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Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： dmitry Lim Alexei Verkhratsky Department of Pharmaceutical sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

History of chronic gastritis:How our perceptions have changed

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World Journal of Gastroenterology 2024年第13期30卷 1851-1858页

作者： dmitry Bordin Maria Livzan Department of Pancreatic Biliary and Upper GI Tract DiseasesA.S.Loginov Moscow Clinical Scientific CenterMoscow 111123Russia Department of Propaedeutic of Internal Diseases and Gastroenterology Russian University of MedicineMoscow 127006Russia Department of Outpatient Therapy and Family Medicine Tver State Medical UniversityTver 170100Russia Department of Internal Medicine and Gastroenterology Omsk State Medical UniversityOmsk 644099Russia

Currently,the diagnostic strategy for chronic gastritis(CG)is aimed not just at fixing the presence of gastric mucosal inflammation,but also at gastric cancer(GC)risk stratification in a particular *** classification approach with the definition of the stage of gastritis determines the need,activities and frequency of dynamic monitoring of a ***,this attitude to the patient suffering from CG was far from *** present publication is a literature review describing the key milestones in the history of CG research,from the description of the first observations of inflammation of the gastric mucosa,assessment of gastritis as a predominantly functional disease,to the advent of endoscopy of the upper digestive tract and diagnostic gastric biopsy,assessment of the role of Helicobacter pylori infection in progression of inflammatory changes to atrophy,intestinal metaplasia,dysplasia and GC.

关键词： Chronic gastritis Intestinal metaplasia Dysplasia Gastric cancer Helicobacter pylori

Probing the endoplasmic reticulummitochondria interaction in Alzheimer's disease:searching far and wide

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Neural Regeneration Research 2024年第10期19卷 2103-2104页

作者： Giulia Dematteis Laura Tapella dmitry Lim Department of Pharmaceutical sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly

Alzheimer's disease(AD)is the most frequent,form of dementia in elderly people and is an incurable disease with an exponentially growing number of *** deposition of amyloid-β(Aβ)plaques and intraneuronal formation o... 详细信息

关键词： Alzheimer Aβ reticulum

Enhanced photoluminescence of a microporous quantum dot color conversion layer by inkjet printing

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Nano Research 2024年第8期17卷 7717-7725页

作者： Junchi Chen Qihao Jin Yidenekachew.J.Donie Orlando.T.Perales dmitry Busko Bryce.s.Richards Uli Lemmer Light Technology Institute(LTI) Karlsruhe Institute of Technology(KIT)Engesserstrasse 1376131 KarlsruheGermany Department of Chemical Engineering and Materials science University of Minnesota(UMN)421 Washington Ave.SEMinneapolisMN 55455-0132USA Institute for Microstructure Technology Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Owing to their high color purity,tunable bandgap,and high efficiency,quantum dots(QDs)have gained significant attention as color conversion materials for high-end display ***,inkjet-printed QD pixels show great potential for realizing full-color mini/micro-light emitting diode(micro-LED)-based *** a color conversion layer,the photoluminescence intensity of QDs is limited by the insufficient absorptance of the excitation light due to the lack of *** scatterers,such as titanium dioxide microparticles,have been applied after additional surface engineering for sufficient dispersity to prevent nozzle clogging in inkjet printing *** our work,as an alternative approach,we use inkjet printing for depositing a phase separating polymer ink based on polystyrene(Ps)and polyethylene glycol(PEG).QD/polymer composite pixels with scattering micropores are *** morphology of the micropores can be tailored by the weight ratio between Ps and PEG which enables the manipulation of scattering *** the presence of the microporous structure,the photoluminescence intensity of the QD film is enhanced by 110%in drop-cast films and by 35.3%in inkjet-printed QD pixel arrays compared to the reference samples.

