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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin dong‑Je Kim Tae‑Min Jang Won Bae Han Joong hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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韩国基于风险的大坝安全管理研究现状

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大坝与安全 2015年第6期29卷 75-79页

作者： dong-hoon Shin Ki-Young Kim Jeong-Yeol lim 崔弘毅许传桂 Korea Water Resources Corporation 不详

大坝一旦完建,大坝业主和大坝工程师的首要职责就是通过实施检查和安全评估对大坝进行合理的维护,这也是相关条例、法规和法案的要求。之前,韩国的大坝安全评估都是基于规范和定性的方法,没有考虑自然的不确定性。最近,基于风险的大坝... 详细信息

大坝一旦完建,大坝业主和大坝工程师的首要职责就是通过实施检查和安全评估对大坝进行合理的维护,这也是相关条例、法规和法案的要求。之前,韩国的大坝安全评估都是基于规范和定性的方法,没有考虑自然的不确定性。最近,基于风险的大坝安全管理被认为是大坝安全管理下一代范例中真正可靠的选择。笔者介绍了目前传统的制度体系在大坝安全管理中是如何运作的,以及基于风险的大坝安全管理是如何作为一种新的大坝安全范例来引进的。笔者还会介绍一些大坝安全导则和法规来追述韩国大坝安全管理的变化历史。最后,笔者将简要介绍某大坝在大坝风险评估方面开展的工作,这是新的大坝安全范例。

关键词：韩国大坝安全管理风险

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减量FOLFIRINOX方案挽救性治疗吉西他滨抵抗的晚期胰腺癌:一项Ⅱ期研究

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癌症 2018年第8期37卷 327-335页

作者： Jung hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung Soon Jang do Hyoung lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalCheonan Department of Internal Medicine Dong-A University Hospital Department of Internal Medicine Kangwon National University School of Medicine Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalSeoul Department of Internal Medicine Ewha Womans UniversityCollege of Medicine Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung-Ang UniversityCollege of Medicine Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer Hospital Department of Hematology-Oncology Ajou University Hospital

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西... 详细信息

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西他滨抵抗的晚期胰腺癌患者的可行性和安全性。方法在14家医院进行了这一多中心II期前瞻、开放标签的单臂研究。经组织学确诊为胰腺浸润性导管腺癌、有可测量或可评价的病灶、东部肿瘤协作组体能状况评分0或1分、器官功能良好、年龄19岁或以上的患者符合入组条件。减量FOLFIRINOX方案的组成:奥沙利铂65 mg/m2、伊立替康135 mg/m2和亚叶酸400 mg/m2,第1天静脉注射;5?氟尿嘧啶2000 mg/m2,第1–2天持续静脉输注46 h;每2周重复。主要终点为FOLIFLIOX治疗起始后的无进展生存期。次要终点为客观缓解率、疾病控制率、总生存期、安全性和耐受性。采用Kaplan?Meier法评估了总生存期和无进展生存期。结果我们招募了来自14个中心的39例患者。客观缓解率为10.3%,疾病控制率为64.1%。6个月和1年总生存率分别为59.0%和15.4%。中位无进展生存期和总生存期分别为3.8个月[95%置信区间(confidence interval,CI)=1.5–6.0个月]和8.5个月(95%CI=5.6–11.4个月)。3或4级不良事件为中性粒细胞减少(41%)、恶心(10.3%)、食欲减退(10.3%)、贫血(7.7%)、黏膜炎(7.7%)、肺炎/胸膜融合(5.1%)和乏力(5.1%)。发生1例由感染性休克引起的治疗相关死亡。结论减量FOLFIRINOX方案有望作为二线方案治疗吉西他滨抵抗的胰腺癌。

关键词：减量FOLFIRINOX方案二线治疗胰腺癌吉西他滨

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跨国公司如何削减采购成本

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中欧商业评论 2019年第1期 30-35页

作者：林莲云黄敏珊全球化专业咨询公司

对家企业来说,开源节流是刻在骨子里的基因。企业往往选择在劳动力成本低的市场进行采购来节约成本。改革开放后,中国凭借较低的劳动力成本、良好的基础设施和投资者友好型的政策,成为了名副其实的“世界工厂”。这样一块大蛋糕对跨国... 详细信息

