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经支气管冷冻肺活检后按需手术肺活检对比即刻手术肺活检诊断间质性肺疾病(COLD研究):一项随机对照临床试验

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中华结核和呼吸杂志 2024年第9期47卷 826-826页

作者： Kalverda KA Ninaber mk Wijmans L 阳胜朱娅琳肖奎不详中南大学湘雅二医院呼吸与危重症医学科中南大学呼吸疾病研究所湖南省呼吸与危重症疾病临床医学研究中心中南大学呼吸疾病诊疗中心长沙410000

背景:间质性肺疾病(ILD)的充分诊断对于临床决策和预后非常重要。大多数ILD患者可通过对临床和放射学数据的评估做出准确诊断,但还有相当一部分患者仍需进行肺活检。手术肺活检(SLB)是获取组织的最常用方法,但其发病率甚至死亡率都很高... 详细信息

背景:间质性肺疾病(ILD)的充分诊断对于临床决策和预后非常重要。大多数ILD患者可通过对临床和放射学数据的评估做出准确诊断,但还有相当一部分患者仍需进行肺活检。手术肺活检(SLB)是获取组织的最常用方法,但其发病率甚至死亡率都很高。最近,临床引入了经支气管冷冻肺活检,其不良反应较SLB少,但诊断率低于SLB。本研究旨在比较两种诊断策略:阶梯策略(经支气管冷冻肺活检,如果冷冻活检获得的信息不够,再进行SLB)与即刻SLB策略。方法:COLD研究是一项在荷兰6家医院开展的多中心、随机对照临床试验。该研究纳入了经多学科团队讨论评估有肺活检指征的ILD患者。以1∶1的比例将患者随机分配到阶梯策略或即刻SLB策略中,并从首次手术开始随访12周。本研究的治疗对患者、临床医生和病理学家均未设盲。主要研究终点是非预期的胸管引流,定义为经支气管冷冻肺活检后需要胸管引流,或SLB后胸管引流时间延长(>24 h)。次要研究终点是诊断率、住院时间、术后疼痛评分和严重不良事件,其中,严重不良事件包括研究期间患者出现死亡、危及患者生命、患者需再次入院或患者住院时长增加[经支气管镜检查超过2 d(1个夜晚),SLB超过4 d(3个夜晚)]。研究进行了改良的意向治疗分析。研究已在荷兰试验注册中心(NL7634)注册,现已结束。结果:在2019年4月8日至2021年10月24日期间,122例ILD患者接受了研究评估;55例患者被随机分配至阶梯组(n=28)或即刻SLB组(n=27);即刻SLB组有3例患者被排除。阶梯组的28例患者中有3例发生意外胸管引流(11%,95%CI:4%~27%),而即刻SLB组24例患者中有11例(46%,95%CI:2%~65%)在24 h内无法拔除胸管,绝对风险降低35%(11%~56%,P=0.0058)。在阶梯策略中,仅经支气管冷冻肺活检后的多学科团队诊断率为82%(64%~92%),在经支气管冷冻肺活检不确定后进行后续SLB时,诊断率增至89%(73%~96%)。在即刻SLB策略中,多学科团队的诊断率为88%(69%~97%)。阶梯组的总住院时间为1 d(IQR 1~1),而即刻SLB组为5 d(IQR 4~6)。阶梯组发生了1起(4%)严重不良事件,而即刻SLB组发生了12起(50%)严重不良事件。结论:在ILD诊断中,如果需要对肺组织进行评估,那么诊断策略应从经支气管冷冻肺活检开始,然后在经支气管冷冻肺活检不能得出诊断结论时进行SLB,这样似乎可显著减轻患者负担,缩短住院时间,且诊断率与即刻SLB相似。

关键词：间质性肺疾病支气管镜检查多学科团队患者负担病理学家肺活检临床决策诊断策略

Recent advances in the diagnosis of human schistosomiasis

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Asian Pacific Journal of Tropical Medicine 2008年第1期1卷 63-68页

作者： Jones mk Australian Centre for International and Tropical Health Queensland Institute of Medical ResearchHerstonQueenslandAustraliaSchool of Veterinary ScienceThe University of QueenslandSt LuciaQueenslandAustralia

Schistosomiasis,caused by parasitic bloodflukes of the genus Schistosoma,is a major source of human disease in developing tropical *** paper reviews the diagnostic various assays for schistosomiasis,with particular reference to recent advances in assays incorporating direct parasitological examination,serology,antigen detection,and polymerase chain reaction detection of parasite genetic material.

