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Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate

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World Journal of Methodology 2017年第3期7卷 73-92页

作者： Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan dominic sc raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas Division of Nephrology Department of MedicineUniversity of New Mexico School of Medicine Division of Nephrology Department of MedicineUniversity of Toledo School of Medicine Renal and Electrolyte Division Department of MedicineUniversity of Pittsburgh School of Medicine Division of Nephrology Department of MedicineJoan C. Edwards School of Medicine Division of Nephrology Department of MedicineGeorge Washington University Marshall University Joan C. Edwards school of Medicine Nephrology Section Medicine ServiceRaymond G. Murphy VA Medical Center Department of Medicine University of New Mexico School of Medicine

The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and *** scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury.

关键词： Chronic kidney disease Serum creatinine Creatinine clearance Creatinine excretion Estimated glomerular filtration rate Cystatin C Renal imaging Hyperfiltration Biomarkers of chronic kidney disease

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紫山姜体外抗氧化及抗癌活性研究(英文)

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中国天然药物 2012年第4期10卷 263-268页

作者： Chinthamony Arul raj Paramasivam Ragavendran dominic Sophia Muthaiyan Ahalliya Rathi Velliyur Kanniappan Gopalakrishnan Department of Biochemistry Karpagam UniversityCoimbatoreTamilnadu 641021India

AIM:Ethylacetate extract of Alpinia purpurata was evaluated for its potential in vitro antioxidant and antican-cer ***:The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl(DPPH) free radical scav-enging method,hydroxyl radical activity,superoxide radical scavenging activity,nitric oxide radical scavenging activity,hy-drogen peroxide radical scavenging activity and reducing power *** viability of OAW42 cells was evaluated by MTT ***:*** exhibited potential antioxidant activity with a concentration-dependent *** extract showed potential anticancer activity at the 48th hour with IC50 of 130.20 μg·mL·1 and exhibited a dose-dependent decrease in cell count for all the concentrations ***:The results suggested that long term consumption of *** exhibited antioxidant and anticancer activity and could be further exploited for their anticancer properties.

关键词： Alpinia purpurata Ethylacetate Antioxidants Anticancer OAW42

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BS-sc Model:A Novel Method for Predicting Child Abuse Using Borderline-SMOTE Enabled Stacking Classifier

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Computer Systems science & Engineering 2023年第8期46卷 1311-1336页

作者： Saravanan Parthasarathy Arun raj Lakshminarayanan s.abdur rahman crescent institute of science and technology gst roadvandalurchennai600048tamil naduindia

For a long time,legal entities have developed and used crime prediction *** techniques are frequently updated based on crime evaluations and responses from scientific *** is a need to develop type-based crime prediction methodologies that can be used to address issues at the subgroup *** maltreatment is not adequately addressed because children are *** a result,the possibility of developing a model for predicting child abuse was investigated in this *** exploratory analysis methods were used to examine the city of Chicago’s child abuse *** data set was balanced using the Borderline-SMOTE technique,and then a stacking classifier was employed to ensemble multiple algorithms to predict various types of child *** proposed approach successfully predicted crime types with 93%of accuracy,precision,recall,and *** AUC value of the same was ***,when compared to the Extra Trees model(17.55),which is the second best,the proposed model’s execution time was significantly longer(476.63).We discovered that Machine Learning methods effectively evaluate the demographic and spatial-temporal characteristics of the crimes and predict the occurrences of various subtypes of child *** results indicated that the proposed Borderline-SMOTE enabled Stacking Classifier model(BS-sc Model)would be effective in the real-time child abuse prediction and prevention process.

关键词： Child abuse sexual offending decision-making machine learning stacking classifier

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Evaluation of In Vitro Enzymatic and Non-Enzymatic Antioxidant Properites of Leaf Extract from Alpinia Purpurata(Vieill.) K. schum.

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Chinese Journal of Integrative Medicine 2016年第9期22卷 691-695页

作者： Chinthamony Arul raj Paramasivam Ragavendran dominic Sophia Thangarajan Starlin Muthian Ahalliya Rathi Velliyur Kanniappan Gopalakrishnan Department of Biochemistry Karpagam University Coimbatore Tamil Nadu India 641021 Department of Bioinformatics Karpagam University Coimbatore Tamil Nadu India 641021 Department of Biochemistry Sree Narayana Guru College of Arts and Science KG. Chavadi Coimbator Tamil Nadu 641021 India