对家企业来说,开源节流是刻在骨子里的基因。企业往往选择在劳动力成本低的市场进行采购来节约成本。改革开放后,中国凭借较低的劳动力成本、良好的基础设施和投资者友好型的政策,成为了名副其实的“世界工厂”。这样一块大蛋糕对跨国企业当然极具吸引力。世纪之交,类似沃尔玛之类的大型公司国际部开始把自己的采购部直接搬到中国,之后不断完善自己在当地的采购能力以争取最优价格。而很多中型公司也纷纷向大型公司学习,我们甚至见过年收入仅几亿美元的公司也在中国建立自己的采购部门。好处当然是显而易见的,这有助于企业跟当地供应商建立更密切的关系,在供应链、制造流程发生状况时也可以快速反应,解决问题。

关键词：跨国公司采购成本劳动力成本跨国企业 “世界工厂” 大型公司采购部门开源节流

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2D MoS_(2) Helical Liquid Crystalline Fibers for Multifunctional Wearable Sensors

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Advanced Fiber Materials 2024年第6期6卷 1813-1824页

作者： Jun Hyun Park Jang Hwan Kim Su Eon Lee Hyokyeong Kim Heo Yeon lim Ji Sung Park Taeyeong Yun Jinyong Lee Simon Kim Ho Jun Jin Kyeong Jun Park Heemin Kang Hoe Joon Kim Hyeong Min Jin Jiwoong Kim Sang Ouk Kim Bong hoon Kim Department of Robotics and Mechatronics Engineering DGISTDaegu 42988Republic of Korea Present Address:Platform Technology R&D Center LG ChemistrySeoul 07795Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Organic Materials and Fiber Engineering Soongsil UniversitySeoul 06978Republic of Korea Nano Convergence Technology Research Center Korea Electronics Technology Institute(KETI)Gyeonggi‑do 13509Republic of Korea Department of Green Chemistry and Materials Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering National Creative Research Initiative Center for Multi‑Dimensional Directed Nanoscale AssemblyKAIST Institute for NanocenturyKAISTDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak‑roYuseong‑guDaejeon 34134Republic of Korea

Fiber-based material systems are emerging as key elements for next-generation wearable devices due to their remarkable advantages,including large mechanical deformability,breathability,and high ***,greatly improved mechani-cal stability has been established in functional fiber systems by introducing atomic-thick two-dimensional(2D)*** development of intelligent fibers that can respond to various external stimuli is strongly needed for versatile *** this work,helical-shaped semiconductive fibers capable of multifunctional sensing are obtained by wet-spinning MoS_(2) liquid crystal(LC)*** mechanical properties of the MoS_(2) fibers were improved by exploiting high-purity LC dispersions consisting of uniformly-sized MoS_(2) ***,three-dimensional(3D)helical fibers with structural chirality were successfully constructed by controlling the wet-spinning process *** helical fibers exhibited multifunctional sensing characteristics,including(1)photodetection,(2)pH monitoring,(3)gas detection,and(4)3D strain sensing.2D materials with semiconducting properties as well as abundant surface reactive sites enable smart multifunctionalities in one-dimensional(1D)and helical fiber geometry,which is potentially useful for diverse applications such as wearable internet of things(IoT)devices and soft robotics.

关键词： Molybdenum disulfide(MoS_(2)) Liquid crystal(LC) Two-dimensional(2D)material Sensor Fiber

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Development of controlled release bi-layered tablets containing oxycodone hydrochloride

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 178-178页

作者： Kyung Hun Kim Kyung Soo Lee Il Woo Jung Jin Seob Oh Seo Hyun lim Sung hoon Lee Woo Heon Song Jun Sang Park GLPharmTech Corporation #714JungangInduspia V137Sagimakgol-roJungwon-guSeongnamGyeonggidoRepublic of Korea Department of Pharmaceutical Engineering Cheongju University298Daeseong-roCheongwon-guCheongjuChungcheongbuk-doRepublic of Korea

Oxycodone hydrochloride is a semi-synthetic opioid agonist that provides very effective relief for moderate to severe pain in cancer and post-operative patients. Controlled release oxycodone formulations have been studied to enhance the therapeutic effect by providing constant release over the whole dosing interval and improve patient’s convenience by reducing the frequency of administration as well.

