,Chinese environmental science students did prefer species-rich forests and attributed to them a higher conservation value because of their higher *** there were no strong preferences for Chinese versus Swiss forests,all participants correctly answered that Chinese forests are more species rich in terms of plants and animals and thus found them less boring and more interesting,but also less managed,than Swiss *** participants highly valued the ecosystem services provided by forests;especially the regulating and supporting ***

关键词： biodiversity preferences cross-cultural comparison forests valuation of ecosystem services

PM_(2.5)characterization of primary and secondary organic aerosols in two urban-industrial areas in the East Mediterranean

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Journal of Environmental Sciences 2021年第3期33卷 98-116页

作者： Marc Fadel Frédéric Ledoux Mariana Farhat Adib Kfoury dominique Courcot Charbel Afif Emissions Measurementsand Modeling of the Atmosphere(EMMA)LaboratoryCARFaculty of SciencesSaint Joseph UniversityBeirutLebanon Unitéde Chimie Environnementale et Interactions sur le Vivant UCEIV UR4492FR CNRS 3417University of Littoral Côte d Opale(ULCO)DunkerqueFrance Department of Environmental Sciences University of BalamandAl KourahLebanon Climate and Atmosphere Research Center The Cyprus InstituteNicosiaCyprus

Primary and secondary organic aerosols in PM_(2.5)were investigated over a one-year campaign at Zouk Mikael and Fiaa,*** n-alkanes concentrations were quite similar at both sites(26-29 ng/m^(3))and mainly explained by anthropogenic emissions rather than natural *** concentrations of total Polycyclic Aromatic Hydrocarbons(PAHs)were nearly three times higher at Zouk Mikael(2.56 ng/m^(3))compared to Fiaa(0.95 ng/m^(3)),especially for indeno[1,2,3-c,d]pyrene linked to the presence of the power plant.A characteristic indeno[1,2,3-c,d]pyrene/(indeno[1,2,3-c,d]pyrene+benzo[g,h,i]perylene)ratio in the range0.8-1.0 was determined for heavy fuel oil combustion from the power *** acids and hopanes were also investigated and were assigned to cooking activities and vehicular emissions *** were identified for the first time in Lebanon with high concentrations at Zouk and Fiaa(106.88 and 97.68 ng/m^(3) respectively).Moreover,the biogenic secondary aerosols revealed higher concentrations in *** total terpene concentration varied between 131 ng/m^(3) at Zouk Mikael in winter to 469 ng/m3 at Fiaa in ***,the concentrations of the dicarboxylic acids especially for adipic and phthalic acids were more influenced by anthropogenic *** analysis of molecular markers and diagnostic ratios indicated that the sites were strongly affected by anthropogenic sources such as waste open burning,diesel private generators,cooking activities,road transport,power plant,and industrial ***,results showed different pattern during winter and summer ***,higher concentrations of biogenic markers were clearly encountered during the summer period.

关键词： PM_(2.5) Secondary organic aerosols PAHs Phthalates Lebanon Urban-industrial sites

Regulated multi-sited practice for physicians in China: incentives and barriers

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Global Health Journal 2018年第1期2卷 14-31页

作者： Lihui Xu Min Zhang dominique Bertrand Doctoral School 262 Sorbonne Paris CitéUniversity(USCP)Facultéde Droit 10 avenue Pierre Larousse92240 MalakoffFrance School of Public Health Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China National Center for the Management of Hospital Practitioners and Senior Staff of the Public Hospital Service(CNG) ParisFrance

The multi-sited practices (MSP) policy in China is expected to exert found implications upon uneven distribution of high-quality medical resources,coupled with the widespread phenomenon of physician's informal practices on multiple *** 2009,the Chinese government has upheld a policy that allows medical doctors to take on secondary jobs for the purpose of encouraging talented physicians to work in medical institutions and underdeveloped areas where their expertise is badly *** paper focuses on the MSP policy in China by examining how it has been implemented at the national and provincial levels through a review of government documents,statistical information,academic papers,and newspaper *** the MSP policy is to offer incentive to physicians at first-tier public hospitals to work in primary care centers or areas where their expertise,the evidence is hard to *** paper identifies several outstanding challenges to the MSP policy:(1) The importance of the MSP policy which is made by the central government is perceived differently at the provincial level by health officials and hospital administrators;(2) Interest in implementing the policy varies among physicians and hospitals;(3) Concerns about quality control and legal responsibilities for medical doctors to take on secondary jobs are ***'s MSP policy differs from the 'dual practice' policy in many countries because of its top-down approach,with its emphasis on government's role and administrative *** paper's findings may be useful for other developing countries where medical expertise is unevenly distributed due to market *** the special occasion of the Alma Ata Declaration's 40th anniversary and for the sake of promoting Universal Health Coverage,this paper also aims at sharing with other countries China's experience in trying to develop an adequate force of primary care *** the end of this paper,a four-point proposal is made for policy

关键词： health human resources multi-sited practice dual-practice health reform China

Pulsed export of carbon in the north-western Mediterranean Sea

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Journal of Oceanology and Limnology 2023年第1期41卷 189-202页

作者： Michel DENIS dominique LEFEVRE Melilotus THYSSEN Ian RJENKINSON Gérald GRÉGORI Aix Marseille Université Universitéde ToulonCNRS/INSUIRDInstitut Méditerranéen d'Océanologie(MIO)Marseille cedex09 13288France Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Agency for Consultation and Research in Oceanography Lavergne19320 La Roche CanillacFrance