关键词： porous structure inkjet printing phase separation quantum dots display technology

Manufacturer encroachment and carbon reduction decisions considering cap-and-trade policy and retailer investment

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Frontiers of Engineering Management 2024年第2期11卷 326-344页

作者： Pengpeng YUAN Jiasen sUN dmitry IVANOV Business school and Dongwu Think Tank Soochow UniversitySuzhou 235031China Berlin school of Economics and Law Berlin 999035Germany

Low-carbon regulation and market competition present new opportunities and challenges for supply chain firms,emphasizing the significance of carbon reduction and channel encroachment in enhancing *** study formulates various game models to evaluate manufacturers’encroachment strategies(with or without encroachment)under different conditions of low-carbon investment by *** investigates the operational decisions and carbon abatement strategies of firms under various *** findings reveal that encroachment elevates unit abatement levels but decreases wholesale prices and retailer profits when unit encroachment costs are below certain *** contrast,the manufacturer consistently benefits from channel ***-initiated low-carbon investments can motivate manufacturers to reduce emissions.A lower carbon price potentially offers financial advantages to retailer engaging in such ***,the likelihood of reduced environmental damage postchannel encroachment,compared to preprofessional encroachment,increases when the retailer invests in low-carbon *** retailer’s profit is inversely related to the carbon price,and a higher carbon price can strengthen the incentive effect of low-carbon investment on the manufacturer’s abatement endeavors.

关键词： carbon cap-and-trade channel encroachment emission reduction low-carbon investment

Wood anatomy chronologies of scots pine in the foothills of the Western sayan(siberia)

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Journal of Forestry Research 2024年第3期35卷 13-27页

作者： Elena A.Babushkina dmitry R.Dergunov Mikhail s.Zharkov Liliana V.Belokopytova Dina F.Zhirnova Bao Yang Jingjing Liu Xiaomei Peng Eugene A.Vaganov Khakass Technical Institute Siberian Federal UniversityAbakan 655017Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and IT Department Siberian Federal UniversityKrasnoyarsk 660036Russia Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China school of Geographic and Oceanographic sciences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

Recent methodological advances in quantitative wood anatomy have provided new insights into the climatic responses of radial growth at the scale of cell structure of tree rings. This study considered long-term chronologies of tracheid measurements, indexed by a novel approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width). To fill gaps in understanding the impact of climate on conifer xylem structure, scots pine(Pinus sylvestris L.)trees > 200 years old were selected within the forest-steppe zone in southern siberia. such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes. Mean and maximum values of cell radial diameter and cell wall thickness were recorded for each tree *** a low level of climatogenic stress, components of cell chronologies independent of cambial activity were separated to obtain significant climatic signals revealing the timing of the specific stages of tracheid differentiation. Cell expansion lasted from mid-April to July and was impacted similarly to tree-ring width(stimulated by precipitation and stressed by heat), maximum cell size formed late June. A switch in the climatic responses of mean anatomical traits indicated transition to latewood in mid-July. secondary wall deposition lasted until mid-september, suppressed by end of season temperatures. Generally, anatomical climatic responses were modulated by a less dry May and september compared with summer months.

关键词： Quantitative wood anatomy Cell radial size Cell wall thickness Pinus sylvestris Climatic response

Multivariate statistical and bioinformatic analyses for the seasonal variations of actinobacterial community structures in a drinking water reservoir

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Journal of Environmental sciences 2024年第3期137卷 1-17页

作者： Haihan Zhang sixuan Pan BenMa Tinglin Huang dmitry B.Kosolapov Manli Ma Xiang Liu Huan Liu Xiaoyan Liu shaanxi Key Laboratory of Environmental Engineering Key Laboratory of Northwest Water ResourceEnvironment and EcologyMOEXi’an University of Architecture and TechnologyXi’an 710055China school of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Papanin Institute for Biology of Inland Waters of Russian Academy of sciences(IBIW RAs) 109BorokNekouzYaroslavl152742Russia

