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Role of ^(18)F-FDG PET/CT in detection of hematogenous metastases of advanced differentiated thyroid carcinoma: a systematic review and meta-analysis

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 213-225页

作者： Natale Quartuccio domenico rubello Nuclear Medicine Unit A.R.N.A.S.CivicoDi Cristina and Benfratelli HospitalsPalermo 90144Italy Nuclear Medicine Unit Santa Maria della Misericordia HospitalRovigo 45100Italy.

The aim of this study was to collect the evidence on the performance of 2-deoxy-2-[^(18)F]fluoro-D-glucose(^(18)F-FDG)Positron Emission Tomography/Computed Tomography(PET/CT)in terms of detection rate(DR)and diagnostic accuracy in identifying hematogenous metastases in patients with differentiated thyroid cancer and compare its performance with that of other imaging techniques.A comprehensive PubMed/MEDLINE database research was carried out to retrieve studies documenting the performance of^(18)F-FDG PET/CT in depicting hematogenous metastases in patients with differentiated thyroid *** analysis was performed on a per-patient and per-lesion *** literature search yielded 15 articles to be included in the systematic review.^(18)F-FDG PET/CT showed a pooled DR of 85.08%on a per-patient analysis and 89.70%on a per-lesion *** bone lesions,a high DR(81.78%)was found for^(18)F-FDG PET/*** the sub-group analysis of lung lesions,pooled DR was 92.77%for^(18)F-FDG PET/CT,95.02%for CT,and 64.93%for magnetic resonance imaging(MRI).On a per-patient analysis,^(18)F-FDG PET/CT demonstrated a pooled sensitivity(SS)of 87.3%[95%confidence interval(CI):77.3%-94%]and a pooled specificity(SP)of 95.6%(95%CI:87.6-99.1).On a per-lesion analysis(328 metastases),PET/CT showed a pooled SS and SP of 86.3%(95%CI:73.5%-93.5%)and 93.4%(95%CI:71.7%-98.8%)in the detection of hematogenous *** presented systematic review and meta-analysis favor the use of^(18)F-FDG PET/CT in the detection of hematogenous metastases in patients with differentiated thyroid *** limited literature warrants further studies to confirm our findings.

关键词： PET/CT hematogenous metastases lung bone thyroid cancer FDG meta-analysis

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Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography

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World Journal of Radiology 2016年第6期8卷 635-655页

作者： Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti Lorraine M Fig domenico rubello Milton D Gross Division of Nuclear Medicine Department of RadiologyUniversity of Michigan Nuclear Medicine Service VA Ann Arbor Healthcare System Radiology Service VA Ann Arbor Healthcare System Department of Nuclear Medicine RadiologyNeuro RadiologyMedical PhysicsSanta Maria della Misericordia Hospital

AIM: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine ***: We performed MEDLINE and Pub Med searches using the terms: "SPECT/CT"; "functional anatomic mapping"; "transmission emission tomography"; "parathyroid adenoma"; "thyroid cancer"; "neuroendocrine tumor"; "adrenal"; "pheochromocytoma"; "paraganglioma"; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this ***: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and ***: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating

关键词： Parathyroid adenoma Neuroendocrine tumor Single photon emission computed tomography/ computed tomography Single photon emission computed tomography-computed tomography Thyroid cancer Pheochromocytoma Paraganglioma

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FDG-PET/CT and parathyroid carcinoma:Review of literature and illustrative case series

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World Journal of Clinical Oncology 2011年第10期2卷 348-354页

作者： Laura Evangelista Nadia Sorgato Francesca Torresan Isabella Merante Boschin Gianmaria Pennelli Giorgio Saladini Andrea Piotto domenico rubello Maria Rosa Pelizzo Radiotherapy and Nuclear Medicine Unit Istituto Oncologico Veneto(IOV-IRCCS)Padova 35128Italy Department of Surgical Pathology Institution of Medical and Surgical SciencesUniversity of PadovaPadova 35100Italy Department of Medical Diagnostic Sciences and Special Therapies(Surgical Pathology and Cytopathology Section) University of PadovaPadova 35100Italy Department of Nuclear Medicine Santa Maria della Misericordia Rovigo HospitalRovigo 45100Italy

