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Asian Journal of Andrology 2021年第1期23卷 74-79页

作者： Se Young Choi Byung hoon Chi Tae-Hyoung Kim Bumjin lim Wonchul Lee Dalsan You Choung-Soo Kim Department of Urology Chung-Ang University HospitalChung-Ang University College of MedicineDongjak-guSeoul 06973Korea Department of Urology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea

We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate *** study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral *** frozen sections of the periurethra,dorsal vein,and bladder neck were *** ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic *** 271 patients,108(39.9%)had PSM and 163(60.1%)had negative *** Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,Pdorsal vein could *** examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.

关键词： biochemical recurrence frozen section positive surgical margin robotic-assisted prostatectomy

Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

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Asian Journal of Pharmaceutical Sciences 2014年第6期9卷 324-329页

作者： Dae Gon lim Won-Wook Jeong Nam Ah Kim Jun Yeul lim Seol-hoon Lee Woo Sun Shim Nae-Gyu Kang Seong hoon Jeong College of Pharmacy Dongguk University-SeoulGoyangGyeonggi 410-820Republic of Korea LG Household&Health Care Daejeon 305-343Republic of Korea

Glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of *** is regarded as a permeation enhancer due to its amphiphilic *** phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy(CLSM).GMO was melted in a vial in a water bath heated to 45℃.Propylene glycol and hexanediol were homogeneously dissolved in the melted *** fluorescein in aqueous solution was diluted to various ratios and thoroughly mixed by an ultrasonic *** GMO/Solvent system with fluorescein was applied onto the epidermal side of excised pig skin and incubated *** was performed to observe how the GMO/solvent system in its different phases affect skin *** and lamellar phase formulations enhanced the fluorescein permeation through the stratum corneum.A solution system had the weakest permeability compared to the other two *** to the amphiphilic nature of GMO,cubic and lamellar phases might reduce the barrier function of stratum corneum which was observed by CLSM as fluorescein accumulated in the *** on the results,the glyceryl monooleate lyotropic mixtures could be applied to enhance skin permeation in various topical and transdermal formulations.

关键词： Confocal microscopy Imaging Glyceryl monooleate Skin permeation Cubic phase Lamellar phase

Gene editing of authentic Brassica rapa flavonol synthase 1 generates dihydroflavonol-accumulating Chinese cabbage

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Horticulture Research 2023年第12期10卷 58-69页

作者： Sangkyu Park Hyo Lee Jaeeun Song Chan Ju lim Jinpyo Oh Sang hoon Lee Saet Buyl Lee Jong-Yeol Lee Sunhyung lim Jin A.Kim Beom-Gi Kim Metabolic Engineering Division National Institute of Agricultural SciencesRural Development AdministrationJeonju54874South Korea Institute of Biotechnology and Breeding Asiaseed Inc.Icheon17414South Korea Food and Nutrition Division National Institute of Agricultural SciencesRural Development AdministrationWanju55365South Korea Department of Horticultural Biotechnology School of BiotechnologyHankyong National UniversityAnseong17579South Korea

Flavonols are the major class of flavonoids of green Chinese cabbage(Brassica rapa ***).The *** genome harbors seven flavonol synthase genes(BrFLSs),but they have not been functionally ***,transcriptome analysis showed four BrFLSs mainly expressed in Chinese *** them,only BrFLS1 showed major FLS activity and additional flavanone 3β-hydroxylase(F3H)activity,while BrFLS2 and BrFLS3.1 exhibited only marginal F3H *** generated BrFLS1-knockout(BrFLS1-KO)Chinese cabbages using CRISPR/Cas9-mediated genome editing and obtained transgene-free homozygous plants without off-target mutation in the T1 generation,which were further advanced to the T2 generation showing normal ***-ESI-QTOF-MS analysis revealed that flavonol glycosides were dramatically decreased in the T2 plants,while dihydroflavonol glycosides accumulated concomitantly to levels corresponding to the reduced levels of *** PCR analysis revealed that the early steps of phenylpropanoid and flavonoid biosynthetic pathway were upregulated in the BrFLS1-KO *** accordance,total phenolic contents were slightly enhanced in the BrFLS1-KO plants,which suggests a negative role of flavonols in phenylpropanoid and flavonoid biosynthesis in Chinese *** surveys revealed that the BrFLS1-KO Chinese cabbages showed normal head formation and reproductive phenotypes,but subtle morphological changes in their heads were *** addition,their seedlings were susceptible to osmotic stress compared to the controls,suggesting that flavonols play a positive role for osmotic stress tolerance in *** *** this study,we showed that CRISPR/Cas9-mediated BrFLS1-KO successfully generated a valuable breeding resource of Chinese cabbage with distinctive metabolic traits and that CRISPR/Cas9 can be efficiently applied in functional Chinese cabbage breeding.

关键词： steps slightly phenolic

Scrub typhus hepatitis confirmed by immunohistochemical staining

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World Journal of Gastroenterology 2012年第36期18卷 5138-5141页

作者： Jong-hoon Chung Sung-Chul lim Na-Ra Yun Sung-Heui Shin Choon-Mee Kim dong-Min Kim Department of Internal Medicine Chosun University College of MedicineGwangju 501-717South Korea Research Center for Resistant Cells Chosun UniversityGwangju 501-717South Korea Department of Pathology Chosun University College of MedicineGwangju 501-717South Korea Department of Microbiology Chosun University College of MedicineGwangju 501-717South Korea

Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi （0. tsutsugamushi）. We report herein the case of a woman who presented with fever and elevated serum levels of liver enzymes and who was definitively diagnosed with scrub typhus by his- topathological examination of liver biopsy specimens, serological tests and nested polymerase chain reaction. Immunohistochemical staining using a monoclonal an- ti-O. tsutsugamushi antibody showed focally scattered positive immunoreactions in the cytoplasm of some hepatocytes. This case suggests that scrub typhus hepatitis causes mild focal inflammation due to direct liver damage without causing piecemeal necrosis or interface hepatitis. Thus, scrub typhus hepatitis differs from acute viral hepatitis secondary to liver damage due to host immune responses, which causes severe Iobular disarray with diffuse hepatocytic degeneration, necrosis and apoptosis as well as findings indicative of hepatic cholestasis, such as hepatic bile plugs or brown pigmentation of hepatocytes.