The short term(hourly scale)variability of heterotrophic prokaryote(HP)vertical distribution and respiratory activity,was investigated in the north-western(NW)Mediterranean *** vertical distribution was determined on board by flow cytometry analysis of seawater samples collected by series of CTD *** counts and viability were determined for all *** respiratory rates were determined later in the laboratory from filtered seawater samples(23 dm^(3))from 300-1150-m *** average cell viability was 94.8%±2.2%(n=240).There was no accumulation of dead cells,due to quick decay of damaged *** the epipelagic layer,three HP groups were distinguished,two(HNA1,HNA2)who se cells exhibited a high nucleic acid content and one(LNA)with low nucleic acid content ***2 was most populated at 50 m but not detected at 90 m and below,presumably aerobic anoxygenic photoheterotrophic bacteria(AAPs).The variability in HP abundance was mainly confined in the upper 80 m.A few secondary peaks of HP abundance were observed(80-150 m)in connection with abundance troughs in the surface *** cells were continuously present in a wide layer around 500 m(mean 191×10^(3)cells/cm^(3)).Below this layer,HP abundance randomly exhibited peaks,coupled to respiratory rate *** HP abundance and variability in the water column was suppressed during a strong wind *** observed sporadic variability was tentatively interpreted through a pulsed carbon-export mechanism induced by the microorganism production of dissolved poly saccharide s,followed by flocculation and rapid *** mechanism would thus contribute to(ⅰ)preventing organic matter accumulation in the epipelagic layer,(ⅱ)seeding the water column with live HP cells,and(ⅲ)supplying the aphotic water column with fre sh and labile organic *** important vertical flux mechanism needs further observations and modelling.

关键词： north-western Mediterranean Sea heterotrophic prokaryote(HP) cell viability cell respiration transparent exopolymeric particle(TEP) aggregation flow cytometry

Current status of emergency treatment of chemical eye burns in workplaces

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 306-309页

作者： Kevin Claassen dominique Rodil Dos Anjos Horst Christoph Broding Faculty of Health Department of Human Medicine Occupational Medicine and Corporate Health ManagementWitten/Herdecke University

Chemical eye burns present an avoidable,but frequent,occupational injury with potentially detrimental consequences for the quality of life and occupational rehabilitation of the injured.A periodical review of guidelines is required to assure the optimal emergency *** reviewed the literature with emphasis on current German guidelines,primarily *** the crucial first-line measure,the injury prevention has failed and an eye burn has been sustained,the immediate and copious rinsing of the eye is the pivotal emergency treatment *** the immediacy and sufficiency of the emergency rinsing are largely unanimous,there is an ongoing debate about the benefits and risks of specific rinsing solutions,and regular updates on guidelines and recommendations for the emergency treatment are *** easiest and readily available rinsing solution is tap water,which fulfils the crucial criteria conveniently in most industrialized countries:purity,sterility,and neutral p *** rinsing solutions are proposing higher osmolality to stabilize the physiological p H,because of their superior buffering ***,there is no compelling evidence for a substantial benefit,and some reports suggest that there could be unwanted side *** combination with the substantially increased expenditure and a more complex handling procedure,currently a general recommendation of any other solution than tap water is not warranted.

关键词： eye burns occupational medicine emergency treatment rinse solutions

Toward a unified model of Altaids geodynamics:Insight from the Palaeozoic polycyclic evolution of West Junggar(NW China)

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Science China Earth Sciences 2016年第1期59卷 25-57页

作者： Flavien CHOULET Michel FAURE dominique CLUZEL CHEN Yan LIN Wei WANG Bo XU Bei UMR6249 Chrono-EnvironnementCNRS/Universite de Bourgogne Franche-ComteBesangonFrance UMR 7327 Institut des Sciences de la Terre d'OrleansBRGM/CNRS/Universite d'OrleansOrleansFrance POle Pluridisciplinaire de la Matiere et de l'Environnement Universite de la Nouvelle CaledonieNoumeaFrance Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Department of Earth Science University of NanjingNanjing 210093China Key Laboratory of Orogenic Belts and Crustal Evolution Peking UniversityBeijing 100871China

The Altaid tectonic collage extends over Central Asia, exposing numerous accretionary orogens that can account for the Palaeozoic continental crust growth. A pluridisciplinary approach, using geochronological, geochemical, structural and palaeomagnetic tools was carried out to unravel the architecture and the evolution of West Junggar （Northwestern China）, a segment of the Altaid Collage. A polycyclic geodynamic evolution is inferred and includes：（1） an Early Palaeozoic cycle, characterized by the closure of two oceanic basins bounded by island-arc systems; （2） an Early Devonian subduction jamming resulting in a minor-scale collision documented by thrusting, syntectonic sedimentation and subsequent crutal thinning associ- ated with alkaline magmatism; （3） a Late Palaeozoic cycle, driven by the evolution of two opposite subduction zones devel- oped upon the Early Palaeozoic basement. Detailed structural analysis and paleomagnetic data provide constraints for the late evolution of Junggar in the frame of the development of the Late Palaeozoic Kazakh orocline, which led to oblique subduction and transpression in the West Junggar accretionary complex. Progressive buckling of the Kazakh orocline further resulted in Late Carboniferous to Permian wrench tectonics, and lateral displacement of lithotectonic units. Block rotations that continued after the Late Triassic are due to diachronous intraplate reactivation. This scenario mirrors the Palaeozoic geodynamics of the Altaid Collage. Multiple Early Palaeozoic collisions of intra-oceanic arcs and micro continents have contributed to the formarion of the Kazakhstan Microconrinent. Since the Late Palaeozoic, subductions formed around this microcontinent and the final oblique closure of oceanic domains resulted in the transcurrent collage of Tarim and Siberia cratons. Palaeozoic strike-slip faults were later reactivated during Mesozoic intracontinental tectonics.

关键词： West Junggar Geodynamics Paleozoic Paleomagnetism Crustal growth

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