Objective： To evaluate the enzymatic and non-enzymatic antioxidants of leaf extract from Alpinia purpurata. Methods： One gram of fresh leaf of Alpinia purpurata was grinded in 2 mL of 50% ethanol and centrifuged at 10,000×g at 4 ℃ for 10 min. The supernatant obtained was used within 4 h for various enzymatic antioxidants assays like superoxide dismutase（SOD）, catalase（CAT）, glutathione peroxidase（GPx）, glutathione S-transferase（GST）, ascorbate oxidase, peroxidase, polyphenol oxidase（PPO） and non-enzymatic antioxidants such as vitamin C, total reduced glutathione（TRG） and lipid peroxidation（LPO）. Results： The leaf extract of Alpinia purpurata possess antioxidants like vitamin C 472.92±6.80 μg/mg protein, GST 372.11±5.70 μmol of 1-chloro 2,4 dinitrobenzene（CDNB）-reduced glutathione（GSH） conjugate formed/min/mg protein, GPx 281.69±6.43 μg of glutathione oxidized/min/mg protein, peroxidases 173.12±9.40 μmol/g tissue, TRG 75.27±3.55 μg/mg protein, SOD 58.03±2.11 U/mg protein, CAT 46.70±2.35 μmol of H_2O_2 consumed/min/mg protein in high amount whereas ascorbate oxidase 17.41±2.46 U/g tissue, LPO 2.71±0.14 nmol/L of malondialdehyde formed/min/mg protein and PPO 1.14±0.11 μmol/g tissue in moderate amount. Conclusion： Alpinia purpurata has the potential to scavenge the free radicals and protect against oxidative stress causing diseases. In future, Alpinia purpurata may serve as a good pharmacotherapeutic agent.

关键词： Alpinia purpurata enzymatic antioxidants non-enzymatic antioxidants oxidative stress free radicals

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Isospin dependent properties of the isotopic chains of scandium and Titanium nuclei within the relativistic mean-field formalism

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Chinese Physics C 2022年第8期46卷 155-169页

作者： Praveen K.Yadav raj Kumar M.Bhuyan school of Physics and Materials science Thapar Institute of Engineering and TechnologyPatiala-147004PunjabIndia Center for Theoretical and Computational Physics Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Institute of Research and Development Duy Tan UniversityDa Nang 550000Vietnam

Density-dependent nuclear symmetry energy is directly related to iso spin asymmetry for finite and infinite nuclear *** is critical to determine the coefficients of symmetry energy and their related observables because they hold great importance in different areas of nuclear physics,such as the analysis of the structure of ground state exotic nuclei and neutron star *** ground state bulk properties of scandium(Z=21) and Titanium(Z=22) nuclei are calculated,such as their nuclear binding energy(B.E.),quadrupole deformation(β_2),two-neutron separation energy(S_(2 n)),differential variation in the two-neutron separation energy(dS_(2 n)),and root-mean-square charge radius(r_(ch)).The iso spin properties,namely the coefficient of nuclear symmetry energy and its components,such as the surface and volume symmetry energy of a finite isotopic chain,from the corresponding quantities of infinite nuclear matter,are also ***,we correlate the neutron-skin thickness with the coefficient of symmetry energy and the related observables corresponding to the isotopic chains of these *** coherent density fluctuation model(CDFM) is used to estimate the iso spin-dependent properties of finite nuclei,such as symmetry energy,surface symmetry energy,and volume symmetry energy,from their corresponding component in infinite nuclear *** relativistic mean-field(RMF) formalism with non-linear NL3 and relativistic-Hartree-Bogoliubov theory with density-dependent DD-ME2 interaction parameters are employed in the *** weight function |F(x)|^(2) is estimated using the total density of each nucleus,which in turn is used with the nuclear matter quantities to obtain the effective symmetry energy and its components in finite *** calculate the ground state bulk properties,such as nuclear binding energy,quadrupole deformation,two-neutron separation energy,differential variation in the two-neutron separation energy,and root-mean-square charge radius,fo

关键词： relativistic energy density functional symmetry energy weight function isospin asymmetry

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红姜叶提取物所含化学成分的抗肿瘤及抗菌作用(英文)

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中西医结合学报 2012年第12期10卷 1460-1464页

作者： Chinthamony Arul raj dominic Sophia Paramasivam Ragavendran Thangarajan Starlin Muthian Ahalliya Rathi Velliyur Kanniappan Gopalakrishnan Department of Biochemistry Karpagam University Department of Bioinformatics Karpagam University Department of Biochemistry Sree Narayana Guru College

目的:研究红姜叶提取物中的化学成分的抗肿瘤及抗菌活性。方法:用自来水充分洗净红姜叶,晾干后制成粉剂,用连续溶剂系统提取其化学成分。对植物化学成分进行评估,运用纸片扩散法检测植物提取物的抗菌活性,利用四甲基偶氮唑盐比色法检测... 详细信息