Parathyroid cancer is an uncommon malignant cancer and is associated with a poor *** staging of parathyroid cancer represents an important issue both at initial diagnosis and after surgery and medical *** role of positron emission tomography/computed tomography(PET/CT)with 18F-Fluorodeoxyglucose(18F-FDG)as an imaging tool in parathyroid cancer is not clearly reported in the literature,although its impact in other cancers is *** aim of the following illustrative clinical cases is to highlight the impact of PET/CT in the management of different phases of parathyroid *** describe five patients with parathyroid malignant lesions,who underwent FDG PET/CT at initial staging,restaging and post-surgery *** each patient we report the value of PET/CT comparing its findings with other common imaging modalities(e.g.,CT,planar scintigraphy with 99mTcsestamibi,magnetic resonance imaging)thus determining the complementary benefit of FDG PET/CT in parathyroid *** hope to provide an insight into the potential role of PET/CT in assessing the extent of disease and response to treatment which are the general principles used to correctly evaluate disease status.

关键词： Parathyroid carcinoma Positron emission tomography/computed tomography 18F-Fluorodeoxyglucose Restaging Staging

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甲状旁腺核素显像在原发性甲状旁腺功能亢进症外科手术治疗中的作用

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中华核医学与分子影像杂志 2018年第7期38卷 508-514页

作者：季艳会(译) 孟召伟(审校) 天津医科大学总医院核医学科 300052

原发性甲状旁腺功能亢进症（PHPT）是一种常见的、具有潜在破坏性的内分泌系统疾病，手术是其唯一治愈方法。过去近20年来甲状旁腺手术方式发生了改变，常规双侧颈部探测不再是唯一的手术方式。鉴于甲状旁腺核素显像能特异性定位甲状旁... 详细信息

原发性甲状旁腺功能亢进症（PHPT）是一种常见的、具有潜在破坏性的内分泌系统疾病，手术是其唯一治愈方法。过去近20年来甲状旁腺手术方式发生了改变，常规双侧颈部探测不再是唯一的手术方式。鉴于甲状旁腺核素显像能特异性定位甲状旁腺手术位置、寻找异位甲状旁腺及多腺体疾病，其在手术方式选择上发挥了重要作用。该文是核医学医师、内分泌及内分泌外科医师互相协作的成果，文章强调了在任何PHPT手术前行甲状旁腺显像的重要性，即使是常规双侧颈部探查也应这样执行；讨论了甲状旁腺切除术的优缺点、甲状旁腺核素显像指导手术利弊；讨论了持续或复发的甲状旁腺功能亢进症再次手术界定腺体范围的最优策略：陈述了新型PET示踪剂的潜在应用价值，特别是^18F-氟代胆碱。

关键词：甲状旁腺功能亢进症 MIBI 双示踪剂甲状旁腺减影显像 SPECT/CT PET/CT ^18F- 氟代胆碱:^11C-蛋氨酸

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Resilience Against Replay Attacks:A Distributed Model Predictive Control Scheme for Networked Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 628-640页

作者： Giuseppe Franzè Francesco Tedesco domenico Famularo DIMES Department University of CalabriaArcavacata di Rende 87036Italy

In this paper,a resilient distributed control scheme against replay attacks for multi-agent networked systems subject to input and state constraints is *** methodological starting point relies on a smart use of predictive arguments with a twofold aim:1)Promptly detect malicious agent behaviors affecting normal system operations;2)Apply specific control actions,based on predictive ideas,for mitigating as much as possible undesirable domino effects resulting from adversary ***,the multi-agent system is topologically described by a leader-follower digraph characterized by a unique leader and set-theoretic receding horizon control ideas are exploited to develop a distributed algorithm capable to instantaneously recognize the attacked ***,numerical simulations are carried out to show benefits and effectiveness of the proposed approach.

关键词： Distributed model predictive control leader-follower networks multi-agent systems replay attacks resilient control

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Biofabrication of nanovesicles for brain diseases

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Neural Regeneration Research 2023年第3期18卷 525-526页

作者： Pasquale Picone domenico Nuzzo Istituto per la Ricerca e l’Innovazione Biomedica CNRDipartimento di Scienze e Tecnologie Biologiche Chimiche e FarmaceuticheUniversitàdi PalermoPalermoItaly

Background:Nanotechnologies promise to improve disease diagnosis and treatment,overcoming the limitations of conventional *** particular,extracellular vesicles(EVs)and artificial vesicles(AVs)are strongly emerging tools in nanomedicine(Leggio et al.,2020).EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane(exosomes)or shed from the plasma membrane(microvesicles).EVs are released by different brain cells(neurons,oligodendrocytes,astrocytes,and microglia)and constitute a physiological intercellular communication ***,EVs can deliver different types of molecules(nucleic acids and proteins),which often influence the phenotype of the recipient *** play a physiological role in the central nervous system(CNS),such as development,myelination,regeneration,and synaptic activity(Lai et al.,2012).Due to their content,EVs could therefore constitute an important biomarker for neurodegenerative diseases,represent candidates for therapeutic use,enclosing regulatory molecules,or be considered as vectors for brain drug delivery(Croese et al.,2018).