Actinobacterial community is a conspicuous part of aquatic ecosystems and displays an important role in the case of biogeochemical cycle,but little is known about the seasonal variation of actinobacterial community in reservoir ecological *** this study,the high-throughput techniques were used to investigate the structure of the aquatic actinobacterial community and its inducing water quality parameters in different *** results showed that the highest diversity and abundance of actinobacterial community occurred in winter,with sporichthya(45.42%)being the most abundant genus and Rhodococcus sp.(29.32%)being the most abundant *** analysis and correlation analysis suggested that in autumn the dynamics of actinobacterial community were infuenced by more factors and Nocardioides ***2R5s2 was the potential keystone species which was negatively correlated with temperature(R=-0.72,Ps in environmental factors could significantly affect the changes in actinobacterial community,and the dynamics of temperature,dissolved oxygen(DO),and turbidity are potential conspicuous factors infuencing seasonal actinobacterial community *** partial least squares path modeling further elucidated that the combined effects of DO and temperature not only in the diversity of actinobacterial community but also in other water qualities,while the physiochemical parameters(path coefficient=1.571,Ps strong environmental factors in natural mixture *** results strengthen our understanding of the dynamics and structures of actinobacterial community in the drinking water reservoirs and provide scientific guidance for further water quality management and protection in water sources.

关键词： source water reservoir High-throughput sequencing Correlation analysis Network analysis Partial least squares path modeling

Expanded Porphyrin Exhibiting Off-Centered Out-of-Plane Coordination to Dysprosium

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CCs Chemistry 2024年第7期6卷 1731-1738页

作者： dmitry I.Nazarov Jorge Labella Alexey V.Kuzmin Maxim A.Faraonov Evgenii N.Ivanov salavat s.Khasanov Tomas Torres Mikhail K.Islyaikin Dmitri V.Konarev Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAs 142432 Chernogolovka Department of Organic Chemistry Universidad Autonoma de Madrid28049 Madrid Institute of solid-state Physics RAs 142432 Chernogolovka Research Institute of Macroheterocycles Ivanovo State University of Chemistry and Technology15300 Ivanovo G.A.Krestov Institute of solution Chemistry of the Russian Academy of sciences 153045 Ivanovo Institute for Advanced Research in Chemical sciences Universidad Autonoma de Madrid28049 Madrid IMDEA-Nanociencia 28049 Madrid

The complexation of high-spin lanthanides to porphyrinoids is a powerful strategy for the development of advanced molecular *** this context,the use of expanded porphyrinoids remains elusive since their coordination chemistry is challenging to ***,taking inspiration from on-surface chemistry,we explored the coordination of Dy^(3+)to a six-membered porphyrinoid,namely,the hemihexaphyrazine ***,we observed the selective formation of a mono-nuclear off-centered,out-of-plane H_(2)Hhp-Dy^(3+)complex when performing the complexation under reductive *** this reaction,the oxidation state of the macrocycle did not *** X-ray diffraction analysis,we found that the coordination number of Dy in this complex was *** macrocycle cocrystallized with decamethylcobaltocene(Cp_(2)^(*)Co)molecules,giving rise to a wellordered solid-state packing,governed byπ-π*** a result of this organization,a small magnetic coupling between the neighboring molecules was *** in all,this work provides key insights into the coordination of magnetically active metals with expanded porphyrinoids,thus motivating the development of advanced spintronic devices.

关键词： porphyrins dysprosium macrocycle coordination chemistry magnetism

Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr s.slavich Georgy A.Ermolaev Mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.Matveeva Dmitriy V.Grudinin Kirill V.Voronin Arslan Mazitov Konstantin V.Kravtsov Alexander V.syuy dmitry M.Tsymbarenko Mikhail s.Mironov sergey M.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.Vyshnevyy Aleksey V.Arsenin Valentyn s.Volkov Kostya s.Novoselov Moscow Center for Advanced studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of Materials science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2s3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2s3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high