Anti-inflammatory activity of Premna corymbosa(Burm.f.) Rottl.& *** extracts in Wistar albino rats

作     者：Karthikeyan M Deepa MK 

作者机构：Department of PharmacologyAl Shifa College of PharmacyPoonthavanam(P.O.)Kizhattur PerinthalmannaMalappuram-679325 Kerala StateIndia Department of PharmaceuticsNehru College of PharmacyPambadyTriruvilwamalaThrissur DistrictKerala State - 680 597India 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第7期

页      面：510-513页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 10[医学] 

主　　题：Premna corymbosa Anti-Inflammatory activity Fresh egg albumin Cotton pellet 

摘      要：Objective:To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract(PCEE) at doses of 200 and 400 mg /kg body weight in acute and chronic models of inflammation in experimental ***:In the acute toxicity study,a single dose of PCEE of 2 000 mg/kg body weight,*** administered and observed for 48 *** acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. Results:In acute models,egg albumin induced paw edema PCEE significantly(P0.01) inhibited the edema *** chronic model,cotton pellet induced granuloma formation in rats PCEE significantly(P0.01) reduced the granuloma formation with percentage inhibition of 35.17%and 50.38%***:The present study establishes the antiinflammatory activity of Premna corymbosa leaves.