关键词： schistosomiasis diagnosis parasitology serology

Anti-inflammatory activity of Premna corymbosa(Burm.f.) Rottl.& *** extracts in Wistar albino rats

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Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 510-513页

作者： Karthikeyan M Deepa mk Department of Pharmacology Al Shifa College of PharmacyPoonthavanam(P.O.)Kizhattur PerinthalmannaMalappuram-679325 Kerala StateIndia Department of Pharmaceutics Nehru College of PharmacyPambadyTriruvilwamalaThrissur DistrictKerala State - 680 597India

Objective:To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract(PCEE) at doses of 200 and 400 mg /kg body weight in acute and chronic models of inflammation in experimental ***:In the acute toxicity study,a single dose of PCEE of 2 000 mg/kg body weight,*** administered and observed for 48 *** acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. Results:In acute models,egg albumin induced paw edema PCEE significantly(P<0.01) inhibited the edema *** chronic model,cotton pellet induced granuloma formation in rats PCEE significantly(P<0.01) reduced the granuloma formation with percentage inhibition of 35.17%and 50.38%***:The present study establishes the antiinflammatory activity of Premna corymbosa leaves.

关键词： Premna corymbosa Anti-Inflammatory activity Fresh egg albumin Cotton pellet

Spinodal Decomposition of Ultrahigh Strength Steel 23Co14Ni12Cr3

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Journal of Materials Science & Technology 1999年第6期15卷 583-584页

作者： Wang, LD Chen, CL Kang, mk Northwestern Polytech Univ Xian 710072 Peoples R China

The depleted and enriched regions of solute atoms formed by spinodal decomposition in the early stage of tempering for ultrahigh strength steel 23Co14Ni12Cr3 were first confirmed by means of transmission electron microscopy (TEM). The segregation of solute atoms provides favorable composition and structure fluctuation for the formation of secondary hardening phase M2C and cementite Fe3C.

关键词： AF1410

Study of Carbon-poor Regions of Austenite during Bainitic Incubation Period by SAM

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Journal of Materials Science & Technology 1995年第5期11卷 353-357页

作者： WU, XL JIA, HS ZHANG, XY KANG, mk Northwestern Polytechnical Univ Xi'an China

The variation of carbon composition in undercooled austenite during bainitic incubation period has been investigated in 40CrMnSiMoVA by scanning auger microprobe (SAM). The results show that the outstanding diffusion and redistribution of carbon occur in isothermally reacted specimens. This leads to the formation of carbon-poor regions (CPR) near austenite grain boundaries and in austenite grains. The carbon content in CPR exceeds the equilibrium carbon composition of ferrite. Furthermore, it is indicated that the existence of CPR is thermodynamically possible.

关键词： Metallographic microstructure

0.27-nm resolution crystal structure of Haemorrhagin I from snake venom of Agkistrodon acutus

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Chinese Science Bulletin 1997年第4期42卷 333-337页

作者： Gong, WM Teng, mk Niu, LW UNIV SCI & TECHNOL CHINA DEPT BIOLYOUNG SCIENTIST LAB STRUCT BIOLHEFEI 230026PEOPLES R CHINA

THE snake venom zinc-metalloproteinases and matrix metalloproteinases (MMP) have the similar active site and biological function. They all belong to the MMP super-family. Some

关键词： crystal structure Haemorrhagin mctalloproteinase snake venom.