关键词： Oxycodone Control release Bi-layered tablet IVIVC

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Electrolyte Effect on Ni/MgO-SiO2 Catalysts for Methane Steam Reforming in DIR-MCFC（摘要）

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华东理工大学学报（自然科学版） 2010年第6期36卷 861-861页

作者： LI Zhen-lan DEVIANTO Hary HAN Jong-Hee YOON Sung Pil lim Tae-hoon LEE Ho-In School of Chemical and Biological Engineering and Research Center for Energy Conversion and Storage Seoul National University Seoul 151-744 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

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Separate支架在治疗胃十二指肠恶性梗阻中的应用

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介入放射学杂志 2003年第6期12卷 431-435页

作者：何旭顾建平楼文胜陈亮苏浩波 Ji-hoon Shin Jin-Oh lim Tae-Hyuang Kim Ho-Young Song 南京医科大学附属南京第一医院介入科 210006 Deaprtment of Radiology Asan Medical CenterUniveristy of Ulsan College of MedicineSeoulKorea

目的　探讨Separate支架置入术在姑息性治疗不能手术的胃肠道恶性梗阻的可行性和有效性。方法　 34例患者采用经口置入Separate支架治疗不能手术的恶性胃十二指肠梗阻。梗阻的原因分别是胃癌 1 1例、胰腺癌 1 2例、转移性肿瘤 3例、胆... 详细信息

目的　探讨Separate支架置入术在姑息性治疗不能手术的胃肠道恶性梗阻的可行性和有效性。方法　 34例患者采用经口置入Separate支架治疗不能手术的恶性胃十二指肠梗阻。梗阻的原因分别是胃癌 1 1例、胰腺癌 1 2例、转移性肿瘤 3例、胆道肿瘤 6例和十二指肠癌 2例。透视下分别将Separate支架的外层带膜支架和内层裸支架同轴重叠释放在狭窄病变处。结果　技术成功率为 97% ,未发生严重并发症。 33例患者胃肠道梗阻症状缓解或消失 ,在Separate支架置入后 ,患者进食能力评分平均从 3.8提高到 1 .2。随访期间未发现支架移位和肿瘤内生性生长等并发症 ,1例患者由于肿瘤浸润致支架近端梗阻复发 ,置入第 2枚支架。

关键词： Separate支架胃十二指肠恶性梗阻支架置入术钡餐检查介入治疗

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Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology:A meta-analysis

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World Journal of Gastroenterology 2015年第19期21卷 6032-6043页

作者： Chang Seok Bang Gwang Ho Baik In Soo Shin Jing Bong Kim Ki Tae Suk Jai hoon Yoon Yeon Soo Kim dong Joon Kim Woon Geon Shin Kyung Ho Kim Hak Yang Kim Hyun lim Ho Seok Kang Jong Hyeok Kim Jin Bae Kim Sung Won Jung Sea Hyub Kae Hyun Joo Jang Min Ho Choi Department of Internal Medicine Hallym University College of Medicine College of Education Jeonju University

AIM: To evaluate the efficacy and safety of endoscopicsubmucosal dissection(ESD) for early gastric cancer(EGC) with undifferentiated-type ***: A systematic literature review was conducted using the core databases. Complete resection,curative resection, en bloc resection, recurrence and adverse event rate were extracted and analyzed. A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. Publication bias was evaluated using a funnel plot, the trim and fill method, Egger's test,and a rank correlation ***: Fourteen retrospective studies between2009 and 2014 were identified(972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as92.1%(95%CI: 87.4%-95.2%) and 77.5%(95%CI:69.3%-84%), respectively. The total curative resection rate was 61.4%(95%CI: 44.5%-75.9%). The overall recurrence rate was 7.6%(95%CI: 3.4%-16%).limited to histologically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were91.2% and 85.6%, respectively. The curative resection rate was 79.8%.CONCLUSION: In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiatedtype histology. Long-term studies are needed to confirm these therapeutic outcomes.

关键词： Carcinoma Endoscopic submucosal dissection Endoscopy Gastric cancer Meta-analysis

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ACUPUNCTURE ON GB34 ACTIVATES THE PRECENTRAL GYRUS AND PREFRONTAL CORTEX IN PARKINSON'S DISEASE

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Journal of Integrative Medicine 2014年第3期 261-261页

作者： Min-gyu Lee Sujung Yeo Hyejin Jung Younghong Kim dong-hoon Shin Sabina lim Kyung Hee University

Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease(PD).Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy *** was conducted on a specific acupoint,the right Yanglingquan(GB34), which is a frequently used acupoint for motor function treatment in the oriental medical ***: Acupuncture stimulation on this acupoint activated the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with *** with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially in the left ***: The neuroimaging results of our study suggest that in future acupuncture research, the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of PD and that GB34 seems to be a suitable ***, acupuncture evoked more different brain activations in patients with PD than that in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture's efficacy.

关键词： PD GB ACUPUNCTURE ON GB34 ACTIVATES THE PRECENTRAL GYRUS AND PREFRONTAL CORTEX IN PARKINSON’S DISEASE

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