目的:研究红姜叶提取物中的化学成分的抗肿瘤及抗菌活性。方法:用自来水充分洗净红姜叶,晾干后制成粉剂,用连续溶剂系统提取其化学成分。对植物化学成分进行评估,运用纸片扩散法检测植物提取物的抗菌活性,利用四甲基偶氮唑盐比色法检测植物叶子的乙酸乙酯提取物的抗肿瘤作用。结果:红姜叶经乙酸乙酯提取后,能最大限度得到有效的植物化学成分。不同浓度的红姜叶植物提取物抑制细菌的区域为5～14mm;并且在48h内、植物提取物半数抑制浓度为110.25μg/mL时表现出抗PA1卵巢癌细胞株活性,且细胞数量呈剂量依赖性递减。结论:红姜叶的乙酸乙酯提取物中的化学成分可有效抑制细菌活性,并具有抗肿瘤的作用。

关键词：山姜属植物提取物抗菌药抗肿瘤药体外研究

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Assessment of different grass species extracts as source of micronutrients in prawn Macrobrachium rosenbergii feeds

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Aquaculture and Fisheries 2024年第6期9卷 937-947页

作者： Kakoli Banerjee Tusharika Mahakur Pramod Kumar Bindhani Gopal raj Khemundu Department of Biodiversity and Conservation of Natural Resources Central University of OdishaSunabedaP.O.NADKoraput763004India

The present research is an attempt to screen five perennial indigenous grass species for their biochemical constituents seasonally for one year in order to determine the exact season for the harvest of the target species which will be used as feed *** them,Cynodon dactylon has shown better result compared to other grass species and was hence incorporated as micronutrient in the formulated *** rosenbergii culture was carried out by feeding conventional and formulated feed(prepared from grass species)in tanks and ponds filled with spring water for 180 days in 2020 in the Eastern Ghats region of Koraput district,Odisha,*** treatments namely T_(1)and T_(2)having four replications each were supplied with commercial feed and formulated *** were applied as per the body weight of prawns at 20%for the 1st month,15%for the 2nd month,10%for the 3rd and the 4th month,5%for the 5th month and 2%till the end of the *** water temperature,pH,dissolved oxygen,transparency,nitrate,phosphate,silicate,Chl a in the culture tanks and ponds were monitored *** results between all the water parameters for both culture tanks and ponds showed significant variation(P<0.05).The survival rate(77.0%±0.89%),daily growth rate(0.233±0.05)g/day,specific growth rate(4.657%±1.04%)per day and condition index(2.638±0.05)were found to be highest in prawns fed formulated *** feed conversion ratio varied from(2.03±0.05)to(2.68±0.04).Benefit cost ratio of field culture were 1.46 with yield of 702 kg/ha in conventional feed and 1.75 with yield of 950 kg/ha in formulated feed *** study proved grass extracts to be efficient micronutrients for prawn feed which can be easily adopted in prawn production.

关键词： Benefit cost ratio C.dactylon Condition index Conventional feed Formulated feed Spring water

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Seasonal variations and health risk assessment of trace elements in the Badigad River,lesser Himalayas,Nepal

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Acta Geochimica 2023年第4期42卷 689-703页

作者： Ramesh raj Pant Kiran Bishwakarma Kshitiz Kandel Sudip Poudel Jharana Nepal Bhanu Bhakta Neupane Virendra Bahadur Singh Central Department of Environmental science Institute of Science and TechnologyTribhuvan UniversityKathmanduNepal University of Chinese Academy of sciences Beijing 100049China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China Central Department of Chemistry Institute of Science and TechnologyTribhuvan UniversityKathmanduNepal Department of Environmental Studies Ram Lal Anand CollegeUniversity of DelhiNew Delhi 110021India

The consumption of contaminated river water can have severe effects on human *** study aims to investigate the trace elements(TEs)content and their health risk assessment in the Badigad River Basin in the lesser Himalayas of *** total,44 water samples were collected from 22 different sites during the pre-monsoon and monsoon seasons,and 25 TEs were *** matrix and principal component analysis(PCA)were used to analyze the potential relationship between the measured TEs and their source ***,the water quality index(WQI),metal index(MI),and cancer index(CI)were *** TEs content in all samples were found to be within the WHO recommended guideline for drinking and domestic *** dominancy order of the TEs was observed as Sr>Ba>Li>Rb>Zn>Cr>sc>Mn>Ti>Cu>As>Ni>Co>U>V>Pb>Cs>Ga>Y>Tl>Th>Zr>Bi>Cd>*** PCA analysis suggested that TEs could have natural,anthropogenic,and mixed *** WQI indicated that the river water is safe from a human health *** MI suggested that Badigad River can be considered safer for drinking purposes,and the cancer index(CI)showed that all the reported TEs are at low-risk *** findings of this study could be useful for government agencies in developing more sustainable water management policies in the ***,it is suggested that further investigations should be conducted in terms of other hydrogeochemical variables,including major ions,at spatiotemporal levels for the sustainability of the river basin.