关键词： Scrub typhus, Immunohistochemistry Ori-entia tsutsugamushi

Driving characteristics of octagon-type ultrasonic motor

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Journal of Central South University 2013年第1期20卷 71-75页

作者： KIM Jong-Wook PARK Choong-Hyo lim Jung-hoon JEONG Seong-Su PARK Jong-Kyu PARK Tae-Gone Changwon National University Sarim-dongChangwon-siGyeongsangnam-do641-773Korea

Structure of the octagon-type ultrasonic motor was proposed and designed so as to allow the motor to drive small actuator. The stator of the motor consisted of the octagon shape elastic body and four rectangular plate ceramics. The four ceramics were attached to outer surfaces of the octagon elastic body. The same phase voltages were applied to the ceramics on horizontal surfaces, and 90° phase difference voltages were applied to the ceramics on vertical surfaces. When the AC voltage with 90° phase difference was applied in ceramics, the elliptical displacement of unimorph bars was generated by generating bending vibration. To find the maximum displacement model that generates elliptical displacement at the centers of the inner surfaces, the finite element analysis program ATILA was used. The analyzed results were compared to the experimental results. As a result, the speed and torque are increased linearly by increasing the input voltage and the speed of motors can be controlled by changing the applied voltages.

关键词： octagon-type 90° phase difference ultrasonic motor ATILA

Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-Woo Kim Chan-hoon An Hyun-Seok Lee Jae-Seon Yi Eun Ju Cheong Sang-Hyun lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon lim Hyo-Jung Lee Bonglee Kim Jeong-Un Choi Yoeok Shin Eun Jung Sohn Sung-hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

Easy calibration method of vision system for in-situ measurement of strain of thin films

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中国有色金属学会会刊：英文版 2009年第B9期19卷 243-249页

作者： Jun-Hyub PARK dong-Joong KANG Myung-Soo SHIN Sung-Jo lim Son-Cheol YU Kwang-Soo LEE Jong-Eun HA Sung-hoon CHOA Department of Mechatronics Engineering Tongmyong University School of Mechanical Engineering Pusan National University Department of Automotive Engineering Hoseo University Department of Automotive Engineering Seoul National University of Technology Department of Nano/IT Engineering Seoul N ational University of Technology

An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials.

关键词：标定方法视觉系统原位测试应变薄膜松

Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2015年第14期21卷 4268-4274页

作者： Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn do Hyoung lim Soon Il Lee Keon Woo Park Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine Division of Hematology-Oncology Department of Internal MedicineInje University Ilsan-Paik Hospital Division of Hematology-Oncology Department of Internal MedicineChung-Ang University Hospital Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University Hospital Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Division of Hematology-Oncology Department of Internal MedicineDankook University College of Medicine

AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was ***-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and *** was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent *** primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely *** control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), ***: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC.

关键词： Clinical trial Phase Ⅱ Chemotherapy Carcinoma,Esop

Role of multidetector computed tomography in patients with acute infectious colitis

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World Journal of Clinical Cases 2022年第12期10卷 3686-3697页

作者： Seung Jung Yu Jae Hyuk Heo Eun Jeong Choi Jong Hyuk Kim Hong Sub Lee Sun Young Kim Jae hoon lim Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Radiology Myongji HospitalHanyang University College of MedicineGoyang 10475South Korea Department of Cancer Control and Population Health National Cancer CenterGoyang 10408South Korea

BACKGROUND The role of multidetector computed tomography(MDCT)in patients with acute infectious colitis is still *** To examine the usefulness of MDCT in distinguishing the etiology of acute infectious *** Overall,244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups(bacterial:204,viral:40)according to causes of acute colitis,based on stool *** MDCT parameters,including wall thickening,submucosal edema,mucosal enhancement,serosa involvement,empty colon sign,small bowel involvement,comb sign,continuous distribution,accordion sign,mucosal thickening,and lymph node enlargement,were constructed in a blinded *** MDCT parameters of wall thickening(OR:13.60;95%CI:5.80–31.88;P<0.001),submucosal edema(OR:36.08;95%CI:13.54–96.13;P<0.001),mucosal enhancement(OR:22.55;95%CI:9.28–54.81;P<0.001),serosal involvement(OR:14.50;95%CI:3.33–63.23;P<0.001),empty colon sign(OR:6.68;95%CI: 2.44–18.32;P < 0.001), continuous distribution (OR: 24.09;95%CI: 9.38–61.90;P < 0.001), accordionsign (OR: 9.02;95%CI: 1.12–72.35;P = 0.038), mucosal thickening (OR: 46.41;95%CI: 10.38–207.51;P< 0.001), and lymph node enlargement (OR: 4.39;95%CI: 1.22–15.72;P = 0.023) were significantlyassociated with bacterial colitis. At least one positive finding in four CT outcomes (submucosaledema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed ahigh probability of bacterial colitis (sensitivity, 41.67;specificity, 92.50;OR: 24.95).CONCLUSIONMDCT provides many clues that can be useful in suggesting a specific etiology of acute infectiouscolitis.

关键词： Colitis Multidetector computed tomography Differential diagnosis Bacterial infections Viral infections