关键词： diseases diagnosis constitute

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Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer

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World Journal of Gastroenterology 2008年第12期14卷 1812-1822页

作者： Gerardo Rosati domenico Bilancia Medical Oncology Unit S. Carlo Hospital Potenza 85100 Italy

Patients older than 65 years are the fastest growing segment of the cancer population. It is estimated that within 20 years over 75% of cases and 85% of deaths from colorectal cancer (CRC) will be in this setting. Concerns about cancer treatment in the elderly relate to comorbidities, which increase proportionally with age, physiological changes associated with aging which may influence drug metabolism and toxicity, and diminishing life expectancy, which particularly impacts decisions surrounding the benefits of adjuvant therapies. Over the last 10 years, significant improvements in the treatment of advanced CRC with combination therapy have been made. The randomized trials which have defined these improvements did not exclude elderly patients. However, the median age of patients in these trials has generally been approximately 60 years. Thus, it appears that some degree of selection is involved with younger and presumably fitter patients being the subjects in most of the pivotal trials. The availability of new molecularly targeted agents and newly improved existing agents has expanded the range of treatment options available. This variety gives greater flexibility in dealing with different subsets of patients, such as the elderly. However, some fit elderly patients seem to tolerate combination therapy reasonably well, while studies on unfit elderly subjects are needed.

关键词： Bevacizumab Chemotherapy Cetuximab Colorectal cancer Elderly patients

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Between plaza and peak: a montological perspective on verticality and urbanization in highland Peru

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Journal of Mountain Science 2023年第10期20卷 2783-2803页

作者： Andreas HALLER domenico BRANCA Deyvis CANO Institute for Interdisciplinary Mountain Research Austrian Academy of SciencesInnsbruck 6020Austria Department of Humanities and Social Sciences University of SassariSassari 07100Italy Programa Académico de Ingeniería Ambiental Universidad de HuánucoHudnuco 10001Peru

Under the influence of concentrated and extended urbanization,Andean cities and the different altitudinal zones of their“hinterlands”are experiencing profound changes in land cover—from the central plazas up to the highest *** complex regional-geographic characteristics of these socioecological systems,such as the vertical complementarity of land use,require a montological perspective on verticality and urbanization:it transcends disciplinary approaches and can be crucial to properly interpret the trajectories of land cover change and formulate hypotheses for future practiceoriented *** trajectories of land cover change characterized altitudinal zones of Andean cities and their surroundings over the last three decades?Are there similarities that allow for the formulation of more general hypotheses?Using the Peruvian cases of Cusco and Huaraz,and combining a traditional altitudinal zonation model of land use in Peru with direct field observations and GIS-based analyses of remotely sensed data from 1991,2001,2011,and 2021,this study identifies the main trajectories of land cover change in the Quechua(>2300–3500 m),Suni(>3500–4000 m),and Puna(>4000–4800 m)regions—and finds insightful similarities between Cusco and Huaraz:(1)an impressive area of built-up land substitutes grassland in the Quechua,which,following regional altitudinal zonation models,is characterized by irrigated and rain-fed cropland;(2)an unexpected expansion of irrigated cropland takes place in the Suni,which,in theory,often lacks irrigation infrastructure and is mostly used for rain-fed tuber cultivation;and(3)a clear change from“other land”to grassland occurs in the Puna—where grassland is thought to predominate,anyway,since pre-Hispanic *** that these changes reflect the interplay between speculative fallow,agricultural intensification,and ecological restoration,the results can be read as vertically complementary,local manifestations of concentrated and extended urba

关键词： Mountain cities Mountain agriculture Land use change Land cover change Rural-urban linkages Montology

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A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1204-1214页

作者： Giuseppe Franzè domenico Famularo Walter Lucia Francesco Tedesco DIMES Department Universitàdella CalabriaVia Pietro Bucci 87036Italy CIISE Department Concordia UniversityMontrealQuebec H3G-1M8Canada IEEE

Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and *** technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic *** this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication *** basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system *** on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks.

关键词： Denial-of-service(DoS)attacks distributed model predictive control leader-follower paradigm resilient control

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Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： domenico Germano Bruno Daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

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