In vitro study of lovastatin interactions with amiodarone and with carbon tetrachloride in isolated rat hepatocytes

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World Journal of Gastroenterology 2007年第15期13卷 2198-2204页

作者： AZ Krasteva mk Mitcheva MS Kondeva-Burdina VA Descatoire Laboratory of Toxicology and Drug metabolism Department of Pharmacology and Toxicology Faculty of PharmacyMedical UniversitySofiaBulgaria Faculty of Medicine Xavier Bichat INSERM U 481 Hopital Bichat16 rue Henri Huchard75018 ParisFrance

AIM： To investigate the interactions at a metabolic level between Iovastatin, amiodarone and carbon tetrachloride in isolated rat hepatocytes.METHODS： For cell isolation two-step collagenase liver perfusion was performed. Lovastatin was administered alone in increasing concentrations （1μmol/L, 3μmol/L, 5μmol/L and 10μmol/L） and in combination with CCh （86μmol/L）. The cells were also pretreated with 14μmol/L amiodarone and then the other two compounds were added. RESULTS： Lovastatin promoted concentration-dependent significant toxicity estimated by decrease in cell viability and GSH level by 45% and 840, respectively, LDH- activity increased by 114% and TBARS content by 90%, CCl4 induced the expected severe damage on the examined parameters, CCh induced toxicity was attenuated after Iovastatin pretreatment, which was expressed in less increased values of LDH activity and TBARS levels, as well as in less decreased cell viability and GSH concentrations, However, the pretreatment of hepatocytes with amiodarone abolished the protective effect of Iovastatin. CONCLUSION： We suggest that the observed cytoprotective effect was due to interactions between Iovastatin, CCh and amiodarone at a metabolic level.

关键词： Hepatocytes Lovastatin Carbon tetrachloride Amiodarone Interaction

THE SHRINKAGE OF EXPANSIVE CONCRETE FILLED STEEL TUBE AND ITS IMPROVEMENT METHOD

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Journal of Wuhan University of Technology(Materials Science) 1999年第1期14卷 46-51页

作者： Li, Y Hu, SG Ding, QJ Zhou, mk Zhang, YS Wuhan Univ Technol Coll Mat & Engn Wuhan 430070 Peoples R China

The shrinkage characteristics tics of expansive concrete filled steel tube (CFST) are analyzed, Cold shrinkage, creep and autogenous shrinkage are considered as the main reasons of causing CFST contraction. In accordance with the shrinkage characteristics of expansive CFST, a kind of energy-stored delayed expansive agent is exploited, which can not only compensate the shrinkage of the core concrete in every stages, but also make CFST expand according to the delayed expansion mechanism. As the result, the prestress loss weill be reduced and expansive energy will be utilized effectively.

关键词： concrete filled steel tube shrinkage mechanism expansive agent expansive model

Glass Formation and Thermal Stability in Rapidly Solidified Al-Fe-V-Si Alloy with Misch Metal Additions

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Journal of Materials Science & Technology 1996年第1期12卷 11-14页

作者： Wang, JQ Zeng, MG Tseng, mk Chen, XF Dong, L Gu, SX LIAONING PROVINCE CTR ANAL & TESTING RES SHENYANG 110015PEOPLES R CHINA

A new amorphous Al(87.3)Fe(4.3)V(0.7)Si(1.7)Mm(6.0)(Mm: misch metal) was prepared by using melt-spinning technique. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) have been used to investigate the crystallization behaviour of this amorphous alloy. It is found that the crystallization process can be concluded as follows: amorphous --> amorphous plus fcc-Al --> fcc-Al plus Al-11(La,Ce)(3) plus i-phase (icosahedral) --> fee-Al plus Al-11(La,Ce)(3) plus i-phase plus ic-phase (icosahedral compounds). The results of microhardness measurement show that HV values are higher than those in AI-Fe-V-Si based alloy, and the maximum HV value corresponds to the coexisting of nanoscale Al particles and i-phase.

关键词： Aluminum alloys