关键词： Trace elements Water quality Health risk assessment Multivariate analysis Badigad River

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Mineralogy and whole-rock geochemistry of the Oligocene Barail Group of rocks of Belt of schuppen,Northeast India:Implications for tectono-provenance and paleo-weathering

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Acta Geochimica 2024年第5期43卷 904-932页

作者： Manash Pratim Gogoi Yunpeng Dong Pradip Borgohain Devojit Bezbaruah Arvind Pandey Yadav Krishna Gogoi Garima Konwar Gautam raj Bawri Bubul Bharali Department of Petroleum Technology Dibrugarh UniversityAssam 786004India Department of Geology Northwest UniversityXi’an 710069China Department of Applied Geology Dibrugarh UniversityAssam 786004India Department of Statistics Central University of RajasthanAjmer 305817India Department of Geology Mizoram UniversityAizawlMizoram 796004India Department of Geology Pachhunga University CollegeAizawlMizoram 796001India

The petrographic and geochemical attributes of the Oligocene Barail Group of rocks are used to decipher the likely source area(s)or tectonic domains,as this sequence of rocks was deposited in a foreland basin governed by orogenic domain,namely the North-east Arunachal *** river system that gave rise to the Brahmaputra River(Yarlung-Tsangpo),which flowed through several tectonic domains of the Himalayan ranges,primarily from BomiChayu,Gangadese Granitoid,Higher Himalayan Leucogranites,and Namche Barwa into the proto Bengal Basin now a part of Assam Arakan Basin and Naga schuppen Belt,was the main source of the sandstone formation of the Barail *** purpose of sandstone petrography,which combines modal analysis with XRF(Major Oxides)and HR-ICPMS(Trace&Rare Earth Elements)research,is to identify the type of source rock(s),their weathering pattern,and its paleo-environmental *** sandstones were formed from recycled orogen and include lithic and sublithic arenite variants with advanced texture and chemical *** sediments were felsic(Th/Co:1.38,Cr/Th:9.78,La/Lu:11.58,Th/sc:0.99,Eu/Eu*:0.66,La/sc:3.05,La/Co:4.18),with contributions from intermediate source rocks and low-rank metamorphics deposited in an active continental margin to a continental island arc *** conditions impacted the sediments of Barails,characterised by being warm and semi-humid to humid which resulted in moderate to a high degree of chemical weathering,as shown by weathering indices like CIA(79.14),PIA(85.47),CIW(86.9),WIP(32.50),ICV(0.71),and Th/U(6.03),which were further additionally supported by C-Value(1.01),PF(1.20),Sr/Cu(2.04),and Rb/Sr(0.97).

关键词： Belt of schuppen Barail Group Sandstone Petrography Geochemistry Provenance Tectonic setting

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Gut microbiome supplementation as therapy for metabolic syndrome

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World Journal of Diabetes 2023年第10期14卷 1502-1513页

作者： Mc Anto Antony Aniqa Chowdhury Dinesh Edem Rishi raj Priyanshu Nain Mansi Joglekar Vipin Verma Ravi Kant Department of Endocrinology Diabetes and MetabolismMedical University of South Carolina/AnMed CampusAndersonSC 29621United States Department of Endocrinology Diabetes and MetabolismUniversity of Arkansas for Medical SciencesLittle RockAK 72205United States Department of Endocrinology Diabetes and MetabolismPikeville Medical CenterPikevilleKY 41501United States Department of Graduate Medical Education Maulana Azad Medical CollegeDelhi 110002India Department of Internal Medicine Medical University of South Carolina/AnMed CampusAndersonSC 29621United States

The gut microbiome is defined as an ecological community of commensal symbiotic and pathogenic microorganisms that exist in our *** microbiome dysbiosis is a condition of dysregulated and disrupted intestinal bacterial homeostasis,and recent evidence has shown that dysbiosis is related to chronic inflammation,insulin resistance,cardiovascular diseases(CVD),type 2 diabetes mellitus(T2DM),and *** is well known that obesity,T2DM and CVD are caused or worsened by multiple factors like genetic predisposition,environmental factors,unhealthy high calorie diets,and sedentary ***,recent evidence from human and mouse models suggest that the gut microbiome is also an active player in the modulation of metabolic syndrome,a set of risk factors including obesity,hyperglycemia,and dyslipidemia that increase the risk for CVD,T2DM,and other *** research aims to identify treatments to increase the number of beneficial microbiota in the gut microbiome in order to modulate metabolic syndrome by reducing chronic inflammation and insulin *** is increasing interest in supplements,classified as prebiotics,probiotics,synbiotics,or postbiotics,and their effect on the gut microbiome and metabolic *** this review article,we have summarized current research on these supplements that are available to improve the abundance of beneficial gut microbiota and to reduce the harmful ones in patients with metabolic syndrome.

关键词： Gut dysbiosis Metabolic syndrome Diabetes mellitus Prebiotics Probiotics Postbiotics

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